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Items: 1 to 20 of 92

1.
Screening of Small Molecule Interactor Library by Using In-Cell NMR Spectroscopy (SMILI-NMR)
Jingjing Xie, Rajiv Thapa, Sergey Reverdatto, David S. Burz, Alexander Shekhtman
J Med Chem. Author manuscript; available in PMC 2011 Jun 10.
Published in final edited form as: J Med Chem. 2009 Jun 11; 52(11): 3516–3522. doi: 10.1021/jm9000743
PMCID:
PMC3111922
AbstractArticlePDF–663K
2.
Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
Y Koltin, L Faucette, D J Bergsma, M A Levy, R Cafferkey, P L Koser, R K Johnson, G P Livi
Mol Cell Biol. 1991 Mar; 11(3): 1718–1723. doi: 10.1128/mcb.11.3.1718
PMCID:
PMC369480
SummaryPage BrowsePDF–1.2M
3.
Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.
L Brizuela, G Chrebet, K A Bostian, S A Parent
Mol Cell Biol. 1991 Sep; 11(9): 4616–4626. doi: 10.1128/mcb.11.9.4616
PMCID:
PMC361345
SummaryPage BrowsePDF–2.1M
4.
FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.
J Heitman, N R Movva, P C Hiestand, M N Hall
Proc Natl Acad Sci U S A. 1991 Mar 1; 88(5): 1948–1952. doi: 10.1073/pnas.88.5.1948
PMCID:
PMC51143
SummaryPage BrowsePDF–1.2M
5.
FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.
G Wiederrecht, L Brizuela, K Elliston, N H Sigal, J J Siekierka
Proc Natl Acad Sci U S A. 1991 Feb 1; 88(3): 1029–1033. doi: 10.1073/pnas.88.3.1029
Correction in:
Proc Natl Acad Sci U S A. 1991 Apr 1; 88(7): 2967.
PMCID:
PMC50948
SummaryPage BrowsePDF–1.2M
6.
Functions of FKBP12 and Mitochondrial Cyclophilin Active Site Residues In Vitro and In Vivo in Saccharomyces cerevisiae
Kara Dolinski, Christian Scholz, R. Scott Muir, Sabine Rospert, Franz X. Schmid, Maria E. Cardenas, Joseph Heitman
Mol Biol Cell. 1997 Nov; 8(11): 2267–2280. doi: 10.1091/mbc.8.11.2267
PMCID:
PMC25707
AbstractArticlePDF–441K
7.
Pterocarpus marsupium extract extends replicative lifespan in budding yeast
Mitchell B. Lee, Michael G. Kiflezghi, Mitsuhiro Tsuchiya, Brian Wasko, Daniel T. Carr, Priya A. Uppal, Katherine A. Grayden, Yordanos C. Elala, Tu Anh Nguyen, Jesse Wang, Priya Ragosti, Sunny Nguyen, Yan Ting Zhao, Deborah Kim, Socheata Thon, Irika Sinha, Thao T. Tang, Ngoc H. B. Tran, Thu H. B. Tran, Margarete D. Moore, Mary Ann K. Li, Karl Rodriguez, Daniel E. L. Promislow, Matt Kaeberlein
GeroScience. 2021 Oct; 43(5): 2595–2609. Published online 2021 Jul 23. doi: 10.1007/s11357-021-00418-x
Correction in:
GeroScience. 2022 Jun; 44(3): 1889.
PMCID:
PMC8599564
AbstractArticlePDF–1.7M
8.
A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae
Mitchell B. Lee, Daniel T. Carr, Michael G. Kiflezghi, Yan Ting Zhao, Deborah B. Kim, Socheata Thon, Margarete D. Moore, Mary Ann K. Li, Matt Kaeberlein
GeroScience. 2017 Aug; 39(4): 419–428. Published online 2017 Jul 13. doi: 10.1007/s11357-017-9988-4
PMCID:
PMC5636783
AbstractArticlePDF–1.4M
9.
Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
K J Dolinski, J Heitman
Genetics. 1999 Mar; 151(3): 935–944. doi: 10.1093/genetics/151.3.935
PMCID:
PMC1460526
SummaryPDF–267K
10.
