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Select item 112425441.

A PNPLA3-Deficient iPSC-Derived Hepatocyte Screen Identifies Pathways to Potentially Reduce Steatosis in Metabolic Dysfunction-Associated Fatty Liver Disease

Caren Doueiry, Christiana S. Kappler, Carla Martinez-Morant, Stephen A. Duncan

Int J Mol Sci. 2024 Jul; 25(13): 7277. Published online 2024 Jul 2. doi: 10.3390/ijms25137277

PMCID:: PMC11242544

Abstract Article PDF–5.8M

Select item 110670372.

The fatty liver disease–causing protein PNPLA3-I148M alters lipid droplet–Golgi dynamics

David J. Sherman, Lei Liu, Jennifer L. Mamrosh, Jiansong Xie, John Ferbas, Brett Lomenick, Mark S. Ladinsky, Rati Verma, Ingrid C. Rulifson, Raymond J. Deshaies

Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18): e2318619121. Published online 2024 Apr 24. doi: 10.1073/pnas.2318619121

PMCID:: PMC11067037

Abstract Article PDF–6.4M

Select item 110549633.

The Role of PNPLA3_rs738409 Gene Variant, Lifestyle Factors, and Bioactive Compounds in Nonalcoholic Fatty Liver Disease: A Population-Based and Molecular Approach towards Healthy Nutrition

Meiling Liu, Sunmin Park

Nutrients. 2024 Apr; 16(8): 1239. Published online 2024 Apr 21. doi: 10.3390/nu16081239

PMCID:: PMC11054963

Abstract Article PDF–2.7M

Select item 108596144.

Association of liver fibrosis with extrahepatic cancer in steatotic liver disease patients with PNPLA3 I148M GG genotype

Jennifer Tai, Chao‐Wei Hsu, Wei‐Ting Chen, Sien‐Sing Yang, Cheng‐Hsun Chiu, Rong‐Nan Chien, Ming‐Ling Chang

Cancer Sci. 2024 Feb; 115(2): 564–574. Published online 2023 Dec 11. doi: 10.1111/cas.16042

PMCID:: PMC10859614

Abstract Article PDF–820K

Select item 105502065.

PNPLA3 genotype and diabetes identify patients with non-alcoholic fatty liver disease at high risk of incident cirrhosis

Vincent L. Chen, Antonino Oliveri, Matthew J. Miller, Karn Wijarnpreecha, Xiaomeng Du, Yanhua Chen, Kelly C. Cushing, Anna S. Lok, Elizabeth K. Speliotes

Gastroenterology. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Gastroenterology. 2023 May; 164(6): 966–977.e17. Published online 2023 Feb 7. doi: 10.1053/j.gastro.2023.01.040

PMCID:: PMC10550206

Abstract Article PDF–860K

Select item 104317386.

The variability of PNPLA3 gene as a potential marker of cold adaptation in Yakuts

Nadezhda Ivanovna Pavlova, Alexey Alexeevich Bochurov, Vladislav Amirovich Alekseev, Lyubov Akhmedovna Sydykova, Vladimir Vladimirovich Dodokhov, Khariton Alekseevich Kurtanov, Alexey Vasilievich Krylov

Int J Circumpolar Health. 2023; 82(1): 2246647. Published online 2023 Aug 15. doi: 10.1080/22423982.2023.2246647

PMCID:: PMC10431738

Abstract Article PDF–1.0M

Select item 102532637.

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction

Yusong Gou, Lifei Wang, Jinhan Zhao, Xiaoyi Xu, Hangfei Xu, Fang Xie, Yanjun Wang, Yingmei Feng, Jing Zhang, Yang Zhang

Int J Mol Sci. 2023 Jun; 24(11): 9681. Published online 2023 Jun 2. doi: 10.3390/ijms24119681

PMCID:: PMC10253263

Abstract Article PDF–3.7M

Select item 100319608.

PNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content

Ákos Nádasdi, Viktor Gál, Tamás Masszi, Anikó Somogyi, Gábor Firneisz

Cardiovasc Diabetol. 2023; 22: 64. Published online 2023 Mar 21. doi: 10.1186/s12933-023-01792-w

PMCID:: PMC10031960

Abstract Article PDF–1.0M

Select item 100266649.

Association of PNPLA3 SNP With the Development of HBV-related Hepatocellular Carcinoma

HIRAYUKI ENOMOTO, NOBUHIRO AIZAWA, NAOTO IKEDA, TOMOYUKI TAKASHIMA, YUKIHISA YURI, MAMIKO OKAMOTO, RYOTA YOSHIOKA, SHOKI KAWATA, KOHEI YOSHIHARA, SHOGO OTA, RYOTA NAKANO, HIDEYUKI SHIOMI, TAKASHI NISHIMURA, HIROKO IIJIMA

In Vivo. 2023 Mar-Apr; 37(2): 763–770. Published online 2023 Mar 3. doi: 10.21873/invivo.13139

PMCID:: PMC10026664

Abstract Article PDF–660K

Select item 999776710.

Patatin-like phospholipase domain-containing 3 gene (PNPLA3) polymorphic (rs738409) single nucleotide polymorphisms and susceptibility to nonalcoholic fatty liver disease: A meta-analysis of twenty studies

Yan Zhao, Wenli Zhao, Jingchao Ma, Maeda Toshiyoshi, Ye Zhao

Medicine (Baltimore) 2023 Mar 10; 102(10): e33110. Published online 2023 Mar 10. doi: 10.1097/MD.0000000000033110

PMCID:: PMC9997767

Abstract Article PDF–3.1M

Select item 982426211.

