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Select item 32575211.

Structural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from S. cerevisiae

Brian C. Smith, Mark A. Anderson, Kelly A. Hoadley, James L. Keck, W. Wallace Cleland, John M. Denu

Biochemistry. Author manuscript; available in PMC 2013 Jan 10.

Published in final edited form as: Biochemistry. 2012 Jan 10; 51(1): 243–256. Published online 2011 Dec 29. doi: 10.1021/bi2015508

PMCID:: PMC3257521

Abstract Article PDF–2.3M

Select item 30101972.

Characterization of Nicotinamidases: Steady-State Kinetic Parameters, Class-wide Inhibition by Nicotinaldehydes and Catalytic Mechanism

Jarrod B. French, Yana Cen, Tracy L. Vrablik, Ping Xu, Eleanor Allen, Wendy Hanna-Rose, Anthony A. Sauve

Biochemistry. Author manuscript; available in PMC 2011 Dec 14.

Published in final edited form as: Biochemistry. 2010 Dec 14; 49(49): 10421–10439. Published online 2010 Nov 15. doi: 10.1021/bi1012518

PMCID:: PMC3010197

Abstract Article PDF–3.7M

Select item 26676673.

The Yeast PNC1 Longevity Gene Is Up-Regulated by mRNA Mistranslation

Raquel M. Silva, Iven C. N. Duarte, João A. Paredes, Tatiana Lima-Costa, Michel Perrot, Hélian Boucherie, Brian J. Goodfellow, Ana C. Gomes, Denisa D. Mateus, Gabriela R. Moura, Manuel A. S. Santos

PLoS One. 2009; 4(4): e5212. Published online 2009 Apr 17. doi: 10.1371/journal.pone.0005212

PMCID:: PMC2667667

Abstract Article PDF–1.1M

Select item 19314994.

Crystal Structure of the Yeast Nicotinamidase Pnc1p

Gang Hu, Alexander B. Taylor, Lee McAlister-Henn, P. John Hart

Arch Biochem Biophys. Author manuscript; available in PMC 2008 May 1.

Published in final edited form as: Arch Biochem Biophys. 2007 May 1; 461(1): 66–75. Published online 2007 Mar 2. doi: 10.1016/j.abb.2007.01.037

PMCID:: PMC1931499

Abstract Article PDF–1.4M

Select item 28254685.

Dynamic Changes in the Subcellular Distribution of Gpd1p in Response to Cell Stress

Sunhee Jung, Marcello Marelli, Richard A. Rachubinski, David R. Goodlett, John D. Aitchison

J Biol Chem. 2010 Feb 26; 285(9): 6739–6749. Published online 2009 Dec 21. doi: 10.1074/jbc.M109.058552

PMCID:: PMC2825468

Abstract Article PDF–4.2M

Select item 3214346.

Nicotinamide Clearance by Pnc1 Directly Regulates Sir2-Mediated Silencing and Longevity

Christopher M. Gallo, Daniel L. Smith, Jr., Jeffrey S. Smith

Mol Cell Biol. 2004 Feb; 24(3): 1301–1312. doi: 10.1128/MCB.24.3.1301-1312.2004

PMCID:: PMC321434

Abstract Article PDF–407K

Select item 60236157.

Temporal profiling of redox-dependent heterogeneity in single cells

Meytal Radzinski, Rosi Fassler, Ohad Yogev, William Breuer, Nadav Shai, Jenia Gutin, Sidra Ilyas, Yifat Geffen, Sabina Tsytkin-Kirschenzweig, Yaakov Nahmias, Tommer Ravid, Nir Friedman, Maya Schuldiner, Dana Reichmann

eLife. 2018; 7: e37623. Published online 2018 Jun 5. doi: 10.7554/eLife.37623

PMCID:: PMC6023615

Abstract Article PDF–2.0M

Select item 50688478.

Nicotinamide Suppresses the DNA Damage Sensitivity of Saccharomyces cerevisiae Independently of Sirtuin Deacetylases

Anthony Rössl, Amanda Bentley-DeSousa, Yi-Chieh Tseng, Christine Nwosu, Michael Downey

Genetics. 2016 Oct; 204(2): 569–579. Published online 2016 Aug 15. doi: 10.1534/genetics.116.193524

PMCID:: PMC5068847

Abstract Article PDF–7.1M

Select item 48028589.

