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Select item 109017811.

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

Yasuo Kubota, Xiaorong Gu, Laila Terkawi, Juraj Bodo, Bartlomiej P. Przychodzen, Hussein Awada, Nakisha Williams, Carmelo Gurnari, Naomi Kawashima, Mai Aly, Arda Durmaz, Minako Mori, Ben Ponvilawan, Tariq Kewan, Waled Bahaj, Manja Meggendorfer, Babal K. Jha, Valeria Visconte, Heesun J. Rogers, Torsten Haferlach, Jaroslaw P. Maciejewski

Nat Commun. 2024; 15: 1832. Published online 2024 Feb 28. doi: 10.1038/s41467-024-46134-w

PMCID:: PMC10901781

Abstract Article PDF–3.7M

Select item 107638102.

Investigating the physiological role of S199A and S199D mutants of PHF6 protein in T-cell acute lymphoblastic leukemia

Gökçe ERDOĞAN, Osman Nidai ÖZEŞ, Alphan KÜPESİZ, Şükran Burçak YOLDAŞ

Turk J Med Sci. 2023; 53(5): 1234–1243. Published online 2023 Aug 11. doi: 10.55730/1300-0144.5689

PMCID:: PMC10763810

Abstract Article PDF–8.1M

Select item 99833203.

PHF6 promotes the progression of endometrial carcinoma by increasing cancer cells growth and decreasing T‐cell infiltration

Xiaomin Wang, Aizhong Fang, Yichen Peng, Jianyu Yu, Chunna Yu, Jinxuan Xie, Yi Zheng, Lairong Song, Parker Li, Jia Li, Xun Kang, Yi Lin, Wenbin Li

J Cell Mol Med. 2023 Mar; 27(5): 609–621. Published online 2023 Feb 8. doi: 10.1111/jcmm.17638

PMCID:: PMC9983320

Abstract Article PDF–3.0M

Select item 99390934.

PHF6 mutation is associated with poor outcome in acute myeloid leukaemia

Kexiu Huang, Lei Wang, Yaling Zheng, Chunyan Yue, Xuedan Xu, Hongbo Chen, Rui Huang, Yuhua Li

Cancer Med. 2023 Feb; 12(3): 2795–2804. Published online 2022 Sep 29. doi: 10.1002/cam4.5173

PMCID:: PMC9939093

Abstract Article PDF–1.7M

Select item 95437855.

Further characterization of Borjeson‐Forssman‐Lehmann syndrome in females due to de novo variants in PHF6

Céline B. Gerber, Anna Fliedner, Oliver Bartsch, Siren Berland, Malin Dewenter, Marte Haug, Ian Hayes, Purificacion Marin‐Reina, Paul R. Mark, Francisco Martinez‐Castellano, Isabelle Maystadt, Deniz Karadurmus, Katharina Steindl, Antje Wiesener, Markus Zweier, Heinrich Sticht, Christiane Zweier

Clin Genet. 2022 Sep; 102(3): 182–190. Published online 2022 Jun 14. doi: 10.1111/cge.14173

PMCID:: PMC9543785

Abstract Article PDF–1.5M

Select item 91851556.

Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair

Silvia Alvarez, Ana C. da Silva Almeida, Robert Albero, Mayukh Biswas, Angelica Barreto-Galvez, Thomas S. Gunning, Anam Shaikh, Tomas Aparicio, Agnieszka Wendorff, Erich Piovan, Pieter Van Vlierberghe, Steven Gygi, Jean Gautier, Advaitha Madireddy, Adolfo A. Ferrando

Blood. 2022 Jun 9; 139(23): 3418–3429. doi: 10.1182/blood.2021014103

PMCID:: PMC9185155

Abstract Article

Select item 85119567.

Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3

Xiaoke Huang, Xuebin Zhang, Le Zong, Qianqian Gao, Chao Zhang, Ran Wei, Yiting Guan, Li Huang, Lijun Zhang, Guoliang Lyu, Wei Tao

J Biol Chem. 2021 Oct; 297(4): 101195. Published online 2021 Sep 11. doi: 10.1016/j.jbc.2021.101195

PMCID:: PMC8511956

Abstract Article PDF–4.7M

Select item 78938048.

Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation

Ting Cai, Wenquan Wu, Longhua Guo, Yongwu Xia, Xiaoxin Jiang, Limei Zhang, Feiding Peng, Pinghong Ming

Mol Med Rep. 2021 Apr; 23(4): 242. Published online 2021 Feb 1. doi: 10.3892/mmr.2021.11881

PMCID:: PMC7893804

Abstract Article PDF–3.5M

Select item 76423909.

Loss of PHF6 leads to aberrant development of human neuron-like cells

Anna Fliedner, Anne Gregor, Fulvia Ferrazzi, Arif B. Ekici, Heinrich Sticht, Christiane Zweier

Sci Rep. 2020; 10: 19030. Published online 2020 Nov 4. doi: 10.1038/s41598-020-75999-2

PMCID:: PMC7642390

Abstract Article PDF–4.8M

Select item 749834510.

The chromatin-binding protein PHF6 functions as an E3 ubiquitin ligase of H2BK120 via H2BK12Ac recognition for activation of trophectodermal genes

Sungryong Oh, Kyungjin Boo, Jaebeom Kim, Seon Ah Baek, Yoon Jeon, Junghyun You, Ho Lee, Hee-Jung Choi, Daechan Park, Ji Min Lee, Sung Hee Baek

Nucleic Acids Res. 2020 Sep 18; 48(16): 9037–9052. Published online 2020 Jul 31. doi: 10.1093/nar/gkaa626

PMCID:: PMC7498345

Abstract Article PDF–4.9M

Select item 694491511.

