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Select item 103121571.

MicroRNA-154-5p suppresses cervical carcinoma growth and metastasis by silencing Cullin2 in vitro and in vivo

Yaqin Li, Yimiao Wei, Honglei Zhang, Ying Bai, Xiuting Wang, Qi Li, Yatao Liu, Shuling Wang, Jiapu Wang, Songquan Wen, Jiarong Li, Weihong Zhao

PeerJ. 2023; 11: e15641. Published online 2023 Jun 27. doi: 10.7717/peerj.15641

PMCID:: PMC10312157

Abstract Article PDF–21M

Select item 91987202.

A close shave: How SARS-CoV-2 induces the loss of cilia

Barbara F. Fonseca, Lisa A. Chakrabarti

J Cell Biol. 2022 Jul 4; 221(7): e202206023. Published online 2022 Jun 13. doi: 10.1083/jcb.202206023

PMCID:: PMC9198720

Abstract Article PDF–858K

Select item 91581123.

CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2

Lingdong Meng, Yihan Zhang, Pengfei Wu, Danrui Li, Yichao Lu, Peng Shen, Taoyue Yang, Guodong Shi, Qun Chen, Hao Yuan, Wanli Ge, Yi Miao, Min Tu, Kuirong Jiang

Mol Cancer. 2022; 21: 121. Published online 2022 Jun 1. doi: 10.1186/s12943-022-01599-5

PMCID:: PMC9158112

Abstract Article PDF–18M

Select item 54625314.

Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

Teresa A.F. Cardote, Morgan S. Gadd, Alessio Ciulli

Structure. 2017 Jun 6; 25(6): 901–911.e3. doi: 10.1016/j.str.2017.04.009

PMCID:: PMC5462531

Abstract Article PDF–3.0M

Select item 39935295.

Analysis of the Cullin Binding Sites of the E4orf6 Proteins of Human Adenovirus E3 Ubiquitin Ligases

Timra Gilson, Chi Ying Cheng, Woosuk Steve Hur, Paola Blanchette, Philip E. Branton

J Virol. 2014 Apr; 88(7): 3885–3897. doi: 10.1128/JVI.03579-13

PMCID:: PMC3993529

Abstract Article PDF–1.3M

Select item 20454126.

Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Cullin 2 Ubiquitin Ligase Complex, Which Contributes to Degradation of the Retinoblastoma Tumor Suppressor

KyungWon Huh, Xiaobo Zhou, Hiroyuki Hayakawa, Je-Yoel Cho, Towia A. Libermann, Jianping Jin, J. Wade Harper, Karl Munger

J Virol. 2007 Sep; 81(18): 9737–9747. Published online 2007 Jul 3. doi: 10.1128/JVI.00881-07

PMCID:: PMC2045412

Abstract Article PDF–384K

Select item 96818847.

Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel–Lindau gene in the ccRCC

Franck Chesnel, Emmanuelle Jullion, Olivier Delalande, Anne Couturier, Adrien Alusse, Xavier Le Goff, Marion Lenglet, Betty Gardie, Caroline Abadie, Yannick Arlot-Bonnemains

Br J Cancer. 2022 Nov 23; 127(11): 1954–1962. Published online 2022 Sep 29. doi: 10.1038/s41416-022-01985-2

PMCID:: PMC9681884

Abstract Article PDF–989K

Select item 94567578.

Adaptive exchange sustains cullin–RING ubiquitin ligase networks and proper licensing of DNA replication

Yaru Zhang, Marco Jost, Ryan A. Pak, Daniel Lu, Jing Li, Brett Lomenick, Spiros D. Garbis, Chi-Ming Li, Jonathan S. Weissman, James Russell Lipford, Raymond J. Deshaies

Proc Natl Acad Sci U S A. 2022 Sep 6; 119(36): e2205608119. Published online 2022 Aug 29. doi: 10.1073/pnas.2205608119

PMCID:: PMC9456757

Abstract Article PDF–2.7M

Select item 77258239.

BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma

Keiichi Tamai, Mao Nakamura-Shima, Rie Shibuya-Takahashi, Shin-Ichiro Kanno, Akira Yasui, Mai Mochizuki, Wataru Iwai, Yuta Wakui, Makoto Abue, Kuniharu Yamamoto, Koh Miura, Masamichi Mizuma, Michiaki Unno, Sadafumi Kawamura, Ikuro Sato, Jun Yasuda, Kazunori Yamaguchi, Kazuo Sugamura, Kennichi Satoh

Sci Rep. 2020; 10: 21592. Published online 2020 Dec 9. doi: 10.1038/s41598-020-78539-0

PMCID:: PMC7725823

Abstract Article PDF–3.4M

Select item 434997210.

The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer

Junfeng Xu, Lihui Li, Guangyang Yu, Wantao Ying, Qiang Gao, Wenjuan Zhang, Xianyu Li, Chen Ding, Yanan Jiang, Dongping Wei, Shengzhong Duan, Qunying Lei, Peng Li, Tieliu Shi, Xiaohong Qian, Jun Qin, Lijun Jia

Mol Cell Proteomics. 2015 Mar; 14(3): 499–509. Published online 2014 Dec 24. doi: 10.1074/mcp.M114.045211

PMCID:: PMC4349972

Abstract Article PDF–1.8M

Select item 108396911.

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells

Michael Ohh, William Y. Kim, Javid J. Moslehi, Yuzhi Chen, Vincent Chau, Margaret A. Read, William G. Kaelin, Jr

EMBO Rep. 2002 Feb 15; 3(2): 177–182. doi: 10.1093/embo-reports/kvf028

PMCID:: PMC1083969

Abstract Article PDF–325K

Select item 10878412.

Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2

Kim M. Lonergan, Othon Iliopoulos, Michael Ohh, Takumi Kamura, Ronald C. Conaway, Joan Weliky Conaway, William G. Kaelin, Jr.

Mol Cell Biol. 1998 Feb; 18(2): 732–741. doi: 10.1128/mcb.18.2.732

PMCID:: PMC108784

Abstract Article PDF–6.8M

Select item 975315013.

Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability

Dacai Xu, Jiawen Wu, Jinghong Chen, Liling Jiang, Juan Chen, Wenhao Bao, Xin Chen, Qianqian Yang, Xiaolan Zhang, Leyi Yao, Huabo Su, Jinbao Liu

FASEB J. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: FASEB J. 2021 Aug; 35(8): e21800. doi: 10.1096/fj.202001146RR

PMCID:: PMC9753150

Abstract Article PDF–1.9M

Select item 668133914.

CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1

Ridvan Nepravishta, Federica Ferrentino, Walter Mandaliti, Anna Mattioni, Janine Weber, Simona Polo, Luisa Castagnoli, Gianni Cesareni, Maurizio Paci, Elena Santonico

Biomolecules. 2019 Jul; 9(7): 284. Published online 2019 Jul 17. doi: 10.3390/biom9070284

Correction in:: Biomolecules. 2019 Dec; 9(12): 803.

PMCID:: PMC6681339

Abstract Article PDF–2.3M

Select item 597288615.

Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation

Joseph A. Westrich, Cody J. Warren, Michael J. Klausner, Kejun Guo, Chang-Wei Liu, Mario L. Santiago, Dohun Pyeon

J Virol. 2018 Apr 1; 92(7): e01318-17. Prepublished online 2018 Jan 24. Published online 2018 Mar 14. doi: 10.1128/JVI.01318-17

PMCID:: PMC5972886

Abstract Article PDF–2.1M

Select item 553165916.

Small molecule perturbation of the CAND1-Cullin1-ubiquitin cycle stabilizes p53 and triggers Epstein-Barr virus reactivation

Nadezhda Tikhmyanova, Steve Tutton, Kayla A. Martin, Fang Lu, Andrew V. Kossenkov, Nicholas Paparoidamis, Shannon Kenney, Joseph M. Salvino, Paul M. Lieberman

PLoS Pathog. 2017 Jul; 13(7): e1006517. Published online 2017 Jul 17. doi: 10.1371/journal.ppat.1006517