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Select item 85840411.

BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma

Toshiyuki Nagata, Kentaro Minami, Masatatsu Yamamoto, Tsubasa Hiraki, Masashi Idogawa, Katsumi Fujimoto, Shun Kageyama, Kazuhiro Tabata, Kohichi Kawahara, Kazuhiro Ueda, Ryuji Ikeda, Yukio Kato, Masaaki Komatsu, Akihide Tanimoto, Tatsuhiko Furukawa, Masami Sato

Int J Mol Sci. 2021 Nov; 22(21): 11509. Published online 2021 Oct 26. doi: 10.3390/ijms222111509

PMCID:: PMC8584041

Abstract Article PDF–7.0M

Select item 81208372.

Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma

Xiao Yang, Jia-shun Wu, Mao Li, Wei-long Zhang, Xiao-lei Gao, Hao-fan Wang, Xiang-hua Yu, Xin Pang, Mei Zhang, Xin-hua Liang, Ya-ling Tang

J Exp Clin Cancer Res. 2021; 40: 169. Published online 2021 May 14. doi: 10.1186/s13046-021-01956-0

PMCID:: PMC8120837

Abstract Article PDF–10M

Select item 75694333.

DEC2 Serves as Potential Tumor Suppressor in Breast Carcinoma

Wentong Fang, Qian Li, Min Wang, Mingjie Zheng, Huirong Xu

Dis Markers. 2020; 2020: 6053154. Published online 2020 Oct 10. doi: 10.1155/2020/6053154

PMCID:: PMC7569433

Abstract Article PDF–2.2M

Select item 71713114.

BHLHE41 suppresses MCF‐7 cell invasion via MAPK/JNK pathway

Di Zhang, Qin Zheng, Chen Wang, Na Zhao, Yang Liu, Enhua Wang

J Cell Mol Med. 2020 Apr; 24(7): 4001–4010. Published online 2020 Feb 19. doi: 10.1111/jcmm.15033

PMCID:: PMC7171311

Abstract Article PDF–1.4M

Select item 64124005.

Overexpression of BHLHE41, correlated with DNA hypomethylation in 3′UTR region, promotes the growth of human clear cell renal cell carcinoma

Zhouji Shen, Ling Zhu, Chao Zhang, Xiaobo Cui, Jun Lu

Oncol Rep. 2019 Apr; 41(4): 2137–2147. Published online 2019 Feb 7. doi: 10.3892/or.2019.7004

PMCID:: PMC6412400

Abstract Article PDF–1.3M

Select item 58797156.

DEC2 modulates orexin expression and regulates sleep

Arisa Hirano, Pei-Ken Hsu, Luoying Zhang, Lijuan Xing, Thomas McMahon, Maya Yamazaki, Louis J. Ptáček, Ying-Hui Fu

Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13): 3434–3439. Published online 2018 Mar 12. doi: 10.1073/pnas.1801693115

PMCID:: PMC5879715

Abstract Article PDF–913K

Select item 51177537.

Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells

Qiang Liu, Yunyan Wu, Tadashi Yoshizawa, Xu Yan, Satoko Morohashi, Hiroko Seino, Yukio Kato, Hiroshi Kijima

Int J Mol Med. 2016 Dec; 38(6): 1727–1733. Published online 2016 Nov 8. doi: 10.3892/ijmm.2016.2798

PMCID:: PMC5117753

Abstract Article PDF–1.0M

Select item 46925478.

Differentially Expressed in Chondrocytes 2 (DEC2) Increases the Expression of IL-1β and Is Abundantly Present in Synovial Membrane in Rheumatoid Arthritis

Juri Olkkonen, Vesa-Petteri Kouri, Joel Hynninen, Yrjö T. Konttinen, Jami Mandelin

PLoS One. 2015; 10(12): e0145279. Published online 2015 Dec 28. doi: 10.1371/journal.pone.0145279

PMCID:: PMC4692547

Abstract Article PDF–2.6M

Select item 42270679.

Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer

Yun Liao, Xiaoying He, Haifeng Qiu, Qi Che, Fangyuan Wang, Wen Lu, Zheng Chen, Meiting Qiu, Jingyun Wang, Huihui Wang, Xiaoping Wan

BMC Cancer. 2014; 14: 487. Published online 2014 Jul 5. doi: 10.1186/1471-2407-14-487

PMCID:: PMC4227067

Abstract Article PDF–3.5M

Select item 1038094810.

Approach to Functions of BHLHE41/DEC2 in Non-Small Lung Cancer Development

Tatsuhiko Furukawa, Kentaro Mimami, Toshiyuki Nagata, Masatasu Yamamoto, Masami Sato, Akihide Tanimoto

Int J Mol Sci. 2023 Jul; 24(14): 11731. Published online 2023 Jul 21. doi: 10.3390/ijms241411731

PMCID:: PMC10380948

Abstract Article PDF–598K

Select item 850876411.