Interaction between the PNPLA3 Gene and Nutritional Factors on NAFLD Development: The Korean Genome and Epidemiology Study

Sooyeon Oh, Jooho Lee, Sukyung Chun, Ja-Eun Choi, Mi Na Kim, Young Eun Chon, Yeonjung Ha, Seong-Gyu Hwang, Sang-Woon Choi, Kyung-Won Hong

Nutrients. 2023 Jan; 15(1): 152. Published online 2022 Dec 28. doi: 10.3390/nu15010152

PMCID:: PMC9824262

Abstract Article PDF–816K

Select item 981842112.

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL

Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth, Beate Katharina Straub

Cells. 2023 Jan; 12(1): 73. Published online 2022 Dec 24. doi: 10.3390/cells12010073

PMCID:: PMC9818421

Abstract Article PDF–18M

Select item 977215013.

IL6/STAT3 axis dictates the PNPLA3-mediated susceptibility to non-alcoholic fatty liver disease

Jiwoon Park, Yuanyuan Zhao, Fan Zhang, Shaoyan Zhang, Andrew C. Kwong, Yujie Zhang, Hans-Heinrich Hoffmann, Leila Bushweller, Xin Wu, Alison W. Ashbrook, Branko Stefanovic, Shuyang Chen, Andrea D. Branch, Christopher E. Mason, Jae U. Jung, Charles M. Rice, Xianfang Wu

J Hepatol. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: J Hepatol. 2023 Jan; 78(1): 45–56. Published online 2022 Aug 30. doi: 10.1016/j.jhep.2022.08.022

PMCID:: PMC9772150

Abstract Article PDF–2.8M

Select item 971489914.

PNPLA3 allele frequency has no impact on biliary bile acid composition or disease course in patients with primary sclerosing cholangitis

Martti Färkkilä, Hannu Kautiainen, Andrea Tenca, Kalle Jokelainen, Johanna Arola

PLoS One. 2022; 17(12): e0277084. Published online 2022 Dec 1. doi: 10.1371/journal.pone.0277084

PMCID:: PMC9714899

Abstract Article PDF–813K

Select item 970688215.

Contribution of PNPLA3 gene polymorphisms to hepatocellular carcinoma susceptibility in the Chinese Han population

Dongwei Gong, Shizong Li, Zhiwei Yu, Kaiqiong Wang, Xin Qiao, Changxiong Wu

BMC Med Genomics. 2022; 15: 248. Published online 2022 Nov 29. doi: 10.1186/s12920-022-01394-7

PMCID:: PMC9706882

Abstract Article PDF–1.0M

Select item 968353716.

Emerging Metabolic and Transcriptomic Signature of PNPLA3-Associated NASH

Debanjan Dhar, Rohit Loomba

Hepatology. Author manuscript; available in PMC 2022 Nov 23.

Published in final edited form as: Hepatology. 2021 Apr; 73(4): 1248–1250. doi: 10.1002/hep.31735

PMCID:: PMC9683537

Article PDF–289K

Select item 953096717.

Synergistic Associations of PNPLA3 I148M Variant, Alcohol Intake, and Obesity With Risk of Cirrhosis, Hepatocellular Carcinoma, and Mortality

Hyun-seok Kim, Xiangjun Xiao, Jinyoung Byun, Goo Jun, Stacia M. DeSantis, Han Chen, Aaron P. Thrift, Hashem B. El-Serag, Fasiha Kanwal, Christopher I. Amos

JAMA Netw Open. 2022 Oct; 5(10): e2234221. Published online 2022 Oct 3. doi: 10.1001/jamanetworkopen.2022.34221

PMCID:: PMC9530967

Abstract Article

Select item 951981318.

PNPLA3 rs738409 and Risk of Fibrosis in NAFLD: Exploring Mediation Pathways Through Intermediate Histological Features

Eduardo Vilar-Gomez, Carlos J. Pirola, Silvia Sookoian, Laura A. Wilson, Tiebing Liang, Naga Chalasani

Hepatology. Author manuscript; available in PMC 2023 Nov 1.

Published in final edited form as: Hepatology. 2022 Nov; 76(5): 1482–1494. Published online 2022 Apr 21. doi: 10.1002/hep.32491

PMCID:: PMC9519813

Abstract Article PDF–904K

Select item 951246919.

Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

Elke Ericson, Linnéa Bergenholm, Anne‐Christine Andréasson, Carly I. Dix, Jane Knöchel, Sara F. Hansson, Richard Lee, Jennifer Schumi, Madeleine Antonsson, Ola Fjellström, Patrik Nasr, Mathias Liljeblad, Björn Carlsson, Stergios Kechagias, Daniel Lindén, Mattias Ekstedt

Hepatol Commun. 2022 Oct; 6(10): 2689–2701. Published online 2022 Jul 14. doi: 10.1002/hep4.2032

PMCID:: PMC9512469

Abstract Article PDF–3.6M

Select item 950171520.

The Risk of Cirrhosis and Its Complications Based on PNPLA3 rs738409 G Allele Frequency

Xue Shao, Haruki Uojima, Taeang Arai, Yuji Ogawa, Toru Setsu, Masanori Atsukawa, Yoshihiro Furuichi, Yoshitaka Arase, Kazue Horio, Hisashi Hidaka, Takahide Nakazawa, Makoto Kako, Tatehiro Kagawa, Katsuhiko Iwakiri, Atsushi Nakajima, Shuji Terai, Yasuhito Tanaka, Wasaburo Koizumi

Dig Dis. 2022 Sep; 40(5): 625–634. Published online 2021 Nov 22. doi: 10.1159/000521062