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Items: 1 to 20 of 86

1.
Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: new sights to clinical decision-making
Jun Zhu, Yanlong Shi, Sheng Lan, Jingyan Wang, Fei Jiang, Caiping Tang, Yuan Cai, Ziyuan Pan, Haokun Jian, Hanlu Fang, Yewei Zhang, Fei Zhong
Apoptosis. 2023; 28(5-6): 769–782. Published online 2023 Mar 7. doi: 10.1007/s10495-023-01823-7
PMCID:
PMC10232623
AbstractArticlePDF–8.3M
2.
Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration
Libin Zhou, Kwangsik Nho, Maria G. Haddad, Nicole Cherepacha, Agne Tubeleviciute-Aydin, Andy P. Tsai, Andrew J. Saykin, P. Jesper Sjöström, Andrea C. LeBlanc
Sci Rep. 2021; 11: 12695. Published online 2021 Jun 16. doi: 10.1038/s41598-021-91367-0
Correction in:
Sci Rep. 2021; 11: 16151.
PMCID:
PMC8209045
AbstractArticlePDF–4.1M
3.
Identification of Allosteric Inhibitors against Active Caspase-6
Agne Tubeleviciute-Aydin, Alexandre Beautrait, Jeffrey Lynham, Gyanesh Sharma, Alexei Gorelik, Ludovic J. Deny, Naoto Soya, Gergely L. Lukacs, Bhushan Nagar, Anne Marinier, Andrea C. LeBlanc
Sci Rep. 2019; 9: 5504. Published online 2019 Apr 2. doi: 10.1038/s41598-019-41930-7
PMCID:
PMC6445123
AbstractArticlePDF–7.2M
4.
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis
Derek J. MacPherson, Caitlyn L. Mills, Mary Jo Ondrechen, Jeanne A. Hardy
J Biol Chem. 2019 Jan 4; 294(1): 71–88. Published online 2018 Nov 12. doi: 10.1074/jbc.RA118.005914
PMCID:
PMC6322879
AbstractArticlePDF–5.6M
5.
Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency
Kevin B. Dagbay, Maureen E. Hill, Elizabeth Barrett, Jeanne A. Hardy
Biochemistry. Author manuscript; available in PMC 2018 Mar 20.
Published in final edited form as: Biochemistry. 2017 Aug 29; 56(34): 4568–4577. Published online 2017 Aug 16. doi: 10.1021/acs.biochem.7b00357
PMCID:
PMC5859315
AbstractArticlePDF–750K
6.
Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity
Agne Tubeleviciute-Aydin, Libin Zhou, Gyanesh Sharma, Ishankumar V. Soni, Sergey N. Savinov, Jeanne A. Hardy, Andrea C. LeBlanc
Sci Rep. 2018; 8: 4428. Published online 2018 Mar 13. doi: 10.1038/s41598-018-22283-z
PMCID:
PMC5849602
AbstractArticlePDF–4.2M
7.
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions
Kevin B. Dagbay, Jeanne A. Hardy
Proc Natl Acad Sci U S A. 2017 Sep 19; 114(38): E7977–E7986. Published online 2017 Sep 1. doi: 10.1073/pnas.1704640114
PMCID:
PMC5617271
AbstractArticlePDF–2.4M
8.
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding
Kevin B. Dagbay, Nicolas Bolik-Coulon, Sergey N. Savinov, Jeanne A. Hardy
J Biol Chem. 2017 Mar 24; 292(12): 4885–4897. Published online 2017 Feb 2. doi: 10.1074/jbc.M116.773499
PMCID:
PMC5377803
AbstractArticlePDF–3.1M
9.
Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment
Benedicte Foveau, Steffen Albrecht, David A. Bennett, José A. Correa, Andrea C. LeBlanc
Acta Neuropathol Commun. 2016; 4: 127. Published online 2016 Dec 8. doi: 10.1186/s40478-016-0400-x
PMCID:
PMC5146837
AbstractArticlePDF–5.0M
10.
Expression and Activation of Caspase-6 in Human Fetal and Adult Tissues
Nelly Godefroy, Bénédicte Foveau, Steffen Albrecht, Cynthia G. Goodyer, Andréa C. LeBlanc
PLoS One. 2013; 8(11): e79313. Published online 2013 Nov 12. doi: 10.1371/journal.pone.0079313
PMCID:
PMC3827169
AbstractArticlePDF–10M
11.
Caspase-6 activity predicts lower episodic memory ability in aged individuals
Jasmine Ramcharitar, Veronica M. Afonso, Steffen Albrecht, David A. Bennett, Andrea C. LeBlanc
Neurobiol Aging. Author manuscript; available in PMC 2014 Jul 1.
