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Select item 112563921.

Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque

Fu-Jun Liao, Shao-Liang Shen, Hai-Long Bao, Hui Li, Quan-Wei Zhao, Long Chen, Cai-Wei Gong, Cheng-Zhu Xiong, Wu-Peng Liu, Wei Li, Da-Nan Liu

J Transl Med. 2024; 22: 668. Published online 2024 Jul 18. doi: 10.1186/s12967-024-05464-5

PMCID:: PMC11256392

Abstract Article PDF–10M

Select item 87470242.

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors

Tamera D. Hughes, Osman F. Güner, Emma Carine Iradukunda, Robert S. Phillips, J. Phillip Bowen

Molecules. 2022 Jan; 27(1): 273. Published online 2022 Jan 2. doi: 10.3390/molecules27010273

PMCID:: PMC8747024

Abstract Article PDF–2.8M

Select item 83933843.

Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas

Gustavo Ignacio Vázquez Cervantes, Benjamín Pineda, Daniela Ramírez Ortega, Alelí Salazar, Dinora Fabiola González Esquivel, Daniel Rembao, Sergio Zavala Vega, Saúl Gómez-Manzo, Gonzalo Pérez de la Cruz, Verónica Pérez de la Cruz

Cells. 2021 Aug; 10(8): 2028. Published online 2021 Aug 8. doi: 10.3390/cells10082028

PMCID:: PMC8393384

Abstract Article PDF–3.4M

Select item 71912604.

Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression

Tzu-Ting Huang, Ling-Ming Tseng, Ji-Lin Chen, Pei-Yi Chu, Chia-Han Lee, Chun-Teng Huang, Wan-Lun Wang, Ka-Yi Lau, Mei-Fang Tseng, Yuan-Ya Chang, Tzu-Yi Chiang, Yune-Fang Ueng, Hsin-Chen Lee, Ming-Shen Dai, Chun-Yu Liu

EBioMedicine. 2020 Apr; 54: 102717. Published online 2020 Apr 27. doi: 10.1016/j.ebiom.2020.102717

PMCID:: PMC7191260

Abstract Article PDF–5.3M

Select item 49900045.

A genome-wide association study of kynurenic acid in cerebrospinal fluid: implications for psychosis and cognitive impairment in bipolar disorder

CM Sellgren, ME Kegel, SE Bergen, CJ Ekman, S Olsson, M Larsson, MP Vawter, L Backlund, PF Sullivan, P Sklar, JW Smoller, PKE Magnusson, CM Hultman, L Walther-Jallow, CI Svensson, P Lichtenstein, M Schalling, G Engberg, S Erhardt, M Landén

Mol Psychiatry. Author manuscript; available in PMC 2016 Aug 18.

Published in final edited form as: Mol Psychiatry. 2014 Mar; 19(3): 334–341. Published online 2013 Mar 5. doi: 10.1038/mp.2013.11

PMCID:: PMC4990004

Abstract Article PDF–556K

Select item 48556666.

Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional nonlinear feedback

K Wilson, M Auer, M Binnie, X Zheng, N T Pham, J P Iredale, S P Webster, D J Mole

Cell Death Dis. 2016 Apr; 7(4): e2197. Published online 2016 Apr 14. doi: 10.1038/cddis.2016.87

PMCID:: PMC4855666

Abstract Article PDF–2.2M

Select item 45162297.

Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia

Ikwunga Wonodi, Robert P. McMahon, Nithin Krishna, Braxton D. Mitchell, Judy Liu, Matthew Glassman, L. Elliot Hong, James M. Gold

Schizophr Res. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Schizophr Res. 2014 Dec; 160(0): 80–87. Published online 2014 Nov 14. doi: 10.1016/j.schres.2014.10.026

PMCID:: PMC4516229

Abstract Article PDF–1004K

Select item 44791338.

Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma

Haojie Jin, Yurong Zhang, Haiyan You, Xuemei Tao, Cun Wang, Guangzhi Jin, Ning Wang, Haoyu Ruan, Dishui Gu, Xisong Huo, Wenming Cong, Wenxin Qin

Sci Rep. 2015; 5: 10466. Published online 2015 Jun 23. doi: 10.1038/srep10466

PMCID:: PMC4479133

Abstract Article PDF–1.9M

Select item 39693029.

Bacterial expression of human kynurenine 3-monooxygenase: Solubility, activity, purification

K. Wilson, D.J. Mole, M. Binnie, N.Z.M. Homer, X. Zheng, B.A. Yard, J.P. Iredale, M. Auer, S.P. Webster

Protein Expr Purif. 2014 Mar; 95(100): 96–103. doi: 10.1016/j.pep.2013.11.015

PMCID:: PMC3969302

Abstract Article

Select item 385554310.

Downregulated Kynurenine 3-Monooxygenase Gene Expression and Enzyme Activity in Schizophrenia and Genetic Association With Schizophrenia Endophenotypes

Ikwunga Wonodi, O. Colin Stine, Korrapati V. Sathyasaikumar, Rosalinda C. Roberts, Braxton D. Mitchell, L. Elliot Hong, Yasushi Kajii, Gunvant K. Thaker, Robert Schwarcz

Arch Gen Psychiatry. Author manuscript; available in PMC 2013 Dec 7.

Published in final edited form as: Arch Gen Psychiatry. 2011 Jul; 68(7): 10.1001/archgenpsychiatry.2011.71. doi: 10.1001/archgenpsychiatry.2011.71

PMCID:: PMC3855543

Abstract Article PDF–429K

Select item 324449911.

