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Select item 98425041.

CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages

Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Tong-Xing Lin, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ju-Li Lin, Ze-Ning Huang, Hua-Long Zheng, Jian-Wei Xie, Chao-Hui Zheng, Chang-Ming Huang

Cancer Gene Ther. 2023; 30(1): 22–37. Published online 2022 Aug 23. doi: 10.1038/s41417-022-00515-9

PMCID:: PMC9842504

Abstract Article PDF–8.1M

Select item 75255662.

CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer

Jian-xian Lin, Changhwan Yoon, Ping Li, Sandra W. Ryeom, Soo-Jeong Cho, Chao-hui Zheng, Jian-wei Xie, Jian-bin Wang, Jun Lu, Qi-yue Chen, Sam S. Yoon, Chang-ming Huang

Br J Cancer. 2020 Sep 29; 123(7): 1131–1144. Published online 2020 Jul 1. doi: 10.1038/s41416-020-0963-y

PMCID:: PMC7525566

Abstract Article PDF–3.2M

Select item 75156353.

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

Madlen Stephani, Lorenzo Picchianti, Alexander Gajic, Rebecca Beveridge, Emilio Skarwan, Victor Sanchez de Medina Hernandez, Azadeh Mohseni, Marion Clavel, Yonglun Zeng, Christin Naumann, Mateusz Matuszkiewicz, Eleonora Turco, Christian Loefke, Baiying Li, Gerhard Dürnberger, Michael Schutzbier, Hsiao Tieh Chen, Alibek Abdrakhmanov, Adriana Savova, Khong-Sam Chia, Armin Djamei, Irene Schaffner, Steffen Abel, Liwen Jiang, Karl Mechtler, Fumiyo Ikeda, Sascha Martens, Tim Clausen, Yasin Dagdas

eLife. 2020; 9: e58396. Published online 2020 Aug 27. doi: 10.7554/eLife.58396

PMCID:: PMC7515635

Abstract Article PDF–12M

Select item 64669614.

CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer

Jun Li, Xinyi Hu, Ming Su, Hongliang Shen, Wei Qiu, Ye Tian

Dis Markers. 2019; 2019: 6171782. Published online 2019 Apr 2. doi: 10.1155/2019/6171782

PMCID:: PMC6466961

Abstract Article PDF–3.1M

Select item 64481265.

Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway

Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Sheng-Liang Qiu, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chang-Ming Huang, Chao-Hui Zheng

Oncol Rep. 2019 May; 41(5): 2739–2752. Published online 2019 Mar 5. doi: 10.3892/or.2019.7042

PMCID:: PMC6448126

Abstract Article PDF–1.5M

Select item 58529596.

CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer

Chao-Hui Zheng, Jia-Bin Wang, Man-Qiang Lin, Peng-Yang Zhang, Li-Chao Liu, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Jian-Wei Xie, Ping Li, Chang-Ming Huang

J Exp Clin Cancer Res. 2018; 37: 59. Published online 2018 Mar 14. doi: 10.1186/s13046-018-0716-4

PMCID:: PMC5852959

Abstract Article PDF–4.5M

Select item 31975207.

Identification of LZAP as a New Candidate Tumor Suppressor in Hepatocellular Carcinoma

Jing-jing Zhao, Ke Pan, Jian-jun Li, Yi-bing Chen, Ju-gao Chen, Lin Lv, Dan-dan Wang, Qiu-zhong Pan, Min-shan Chen, Jian-chuan Xia

PLoS One. 2011; 6(10): e26608. Published online 2011 Oct 19. doi: 10.1371/journal.pone.0026608

PMCID:: PMC3197520

Abstract Article PDF–670K

Select item 31466248.

A Functional Variant of IC53 Correlates with the Late Onset of Colorectal Cancer

Jingzhou Chen, Yi Shi, Ziyu Li, Hui Yu, Yu Han, Xiaojian Wang, Kai Sun, Tao Yang, Kejia Lou, Yan Song, Yinhui Zhang, Yisong Zhen, Guiguo Zhang, Ying Hu, Jiafu Ji, Rutai Hui

Mol Med. 2011 Jul-Aug; 17(7-8): 607–618. Published online 2011 Mar 2. doi: 10.2119/molmed.2010.00192

PMCID:: PMC3146624

Abstract Article PDF–2.4M

Select item 65571279.