Published in final edited form as: Neurobiol Aging. 2013 Jul; 34(7): 1815–1824. Published online 2013 Feb 10. doi: 10.1016/j.neurobiolaging.2013.01.007
PMCID:
PMC3772349
AbstractArticlePDF–6.6M
12.
Zinc-mediated Allosteric Inhibition of Caspase-6
Elih M. Velázquez-Delgado, Jeanne A. Hardy
J Biol Chem. 2012 Oct 19; 287(43): 36000–36011. Published online 2012 Aug 13. doi: 10.1074/jbc.M112.397752
Correction in:
J Biol Chem. 2013 Apr 19; 288(16): 11508.
PMCID:
PMC3476268
AbstractArticlePDF–2.3M
13.
Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays
Qin Cao, Xiao-Jun Wang, Cheng-Wen Liu, Dai-Fei Liu, Lan-Fen Li, Yi-Qin Gao, Xiao-Dong Su
J Biol Chem. 2012 May 4; 287(19): 15371–15379. Published online 2012 Mar 20. doi: 10.1074/jbc.M112.351213
PMCID:
PMC3346075
AbstractArticlePDF–2.6M
14.
Caspase-6 Activation in Familial Alzheimer Disease Brains Carrying Amyloid Precursor Protein, Presenilin I or Presenilin II Mutations
Steffen Albrecht, Nenad Bogdanovic, Bernardino Ghetti, Bengt Winblad, Andréa C. LeBlanc
J Neuropathol Exp Neurol. Author manuscript; available in PMC 2011 Apr 19.
Published in final edited form as: J Neuropathol Exp Neurol. 2009 Dec; 68(12): 1282–1293. doi: 10.1097/NEN.0b013e3181c1da10
Correction in:
volume 69 on page 110
PMCID:
PMC3079356
AbstractArticlePDF–2.2M
15.
Substrate-induced conformational changes occur in all cleaved forms of caspase-6
Sravanti Vaidya, Elih M. Velázquez-Delgado, Genevieve Abbruzzese, Jeanne A. Hardy
J Mol Biol. Author manuscript; available in PMC 2012 Feb 11.
Published in final edited form as: J Mol Biol. 2011 Feb 11; 406(1): 75–91. Published online 2010 Nov 25. doi: 10.1016/j.jmb.2010.11.031
PMCID:
PMC3030624
AbstractArticlePDF–2.8M
16.
Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A
Andrea W. Lee, Nathalie Champagne, Xiaojun Wang, Xiao-Dong Su, Cynthia Goodyer, Andrea C. LeBlanc
J Biol Chem. 2010 Oct 15; 285(42): 31974–31984. Published online 2010 Aug 3. doi: 10.1074/jbc.M110.152744
PMCID:
PMC2952198
AbstractArticlePDF–2.1M
17.
Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis
Hirokazu Hirata, Atsushi Takahashi, Susumu Kobayashi, Shin Yonehara, Hirofumi Sawai, Toshiro Okazaki, Kokichi Yamamoto, Masataka Sasada
J Exp Med. 1998 Feb 16; 187(4): 587–600. doi: 10.1084/jem.187.4.587
PMCID:
PMC2212161
AbstractArticlePDF–325K
18.
Activation of Caspase-6 in Aging and Mild Cognitive Impairment
Steffen Albrecht, Martine Bourdeau, David Bennett, Elliott J. Mufson, Meena Bhattacharjee, Andréa C. LeBlanc
Am J Pathol. 2007 Apr; 170(4): 1200–1209. doi: 10.2353/ajpath.2007.060974
PMCID:
PMC1829454
AbstractArticlePDF–2.7M
19.
Streptococcus pneumoniae-Induced Caspase 6-Dependent Apoptosis in Lung Epithelium
Bernd Schmeck, Ralph Gross, Phillipe Dje N′Guessan, Andreas C. Hocke, Sven Hammerschmidt, Tim J. Mitchell, Simone Rosseau, Norbert Suttorp, Stefan Hippenstiel
Infect Immun. 2004 Sep; 72(9): 4940–4947. doi: 10.1128/IAI.72.9.4940-4947.2004
PMCID:
PMC517413
AbstractArticlePDF–550K
20.
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
A Takahashi, E S Alnemri, Y A Lazebnik, T Fernandes-Alnemri, G Litwack, R D Moir, R D Goldman, G G Poirier, S H Kaufmann, W C Earnshaw
Proc Natl Acad Sci U S A. 1996 Aug 6; 93(16): 8395–8400. doi: 10.1073/pnas.93.16.8395
PMCID:
PMC38682
SummaryPage BrowsePDF–1.6M

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