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Select item 111504811.

In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia

Deepak M. Sahasrabudhe, Jane L. Liesveld, Mohammad Minhajuddin, Niloy A. Singh, Subhangi Nath, Vishuwes Muthu Kumar, Marlene Balys, Andrew G. Evans, Mitra Azadniv, Jeanne N. Hansen, Michael W. Becker, Ashoke Sharon, V. Kaye Thomas, Richard G. Moore, Manoj K. Khera, Craig T. Jordan, Rakesh K. Singh

Sci Rep. 2024; 14: 12868. Published online 2024 Jun 4. doi: 10.1038/s41598-024-63392-2

PMCID:: PMC11150481

Abstract Article PDF–6.8M

Select item 111170732.

Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Morgan L. Pimm, Brian K. Haarer, Alexander D. Nobles, Laura M. Haney, Alexandra G. Marcin, Marcela Alcaide Eligio, Jessica L. Henty-Ridilla

J Cell Biol. 2024 Sep 2; 223(9): e202305065. Published online 2024 May 24. doi: 10.1083/jcb.202305065

PMCID:: PMC11117073

Abstract Article PDF–6.9M

Select item 102995093.

7-Ketocholesterol Promotes Retinal Pigment Epithelium Senescence and Fibrosis of Choroidal Neovascularization via IQGAP1 Phosphorylation-Dependent Signaling

Haibo Wang, Aniket Ramshekar, Thaonhi Cung, Chris Wallace-Carrete, Chandler Zaugg, Jasmine Nguyen, Gregory J. Stoddard, M. Elizabeth Hartnett

Int J Mol Sci. 2023 Jun; 24(12): 10276. Published online 2023 Jun 17. doi: 10.3390/ijms241210276

PMCID:: PMC10299509

Abstract Article PDF–2.7M

Select item 101205954.

The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling

Louise Thines, Francis J. Roushar, Andrew C. Hedman, David B. Sacks

J Cell Biol. 2023 Jun 5; 222(6): e202205062. Published online 2023 Apr 18. doi: 10.1083/jcb.202205062

PMCID:: PMC10120595

Abstract Article PDF–2.4M

Select item 97273355.

Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT116 as a Surrogate Model Colorectal Carcinoma

Khairy M A Zoheir, Khaled Mahmoud, Gamaleldin I. Harisa, Abdelkader Ashour, Hala E. Abdel-Hamied, Amro A. Amara, Karima F. Mahrous, Ahmed A. Abd-Rabou

Asian Pac J Cancer Prev. 2022 Jul; 23(7): 2387–2395. doi: 10.31557/APJCP.2022.23.7.2387

PMCID:: PMC9727335

Abstract Article PDF–584K

Select item 88868176.

Single-molecule imaging of IQGAP1 regulating actin filament dynamics

Gregory J. Hoeprich, Amy N. Sinclair, Shashank Shekhar, Bruce L. Goode

Mol Biol Cell. 2022 Jan 1; 33(1): ar2. doi: 10.1091/mbc.E21-04-0211

PMCID:: PMC8886817

Abstract Article PDF–3.6M

Select item 79266637.

IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway

Niall P. Quinn, Lucía García-Gutiérrez, Carolanne Doherty, Alexander von Kriegsheim, Emma Fallahi, David B. Sacks, David Matallanas

Cells. 2021 Feb; 10(2): 478. Published online 2021 Feb 23. doi: 10.3390/cells10020478

PMCID:: PMC7926663

Abstract Article PDF–3.3M

Select item 79105878.

The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry

Nicholas M. Negretti, Christopher R. Gourley, Prabhat K. Talukdar, Geremy Clair, Courtney M. Klappenbach, Cody J. Lauritsen, Joshua N. Adkins, Michael E. Konkel

Nat Commun. 2021; 12: 1339. Published online 2021 Feb 26. doi: 10.1038/s41467-021-21579-5

PMCID:: PMC7910587

Abstract Article PDF–1.9M

Select item 71527619.

Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42

Laëtitia Gorisse, Zhigang Li, Craig D. Wagner, David K. Worthylake, Francesca Zappacosta, Andrew C. Hedman, Roland S. Annan, David B. Sacks

J Biol Chem. 2020 Apr 10; 295(15): 4822–4835. Published online 2020 Feb 24. doi: 10.1074/jbc.RA119.011491

PMCID:: PMC7152761

Abstract Article PDF–2.3M

Select item 701593110.

The scaffold protein IQGAP1 is crucial for extravasation and metastasis

Jess D. Hebert, Chenxi Tian, John M. Lamar, Steffen Rickelt, Genevieve Abbruzzese, Xiaotie Liu, Richard O. Hynes

Sci Rep. 2020; 10: 2439. Published online 2020 Feb 12. doi: 10.1038/s41598-020-59438-w

PMCID:: PMC7015931

Abstract Article PDF–1.7M

Select item 694263011.