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

Rozalyn M. Anderson, Kevin J. Bitterman, Jason G. Wood, Oliver Medvedik, David A. Sinclair

Nature. Author manuscript; available in PMC 2016 Mar 22.

Published in final edited form as: Nature. 2003 May 8; 423(6936): 181–185. doi: 10.1038/nature01578

PMCID:: PMC4802858

Abstract Article PDF–823K

Select item 256738110.

Pnc1p-Mediated Nicotinamide Clearance Modifies the Epigenetic Properties of rDNA Silencing in Saccharomyces cerevisiae

Julie M. McClure, Christopher M. Gallo, Daniel L. Smith, Jr., Mirela Matecic, Robert D. Hontz, Stephen W. Buck, Frances G. Racette, Jeffrey S. Smith

Genetics. 2008 Oct; 180(2): 797–810. doi: 10.1534/genetics.108.091090

PMCID:: PMC2567381

Abstract Article PDF–1.3M

Select item 309276411.

Nrt1 and Tna1-Independent Export of NAD⁺ Precursor Vitamins Promotes NAD⁺ Homeostasis and Allows Engineering of Vitamin Production

Peter Belenky, Rebecca Stebbins, Katrina L. Bogan, Charles R. Evans, Charles Brenner

PLoS One. 2011; 6(5): e19710. Published online 2011 May 11. doi: 10.1371/journal.pone.0019710

PMCID:: PMC3092764

Abstract Article PDF–906K

Select item 279469112.

Redox responses in yeast to acetate as the carbon source

Karyl I. Minard, L. McAlister-Henn

Arch Biochem Biophys. Author manuscript; available in PMC 2009 Dec 16.

Published in final edited form as: Arch Biochem Biophys. 2009 Mar 1; 483(1): 136–143. Published online 2008 Dec 30. doi: 10.1016/j.abb.2008.12.014

PMCID:: PMC2794691

Abstract Article PDF–1.5M

Select item 146200513.

Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway.

Joseph J Sandmeier, Ivana Celic, Jef D Boeke, Jeffrey S Smith

Genetics. 2002 Mar; 160(3): 877–889. doi: 10.1093/genetics/160.3.877

PMCID:: PMC1462005

Summary PDF–743K

Select item 365747814.

NAD⁺ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins

Alejandro Ocampo, Jingjing Liu, Antoni Barrientos

Hum Mol Genet. 2013 May 1; 22(9): 1699–1708. Published online 2013 Jan 18. doi: 10.1093/hmg/ddt016

PMCID:: PMC3657478

Abstract Article PDF–533K

Select item 337551915.

Isonicotinamide Enhances Sir2 Protein-mediated Silencing and Longevity in Yeast by Raising Intracellular NAD⁺ Concentration

Julie M. McClure, Margaret B. Wierman, Nazif Maqani, Jeffrey S. Smith

J Biol Chem. 2012 Jun 15; 287(25): 20957–20966. Published online 2012 Apr 26. doi: 10.1074/jbc.M112.367524

PMCID:: PMC3375519

Abstract Article PDF–3.0M

Select item 31426716.

Calorie restriction extends yeast life span by lowering the level of NADH

Su-Ju Lin, Ethan Ford, Marcia Haigis, Greg Liszt, Leonard Guarente

Genes Dev. 2004 Jan 1; 18(1): 12–16. doi: 10.1101/gad.1164804

PMCID:: PMC314267

Abstract Article PDF–184K

Select item 516735017.

Loss of Nat4 and its associated histone H4 N‐terminal acetylation mediates calorie restriction‐induced longevity

Diego Molina‐Serrano, Vassia Schiza, Christis Demosthenous, Emmanouil Stavrou, Jan Oppelt, Dimitris Kyriakou, Wei Liu, Gertrude Zisser, Helmut Bergler, Weiwei Dang, Antonis Kirmizis

EMBO Rep. 2016 Dec; 17(12): 1829–1843. Published online 2016 Oct 31. doi: 10.15252/embr.201642540