PMC Links for Gene (Select 83382) - PMC

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Select item 103659111.

Polysialic acid promotes remyelination in cerebellar slice cultures by Siglec-E-dependent modulation of microglia polarization

Lara-Jasmin Schröder, Hauke Thiesler, Lina Gretenkort, Thiemo Malte Möllenkamp, Martin Stangel, Viktoria Gudi, Herbert Hildebrandt

Front Cell Neurosci. 2023; 17: 1207540. Published online 2023 Jul 10. doi: 10.3389/fncel.2023.1207540

Correction in:: Front Cell Neurosci. 2023; 17: 1275048.

PMCID:: PMC10365911

Abstract Article PDF–6.8M

Select item 93018482.

Ablation of Siglec-E augments brain inflammation and ischemic injury

Lexiao Li, Yu Chen, Madison N. Sluter, Ruida Hou, Jiukuan Hao, Yin Wu, Guo-Yun Chen, Ying Yu, Jianxiong Jiang

J Neuroinflammation. 2022; 19: 191. Published online 2022 Jul 20. doi: 10.1186/s12974-022-02556-1

PMCID:: PMC9301848

Abstract Article PDF–7.6M

Select item 86538223.

O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells

Jinghua Yang, Wei Ma, Yuanyuan Wu, Hui Zhou, Siyu Song, Yuqi Cao, Chengxu Wang, Xiangyuan Liu, Jinwei Ren, Jinyou Duan, Zhichao Pei, Cheng Jin

Microbiol Spectr. 2021 Nov-Dec; 9(3): e00399-21. Published online 2021 Dec 8. doi: 10.1128/spectrum.00399-21

PMCID:: PMC8653822

Abstract Article PDF–3.3M

Select item 82560004.

Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity

Itziar Ibarlucea-Benitez, Polina Weitzenfeld, Patrick Smith, Jeffrey V. Ravetch

Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26): e2107424118. Published online 2021 Jun 21. doi: 10.1073/pnas.2107424118

PMCID:: PMC8256000

Abstract Article PDF–2.0M

Select item 79047305.

Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation

Hauke Thiesler, Julia Beimdiek, Herbert Hildebrandt

Cell Mol Life Sci. 2021 Feb; 78(4): 1637–1653. Published online 2020 Jul 28. doi: 10.1007/s00018-020-03601-z

PMCID:: PMC7904730

Abstract Article PDF–9.3M

Select item 64620886.

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing

Satoshi Uchiyama, Josh Sun, Kyoko Fukahori, Nao Ando, Mengyou Wu, Flavio Schwarz, Shoib S. Siddiqui, Ajit Varki, Jamey D. Marth, Victor Nizet

Proc Natl Acad Sci U S A. 2019 Apr 9; 116(15): 7465–7470. Published online 2019 Mar 25. doi: 10.1073/pnas.1815572116

PMCID:: PMC6462088

Abstract Article PDF–1.2M

Select item 63558497.

Siglec genes confer resistance to systemic lupus erythematosus in humans and mice

Rhonda Flores, Peng Zhang, Wei Wu, Xu Wang, Peiying Ye, Pan Zheng, Yang Liu

Cell Mol Immunol. 2019 Feb; 16(2): 154–164. Published online 2018 Mar 5. doi: 10.1038/cmi.2017.160

PMCID:: PMC6355849

Abstract Article PDF–5.3M

Select item 52476378.

Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E

Shoib Siddiqui, Flavio Schwarz, Stevan Springer, Zahra Khedri, Hai Yu, Lingquan Deng, Andrea Verhagen, Yuko Naito-Matsui, Weiping Jiang, Daniel Kim, Jie Zhou, Beibei Ding, Xi Chen, Nissi Varki, Ajit Varki

J Biol Chem. 2017 Jan 20; 292(3): 1029–1037. Published online 2016 Dec 5. doi: 10.1074/jbc.M116.738351

PMCID:: PMC5247637

Abstract Article PDF–2.5M

Select item 49754369.

Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm

Saptarshi Roy, Chitra Mandal

PLoS Negl Trop Dis. 2016 Aug; 10(8): e0004904. Published online 2016 Aug 5. doi: 10.1371/journal.pntd.0004904

PMCID:: PMC4975436

Abstract Article PDF–6.5M

Select item 438463810.

Siglec receptors impact mammalian lifespan by modulating oxidative stress

Flavio Schwarz, Oliver MT Pearce, Xiaoxia Wang, Annie N Samraj, Heinz Läubli, Javier O Garcia, Hongqiao Lin, Xiaoming Fu, Andrea Garcia-Bingman, Patrick Secrest, Casey E Romanoski, Charles Heyser, Christopher K Glass, Stanley L Hazen, Nissi Varki, Ajit Varki, Pascal Gagneux

eLife. 2015; 4: e06184. Published online 2015 Apr 7. doi: 10.7554/eLife.06184

PMCID:: PMC4384638

Abstract Article PDF–1.6M

Select item 387936711.

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

Yung-Chi Chang, Joshua Olson, Federico C. Beasley, Christine Tung, Jiquan Zhang, Paul R. Crocker, Ajit Varki, Victor Nizet

PLoS Pathog. 2014 Jan; 10(1): e1003846. Published online 2014 Jan 2. doi: 10.1371/journal.ppat.1003846

PMCID:: PMC3879367

Abstract Article PDF–967K

Select item 318643712.

Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E

Pierre Redelinghuys, Aristotelis Antonopoulos, Yan Liu, Maria A. Campanero-Rhodes, Emma McKenzie, Stuart M. Haslam, Anne Dell, Ten Feizi, Paul R. Crocker

J Biol Chem. 2011 Oct 7; 286(40): 34522–34532. Published online 2011 Aug 11. doi: 10.1074/jbc.M111.243410

PMCID:: PMC3186437

Abstract Article PDF–4.8M

Select item 1063060713.

