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1.
Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9
Kyuwon Baek, Raymond S. Brown, Gabriel Birrane, John A.A. Ladias
J Mol Biol. Author manuscript; available in PMC 2007 Apr 17.
Published in final edited form as: J Mol Biol. 2007 Feb 16; 366(2): 563–573. Published online 2006 Nov 18. doi: 10.1016/j.jmb.2006.11.057
PMCID:
PMC1852425
AbstractArticlePDF–3.3M
2.
CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer
Rui Sun, Ting Wei, Donglin Ding, Jianong Zhang, Sujun Chen, Housheng Hansen He, Liguo Wang, Haojie Huang
Proc Natl Acad Sci U S A. 2022 Sep 27; 119(39): e2205509119. Published online 2022 Sep 21. doi: 10.1073/pnas.2205509119
PMCID:
PMC9522376
AbstractArticlePDF–2.7M
3.
De Novo Mutations of CCNK Cause a Syndromic Neurodevelopmental Disorder with Distinctive Facial Dysmorphism
Yanjie Fan, Wu Yin, Bing Hu, Antonie D. Kline, Victor Wei Zhang, Desheng Liang, Yu Sun, Lili Wang, Sha Tang, Zöe Powis, Lei Li, Huifang Yan, Zhen Shi, Xiaoping Yang, Yinyin Chen, Jingmin Wang, Yuwu Jiang, Hu Tan, Xuefan Gu, Lingqian Wu, Yongguo Yu
Am J Hum Genet. 2018 Sep 6; 103(3): 448–455. Published online 2018 Aug 16. doi: 10.1016/j.ajhg.2018.07.019
PMCID:
PMC6128244
AbstractArticlePDF–1.9M
4.
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
Tingjun Lei, Peixuan Zhang, Xudong Zhang, Xue Xiao, Jingli Zhang, Tong Qiu, Qian Dai, Yujun Zhang, Ling Min, Qian Li, Rutie Yin, Ping Ding, Ni Li, Yi Qu, Dezhi Mu, Jun Qin, Xiaofeng Zhu, Zhi-Xiong Xiao, Qintong Li
Nat Commun. 2018; 9: 1876. Published online 2018 May 14. doi: 10.1038/s41467-018-04258-w
PMCID:
PMC5951916
AbstractArticlePDF–2.0M
5.
Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding
Sarah E. Dixon-Clarke, Jonathan M. Elkins, S.-W. Grace Cheng, Gregg B. Morin, Alex N. Bullock
Sci Rep. 2015; 5: 17122. Published online 2015 Nov 24. doi: 10.1038/srep17122
PMCID:
PMC4656997
AbstractArticlePDF–2.0M
6.
Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
Kingsley M. Ekumi, Hana Paculova, Tina Lenasi, Vendula Pospichalova, Christian A. Bösken, Jana Rybarikova, Vitezslav Bryja, Matthias Geyer, Dalibor Blazek, Matjaz Barboric
Nucleic Acids Res. 2015 Mar 11; 43(5): 2575–2589. Published online 2015 Feb 20. doi: 10.1093/nar/gkv101
PMCID:
PMC4357706
AbstractArticlePDF–4.6M
7.
A Distinct Expression Pattern of Cyclin K in Mammalian Testes Suggests a Functional Role in Spermatogenesis
Xiaocong Xiang, Li Deng, Jingli Zhang, Xudong Zhang, Tingjun Lei, Guangxin Luan, Chunlei Yang, Zhi-Xiong Xiao, Qian Li, Qintong Li
PLoS One. 2014; 9(7): e101539. Published online 2014 Jul 8. doi: 10.1371/journal.pone.0101539
PMCID:
PMC4086901
AbstractArticlePDF–11M
8.
Cyclin K and cyclin D1b are oncogenic in myeloma cells
Véronique Marsaud, Guergana Tchakarska, Geoffroy Andrieux, Jian-Miao Liu, Doulaye Dembele, Bernard Jost, Joanna Wdzieczak-Bakala, Jack-Michel Renoir, Brigitte Sola
Mol Cancer. 2010; 9: 103. Published online 2010 May 10. doi: 10.1186/1476-4598-9-103
PMCID:
PMC2881116
AbstractArticlePDF–2.5M
9.
Cyclin K as a Direct Transcriptional Target of the p53 Tumor Suppressor
Toshiki Mori, Yoshio Anazawa, Kuniko Matsui, Seisuke Fukuda, Yusuke Nakamura, Hirofumi Arakawa
Neoplasia. 2002 May; 4(3): 268–274. doi: 10.1038/sj.neo.7900235
PMCID:
PMC1531701
AbstractArticlePDF–471K
10.
HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity
Qingqing Chai, Sunan Li, Morgan K. Collins, Rongrong Li, Iqbal Ahmad, Silas F. Johnson, Dylan A. Frabutt, Zhichang Yang, Xiaojing Shen, Liangliang Sun, Jian Hu, Judd F. Hultquist, B. Matija Peterlin, Yong-Hui Zheng
Cell Rep. Author manuscript; available in PMC 2021 Aug 25.
Published in final edited form as: Cell Rep. 2021 Aug 10; 36(6): 109514. doi: 10.1016/j.celrep.2021.109514
PMCID:
PMC8385645
AbstractArticlePDF–2.1M
11.