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
M E Cardenas, C Hemenway, R S Muir, R Ye, D Fiorentino, J Heitman
EMBO J. 1994 Dec 15; 13(24): 5944–5957. doi: 10.1002/j.1460-2075.1994.tb06940.x
PMCID:
PMC395570
SummaryPage BrowsePDF–3.4M
11.
FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae.
C M Alarcón, J Heitman
Mol Cell Biol. 1997 Oct; 17(10): 5968–5975. doi: 10.1128/mcb.17.10.5968
PMCID:
PMC232445
SummaryPDF–1.2M
12.
A yeast cyclophilin gene essential for lactate metabolism at high temperature.
E S Davis, A Becker, J Heitman, M N Hall, M B Brennan
Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23): 11169–11173. doi: 10.1073/pnas.89.23.11169
PMCID:
PMC50511
SummaryPage BrowsePDF–1.2M
13.
Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2.
J B Nielsen, F Foor, J J Siekierka, M J Hsu, N Ramadan, N Morin, A Shafiee, A M Dahl, L Brizuela, G Chrebet, et al.
Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16): 7471–7475. doi: 10.1073/pnas.89.16.7471
PMCID:
PMC49732
SummaryPage BrowsePDF–1.2M
14.
A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus
J Cell Biol. 1994 Nov 1; 127(3): 623–639. doi: 10.1083/jcb.127.3.623
PMCID:
PMC2120238
SummaryPDF–4.0M
15.
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.
R Cafferkey, P R Young, M M McLaughlin, D J Bergsma, Y Koltin, G M Sathe, L Faucette, W K Eng, R K Johnson, G P Livi
Mol Cell Biol. 1993 Oct; 13(10): 6012–6023. doi: 10.1128/mcb.13.10.6012
PMCID:
PMC364661
SummaryPage BrowsePDF–2.6M
16.
Proline isomerases function during heat shock.
K Sykes, M J Gething, J Sambrook
Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12): 5853–5857. doi: 10.1073/pnas.90.12.5853
PMCID:
PMC46821
SummaryPage BrowsePDF–1.2M
17.
Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis
Nelson Martínez-Matías, Nataliya Chorna, Sahily González-Crespo, Lilliam Villanueva, Ingrid Montes-Rodríguez, Loyda M. Melendez-Aponte, Abiel Roche-Lima, Kelvin Carrasquillo-Carrión, Ednalise Santiago-Cartagena, Brian C. Rymond, Mohan Babu, Igor Stagljar, José R. Rodríguez-Medina
Sci Rep. 2021; 11: 7411. Published online 2021 Apr 1. doi: 10.1038/s41598-021-86671-8
PMCID:
PMC8016984
AbstractArticlePDF–2.5M
18.
A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
Cheuk Hei Ho, Leslie Magtanong, Sarah L Barker, David Gresham, Shinichi Nishimura, Paramasivam Natarajan, Judice L Y Koh, Justin Porter, Christopher A Gray, Raymond J Andersen, Guri Giaever, Corey Nislow, Brenda Andrews, David Botstein, Todd R Graham, Minoru Yoshida, Charles Boone
Nat Biotechnol. Author manuscript; available in PMC 2013 Dec 9.
Published in final edited form as: Nat Biotechnol. 2009 Apr; 27(4): 10.1038/nbt.1534. Published online 2009 Apr 6. doi: 10.1038/nbt.1534
PMCID:
PMC3856559
AbstractArticlePDF–791K
19.
FKBP12 Controls Aspartate Pathway Flux in Saccharomyces cerevisiae To Prevent Toxic Intermediate Accumulation
Miguel Arévalo-Rodríguez, Xuewen Pan, Jef D. Boeke, Joseph Heitman
Eukaryot Cell. 2004 Oct; 3(5): 1287–1296. doi: 10.1128/EC.3.5.1287-1296.2004
PMCID:
PMC522611
AbstractArticlePDF–386K
20.
Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
T Breuder, C S Hemenway, N R Movva, M E Cardenas, J Heitman
Proc Natl Acad Sci U S A. 1994 Jun 7; 91(12): 5372–5376. doi: 10.1073/pnas.91.12.5372
PMCID:
PMC43997
SummaryPage BrowsePDF–1.3M

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