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Items: 1 to 20 of 123

1.
Decreased NSD2 impairs stromal cell proliferation in human endometrium via reprogramming H3K36me2
Chuan-Mei Qin, Xiao-Wei Wei, Jia-Yi Wu, Xue-Qing Liu, Yi Lin
Reproduction. 2024 Mar 1; 167(3): e230254. Prepublished online 2024 Jan 18. Published online 2024 Feb 12. doi: 10.1530/REP-23-0254
PMCID:
PMC10895284
AbstractArticlePDF–9.0M
2.
Clinical details of individuals with Rauch–Steindl syndrome due to NSD2 truncating variants
Eriko Nishi, Kumiko Yanagi, Tadashi Kaname, Nobuhiko Okamoto
Mol Genet Genomic Med. 2024 Feb; 12(2): e2396. Published online 2024 Feb 14. doi: 10.1002/mgg3.2396
PMCID:
PMC10865147
AbstractArticlePDF–1.6M
3.
WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression
Jia Yan, Ming Yang Zhang, Jing Lin, Ke Xin Li, Zhi Min Zhao, Yu Min Gao, Xiu Ling Deng, Chang Shan Wang, Hai Sheng Wang
J Cell Mol Med. 2023 May; 27(10): 1436–1441. Published online 2023 Apr 18. doi: 10.1111/jcmm.17743
PMCID:
PMC10183708
AbstractArticlePDF–4.3M
4.
The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM
Nicholas Stong, María Ortiz-Estévez, Fadi Towfic, Mehmet Samur, Amit Agarwal, Jill Corre, Erin Flynt, Nikhil Munshi, Hervé Avet-Loiseau, Anjan Thakurta
Blood. 2023 Mar 30; 141(13): 1574–1583. Published online 2022 Aug 23. doi: 10.1182/blood.2022016212
PMCID:
PMC10163314
AbstractArticle
5.
NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization
Sonali Narang, Nikki A. Evensen, Jason Saliba, Joanna Pierro, Mignon L. Loh, Patrick A. Brown, Pandurang Kolekar, Heather Mulder, Ying Shao, John Easton, Xiaotu Ma, Aristotelis Tsirigos, William L. Carroll
Genome Biol. 2023; 24: 64. Published online 2023 Apr 4. doi: 10.1186/s13059-023-02905-0
PMCID:
PMC10071675
AbstractArticlePDF–11M
6.
H3K36me2 methyltransferase NSD2 orchestrates epigenetic reprogramming during spermatogenesis
Zhiming Li, Xinzong Zhang, Shiming Xie, Xingping Liu, Caifeng Fei, Xunbin Huang, Yunge Tang, Li-quan Zhou
Nucleic Acids Res. 2022 Jul 8; 50(12): 6786–6800. Published online 2022 Jun 23. doi: 10.1093/nar/gkac533
PMCID:
PMC9262605
AbstractArticlePDF–5.9M
7.
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
David Dilworth, Ronan P. Hanley, Renato Ferreira de Freitas, Abdellah Allali-Hassani, Mengqi Zhou, Naimee Mehta, Matthew R. Marunde, Suzanne Ackloo, Raquel Arminda Carvalho Machado, Aliakbar Khalili Yazdi, Dominic D. G. Owens, Victoria Vu, David Y. Nie, Mona Alqazzaz, Edyta Marcon, Fengling Li, Irene Chau, Albina Bolotokova, Su Qin, Ming Lei, Yanli Liu, Magdalena M. Szewczyk, Aiping Dong, Sina Kazemzadeh, Tigran Abramyan, Irina K. Popova, Nathan W. Hall, Matthew J. Meiners, Marcus A. Cheek, Elisa Gibson, Dmitri Kireev, Jack F. Greenblatt, Michael-C. Keogh, Jinrong Min, Peter J. Brown, Masoud Vedadi, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy, Lindsey I. James, Matthieu Schapira
Nat Chem Biol. Author manuscript; available in PMC 2023 Jan 1.
Published in final edited form as: Nat Chem Biol. 2022 Jan; 18(1): 56–63. Published online 2021 Nov 15. doi: 10.1038/s41589-021-00898-0
PMCID:
PMC9189931
AbstractArticlePDF–3.2M
8.
