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Items: 1 to 20 of 71

1.
The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites
Rebeca Ibarra, Heather R. Borror, Bryce Hart, Richard G. Gardner, Gary Kleiger
Biomolecules. 2021 Nov; 11(11): 1619. Published online 2021 Nov 2. doi: 10.3390/biom11111619
PMCID:
PMC8615460
AbstractArticlePDF–3.3M
2.
Intranuclear Degradation of Polyglutamine Aggregates by the Ubiquitin-Proteasome System
Atsushi Iwata, Yu Nagashima, Lumine Matsumoto, Takahiro Suzuki, Tomoyuki Yamanaka, Hidetoshi Date, Ken Deoka, Nobuyuki Nukina, Shoji Tsuji
J Biol Chem. 2009 Apr 10; 284(15): 9796–9803. doi: 10.1074/jbc.M809739200
PMCID:
PMC2665101
AbstractArticlePDF–659K
3.
Inefficient Quality Control of Thermosensitive Proteins on the Plasma Membrane
Michael J. Lewis, Hugh R. B. Pelham
PLoS One. 2009; 4(4): e5038. Published online 2009 Apr 1. doi: 10.1371/journal.pone.0005038
PMCID:
PMC2659772
AbstractArticlePDF–448K
4.
The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing.
Q Xu, G C Johnston, R A Singer
Mol Cell Biol. 1993 Dec; 13(12): 7553–7565. doi: 10.1128/mcb.13.12.7553
PMCID:
PMC364827
SummaryPage BrowsePDF–2.8M
5.
The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate
Ramon D. Jones, Charisma Enam, Rebeca Ibarra, Heather R. Borror, Kaitlyn E. Mostoller, Eric K. Fredrickson, JiaBei Lin, Edward Chuang, Zachary March, James Shorter, Tommer Ravid, Gary Kleiger, Richard G. Gardner
Mol Biol Cell. 2020 Feb 1; 31(3): 221–233. doi: 10.1091/mbc.E18-02-0121
PMCID:
PMC7001477
AbstractArticlePDF–2.0M
6.
Fine-Tuning of FACT by the Ubiquitin Proteasome System in Regulation of Transcriptional Elongation
Rwik Sen, Jannatul Ferdoush, Amala Kaja, Sukesh R. Bhaumik
Mol Cell Biol. 2016 Jun 1; 36(11): 1691–1703. Prepublished online 2016 Apr 4. Published online 2016 May 16. doi: 10.1128/MCB.01112-15
Correction in:
Mol Cell Biol. 2017 Jul 15; 37(14): e00281-17.
PMCID:
PMC4959319
AbstractArticlePDF–3.6M
7.
Substrate Recognition in Nuclear Protein Quality Control Degradation Is Governed by Exposed Hydrophobicity That Correlates with Aggregation and Insolubility
Eric K. Fredrickson, Pamela S. Gallagher, Sarah V. Clowes Candadai, Richard G. Gardner
J Biol Chem. 2013 Mar 1; 288(9): 6130–6139. Published online 2013 Jan 18. doi: 10.1074/jbc.M112.406710
PMCID:
PMC3585050
AbstractArticlePDF–2.0M
8.
Proteasome inhibition rescues clinically significant unstable variants of the mismatch repair protein Msh2
Tim Arlow, Kristan Scott, Aubrey Wagenseller, Alison Gammie
Proc Natl Acad Sci U S A. 2013 Jan 2; 110(1): 246–251. Published online 2012 Dec 17. doi: 10.1073/pnas.1215510110
PMCID:
PMC3538226
AbstractArticlePDF–1.0M
9.
The yeast protein complex containing cdc68 and pob3 mediates core-promoter repression through the cdc68 N-terminal domain.
D R Evans, N K Brewster, Q Xu, A Rowley, B A Altheim, G C Johnston, R A Singer
Genetics. 1998 Dec; 150(4): 1393–1405. doi: 10.1093/genetics/150.4.1393
PMCID:
PMC1460419
SummaryPDF–289K
10.
Genetic and Molecular Characterization of Suppressors of Sir4 Mutations in Saccharomyces Cerevisiae
R. Schnell, L. D'Ari, M. Foss, D. Goodman, J. Rine
Genetics. 1989 May; 122(1): 29–46. doi: 10.1093/genetics/122.1.29
PMCID:
PMC1203690
SummaryPDF–6.0M
11.
