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Select item 77826911.

Humanizing the yeast origin recognition complex

Clare S. K. Lee, Ming Fung Cheung, Jinsen Li, Yongqian Zhao, Wai Hei Lam, Vincy Ho, Remo Rohs, Yuanliang Zhai, Danny Leung, Bik-Kwoon Tye

Nat Commun. 2021; 12: 33. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20277-y

PMCID:: PMC7782691

Abstract Article PDF–2.7M

Select item 56581922.

Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast

Joseph C. Sanchez, Elizabeth X. Kwan, Thomas J. Pohl, Haley M. Amemiya, M. K. Raghuraman, Bonita J. Brewer

PLoS Genet. 2017 Oct; 13(10): e1007041. Published online 2017 Oct 16. doi: 10.1371/journal.pgen.1007041

PMCID:: PMC5658192

Abstract Article PDF–6.7M

Select item 27788713.

The Origin Recognition Complex Interacts with a Subset of Metabolic Genes Tightly Linked to Origins of Replication

Erika Shor, Christopher L. Warren, Joshua Tietjen, Zhonggang Hou, Ulrika Müller, Ilaria Alborelli, Florence H. Gohard, Adrian I. Yemm, Lev Borisov, James R. Broach, Michael Weinreich, Conrad A. Nieduszynski, Aseem Z. Ansari, Catherine A. Fox

PLoS Genet. 2009 Dec; 5(12): e1000755. Published online 2009 Dec 4. doi: 10.1371/journal.pgen.1000755

PMCID:: PMC2778871

Abstract Article PDF–1015K

Select item 30332014.

Cdc6 ATPase ACTIVITY REGULATES ORC-Cdc6 STABILITY AND THE SELECTION OF SPECIFIC DNA SEQUENCES AS ORIGINS OF DNA REPLICATION

Christian Speck, Bruce Stillman

J Biol Chem. Author manuscript; available in PMC 2011 Feb 3.

Published in final edited form as: J Biol Chem. 2007 Apr 20; 282(16): 11705–11714. Published online 2007 Feb 21. doi: 10.1074/jbc.M700399200

PMCID:: PMC3033201

Abstract Article PDF–1.2M

Select item 23353125.

Multiple pathways inhibit NHEJ at telomeres

Stéphane Marcand, Benjamin Pardo, Ariane Gratias, Sabrina Cahun, Isabelle Callebaut

Genes Dev. 2008 May 1; 22(9): 1153–1158. doi: 10.1101/gad.455108

PMCID:: PMC2335312

Abstract Article PDF–614K

Select item 17984256.

Mechanism for the degradation of origin recognition complex containing Orc5p with a defective Walker A motif and its suppression by over-production of Orc4p in yeast cells

Masaki Makise, Naoko Takahashi, Kazuya Matsuda, Fumiko Yamairi, Keitarou Suzuki, Tomofusa Tsuchiya, Tohru Mizushima

Biochem J. 2007 Mar 1; 402(Pt 2): 397–403. Prepublished online 2004 Nov 15. Published online 2007 Feb 12. doi: 10.1042/BJ20060841

PMCID:: PMC1798425

Abstract Article PDF–371K

Select item 20491927.

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2–7 loading

Shuyan Chen, Milan A. de Vries, Stephen P. Bell

Genes Dev. 2007 Nov 15; 21(22): 2897–2907. doi: 10.1101/gad.1596807

PMCID:: PMC2049192

Abstract Article PDF–492K

Select item 75609028.

Evolution of DNA replication origin specification and gene silencing mechanisms

Y. Hu, A. Tareen, Y-J. Sheu, W. T. Ireland, C. Speck, H. Li, L. Joshua-Tor, J. B. Kinney, B. Stillman

Nat Commun. 2020; 11: 5175. Published online 2020 Oct 14. doi: 10.1038/s41467-020-18964-x

PMCID:: PMC7560902

Abstract Article PDF–2.4M

Select item 37720979.

A Link between ORC-Origin Binding Mechanisms and Origin Activation Time Revealed in Budding Yeast

Timothy Hoggard, Erika Shor, Carolin A. Müller, Conrad A. Nieduszynski, Catherine A. Fox

PLoS Genet. 2013 Sep; 9(9): e1003798. Published online 2013 Sep 12. doi: 10.1371/journal.pgen.1003798

PMCID:: PMC3772097

Abstract Article PDF–2.0M

Select item 23257310.