PHF6 promotes non‐homologous end joining and G2 checkpoint recovery

Daniël O Warmerdam, Ignacio Alonso‐de Vega, Wouter W Wiegant, Bram van den Broek, Magdalena B Rother, Rob MF Wolthuis, Raimundo Freire, Haico van Attikum, René H Medema, Veronique AJ Smits

EMBO Rep. 2020 Jan 7; 21(1): e48460. Published online 2019 Nov 29. doi: 10.15252/embr.201948460

PMCID:: PMC6944915

Abstract Article PDF–913K

Select item 510284312.

Pathogenesis of Börjeson-Forssman-Lehmann Syndrome: Insights from PHF6 Function

Arezu Jahani-Asl, Cheng Cheng, Chi Zhang, Azad Bonni

Neurobiol Dis. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Neurobiol Dis. 2016 Dec; 96: 227–235. Published online 2016 Sep 12. doi: 10.1016/j.nbd.2016.09.011

PMCID:: PMC5102843

Abstract Article PDF–529K

Select item 502768513.

The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events

Matthew A M Todd, Michael S Huh, David J Picketts

Eur J Hum Genet. 2016 Oct; 24(10): 1453–1459. Published online 2016 May 11. doi: 10.1038/ejhg.2016.40

PMCID:: PMC5027685

Abstract Article PDF–1.9M

Select item 435840014.

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

Corbin E. Meacham, Lee N. Lawton, Yadira M. Soto-Feliciano, Justin R. Pritchard, Brian A. Joughin, Tobias Ehrenberger, Nina Fenouille, Johannes Zuber, Richard T. Williams, Richard A. Young, Michael T. Hemann

Genes Dev. 2015 Mar 1; 29(5): 483–488. doi: 10.1101/gad.254151.114

PMCID:: PMC4358400

Abstract Article PDF–759K

Select item 411683115.

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien Mets, Gert Van Peer, Joni Van der Meulen, Michael Boice, Tom Taghon, Steven Goossens, Pieter Mestdagh, Yves Benoit, Barbara De Moerloose, Nadine Van Roy, Bruce Poppe, Jo Vandesompele, Hans-Guido Wendel, Pieter Van Vlierberghe, Frank Speleman, Pieter Rondou

Haematologica. 2014 Aug; 99(8): 1326–1333. doi: 10.3324/haematol.2013.099515

PMCID:: PMC4116831

Abstract Article PDF–343K

Select item 387865916.

PHF6 mutations in adult acute myeloid leukemia

Pieter Van Vlierberghe, Jay Patel, Omar Abdel-Wahab, Camille Lobry, Cyrus V. Hedvat, Milagros Balbin, Concepcion Nicolas, Angel Ramirez Payer, Hugo F. Fernandez, Martin S. Tallman, Elisabeth Paietta, Ari Melnick, Peter Vandenberghe, Frank Speleman, Iannis Aifantis, Jan Cools, Ross Levine, Adolfo Ferrando

Leukemia. Author manuscript; available in PMC 2014 Jan 2.

Published in final edited form as: Leukemia. 2011 Jan; 25(1): 10.1038/leu.2010.247. Published online 2010 Oct 29. doi: 10.1038/leu.2010.247

PMCID:: PMC3878659

Abstract Article PDF–992K

Select item 356153917.

PHF6 Regulates Cell Cycle Progression by Suppressing Ribosomal RNA Synthesis

Jiadong Wang, Justin Wai-chung Leung, Zihua Gong, Lin Feng, Xiaobing Shi, Junjie Chen

J Biol Chem. 2013 Feb 1; 288(5): 3174–3183. Published online 2012 Dec 10. doi: 10.1074/jbc.M112.414839

PMCID:: PMC3561539

Abstract Article PDF–1.9M

Select item 321495918.

PHF6 Deletions May Cause Borjeson-Forssman-Lehmann Syndrome in Females

S. Berland, K. Alme, A. Brendehaug, G. Houge, R. Hovland

Mol Syndromol. 2011 Sep; 1(6): 294–300. Published online 2011 Jul 19. doi: 10.1159/000330111

PMCID:: PMC3214959

Abstract Article PDF–327K

Select item 293308419.

T-cell Acute Lymphoblastic Leukemia in Association with Börjeson-Forssman-Lehmann Syndrome Due to a Mutation in PHF6

Mwe Mwe Chao, Matthew A. Todd, Udo Kontny, Katherine Neas, Michael J. Sullivan, Alasdair G. Hunter, David J. Picketts, Christian P. Kratz

Pediatr Blood Cancer. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Pediatr Blood Cancer. 2010 Oct; 55(4): 722–724. doi: 10.1002/pbc.22574

PMCID:: PMC2933084

Abstract Article PDF–125K

Select item 284736420.

PHF6 mutations in T-cell acute lymphoblastic leukemia

Pieter Van Vlierberghe, Teresa Palomero, Hossein Khiabanian, Joni Van der Meulen, Mireia Castillo, Nadine Van Roy, Barbara De Moerloose, Jan Philippé, Sara González-García, María L Toribio, Tom Taghon, Linda Zuurbier, Barbara Cauwelier, Christine J Harrison, Claire Schwab, Markus Pisecker, Sabine Strehl, Anton W Langerak, Jozef Gecz, Edwin Sonneveld, Rob Pieters, Elisabeth Paietta, Jacob M Rowe, Peter H Wiernik, Yves Benoit, Jean Soulier, Bruce Poppe, Xiaopan Yao, Carlos Cordon-Cardo, Jules Meijerink, Raul Rabadan, Frank Speleman, Adolfo Ferrando

Nat Genet. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: Nat Genet. 2010 Apr; 42(4): 338–342. Published online 2010 Mar 14. doi: 10.1038/ng.542

PMCID:: PMC2847364

Abstract Article PDF–1.0M

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