From Wolf-Hirschhorn syndrome to NSD2 haploinsufficiency: a shifting paradigm through the description of a new case and a review of the literature
Luisa Cortellazzo Wiel, Irene Bruno, Egidio Barbi, Fabio Sirchia
Ital J Pediatr. 2022; 48: 72. Published online 2022 May 12. doi: 10.1186/s13052-022-01267-w
PMCID:
PMC9097050
AbstractArticlePDF–766K
9.
Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2
Ko Sato, Amarjeet Kumar, Keisuke Hamada, Chikako Okada, Asako Oguni, Ayumi Machiyama, Shun Sakuraba, Tomohiro Nishizawa, Osamu Nureki, Hidetoshi Kono, Kazuhiro Ogata, Toru Sengoku
Nat Commun. 2021; 12: 6605. Published online 2021 Nov 15. doi: 10.1038/s41467-021-26913-5
PMCID:
PMC8593083
AbstractArticlePDF–2.2M
10.
NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
Deepanwita Sengupta, Liyong Zeng, Yumei Li, Simone Hausmann, Debopam Ghosh, Gang Yuan, Thuyen N. Nguyen, Ruitu Lyu, Marcello Caporicci, Ana Morales Benitez, Garry L. Coles, Vladlena Kharchenko, Iwona Czaban, Dulat Azhibek, Wolfgang Fischle, Mariusz Jaremko, Ignacio I. Wistuba, Julien Sage, Łukasz Jaremko, Wei Li, Pawel K. Mazur, Or Gozani
Mol Cell. Author manuscript; available in PMC 2022 Nov 4.
Published in final edited form as: Mol Cell. 2021 Nov 4; 81(21): 4481–4492.e9. Published online 2021 Sep 22. doi: 10.1016/j.molcel.2021.08.034
PMCID:
PMC8571016
AbstractArticlePDF–2.2M
11.
Identification of histone methyltransferase NSD2 as an important oncogenic gene in colorectal cancer
Li-hao Zhao, Quan Li, Zhi-Jun Huang, Mi-Xue Sun, Jing-jing Lu, Xiao-hua Zhang, Gang Li, Fang Wu
Cell Death Dis. 2021 Nov; 12(11): 974. Published online 2021 Oct 20. doi: 10.1038/s41419-021-04267-6
PMCID:
PMC8528846
AbstractArticlePDF–4.5M
12.
Loss-of-function and missense variants in NSD2 cause decreased methylation activity and are associated with a distinct developmental phenotype
Paolo Zanoni, Katharina Steindl, Deepanwita Sengupta, Pascal Joset, Angela Bahr, Heinrich Sticht, Mariarosaria Lang-Muritano, Conny M. A. van Ravenswaaij-Arts, Marwan Shinawi, Marisa Andrews, Tania Attie-Bitach, Isabelle Maystadt, Newell Belnap, Valerie Benoit, Geoffroy Delplancq, Bert B. A. de Vries, Sarah Grotto, Didier Lacombe, Austin Larson, Jeroen Mourmans, Katrin Õunap, Giulia Petrilli, Rolph Pfundt, Keri Ramsey, Lot Snijders Blok, Vassilis Tsatsaris, Antonio Vitobello, Laurence Faivre, Patricia G. Wheeler, Marijke R. Wevers, Monica Wojcik, Markus Zweier, Or Gozani, Anita Rauch
Genet Med. 2021; 23(8): 1474–1483. Published online 2021 May 3. doi: 10.1038/s41436-021-01158-1
PMCID:
PMC8354849
AbstractArticlePDF–2.3M
13.
WHSC1/NSD2 regulates immune infiltration in prostate cancer
Muzamil Y Want, Takemasa Tsuji, Prashant K Singh, James L Thorne, Junko Matsuzaki, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Richard C. Koya, Amit Lugade, Kunle Odunsi, Sebastiano Battaglia
J Immunother Cancer. 2021; 9(2): e001374. Published online 2021 Feb 15. doi: 10.1136/jitc-2020-001374
PMCID:
PMC7887377
AbstractArticlePDF–5.1M
14.
The first familial NSD2 cases with a novel variant in a Chinese father and daughter with atypical WHS facial features and a 7.5-year follow-up of growth hormone therapy
Xuyun Hu, Di Wu, Yuchuan Li, Liya Wei, Xiaoqiao Li, Miao Qin, Hongdou Li, Mengting Li, Shaoke Chen, Chunxiu Gong, Yiping Shen
BMC Med Genomics. 2020; 13: 181. Published online 2020 Dec 4. doi: 10.1186/s12920-020-00831-9
PMCID:
PMC7716467
AbstractArticlePDF–1.4M
15.
Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes
Junjian Wang, Zhijian Duan, Zoann Nugent, June X. Zou, Alexander D. Borowsky, Yanhong Zhang, Clifford G. Tepper, Jian Jian Li, Oliver Fienh, Jianzhen Xu, Hsing-Jien Kung, Leigh Murphy, Hong-Wu Chen
Cancer Lett. Author manuscript; available in PMC 2020 Sep 21.
Published in final edited form as: Cancer Lett. 2016 Aug 10; 378(2): 69–79. Published online 2016 May 6. doi: 10.1016/j.canlet.2016.05.004
PMCID:
PMC7505026
AbstractArticlePDF–992K
16.
The NSD2 p.E1099K Mutation is Enriched at Relapse and Confers Drug Resistance in a Cell Context Dependent Manner in Pediatric Acute Lymphoblastic Leukemia
Joanna Pierro, Jason Saliba, Sonali Narang, Gunjan Sethia, Shella Saint Fleur-Lominy, Ashfiyah Chowdhury, Anita Qualls, Hannah Fay, Harrison L. Kilberg, Takaya Moriyama, Tori J. Fuller, David T. Teachey, Kjeld Schmiegelow, Jun J. Yang, Mignon L. Loh, Patrick A. Brown, Jinghui Zhang, Xiaotu Ma, Aristotelis Tsirigos, Nikki A. Evensen, William L. Carroll
Mol Cancer Res. Author manuscript; available in PMC 2021 Feb 1.
Published in final edited form as: Mol Cancer Res. 2020 Aug; 18(8): 1153–1165. Published online 2020 Apr 24. doi: 10.1158/1541-7786.MCR-20-0092
PMCID:
PMC7415532
AbstractArticlePDF–1.7M
17.
Knockdown of NSD2 Suppresses Renal Cell Carcinoma Metastasis by Inhibiting Epithelial-Mesenchymal Transition
Xu Han, Lianhua Piao, Xiaofeng Yuan, Luhui Wang, Zhiwei Liu, Xiaozhou He
Int J Med Sci. 2019; 16(10): 1404–1411. Published online 2019 Sep 20. doi: 10.7150/ijms.36128
PMCID:
PMC6818196
AbstractArticlePDF–1.7M
18.
NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
Priscillia Lhoumaud, Sana Badri, Javier Rodriguez-Hernaez, Theodore Sakellaropoulos, Gunjan Sethia, Andreas Kloetgen, MacIntosh Cornwell, Sourya Bhattacharyya, Ferhat Ay, Richard Bonneau, Aristotelis Tsirigos, Jane A. Skok
Nat Commun. 2019; 10: 4843. Published online 2019 Oct 24. doi: 10.1038/s41467-019-12811-4
PMCID:
PMC6813313
AbstractArticlePDF–4.4M
19.
De novo truncating variant in NSD2gene leading to atypical Wolf-Hirschhorn syndrome phenotype
Yanrui Jiang, Huizhen Sun, Qingmin Lin, Zengge Wang, Guanghai Wang, Jian Wang, Fan Jiang, Ruen Yao
BMC Med Genet. 2019; 20: 134. Published online 2019 Aug 5. doi: 10.1186/s12881-019-0863-2
PMCID:
PMC6683463
AbstractArticlePDF–594K
20.
An Activating Mutation of the NSD2 Histone Methyltransferase Drives Oncogenic Reprogramming in Acute Lymphocytic Leukemia
Alok Swaroop, Jon A. Oyer, Christine M. Will, Xiaoxiao Huang, Wenbo Yu, Catalina Troche, Marinka Bulic, Benjamin H. Durham, Qiang Jeremy Wen, John D. Crispino, Alexander D. MacKerell, Jr, Richard L. Bennett, Neil L. Kelleher, Jonathan D. Licht
Oncogene. Author manuscript; available in PMC 2019 Feb 28.
Published in final edited form as: Oncogene. 2019 Jan; 38(5): 671–686. Published online 2018 Aug 31. doi: 10.1038/s41388-018-0474-y
PMCID:
PMC6358490
AbstractArticlePDF–1.1M

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