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Items: 1 to 20 of 30

1.
GPR65 inhibits human trophoblast cell adhesion through upregulation of MYLK and downregulation of fibronectin via cAMP-ERK signaling in a low pH environment
Jia Mao, Ying Feng, Yayun Zheng, Yaqiu Gao, Linyu Zhang, Xinrui Sun, Yilun Wu, Xiaofeng Zhu, Fang Ma
Cell Commun Signal. 2023; 21: 238. Published online 2023 Sep 18. doi: 10.1186/s12964-023-01249-3
PMCID:
PMC10506227
AbstractArticlePDF–13M
2.
IBD-associated G Protein-Coupled Receptor 65 variant compromises signalling and impairs key functions involved in inflammation
Virginie Mercier, Gabrielle Boucher, Dominic Devost, Kyla Bourque, Azadeh Alikashani, Claudine Beauchamp, Alain Bitton, Sylvain Foisy, Philippe Goyette, Guy Charron, Terence E. Hébert, John D. Rioux
Cell Signal. Author manuscript; available in PMC 2023 May 1.
Published in final edited form as: Cell Signal. 2022 May; 93: 110294. Published online 2022 Feb 24. doi: 10.1016/j.cellsig.2022.110294
PMCID:
PMC9536022
AbstractArticlePDF–2.1M
3.
Carbon dioxide inhibits UVB-induced inflammatory response by activating the proton-sensing receptor, GPR65, in human keratinocytes
Keimon Sayama, Katsuyuki Yuki, Keiichi Sugata, Satoko Fukagawa, Tetsuji Yamamoto, Shigaku Ikeda, Takatoshi Murase
Sci Rep. 2021; 11: 379. Published online 2021 Jan 11. doi: 10.1038/s41598-020-79519-0
PMCID:
PMC7801444
AbstractArticlePDF–2.1M
4.
The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
Irina V. Tcymbarevich, Jyrki J. Eloranta, Jean-Benoît Rossel, Nicole Obialo, Marianne Spalinger, Jesus Cosin-Roger, Silvia Lang, Gerd A. Kullak-Ublick, Carsten A. Wagner, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Gerhard Rogler, Cheryl de Vallière, Benjamin Misselwitz, on behalf of the Swiss IBD Cohort Study Group
BMC Gastroenterol. 2019; 19: 2. Published online 2019 Jan 7. doi: 10.1186/s12876-018-0922-8
PMCID:
PMC6323805
AbstractArticlePDF–699K
5.
Acid-sensing T Cell Death Associated Gene-8 Receptor Expression in Panic Disorder
Jeffrey R. Strawn, Lauren L. Vollmer, Katherine M.J. McMurray, Jeffrey A. Mills, Sarah A. Mossman, Sara T. Varney, Heidi K. Schroeder, Renu Sah
Brain Behav Immun. Author manuscript; available in PMC 2019 Jan 1.
Published in final edited form as: Brain Behav Immun. 2018 Jan; 67: 36–41. Published online 2017 Jul 20. doi: 10.1016/j.bbi.2017.07.014
PMCID:
PMC5696091
AbstractArticlePDF–686K
6.
Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
Calvin R. Justus, Edward J. Sanderlin, Lixue Dong, Tianai Sun, Jen-Tsan Chi, Kvin Lertpiriyapong, Li V. Yang
J Transl Med. 2017; 15: 204. Published online 2017 Oct 10. doi: 10.1186/s12967-017-1305-6
PMCID:
PMC5634876
AbstractArticlePDF–2.0M
7.
Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation
Dong-Soon Im, Christopher E. Heise, Tuan Nguyen, Brian F. O'Dowd, Kevin R. Lynch
J Cell Biol. 2001 Apr 16; 153(2): 429–434. doi: 10.1083/jcb.153.2.429
PMCID:
PMC2169470
AbstractArticlePDF–395K
8.
Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
Kun Zhang, Meng-Xia Zhang, Xiao-Xiang Meng, Jing Zhu, Jia-Jun Wang, Yi-Fan He, Ye-Hua Li, Si-Cong Zhao, Zhe-Min Shi, Li-Na Zheng, Tao Han, Wei Hong
Mil Med Res. 2023; 10: 56. Published online 2023 Nov 25. doi: 10.1186/s40779-023-00494-4
PMCID:
PMC10675918
AbstractArticlePDF–21M
9.
Intestinal epithelial pH-sensing receptor GPR65 maintains mucosal homeostasis via regulating antimicrobial defense and restrains gut inflammation in inflammatory bowel disease
Gengfeng Li, Jian Lin, Xiang Gao, Huiling Su, Ritian Lin, Han Gao, Zhongsheng Feng, Huili Wu, Baisui Feng, Keqiang Zuo, Yingchuan Li, Wei Wu, Leilei Fang, Zhanju Liu
Gut Microbes. 2023; 15(2): 2257269. Published online 2023 Sep 25. doi: 10.1080/19490976.2023.2257269
PMCID:
PMC10524779
AbstractArticlePDF–10M
10.
