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Select item 103803961.

SKAP1 Is a Novel Biomarker and Therapeutic Target for Gastric Cancer: Evidence from Expression, Functional, and Bioinformatic Analyses

Lingqin Zhu, Qiongfang Yu, Yuanheng Li, Meng Zhang, Zhiwei Peng, Song Wang, Ziyi Quan, Dian Gao

Int J Mol Sci. 2023 Jul; 24(14): 11870. Published online 2023 Jul 24. doi: 10.3390/ijms241411870

PMCID:: PMC10380396

Abstract Article PDF–11M

Select item 38714282.

The N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms

Michael J. Ophir, Beiyun C. Liu, Stephen C. Bunnell

J Cell Biol. 2013 Dec 23; 203(6): 1021–1041. doi: 10.1083/jcb.201305088

PMCID:: PMC3871428

Abstract Article PDF–5.3M

Select item 99964393.

Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes

Daffodil M. Canson, Tracy A. O’Mara, Amanda B. Spurdle, Dylan M. Glubb

HGG Adv. 2023 Apr 13; 4(2): 100185. Published online 2023 Feb 15. doi: 10.1016/j.xhgg.2023.100185

PMCID:: PMC9996439

Abstract Article PDF–2.0M

Select item 53594224.

D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes

Amelie Witte, Bernhard Meineke, Jana Sticht, Lars Philipsen, Benno Kuropka, Andreas J. Müller, Christian Freund, Burkhart Schraven, Stefanie Kliche

Mol Cell Biol. 2017 Apr 1; 37(7): e00509-16. Prepublished online 2017 Jan 4. Published online 2017 Mar 17. doi: 10.1128/MCB.00509-16

PMCID:: PMC5359422

Abstract Article PDF–1.9M

Select item 22132735.

An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R

Eun-Kyeong Jo, Hongyan Wang, Christopher E. Rudd

J Exp Med. 2005 Jun 6; 201(11): 1733–1739. doi: 10.1084/jem.20042577

PMCID:: PMC2213273

Abstract Article PDF–1.6M

Select item 2033416.

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

Hyun Kang, Christian Freund, Jonathan S. Duke-Cohan, Andrea Musacchio, Gerhard Wagner, Christopher E. Rudd

EMBO J. 2000 Jun 15; 19(12): 2889–2899. doi: 10.1093/emboj/19.12.2889

PMCID:: PMC203341

Abstract Article PDF–798K

Select item 82901987.

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events

Nirdosh Dadwal, Charlie Mix, Annegret Reinhold, Amelie Witte, Christian Freund, Burkhart Schraven, Stefanie Kliche

Front Immunol. 2021; 12: 703534. Published online 2021 Jul 6. doi: 10.3389/fimmu.2021.703534

PMCID:: PMC8290198

Abstract Article PDF–1.3M

Select item 1337208.

SKAP55 Coupled with CD45 Positively Regulates T-Cell Receptor-Mediated Gene Transcription

Liangtang Wu, Jun Fu, Shi-Hsiang Shen

Mol Cell Biol. 2002 Apr; 22(8): 2673–2686. doi: 10.1128/MCB.22.8.2673-2686.2002

PMCID:: PMC133720

Abstract Article PDF–815K

Select item 211539.

FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

Junke Liu, Hyun Kang, Monika Raab, Antonio J. da Silva, Stine-Kathrein Kraeft, Christopher E. Rudd

Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15): 8779–8784. doi: 10.1073/pnas.95.15.8779

PMCID:: PMC21153

Abstract Article PDF–453K

Select item 381284710.

T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes

Monika Raab, Hongyan Wang, Yuning Lu, Xin Smith, Zhonglin Wu, Klaus Strebhardt, John E. Ladbury, Christopher E. Rudd

Immunity. Author manuscript; available in PMC 2013 Oct 30.

Published in final edited form as: Immunity. 2010 Apr 23; 32(4): 10.1016/j.immuni.2010.03.007. Published online 2010 Mar 25. doi: 10.1016/j.immuni.2010.03.007

PMCID:: PMC3812847

Abstract Article PDF–3.7M

Select item 319100711.

SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1

Monika Raab, Xin Smith, Yves Matthess, Klaus Strebhardt, Christopher E. Rudd

J Biol Chem. 2011 Aug 26; 286(34): 29663–29670. Published online 2011 Jun 13. doi: 10.1074/jbc.M111.222661

PMCID:: PMC3191007

Abstract Article PDF–1.2M

Select item 159288412.

The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1

Stefanie Kliche, Dennis Breitling, Mauro Togni, Rico Pusch, Katja Heuer, Xiaoqian Wang, Christian Freund, Ana Kasirer-Friede, Gael Menasche, Gary A. Koretzky, Burkhart Schraven

Mol Cell Biol. 2006 Oct; 26(19): 7130–7144. doi: 10.1128/MCB.00331-06

PMCID:: PMC1592884

Abstract Article PDF–922K

Select item 458304913.