Cyclin K interacts with β-catenin to induce Cyclin D1 expression and facilitates tumorigenesis and radioresistance in lung cancer
Guojun Yao, Jing Tang, Xijie Yang, Ye Zhao, Rui Zhou, Rui Meng, Sheng Zhang, Xiaorong Dong, Tao Zhang, Kunyu Yang, Gang Wu, Shuangbing Xu
Theranostics. 2020; 10(24): 11144–11158. Published online 2020 Sep 11. doi: 10.7150/thno.42578
PMCID:
PMC7532664
AbstractArticlePDF–3.2M
12.
Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation
Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yue Cui, Qingcui Wu, Jiaojiao Li, Jian-Hua Wang, Meng-Qiu Dong, Xiangbing Qi, Ting Han
eLife. 2020; 9: e59994. Published online 2020 Aug 17. doi: 10.7554/eLife.59994
PMCID:
PMC7462607
AbstractArticlePDF–5.2M
13.
Interaction of Cyclin-Dependent Kinase 12/CrkRS with Cyclin K1 Is Required for the Phosphorylation of the C-Terminal Domain of RNA Polymerase II
S.-W. Grace Cheng, Michael A. Kuzyk, Annie Moradian, Taka-Aki Ichu, Vicky C.-D. Chang, Jerry F. Tien, Sarah E. Vollett, Malachi Griffith, Marco A. Marra, Gregg B. Morin
Mol Cell Biol. 2012 Nov; 32(22): 4691–4704. doi: 10.1128/MCB.06267-11
PMCID:
PMC3486194
AbstractArticlePDF–1.3M
14.
Cyclin K Inhibits HIV-1 Gene Expression and Replication by Interfering with Cyclin-dependent Kinase 9 (CDK9)-Cyclin T1 Interaction in Nef-dependent Manner
Sohrab Zafar Khan, Debashis Mitra
J Biol Chem. 2011 Jul 1; 286(26): 22943–22954. Published online 2011 May 9. doi: 10.1074/jbc.M110.201194
PMCID:
PMC3123062
AbstractArticlePDF–2.7M
15.
Cyclin-dependent kinase 9–cyclin K functions in the replication stress response
David S Yu, Runxiang Zhao, Emory L Hsu, Jennifer Cayer, Fei Ye, Yan Guo, Yu Shyr, David Cortez
EMBO Rep. 2010 Nov; 11(11): 876–882. Published online 2010 Oct 8. doi: 10.1038/embor.2010.153
PMCID:
PMC2966956
AbstractArticlePDF–788K
16.
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, Richard Bunker, Katherine A. Donovan, Quinlan L. Sievers, Jonas Koeppel, Dakota Suchyta, Adam S. Sperling, Emma C. Fink, Jessica A. Gasser, Li R. Wang, Steven M. Corsello, Rob S. Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R. Golub, Eric S. Fischer, Nicolas H. Thomä, Benjamin L. Ebert
Nature. Author manuscript; available in PMC 2020 Dec 3.
Published in final edited form as: Nature. 2020 Sep; 585(7824): 293–297. Published online 2020 Jun 3. doi: 10.1038/s41586-020-2374-x
PMCID:
PMC7486275
AbstractArticlePDF–4.0M
17.
The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes
Dalibor Blazek, Jiri Kohoutek, Koen Bartholomeeusen, Eric Johansen, Petra Hulinkova, Zeping Luo, Peter Cimermancic, Jernej Ule, B. Matija Peterlin
Genes Dev. 2011 Oct 15; 25(20): 2158–2172. doi: 10.1101/gad.16962311
PMCID:
PMC3205586
AbstractArticlePDF–1.9M
18.
Human Cyclin K, a Novel RNA Polymerase II-Associated Cyclin Possessing Both Carboxy-Terminal Domain Kinase and Cdk-Activating Kinase Activity
Michael C. Edwards, Calvin Wong, Stephen J. Elledge
Mol Cell Biol. 1998 Jul; 18(7): 4291–4300. doi: 10.1128/mcb.18.7.4291
PMCID:
PMC109013
AbstractArticlePDF–1.0M
19.
Cyclin K-containing Kinase Complexes Maintain Self-renewal in Murine Embryonic Stem Cells
Qian Dai, Tingjun Lei, Changhong Zhao, Jianqiao Zhong, Yi-zhi Tang, Bin Chen, Jie Yang, Chenghua Li, Siyu Wang, Xu Song, Li Li, Qintong Li
J Biol Chem. 2012 Jul 20; 287(30): 25344–25352. Published online 2012 Apr 30. doi: 10.1074/jbc.M111.321760
PMCID:
PMC3408147
AbstractArticlePDF–2.1M
20.
A non-catalytic function of SETD1A regulates Cyclin-K and the DNA damage response
Takayuki Hoshii, Paolo Cifani, Zhaohui Feng, Chun-Hao Huang, Richard Koche, Chun-Wei Chen, Christopher D. Delaney, Scott W. Lowe, Alex Kentsis, Scott A. Armstrong
Cell. Author manuscript; available in PMC 2019 Feb 22.
Published in final edited form as: Cell. 2018 Feb 22; 172(5): 1007–1021.e17. doi: 10.1016/j.cell.2018.01.032
PMCID:
PMC6052445
AbstractArticlePDF–2.3M

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