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Select item 54384881.

Recognition of a structural domain (RWDBD) in Gcn1 proteins that interacts with the RWD domain containing proteins

Ramachandran Rakesh, Rangachari Krishnan, Evelyn Sattlegger, Narayanaswamy Srinivasan

Biol Direct. 2017; 12: 12. Published online 2017 May 19. doi: 10.1186/s13062-017-0184-3

PMCID:: PMC5438488

Abstract Article PDF–1.8M

Select item 97046362.

A genetic approach to identify amino acids in Gcn1 required for Gcn2 activation

Susanne Gottfried, Siaosi M. B. M. J. Koloamatangi, Clement Daube, Anja H. Schiemann, Evelyn Sattlegger

PLoS One. 2022; 17(11): e0277648. Published online 2022 Nov 28. doi: 10.1371/journal.pone.0277648

PMCID:: PMC9704636

Abstract Article PDF–3.4M

Select item 78675953.

Ribosome-quality control antagonizes the activation of the integrated-stress response on colliding ribosomes

Liewei L. Yan, Hani S. Zaher

Mol Cell. Author manuscript; available in PMC 2022 Feb 4.

Published in final edited form as: Mol Cell. 2021 Feb 4; 81(3): 614–628.e4. Published online 2020 Dec 17. doi: 10.1016/j.molcel.2020.11.033

PMCID:: PMC7867595

Abstract Article PDF–1.8M

Select item 3943804.

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.

C R Vazquez de Aldana, M J Marton, A G Hinnebusch

EMBO J. 1995 Jul 3; 14(13): 3184–3199. doi: 10.1002/j.1460-2075.1995.tb07321.x

PMCID:: PMC394380

Summary Page Browse PDF–4.0M

Select item 3670505.

Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae.

P L Myers, R C Skvirsky, M L Greenberg, H Greer

Mol Cell Biol. 1986 Sep; 6(9): 3150–3155. doi: 10.1128/mcb.6.9.3150

PMCID:: PMC367050

Summary Page Browse PDF–1.3M

Select item 3605206.

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

M Ramirez, R C Wek, C R Vazquez de Aldana, B M Jackson, B Freeman, A G Hinnebusch

Mol Cell Biol. 1992 Dec; 12(12): 5801–5815. doi: 10.1128/mcb.12.12.5801

PMCID:: PMC360520

Summary Page Browse PDF–3.3M

Select item 3598247.

GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.

M J Marton, D Crouch, A G Hinnebusch

Mol Cell Biol. 1993 Jun; 13(6): 3541–3556. doi: 10.1128/mcb.13.6.3541

PMCID:: PMC359824

Summary Page Browse PDF–4.4M

Select item 3058488.

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

Evelyn Sattlegger, Alan G. Hinnebusch

EMBO J. 2000 Dec 1; 19(23): 6622–6633. doi: 10.1093/emboj/19.23.6622

PMCID:: PMC305848

Abstract Article PDF–406K

Select item 110888789.

Evidence that Xrn1 is in complex with Gcn1, and is required for full levels of eIF2α phosphorylation

Renuka Shanmugam, Reuben Anderson, Anja H. Schiemann, Evelyn Sattlegger

Biochem J. 2024 Apr 10; 481(7): 481–498. Published online 2024 Mar 28. doi: 10.1042/BCJ20220531

PMCID:: PMC11088878

Abstract Article PDF–3.2M

Select item 1110652810.

Inability to rescue stalled ribosomes results in overactivation of the integrated stress response

Ankanahalli N. Nanjaraj Urs, Victor Lasehinde, Lucas Kim, Elesa McDonald, Liewei L. Yan, Hani S. Zaher

J Biol Chem. 2024 May; 300(5): 107290. Published online 2024 Apr 16. doi: 10.1016/j.jbc.2024.107290

PMCID:: PMC11106528

Abstract Article PDF–1.6M

Select item 515435811.

eIF2 kinases mediate β-lapachone toxicity in yeast and human cancer cells

Mauricio Menacho-Márquez, Carlos J Rodríguez-Hernández, M Ángeles Villaronga, Jorge Pérez-Valle, José Gadea, Borja Belandia, José R Murguía

Cell Cycle. 2015; 14(4): 630–640. Published online 2015 Jan 15. doi: 10.4161/15384101.2014.994904

PMCID:: PMC5154358

Abstract Article PDF–633K

Select item 407350312.