A nuclear-based quality control pathway for non-imported mitochondrial proteins
Viplendra PS Shakya, William A Barbeau, Tianyao Xiao, Christina S Knutson, Max H Schuler, Adam L Hughes
eLife. 2021; 10: e61230. Published online 2021 Mar 18. doi: 10.7554/eLife.61230
PMCID:
PMC7993989
AbstractArticlePDF–2.9M
12.
Genetic Selection Based on a Ste6*C-HA-Ura3 Substrate Identifies New Cytosolic Quality Control Alleles in Saccharomyces cerevisiae
Shu Ning Chan, Rupali Prasad, Paul Matsudaira
G3 (Bethesda) 2020 Jun; 10(6): 1879–1891. Published online 2020 Apr 16. doi: 10.1534/g3.120.401186
PMCID:
PMC7263692
AbstractArticlePDF–2.5M
13.
Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
Rahul S. Samant, Christine M. Livingston, Judith Frydman
Nature. Author manuscript; available in PMC 2019 Aug 23.
Published in final edited form as: Nature. 2018 Nov; 563(7731): 407–411. Published online 2018 Oct 31. doi: 10.1038/s41586-018-0678-x
PMCID:
PMC6707801
AbstractArticlePDF–2.3M
14.
The San1 Ubiquitin Ligase Functions Preferentially with Ubiquitin-conjugating Enzyme Ubc1 during Protein Quality Control
Rebeca Ibarra, Daniella Sandoval, Eric K. Fredrickson, Richard G. Gardner, Gary Kleiger
J Biol Chem. 2016 Sep 2; 291(36): 18778–18790. Published online 2016 Jul 12. doi: 10.1074/jbc.M116.737619
PMCID:
PMC5009252
AbstractArticlePDF–2.1M
15.
MutSα mismatch repair protein stability is governed by subunit interaction, acetylation, and ubiquitination
Tim Arlow, Junwon Kim, Joanna E. Haye-Bertolozzi, Cristina Balbás Martínez, Caitlin Fay, Emma Zorensky, Mark D. Rose, Alison E. Gammie
G3 (Bethesda) 2021 Mar; 11(3): jkaa065. Published online 2021 Jan 8. doi: 10.1093/g3journal/jkaa065
PMCID:
PMC8063085
AbstractArticlePDF–1.2M
16.
Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction
Eric K. Fredrickson, Sarah V. Clowes Candadai, Cheuk Ho Tam, Richard G. Gardner
Mol Biol Cell. 2013 Apr 1; 24(7): 1041–1052. doi: 10.1091/mbc.E12-11-0811
PMCID:
PMC3608492
AbstractArticlePDF–3.1M
17.
Transcriptional Profiling of Biofilm Regulators Identified by an Overexpression Screen in Saccharomyces cerevisiae
Gareth A. Cromie, Zhihao Tan, Michelle Hays, Amy Sirr, Eric W. Jeffery, Aimée M. Dudley
G3 (Bethesda) 2017 Aug; 7(8): 2845–2854. Published online 2017 Jul 3. doi: 10.1534/g3.117.042440
PMCID:
PMC5555487
AbstractArticlePDF–1.2M
18.
Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast
Matthew J. Maurer, Eric D. Spear, Allen T. Yu, Evan J. Lee, Saba Shahzad, Susan Michaelis
G3 (Bethesda) 2016 Jul; 6(7): 1853–1866. Published online 2016 Apr 26. doi: 10.1534/g3.116.027953
PMCID:
PMC4938640
AbstractArticlePDF–2.0M
19.
The Type II Hsp40 Sis1 Cooperates with Hsp70 and the E3 Ligase Ubr1 to Promote Degradation of Terminally Misfolded Cytosolic Protein
Daniel W. Summers, Katie J. Wolfe, Hong Yu Ren, Douglas M. Cyr
PLoS One. 2013; 8(1): e52099. Published online 2013 Jan 16. doi: 10.1371/journal.pone.0052099
PMCID:
PMC3547041
AbstractArticlePDF–1.3M
20.
Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability
Hery Ratsima, Anne-Marie Ladouceur, Mirela Pascariu, Véronique Sauvé, Zeina Salloum, Paul S. Maddox, Damien D'Amours
Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43): E914–E923. Published online 2011 Oct 10. doi: 10.1073/pnas.1106448108
PMCID:
PMC3203808
AbstractArticlePDF–1.4M

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