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Select item 82879261.

Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2

Mengfan Tang, Guangsheng Pei, Dan Su, Chao Wang, Xu Feng, Mrinal Srivastava, Zhen Chen, Zhongming Zhao, Junjie Chen

Nucleic Acids Res. 2021 Jul 21; 49(13): 7476–7491. Published online 2021 Jul 1. doi: 10.1093/nar/gkab540

PMCID:: PMC8287926

Abstract Article PDF–3.6M

Select item 31442542.

Cyclin C regulates human hematopoietic stem/progenitor cell quiescence

Yasuhiko Miyata, Yan Liu, Vladimir Jankovic, Goro Sashida, Jennifer May Lee, Jae-Hung Shieh, Tomoki Naoe, Malcolm Moore, Stephen D. Nimer

Stem Cells. Author manuscript; available in PMC 2011 Jul 26.

Published in final edited form as: Stem Cells. 2010 Feb; 28(2): 308–317. doi: 10.1002/stem.270

PMCID:: PMC3144254

Abstract Article PDF–882K

Select item 2958403.

Disappearance of cyclin A correlates with permanent withdrawal of cardiomyocytes from the cell cycle in human and rat hearts.

M Yoshizumi, W S Lee, C M Hsieh, J C Tsai, J Li, M A Perrella, C Patterson, W O Endege, R Schlegel, M E Lee

J Clin Invest. 1995 May; 95(5): 2275–2280. doi: 10.1172/JCI117918

PMCID:: PMC295840

Summary Page Browse PDF–2.0M

Select item 65895754.

Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission

Vidyaramanan Ganesan, Stephen D. Willis, Kai-Ti Chang, Samuel Beluch, Katrina F. Cooper, Randy Strich

Mol Biol Cell. 2019 Feb 1; 30(3): 302–311. doi: 10.1091/mbc.E18-07-0463

PMCID:: PMC6589575

Abstract Article PDF–1.1M

Select item 46774595.

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Trevor Dale, Paul A. Clarke, Christina Esdar, Dennis Waalboer, Olajumoke Adeniji-Popoola, Maria-Jesus Ortiz-Ruiz, Aurélie Mallinger, Rahul S. Samant, Paul Czodrowski, Djordje Musil, Daniel Schwarz, Klaus Schneider, Mark Stubbs, Ken Ewan, Elizabeth Fraser, Robert TePoele, Will Court, Gary Box, Melanie Valenti, Alexis de Haven Brandon, Sharon Gowan, Felix Rohdich, Florence Raynaud, Richard Schneider, Oliver Poeschke, Andree Blaukat, Paul Workman, Kai Schiemann, Suzanne A. Eccles, Dirk Wienke, Julian Blagg

Nat Chem Biol. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Nat Chem Biol. 2015 Dec; 11(12): 973–980. Published online 2015 Oct 26. doi: 10.1038/nchembio.1952

PMCID:: PMC4677459

Abstract Article PDF–2.2M

Select item 41226396.

All-atomic Molecular Dynamic Studies of Human CDK8: Insight into the A-loop, Point Mutations and Binding with Its Partner CycC

Wu Xu, Benjamin Amire-Brahimi, Xiao-Jun Xie, Liying Huang, Jun-Yuan Ji

Comput Biol Chem. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Comput Biol Chem. 2014 Aug; 51: 1–11. Published online 2014 Apr 3. doi: 10.1016/j.compbiolchem.2014.03.003

PMCID:: PMC4122639

Abstract Article PDF–2.8M

Select item 36577687.

Structure–kinetic relationship study of CDK8/CycC specific compounds

Elisabeth V. Schneider, Jark Böttcher, Robert Huber, Klaus Maskos, Lars Neumann

Proc Natl Acad Sci U S A. 2013 May 14; 110(20): 8081–8086. Published online 2013 Apr 29. doi: 10.1073/pnas.1305378110

PMCID:: PMC3657768

Abstract Article PDF–876K

Select item 89583518.

Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer

Hong‐yue Jiang, Ying‐ling Chen, Xing‐xing Xu, Chuan‐yin Li, Yun Chen, Dong‐ping Li, Xiao‐qing Zeng, Hong Gao

Clin Transl Med. 2022 Mar; 12(3): e770. Published online 2022 Mar 28. doi: 10.1002/ctm2.770

PMCID:: PMC8958351

Abstract Article PDF–3.6M

Select item 84212119.