A PI3K/AKT Scaffolding Protein, IQ motif-containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis

Tao Wei, Suyong Choi, Darya Buehler, Richard A. Anderson, Paul F. Lambert

Clin Cancer Res. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Clin Cancer Res. 2020 Jan 1; 26(1): 301–311. Published online 2019 Oct 9. doi: 10.1158/1078-0432.CCR-19-1063

PMCID:: PMC6942630

Abstract Article PDF–1.5M

Select item 659125212.

The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif

Mo Chen, Suyong Choi, Oisun Jung, Tianmu Wen, Christina Baum, Narendra Thapa, Paul F. Lambert, Alan C. Rapraeger, Richard A. Anderson

Sci Rep. 2019; 9: 9126. Published online 2019 Jun 24. doi: 10.1038/s41598-019-45671-5

PMCID:: PMC6591252

Abstract Article PDF–9.8M

Select item 652516413.

IQGAP1 promotes pancreatic cancer progression and epithelial-mesenchymal transition (EMT) through Wnt/β-catenin signaling

Wei Hu, Zhongxia Wang, Shan Zhang, Xian Lu, Junyi Wu, Kuanyong Yu, Anlai Ji, Wei Lu, Zhong Wang, Junhua Wu, Chunping Jiang

Sci Rep. 2019; 9: 7539. Published online 2019 May 17. doi: 10.1038/s41598-019-44048-y

PMCID:: PMC6525164

Abstract Article PDF–7.1M

Select item 629398814.

IQGAP1 Maintains Pancreatic Ductal Adenocarcinoma Clonogenic Growth and Metastasis

Joey H. Li, Ross H. McMillan, Asma Begum, Christian B. Gocke, William Matsui

Pancreas. Author manuscript; available in PMC 2020 Jan 1.

Published in final edited form as: Pancreas. 2019 Jan; 48(1): 94–98. doi: 10.1097/MPA.0000000000001198

PMCID:: PMC6293988

Abstract Article PDF–572K

Select item 605344315.

The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma

Martina Sanlorenzo, Igor Vujic, Rosaura Esteve-Puig, Kevin Lai, Marin Vujic, Kevin Lin, Christian Posch, Michelle Dimon, Adrian Moy, Mitchell Zekhtser, Katia Johnston, Deborah Gho, Wilson Ho, Abhinay Gajjala, Juan Oses Prieto, Alma Burlingame, Adil Daud, Klemens Rappersberger, Susana Ortiz-Urda

Sci Rep. 2018; 8: 10902. Published online 2018 Jul 19. doi: 10.1038/s41598-018-27643-3

PMCID:: PMC6053443

Abstract Article PDF–1.4M

Select item 599113616.

Ras GTPase-Activating-Like Protein IQGAP1 (IQGAP1) Promotes Breast Cancer Proliferation and Invasion and Correlates with Poor Clinical Outcomes

Fanye Zeng, Weihua Jiang, Wei Zhao, Yuxiang Fan, Yanhua Zhu, Hongliang Zhang

Med Sci Monit. 2018; 24: 3315–3323. Published online 2018 May 20. doi: 10.12659/MSM.909916

PMCID:: PMC5991136

Abstract Article PDF–1.1M

Select item 571430417.

The scaffolding protein IQGAP1 interacts with Nucleotide Binding Domain Leucine Rich Repeat CARD containing protein (NLRC3) and inhibits type I interferon production

Aaron M. Tocker, Emily Durocher, Kimberly D. Jacob, Kate E. Trieschman, Suzanna M. Talento, Alma A. Rechnitzer, David M. Roberts, Beckley K. Davis

J Immunol. Author manuscript; available in PMC 2018 Oct 15.

Published in final edited form as: J Immunol. 2017 Oct 15; 199(8): 2896–2909. Published online 2017 Sep 1. doi: 10.4049/jimmunol.1601370

PMCID:: PMC5714304

Abstract Article PDF–2.9M

Select item 529778318.

IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Dolores Pérez-Rodríguez, Manuel Morales, María del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Int J Mol Sci. 2017 Jan; 18(1): 150. Published online 2017 Jan 13. doi: 10.3390/ijms18010150

PMCID:: PMC5297783

Abstract Article PDF–8.3M

Select item 472966319.

IQGAP1 is a Phosphoinositide Effector and Kinase Scaffold

Suyong Choi, Richard A. Anderson

Adv Biol Regul. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Adv Biol Regul. 2016 Jan; 60: 29–35. Published online 2015 Oct 28. doi: 10.1016/j.jbior.2015.10.004

PMCID:: PMC4729663

Abstract Article PDF–738K

Select item 448069120.

Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1

Hyeongsun Moon, Jayde E. Ruelcke, Eunju Choi, Laura J. Sharpe, Zeyad D. Nassar, Helle Bielefeldt-Ohmann, Marie-Odile Parat, Anup Shah, Mathias Francois, Kerry L. Inder, Andrew J. Brown, Pamela J. Russell, Robert G. Parton, Michelle M. Hill

Oncotarget. 2015 Apr 10; 6(10): 7438–7453. Published online 2015 Mar 2. doi: 10.18632/oncotarget.3476