A genetic approach of wine yeast fermentation capacity in nitrogen-starvation reveals the key role of nitrogen signaling

Claire Brice, Isabelle Sanchez, Frédéric Bigey, Jean-Luc Legras, Bruno Blondin

BMC Genomics. 2014; 15(1): 495. Published online 2014 Jun 19. doi: 10.1186/1471-2164-15-495

PMCID:: PMC4073503

Abstract Article PDF–2.4M

Select item 306048813.

Gcn1 and Actin Binding to Yih1: IMPLICATIONS FOR ACTIVATION OF THE eIF2 KINASE GCN2

Evelyn Sattlegger, João A. R. G. Barbosa, Maria Carolina S. Moraes, Rafael M. Martins, Alan G. Hinnebusch, Beatriz A. Castilho

J Biol Chem. 2011 Mar 25; 286(12): 10341–10355. Published online 2011 Jan 14. doi: 10.1074/jbc.M110.171587

PMCID:: PMC3060488

Abstract Article PDF–3.6M

Select item 118231114.

Inhibition of Translation Initiation by Volatile Anesthetics Involves Nutrient-sensitive GCN-independent and -dependent Processes in Yeast

Laura K. Palmer, Jessica L. Shoemaker, Beverly A. Baptiste, Darren Wolfe, Ralph L. Keil

Mol Biol Cell. 2005 Aug; 16(8): 3727–3739. doi: 10.1091/mbc.E05-02-0127

PMCID:: PMC1182311

Abstract Article PDF–423K

Select item 36017415.

Complex formation by positive and negative translational regulators of GCN4.

A M Cigan, M Foiani, E M Hannig, A G Hinnebusch

Mol Cell Biol. 1991 Jun; 11(6): 3217–3228. doi: 10.1128/mcb.11.6.3217

PMCID:: PMC360174

Summary Page Browse PDF–3.1M

Select item 36016316.

Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.

R J Rolfes, A G Hinnebusch

Mol Cell Biol. 1993 Aug; 13(8): 5099–5111. doi: 10.1128/mcb.13.8.5099

PMCID:: PMC360163

Summary Page Browse PDF–2.8M

Select item 30201317.

Association of GCN1–GCN20 regulatory complex with the N-terminus of eIF2α kinase GCN2 is required for GCN2 activation

Minerva Garcia-Barrio, Jinsheng Dong, Sandra Ufano, Alan G. Hinnebusch

EMBO J. 2000 Apr 17; 19(8): 1887–1899. doi: 10.1093/emboj/19.8.1887

PMCID:: PMC302013

Abstract Article PDF–835K

Select item 23230118.

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.

M J Marton, C R Vazquez de Aldana, H Qiu, K Chakraburtty, A G Hinnebusch

Mol Cell Biol. 1997 Aug; 17(8): 4474–4489. doi: 10.1128/mcb.17.8.4474

PMCID:: PMC232301

Summary PDF–2.8M

Select item 804080619.

Structure of Gcn1 bound to stalled and colliding 80S ribosomes

Agnieszka A. Pochopien, Bertrand Beckert, Sergo Kasvandik, Otto Berninghausen, Roland Beckmann, Tanel Tenson, Daniel N. Wilson

Proc Natl Acad Sci U S A. 2021 Apr 6; 118(14): e2022756118. Published online 2021 Mar 31. doi: 10.1073/pnas.2022756118

PMCID:: PMC8040806

Abstract Article PDF–2.2M

Select item 531416420.

General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae

Wenjie Yuan, Shuguang Guo, Jiaoqi Gao, Mingming Zhong, Gonghong Yan, Wangmeng Wu, Yapeng Chao, Yu Jiang

J Biol Chem. 2017 Feb 17; 292(7): 2660–2669. Published online 2017 Jan 5. doi: 10.1074/jbc.M116.772194

PMCID:: PMC5314164

Abstract Article PDF–1.4M

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