MicroRNAs combined with the TLR4/TDAG8 mRNAs and proinflammatory cytokines are biomarkers for the rapid diagnosis of sepsis
Xiyuan Xu, Baoying Bu, Hongjun Tian, Rina Wu, Jingping Yang
Mol Med Rep. 2022 Nov; 26(5): 334. Published online 2022 Sep 12. doi: 10.3892/mmr.2022.12850
PMCID:
PMC9494599
AbstractArticlePDF–1.3M
11.
The role of acid-sensitive ion channels in panic disorder: a systematic review of animal studies and meta-analysis of human studies
Laiana A. Quagliato, Rafael C. Freire, Antonio E. Nardi
Transl Psychiatry. 2018; 8: 185. Published online 2018 Sep 7. doi: 10.1038/s41398-018-0238-z
PMCID:
PMC6128878
AbstractArticlePDF–958K
12.
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk
Kara G. Lassen, Craig I. McKenzie, Muriel Mari, Tatsuro Murano, Jakob Begun, Leigh A. Baxt, Gautam Goel, Eduardo J. Villablanca, Szu-Yu Kuo, Hailiang Huang, Laurence Macia, Atul K. Bhan, Marcel Batten, Mark J. Daly, Fulvio Reggiori, Charles R. Mackay, Ramnik J. Xavier
Immunity. Author manuscript; available in PMC 2017 Jun 21.
Published in final edited form as: Immunity. 2016 Jun 21; 44(6): 1392–1405. Published online 2016 Jun 7. doi: 10.1016/j.immuni.2016.05.007
PMCID:
PMC4936415
AbstractArticlePDF–1.1M
13.
Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8
Zhigang Li, Lixue Dong, Eric Dean, Li V. Yang
Int J Mol Sci. 2013 Oct; 14(10): 20236–20255. Published online 2013 Oct 11. doi: 10.3390/ijms141020236
PMCID:
PMC3821613
AbstractArticlePDF–1.5M
14.
Acidosis Promotes Bcl-2 Family-mediated Evasion of Apoptosis: INVOLVEMENT OF ACID-SENSING G PROTEIN-COUPLED RECEPTOR GPR65 SIGNALING TO MEK/ERK
Christopher Ryder, Karen McColl, Fei Zhong, Clark W. Distelhorst
J Biol Chem. 2012 Aug 10; 287(33): 27863–27875. Published online 2012 Jun 8. doi: 10.1074/jbc.M112.384685
PMCID:
PMC3431637
AbstractArticlePDF–813K
15.
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor
Yuichiro Ihara, Yasuyuki Kihara, Fumie Hamano, Keisuke Yanagida, Yasuyuki Morishita, Akiko Kunita, Takao Yamori, Masashi Fukayama, Hiroyuki Aburatani, Takao Shimizu, Satoshi Ishii
Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40): 17309–17314. Published online 2010 Sep 20. doi: 10.1073/pnas.1001165107
PMCID:
PMC2951433
AbstractArticlePDF–1012K
16.
The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis
Fionä Caratis, Mikołaj Opiełka, Martin Hausmann, Maria Velasco-Estevez, Bartłomiej Rojek, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra Rutkowska
PLoS One. 2024; 19(3): e0283060. Published online 2024 Mar 25. doi: 10.1371/journal.pone.0283060
PMCID:
PMC10962805
AbstractArticlePDF–1.6M
17.
The evolution and mechanism of GPCR proton sensing
Jacob B. Rowe, Nicholas J. Kapolka, Geoffrey J. Taghon, William M. Morgan, Daniel G. Isom
J Biol Chem. 2021 Jan-Jun; 296: 100167. Published online 2020 Dec 13. doi: 10.1074/jbc.RA120.016352
PMCID:
PMC7948426
AbstractArticlePDF–4.1M
18.
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
Xi-Ping Huang, Joel Karpiak, Wesley K. Kroeze, Hu Zhu, Xin Chen, Sheryl S. Moy, Kara A. Saddoris, Viktoriya Nikolova, Martilias S. Farrell, Sheng Wang, Thomas J. Mangano, Deepak A. Deshpande, Alice Jiang, Raymond B. Penn, Jian Jin, Beverly H. Koller, Terry Kenakin, Brian K. Shoichet, Bryan L. Roth
Nature. Author manuscript; available in PMC 2016 Nov 26.
Published in final edited form as: Nature. 2015 Nov 26; 527(7579): 477–483. Published online 2015 Nov 9. doi: 10.1038/nature15699
PMCID:
PMC4796946
AbstractArticlePDF–2.2M
19.
GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2
Ritian Lin, Wei Wu, Huimin Chen, Han Gao, Xiaohan Wu, Gengfeng Li, Qiong He, Huiying Lu, Mingming Sun, Zhanju Liu
Clin Transl Med. 2022 Mar; 12(3): e771. Published online 2022 Mar 28. doi: 10.1002/ctm2.771
PMCID:
PMC8958354
AbstractArticlePDF–6.6M
20.
The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model
Koichi Sato, Ayaka Tobo, Chihiro Mogi, Masayuki Tobo, Nobuhiro Yamane, Masahiko Tosaka, Hideaki Tomura, Dong-Soon Im, Fumikazu Okajima
Sci Rep. 2020; 10: 17193. Published online 2020 Oct 14. doi: 10.1038/s41598-020-74372-7
PMCID:
PMC7566628
AbstractArticlePDF–4.2M

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