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration

Dan Cao, Zeqi Su, Wenwen Wang, Huihui Wu, Xing Liu, Saima Akram, Bo Qin, Jiajia Zhou, Xiaoxuan Zhuang, Gregory Adams, Changjiang Jin, Xiwei Wang, Lifang Liu, Donald L. Hill, Dongmei Wang, Xia Ding, Xuebiao Yao

J Biol Chem. 2015 Sep 25; 290(39): 23766–23780. Published online 2015 Aug 4. doi: 10.1074/jbc.M115.673517

PMCID:: PMC4583049

Abstract Article PDF–3.4M

Select item 302023114.

A Genome-Wide Association Study Identifies Susceptibility Loci for Ovarian Cancer at 2q31 and 8q24

Ellen L. Goode, Georgia Chenevix-Trench, Honglin Song, Susan J. Ramus, Maria Notaridou, Kate Lawrenson, Martin Widschwendter, Robert A. Vierkant, Melissa C. Larson, Susanne K. Kjaer, Michael J. Birrer, Andrew Berchuck, Joellen Schildkraut, Ian Tomlinson, Lambertus A. Kiemeney, Linda S. Cook, Jacek Gronwald, Montserrat Garcia-Closas, Martin E. Gore, Ian Campbell, Alice S. Whittemore, Rebecca Sutphen, Catherine Phelan, Hoda Anton-Culver, Celeste Leigh Pearce, Diether Lambrechts, Mary Anne Rossing, Jenny Chang-Claude, Kirsten B. Moysich, Marc T. Goodman, Thilo Dörk, Heli Nevanlinna, Roberta B. Ness, Thorunn Rafnar, Claus Hogdall, Estrid Hogdall, Brooke L. Fridley, Julie M. Cunningham, Weiva Sieh, Valerie McGuire, Andrew K. Godwin, Daniel W. Cramer, Dena Hernandez, Douglas Levine, Karen Lu, Edwin S. Iversen, Rachel T. Palmieri, Richard Houlston, Anne M. van Altena, Katja K.H. Aben, Leon F.A.G. Massuger, Angela Brooks-Wilson, Linda E. Kelemen, Nhu D. Le, Anna Jakubowska, Jan Lubinski, Krzysztof Medrek, Anne Stafford, Douglas F. Easton, Jonathan Tyrer, Kelly L. Bolton, Patricia Harrington, Diana Eccles, Ann Chen, Ashley N. Molina, Barbara N. Davila, Hector Arango, Ya-Yu Tsai, Zhihua Chen, Harvey A. Risch, John McLaughlin, Steven A. Narod, Argyrios Ziogas, Wendy Brewster, Aleksandra Gentry-Maharaj, Usha Menon, Anna H. Wu, Daniel O. Stram, Malcolm C. Pike, The Wellcome Trust Case-Control Consortium, Jonathan Beesley, Penelope M. Webb, The Australian Cancer Study (Ovarian Cancer), The Australian Ovarian Cancer Study Group, Xiaoqing Chen, Arif B. Ekici, Falk C. Thiel, Matthias W. Beckmann, Hannah Yang, Nicolas Wentzensen, Jolanta Lissowska, Peter A. Fasching, Evelyn Despierre, Frederic Amant, Ignace Vergote, Jennifer Doherty, Rebecca Hein, Shan Wang-Gohrke, Galina Lurie, Michael E. Carney, Pamela J. Thompson, Ingo Runnebaum, Peter Hillemanns, Matthias Dürst, Natalia Antonenkova, Natalia Bogdanova, Arto Leminen, Ralf Butzow, Tuomas Heikkinen, Kari Stefansson, Patrick Sulem, Sören Besenbacher, Thomas A. Sellers, Simon A. Gayther, Paul D.P. Pharoah

Nat Genet. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Nat Genet. 2010 Oct; 42(10): 874–879. Published online 2010 Sep 19. doi: 10.1038/ng.668

PMCID:: PMC3020231

Abstract Article PDF–699K

Select item 369318315.