The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation

Xingzhi Wang, Fuyuki Sato, Keiji Tanimoto, Niveda Rajeshwaran, Lakshmi Thangavelu, Makoto Makishima, Ujjal K. Bhawal

Int J Mol Sci. 2021 Oct; 22(19): 10349. Published online 2021 Sep 26. doi: 10.3390/ijms221910349

PMCID:: PMC8508764

Abstract Article PDF–747K

Select item 613166312.

Correlation between DEC1/DEC2 and epithelial-mesenchymal transition in human prostate cancer PC-3 cells

Qiang Liu, Yunyan Wu, Hiroko Seino, Toshihiro Haga, Tadashi Yoshizawa, Satoko Morohashi, Hiroshi Kijima

Mol Med Rep. 2018 Oct; 18(4): 3859–3865. Published online 2018 Aug 9. doi: 10.3892/mmr.2018.9367

PMCID:: PMC6131663

Abstract Article PDF–1.6M

Select item 591539113.

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qi-Ling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J. Deshpande, Robert S. Welner, Ruud Delwel, Henry Yang, Thomas A. Milne, Reshma Taneja, Daniel G. Tenen

Nat Commun. 2018; 9: 1622. Published online 2018 Apr 24. doi: 10.1038/s41467-018-03854-0

PMCID:: PMC5915391

Abstract Article PDF–2.1M

Select item 553643414.

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, Franziska Kranz, James L. Platt, James Smythies, Hani Choudhry, Margarete Goppelt-Struebe, Peter J. Ratcliffe, David R. Mole, Johannes Schödel

PLoS Genet. 2017 Jul; 13(7): e1006872. Published online 2017 Jul 17. doi: 10.1371/journal.pgen.1006872

PMCID:: PMC5536434

Abstract Article PDF–3.8M

Select item 494105515.

Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41

Pierre Bigot, Leandro M. Colli, Mitchell J. Machiela, Lea Jessop, Timothy A. Myers, Julie Carrouget, Sarah Wagner, David Roberson, Caroline Eymerit, Daniel Henrion, Stephen J. Chanock

Nat Commun. 2016; 7: 12098. Published online 2016 Jul 7. doi: 10.1038/ncomms12098

PMCID:: PMC4941055

Abstract Article PDF–1.5M

Select item 437971216.

DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas

Tu Hu, Nengbin He, Yunsong Yang, Chengqian Yin, Nianli Sang, Qingcheng Yang

J Exp Clin Cancer Res. 2015; 34(1): 22. Published online 2015 Feb 28. doi: 10.1186/s13046-015-0135-8

PMCID:: PMC4379712

Abstract Article PDF–1.5M

Select item 405341217.

SHARP1 Suppresses Angiogenesis of Endometrial Cancer by Decreasing Hypoxia-Inducible Factor-1α Level

Yun Liao, Wen Lu, Qi Che, Tingting Yang, Haifeng Qiu, Huijuan Zhang, Xiaoying He, Jingyun Wang, Meiting Qiu, Yingfen Zou, Wei Gu, Xiaoping Wan

PLoS One. 2014; 9(6): e99907. Published online 2014 Jun 11. doi: 10.1371/journal.pone.0099907

PMCID:: PMC4053412

Abstract Article PDF–11M

Select item 368256618.

Sumoylation of the Basic Helix-Loop-Helix Transcription Factor Sharp-1 Regulates Recruitment of the Histone Methyltransferase G9a and Function in Myogenesis

Yaju Wang, Shilpa Rani Shankar, Devaki Kher, Belinda Mei Tze Ling, Reshma Taneja

J Biol Chem. 2013 Jun 14; 288(24): 17654–17662. Published online 2013 Apr 30. doi: 10.1074/jbc.M113.463257

PMCID:: PMC3682566

Abstract Article PDF–2.2M

Select item 288498819.

The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

Ying He, Christopher R. Jones, Nobuhiro Fujiki, Ying Xu, Bin Guo, Jimmy L. Holder, Jr., Moritz J. Rossner, Seiji Nishino, Ying-Hui Fu

Science. Author manuscript; available in PMC 2010 Jun 14.

Published in final edited form as: Science. 2009 Aug 14; 325(5942): 866–870. doi: 10.1126/science.1174443

PMCID:: PMC2884988

Abstract Article PDF–701K

Select item 768695720.

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

Kimberly L. Carey, Geraldine L.C. Paulus, Lingfei Wang, Dale R. Balce, Jessica W. Luo, Phil Bergman, Ianina C. Ferder, Lingjia Kong, Nicole Renaud, Shantanu Singh, Maria Kost-Alimova, Beat Nyfeler, Kara G. Lassen, Herbert W. Virgin, Ramnik J. Xavier

Cell Rep. Author manuscript; available in PMC 2020 Nov 25.

Published in final edited form as: Cell Rep. 2020 Nov 10; 33(6): 108371. doi: 10.1016/j.celrep.2020.108371