C53: A Novel Particulate Guanylyl Cyclase B Receptor Activator That Has Sustained Activity In Vivo With Anti-Fibrotic Actions in Human Cardiac and Renal Fibroblasts

Yang Chen, Ye Zheng, Seethalakshmi R. Iyer, Gerald E. Harders, Shuchong Pan, Horng H. Chen, Tomoko Ichiki, John C. Burnett, Jr, S. Jeson Sangaralingham

J Mol Cell Cardiol. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: J Mol Cell Cardiol. 2019 May; 130: 140–150. Published online 2019 Apr 4. doi: 10.1016/j.yjmcc.2019.03.024

PMCID:: PMC6557127

Abstract Article PDF–2.2M

Select item 614133610.

Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer

Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chang-Ming Huang

World J Gastroenterol. 2018 Sep 14; 24(34): 3898–3907. Published online 2018 Sep 14. doi: 10.3748/wjg.v24.i34.3898

PMCID:: PMC6141336

Abstract Article PDF–2.0M

Select item 461125411.

Induction of HSF1 expression is associated with sporadic colorectal cancer

Hui Cen, Shu Zheng, Yong-Ming Fang, Xiao-Ping Tang, Qi Dong

World J Gastroenterol. 2004 Nov 1; 10(21): 3122–3126. Published online 2004 Nov 1. doi: 10.3748/wjg.v10.i21.3122

PMCID:: PMC4611254

Abstract Article PDF–103K

Select item 340913112.

CDK5RAP3 Is a Novel Repressor of p14^ARF in Hepatocellular Carcinoma Cells

Grace Wing-Yan Mak, Wai-Lung Lai, Yuan Zhou, Mingtao Li, Irene Oi-Lin Ng, Yick-Pang Ching

PLoS One. 2012; 7(7): e42210. Published online 2012 Jul 31. doi: 10.1371/journal.pone.0042210

PMCID:: PMC3409131

Abstract Article PDF–1.0M

Select item 1107737213.

TSPAN6 reinforces the malignant progression of glioblastoma via interacting with CDK5RAP3 and regulating STAT3 signaling pathway

Chong Zhang, Fei-hua Du, Rou-xin Wang, Wen-bo Han, Xing Lv, Ling-hui Zeng, Guo-qing Chen

Int J Biol Sci. 2024; 20(7): 2440–2453. Published online 2024 Apr 15. doi: 10.7150/ijbs.85984

PMCID:: PMC11077372

Abstract Article PDF–13M

Select item 627917514.

Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice

Ming-Lei Zhuo, Yue Huang, Jing-Zhou Chen, Li-Hong Sun, Rui-Feng Yang, Hou-Zao Chen, Xiang Lv, Hong-Liang Li, Yu-Sheng Wei, Guang Liu, Ran Zhang, Tie-Min Ma, Hua Cai, Ru-Tai Hui, De-Pei Liu, Chih-Chuan Liang

Cardiovasc Res. 2009 Nov 1; 84(2): 292–299. Published online 2009 Jun 18. doi: 10.1093/cvr/cvp204

PMCID:: PMC6279175

Abstract Article PDF–297K

Select item 364159815.

Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope

Jianchun Wu, Hai Jiang, Shouqing Luo, Mingsheng Zhang, Yinghua Zhang, Fei Sun, Shuang Huang, Honglin Li

Cell Res. 2013 May; 23(5): 691–704. Published online 2013 Mar 12. doi: 10.1038/cr.2013.36

PMCID:: PMC3641598

Abstract Article PDF–1.1M

Select item 344445616.

Expression of TIP-1 Confers Radioresistance of Malignant Glioma Cells

Miaojun Han, Hailun Wang, Hua-Tang Zhang, Zhaozhong Han

PLoS One. 2012; 7(9): e45402. Published online 2012 Sep 17. doi: 10.1371/journal.pone.0045402

PMCID:: PMC3444456

Abstract Article PDF–3.5M

Select item 1093738017.

The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons

Linda Makhlouf, Joshua J. Peter, Helge M. Magnussen, Rohan Thakur, David Millrine, Thomas C. Minshull, Grace Harrison, Joby Varghese, Frederic Lamoliatte, Martina Foglizzo, Thomas Macartney, Antonio N. Calabrese, Elton Zeqiraj, Yogesh Kulathu

Nature. 2024; 627(8003): 437–444. Published online 2024 Feb 21. doi: 10.1038/s41586-024-07093-w

PMCID:: PMC10937380

Abstract Article PDF–16M

Select item 962766618.

A non‐canonical scaffold‐type E3 ligase complex mediates protein UFMylation

Joshua J Peter, Helge M Magnussen, Paul A DaRosa, David Millrine, Stephen P Matthews, Frederic Lamoliatte, Ramasubramanian Sundaramoorthy, Ron R Kopito, Yogesh Kulathu

EMBO J. 2022 Nov; 41(21): e111015. Published online 2022 Sep 19. doi: 10.15252/embj.2022111015