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls

Maria Holtze, Peter Saetre, Göran Engberg, Lilly Schwieler, Thomas Werge, Ole A. Andreassen, Håkan Hall, Lars Terenius, Ingrid Agartz, Erik G. Jönsson, Martin Schalling, Sophie Erhardt

J Psychiatry Neurosci. 2012 Jan; 37(1): 53–57. doi: 10.1503/jpn.100175

PMCID:: PMC3244499

Abstract Article PDF–182K

Select item 734184612.

Dysregulation at multiple points of the kynurenine pathway is a ubiquitous feature of renal cancer: implications for tumour immune evasion

Nick Hornigold, Karen R. Dunn, Rachel A. Craven, Alexandre Zougman, Sebastian Trainor, Rebecca Shreeve, Joanne Brown, Helen Sewell, Michael Shires, Margaret Knowles, Tsutomu Fukuwatari, Eamonn R. Maher, Julie Burns, Selina Bhattarai, Mini Menon, Alvis Brazma, Ghislaine Scelo, Lara Feulner, Yasser Riazalhosseini, Mark Lathrop, Adrian Harris, Peter J. Selby, Rosamonde E. Banks, Naveen S. Vasudev

Br J Cancer. 2020 Jul 7; 123(1): 137–147. Published online 2020 May 11. doi: 10.1038/s41416-020-0874-y

PMCID:: PMC7341846

Abstract Article PDF–1.3M

Select item 487126813.

Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Damian J Mole, Scott P Webster, Iain Uings, Xiaozhong Zheng, Margaret Binnie, Kris Wilson, Jonathan P Hutchinson, Olivier Mirguet, Ann Walker, Benjamin Beaufils, Nicolas Ancellin, Lionel Trottet, Véronique Bénéton, Christopher G Mowat, Martin Wilkinson, Paul Rowland, Carl Haslam, Andrew McBride, Natalie ZM Homer, James E Baily, Matthew GF Sharp, O James Garden, Jeremy Hughes, Sarah EM Howie, Duncan S Holmes, John Liddle, John P Iredale

Nat Med. Author manuscript; available in PMC 2016 Jul 11.

Published in final edited form as: Nat Med. 2016 Feb; 22(2): 202–209. Published online 2016 Jan 11. doi: 10.1038/nm.4020

PMCID:: PMC4871268

Abstract Article PDF–1.1M

Select item 373609614.

Structural basis of kynurenine 3-monooxygenase inhibition

Marta Amaral, Colin Levy, Derren J. Heyes, Pierre Lafite, Tiago F. Outeiro, Flaviano Giorgini, David Leys, Nigel S. Scrutton

Nature. Author manuscript; available in PMC 2013 Oct 18.

Published in final edited form as: Nature. 2013 Apr 18; 496(7445): 382–385. Published online 2013 Apr 10. doi: 10.1038/nature12039

PMCID:: PMC3736096

Abstract Article PDF–905K

Select item 508488315.

Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria

Ron Korstanje, Konstantin Deutsch, Patricia Bolanos-Palmieri, Nils Hanke, Patricia Schroder, Lynne Staggs, Jan H. Bräsen, Ian S.D. Roberts, Susan Sheehan, Holly Savage, Hermann Haller, Mario Schiffer

J Am Soc Nephrol. 2016 Nov; 27(11): 3271–3277. Published online 2016 Mar 28. doi: 10.1681/ASN.2015070835

PMCID:: PMC5084883

Abstract Article

Select item 765475516.

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics

Daniel C. Maddison, Mónica Alfonso-Núñez, Aisha M. Swaih, Carlo Breda, Susanna Campesan, Natalie Allcock, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Flaviano Giorgini

PLoS Genet. 2020 Nov; 16(11): e1009129. Published online 2020 Nov 10. doi: 10.1371/journal.pgen.1009129

PMCID:: PMC7654755

Abstract Article PDF–2.7M

Select item 1113886417.

Enzymology of NAD+ homeostasis in man

G. Magni, A. Amici, M. Emanuelli, G. Orsomando, N. Raffaelli, S. Ruggieri

Cell Mol Life Sci. 2004 Jan; 61(1): 19–34. doi: 10.1007/s00018-003-3161-1

PMCID:: PMC11138864

Abstract Article PDF–291K

Select item 276555218.

Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis

Jacob L. McCauley, Rebecca L. Zuvich, Yuki Bradford, Shannon J. Kenealy, Nathalie Schnetz-Boutaud, Simon G. Gregory, Stephen L. Hauser, Jorge R. Oksenberg, Douglas P. Mortlock, Margaret A. Pericak-Vance, Jonathan L. Haines

Genes Immun. Author manuscript; available in PMC 2010 Apr 1.

Published in final edited form as: Genes Immun. 2009 Oct; 10(7): 624–630. Published online 2009 Jul 23. doi: 10.1038/gene.2009.53

PMCID:: PMC2765552

Abstract Article PDF–802K

Select item 625176119.

Endogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders

Brent Wilkinson, Oleg Evgrafov, DongQing Zheng, Nicolas Hartel, James A. Knowles, Nicholas A. Graham, Justin Ichida, Marcelo P. Coba

Biol Psychiatry. Author manuscript; available in PMC 2020 Feb 15.

Published in final edited form as: Biol Psychiatry. 2019 Feb 15; 85(4): 305–316. Published online 2018 May 23. doi: 10.1016/j.biopsych.2018.05.009

PMCID:: PMC6251761

Abstract Article PDF–1.6M

Select item 526093920.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

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