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

Paul D. P. Pharoah, Ya-Yu Tsai, Susan J. Ramus, Catherine M. Phelan, Ellen L. Goode, Kate Lawrenson, Melissa Price, Brooke L. Fridley, Jonathan P. Tyrer, Howard Shen, Rachel Weber, Rod Karevan, Melissa C. Larson, Honglin Song, Daniel C. Tessier, François Bacot, Daniel Vincent, Julie M. Cunningham, Joe Dennis, Ed Dicks, Australian Cancer Study, Australian Ovarian Cancer Study Group, Katja K. Aben, Hoda Anton-Culver, Natalia Antonenkova, Sebastian M. Armasu, Laura Baglietto, Elisa V. Bandera, Matthias W. Beckmann, Michael J. Birrer, Greg Bloom, Natalia Bogdanova, James D. Brenton, Louise A. Brinton, Angela Brooks-Wilson, Robert Brown, Ralf Butzow, Ian Campbell, Michael E Carney, Renato S. Carvalho, Jenny Chang-Claude, Y. Anne Chen, Zhihua Chen, Wong-Ho Chow, Mine S. Cicek, Gerhard Coetzee, Linda S. Cook, Daniel W. Cramer, Cezary Cybulski, Agnieszka Dansonka-Mieszkowska, Evelyn Despierre, Jennifer A Doherty, Thilo Dörk, Andreas du Bois, Matthias Dürst, Diana Eccles, Robert Edwards, Arif B. Ekici, Peter A. Fasching, David Fenstermacher, James Flanagan, Yu-Tang Gao, Montserrat Garcia-Closas, Aleksandra Gentry-Maharaj, Graham Giles, Anxhela Gjyshi, Martin Gore, Jacek Gronwald, Qi Guo, Mari K Halle, Philipp Harter, Alexander Hein, Florian Heitz, Peter Hillemanns, Maureen Hoatlin, Estrid Høgdall, Claus K. Høgdall, Satoyo Hosono, Anna Jakubowska, Allan Jensen, Kimberly R. Kalli, Beth Y. Karlan, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne Krüger Kjaer, Gottfried E. Konecny, Camilla Krakstad, Jolanta Kupryjanczyk, Diether Lambrechts, Sandrina Lambrechts, Nhu D. Le, Nathan Lee, Janet Lee, Arto Leminen, Boon Kiong Lim, Jolanta Lissowska, Jan Lubinski, Lene Lundvall, Galina Lurie, Leon F.A.G. Massuger, Keitaro Matsuo, Valerie McGuire, John R McLaughlin, Usha Menon, Francesmary Modugno, Kirsten B. Moysich, Toru Nakanishi, Steven A. Narod, Roberta B. Ness, Heli Nevanlinna, Stefan Nickels, Houtan Noushmehr, Kunle Odunsi, Sara Olson, Irene Orlow, James Paul, Tanja Pejovic, Liisa M Pelttari, Jenny Permuth-Wey, Malcolm C Pike, Elizabeth M Poole, Xiaotao Qu, Harvey A. Risch, Lorna Rodriguez-Rodriguez, Mary Anne Rossing, Anja Rudolph, Ingo Runnebaum, Iwona K Rzepecka, Helga B. Salvesen, Ira Schwaab, Gianluca Severi, Hui Shen, Vijayalakshmi Shridhar, Xiao-Ou Shu, Weiva Sieh, Melissa C. Southey, Paul Spellman, Kazuo Tajima, Soo-Hwang Teo, Kathryn L. Terry, Pamela J Thompson, Agnieszka Timorek, Shelley S. Tworoger, Anne M. van Altena, David Van Den Berg, Ignace Vergote, Robert A. Vierkant, Allison F. Vitonis, Shan Wang-Gohrke, Nicolas Wentzensen, Alice S. Whittemore, Elisabeth Wik, Boris Winterhoff, Yin Ling Woo, Anna H Wu, Hannah P. Yang, Wei Zheng, Argyrios Ziogas, Famida Zulkifli, Marc T. Goodman, Per Hall, Douglas F Easton, Celeste L Pearce, Andrew Berchuck, Georgia Chenevix-Trench, Edwin Iversen, Alvaro N.A. Monteiro, Simon A. Gayther, Joellen M. Schildkraut, Thomas A. Sellers

Nat Genet. Author manuscript; available in PMC 2013 Oct 1.

Published in final edited form as: Nat Genet. 2013 Apr; 45(4): 362–370e2. doi: 10.1038/ng.2564

PMCID:: PMC3693183

Abstract Article PDF–977K

Select item 387065916.

HIV-1 gp120 impairs B cell proliferation by inducing TGF-ß1 production and FcRL4 expression

Katija Jelicic, Raffaello Cimbro, Fatima Nawaz, Da Wei Huang, Xin Zheng, Jun Yang, Richard A. Lempicki, Massimiliano Pascuccio, Donald Van Ryk, Catherine Schwing, Joseph Hiatt, Noreen Okwara, Danlan Wei, Gregg Roby, Antonio David, Young Hwang, II, John H. Kehrl, James Arthos, Claudia Cicala, Anthony S. Fauci

Nat Immunol. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Nat Immunol. 2013 Dec; 14(12): 1256–1265. Published online 2013 Oct 27. doi: 10.1038/ni.2746

PMCID:: PMC3870659

Abstract Article PDF–1.4M

Select item 318838817.

Leveraging the power of next-generation sequencing to generate interactome datasets

Haiyuan Yu, Leah Tardivo, Stanley Tam, Evan Weiner, Fana Gebreab, Changyu Fan, Nenad Svrzikapa, Tomoko Hirozane-Kishikawa, Edward Rietman, Xinping Yang, Julie Sahalie, Kourosh Salehi-Ashtiani, Tong Hao, Michael E. Cusick, David E. Hill, Frederick P. Roth, Pascal Braun, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Nat Methods. 2011 Jun; 8(6): 478–480. Published online 2011 Apr 24. doi: 10.1038/nmeth.1597

PMCID:: PMC3188388

Abstract Article PDF–932K

Select item 674264618.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 319082619.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 289646420.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

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