Architecture of the yeast origin recognition complex bound to origins of DNA replication.

D G Lee, S P Bell

Mol Cell Biol. 1997 Dec; 17(12): 7159–7168. doi: 10.1128/mcb.17.12.7159

PMCID:: PMC232573

Summary PDF–1.6M

Select item 537340911.

Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in S. cerevisiae

A. Zachary Ostrow, Reza Kalhor, Yan Gan, Sandra K. Villwock, Christian Linke, Matteo Barberis, Lin Chen, Oscar M. Aparicio

Proc Natl Acad Sci U S A. 2017 Mar 21; 114(12): E2411–E2419. Published online 2017 Mar 6. doi: 10.1073/pnas.1612422114

PMCID:: PMC5373409

Abstract Article PDF–1.5M

Select item 460107512.

Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues

Hironori Kawakami, Eiji Ohashi, Shota Kanamoto, Toshiki Tsurimoto, Tsutomu Katayama

Sci Rep. 2015; 5: 14929. Published online 2015 Oct 12. doi: 10.1038/srep14929

PMCID:: PMC4601075

Abstract Article PDF–2.3M

Select item 329998513.

Cdc6-induced Conformational Changes in ORC Bound To Origin DNA Revealed by Cryo-Electron Microscopy

Jingchuan Sun, Hironori Kawakami, Juergen Zech, Christian Speck, Bruce Stillman, Huilin Li

Structure. Author manuscript; available in PMC 2013 Mar 7.

Published in final edited form as: Structure. 2012 Mar 7; 20(3): 534–544. doi: 10.1016/j.str.2012.01.011

PMCID:: PMC3299985

Abstract Article PDF–3.3M

Select item 295229414.

ATPase-dependent, cooperative binding of ORC and Cdc6p to origin DNA

Christian Speck, Zhiqiang Chen, Huilin Li, Bruce Stillman

Nat Struct Mol Biol. Author manuscript; available in PMC 2010 Oct 10.

Published in final edited form as: Nat Struct Mol Biol. 2005 Nov; 12(11): 965–971. doi: 10.1038/nsmb1002

PMCID:: PMC2952294

Abstract Article PDF–2.0M

Select item 248061515.

The architecture of the DNA replication origin recognition complex in Saccharomyces cerevisiae

Zhiqiang Chen, Christian Speck, Patricia Wendel, Chunyan Tang, Bruce Stillman, Huilin Li

Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30): 10326–10331. Published online 2008 Jul 22. doi: 10.1073/pnas.0803829105

PMCID:: PMC2480615

Abstract Article PDF–932K

Select item 45249116.

ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.

C Santocanale, J F Diffley

EMBO J. 1996 Dec 2; 15(23): 6671–6679.

PMCID:: PMC452491

Summary Page Browse PDF–2.8M

Select item 31673217.

Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro

Tohru Mizushima, Naoko Takahashi, Bruce Stillman

Genes Dev. 2000 Jul 1; 14(13): 1631–1641.

PMCID:: PMC316732

Abstract Article PDF–3.1M

Select item 19622418.

Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin

Madeleine A. Palacios DeBeer, Ulrika Müller, Catherine A. Fox

Genes Dev. 2003 Aug 1; 17(15): 1817–1822. doi: 10.1101/gad.1096703

PMCID:: PMC196224

Abstract Article PDF–222K

Select item 888161119.

A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6

Jan Marten Schmidt, Ran Yang, Ashish Kumar, Olivia Hunker, Jan Seebacher, Franziska Bleichert

Nat Commun. 2022; 13: 1059. Published online 2022 Feb 25. doi: 10.1038/s41467-022-28695-w

PMCID:: PMC8881611

Abstract Article PDF–4.5M

Select item 821968120.

Inhibition of MRN activity by a telomere protein motif

Freddy Khayat, Elda Cannavo, Majedh Alshmery, William R. Foster, Charly Chahwan, Martino Maddalena, Christopher Smith, Antony W. Oliver, Adam T. Watson, Antony M. Carr, Petr Cejka, Alessandro Bianchi

Nat Commun. 2021; 12: 3856. Published online 2021 Jun 22. doi: 10.1038/s41467-021-24047-2