The prognostic impact of SIGLEC5-induced impairment of CD8⁺ T cell activation in sepsis

Roberto Lozano-Rodríguez, José Avendaño-Ortíz, Karla Montalbán-Hernández, Juan Carlos Ruiz-Rodríguez, Ricardo Ferrer, Alejandro Martín-Quirós, Charbel Maroun-Eid, Juan José González-López, Anna Fàbrega, Verónica Terrón-Arcos, María Gutiérrez-Fernández, Elisa Alonso-López, Carolina Cubillos-Zapata, María Fernández-Velasco, Rebeca Pérez de Diego, Pablo Pelegrin, Carlos García-Palenciano, Francisco J. Cueto, Carlos del Fresno, Eduardo López-Collazo

eBioMedicine. 2023 Nov; 97: 104841. Published online 2023 Oct 25. doi: 10.1016/j.ebiom.2023.104841

PMCID:: PMC10630607

Abstract Article PDF–1.8M

Select item 620540814.

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

Michal A. Stanczak, Shoib S. Siddiqui, Marcel P. Trefny, Daniela S. Thommen, Kayluz Frias Boligan, Stephan von Gunten, Alexandar Tzankov, Lothar Tietze, Didier Lardinois, Viola Heinzelmann-Schwarz, Michael von Bergwelt-Baildon, Wu Zhang, Heinz-Josef Lenz, Younghun Han, Christopher I. Amos, Mohammedyaseen Syedbasha, Adrian Egli, Frank Stenner, Daniel E. Speiser, Ajit Varki, Alfred Zippelius, Heinz Läubli

J Clin Invest. 2018 Nov 1; 128(11): 4912–4923. Published online 2018 Sep 24. doi: 10.1172/JCI120612

PMCID:: PMC6205408

Abstract Article PDF–4.8M

Select item 558079315.

Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production

Caroline R. Boyd, Selinda J. Orr, Shaun Spence, James F. Burrows, Joanne Elliott, Helen P. Carroll, Kiva Brennan, Joan Ní Gabhann, Wilson A. Coulter, James A. Johnston, Caroline A. Jefferies

J Immunol. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: J Immunol. 2009 Dec 15; 183(12): 7703–7709. doi: 10.4049/jimmunol.0902780

PMCID:: PMC5580793

Abstract Article PDF–1.4M

Select item 510116216.

Siglec-E negatively regulates the activation of Toll-like Receptor 4 by controlling its endocytosis

Yin Wu, Dongren Ren, Guo-Yun Chen

J Immunol. Author manuscript; available in PMC 2017 Oct 15.

Published in final edited form as: J Immunol. 2016 Oct 15; 197(8): 3336–3347. Published online 2016 Sep 12. doi: 10.4049/jimmunol.1600772

PMCID:: PMC5101162

Abstract Article PDF–3.3M

Select item 419178817.

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

Heinz Läubli, Oliver M. T. Pearce, Flavio Schwarz, Shoib S. Siddiqui, Lingquan Deng, Michal A. Stanczak, Liwen Deng, Andrea Verhagen, Patrick Secrest, Chrissy Lusk, Ann G. Schwartz, Nissi M. Varki, Jack D. Bui, Ajit Varki

Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39): 14211–14216. Published online 2014 Sep 15. doi: 10.1073/pnas.1409580111

PMCID:: PMC4191788

Abstract Article PDF–1.2M

Select item 410634918.

Siglec-E Promotes β2-Integrin-dependent NADPH Oxidase Activation to Suppress Neutrophil Recruitment to the Lung

Sarah J. McMillan, Ritu S. Sharma, Hannah E. Richards, Vikas Hegde, Paul R. Crocker

J Biol Chem. 2014 Jul 18; 289(29): 20370–20376. Published online 2014 Jun 3. doi: 10.1074/jbc.M114.574624

PMCID:: PMC4106349

Abstract Article PDF–1.2M

Select item 382847219.

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

Janine Claude, Bettina Linnartz-Gerlach, Alexei P. Kudin, Wolfram S. Kunz, Harald Neumann

J Neurosci. 2013 Nov 13; 33(46): 18270–18276. doi: 10.1523/JNEUROSCI.2211-13.2013

PMCID:: PMC3828472

Abstract Article PDF–1.9M

Select item 359696820.

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin–dependent signaling

Sarah J. McMillan, Ritu S. Sharma, Emma J. McKenzie, Hannah E. Richards, Jiquan Zhang, Alan Prescott, Paul R. Crocker

Blood. 2013 Mar 14; 121(11): 2084–2094. Prepublished online 2013 Jan 11. doi: 10.1182/blood-2012-08-449983

PMCID:: PMC3596968

Abstract Article

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PMC Links for Gene (Select 83382) (35)
PMC
RecName: Full=Transmembrane protein 141
RecName: Full=Transmembrane protein 141
gi|152112332|sp|A2AJB2.1|TM141_MOUS

Protein
MULTISPECIES: DUF4843 domain-containing protein [Bacteroides]
MULTISPECIES: DUF4843 domain-containing protein [Bacteroides]
gi|495298890|ref|WP_008023642.1|

Protein
Ammonium Chloride
Ammonium Chloride
An acidifying agent that has expectorant and diuretic effects. Also used in etching and batteries and as a flux in electroplating.<br/>

MeSH
Surrogate Mothers
Surrogate Mothers
Women who allow themselves to be impregnated with the understanding that the offspring are to be given over to the parents who have commissioned the surrogate....<br/>Year introduced: 1990(1986)

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