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress

Rebecca L Lloyd, Vaclav Urban, Francisco Muñoz-Martínez, Iñigo Ayestaran, John C Thomas, Christelle de Renty, Mark J O’Connor, Josep V Forment, Yaron Galanty, Stephen P Jackson

Nucleic Acids Res. 2021 Sep 7; 49(15): 8665–8683. Published online 2021 Jul 30. doi: 10.1093/nar/gkab628

PMCID:: PMC8421211

Abstract Article PDF–6.2M

Select item 588013910.

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Min Ju Park, Hailian Shen, Jason M. Spaeth, Jaana H. Tolvanen, Courtney Failor, Jennifer F. Knudtson, Jessica McLaughlin, Sunil K. Halder, Qiwei Yang, Serdar E. Bulun, Ayman Al-Hendy, Robert S. Schenken, Lauri A. Aaltonen, Thomas G. Boyer

J Biol Chem. 2018 Mar 30; 293(13): 4870–4882. Published online 2018 Feb 13. doi: 10.1074/jbc.RA118.001725

PMCID:: PMC5880139

Abstract Article PDF–2.4M

Select item 263068511.

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

Matthew T. Knuesel, Krista D. Meyer, Aaron J. Donner, Joaquin M. Espinosa, Dylan J. Taatjes

Mol Cell Biol. 2009 Feb; 29(3): 650–661. Published online 2008 Dec 1. doi: 10.1128/MCB.00993-08

PMCID:: PMC2630685

Abstract Article PDF–1.5M

Select item 4106912.

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.

J P Tassan, M Jaquenoud, P Léopold, S J Schultz, E A Nigg

Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19): 8871–8875. doi: 10.1073/pnas.92.19.8871

PMCID:: PMC41069

Summary Page Browse PDF–1.1M

Select item 108789813.

Regulation of the human cyclin C gene via multiple vitamin D₃-responsive regions in its promoter

Lasse Sinkkonen, Marjo Malinen, Katri Saavalainen, Sami Väisänen, Carsten Carlberg

Nucleic Acids Res. 2005; 33(8): 2440–2451. Published online 2005 Apr 29. doi: 10.1093/nar/gki502

PMCID:: PMC1087898

Abstract Article PDF–250K

Select item 599696014.

A complex molecular switch directs stress-induced cyclin C nuclear release through SCF^Grr1-mediated degradation of Med13

David C. Stieg, Stephen D. Willis, Vidyaramanan Ganesan, Kai Li Ong, Joseph Scuorzo, Mia Song, Julianne Grose, Randy Strich, Katrina F. Cooper

Mol Biol Cell. 2018 Feb 1; 29(3): 363–375. doi: 10.1091/mbc.E17-08-0493

PMCID:: PMC5996960

Abstract Article PDF–2.0M

Select item 8712315.

Characterization of Mediator Complexes from HeLa Cell Nuclear Extract

Gang Wang, Greg T. Cantin, Jennitte L. Stevens, Arnold J. Berk

Mol Cell Biol. 2001 Jul; 21(14): 4604–4613. doi: 10.1128/MCB.21.14.4604-4613.2001

PMCID:: PMC87123

Abstract Article PDF–417K

Select item 445637416.

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)

Daorong Feng, Dou Yeon Youn, Xiaoping Zhao, Yanguang Gao, William J. Quinn, 3rd, Alus M. Xiaoli, Yan Sun, Morris J. Birnbaum, Jeffrey E. Pessin, Fajun Yang

PLoS One. 2015; 10(6): e0126240. Published online 2015 Jun 4. doi: 10.1371/journal.pone.0126240

PMCID:: PMC4456374

Abstract Article PDF–5.0M

Select item 14732717.

Factors associated with the mammalian RNA polymerase II holoenzyme.

A S Neish, S F Anderson, B P Schlegel, W Wei, J D Parvin

Nucleic Acids Res. 1998 Feb 1; 26(3): 847–853. doi: 10.1093/nar/26.3.847

PMCID:: PMC147327

Summary PDF–255K

Select item 637714818.

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P. Ponting, Ambrosius P. Snijders, Regina Feederle, Aloys Schepers, Dominik Boos

PLoS Biol. 2019 Jan; 17(1): e2006767. Published online 2019 Jan 29. doi: 10.1371/journal.pbio.2006767

PMCID:: PMC6377148

Abstract Article PDF–4.1M

Select item 423577319.

Cyclin C is a haploinsufficient tumor suppressor

Na Li, Anne Fassl, Joel Chick, Hiroyuki Inuzuka, Xiaoyu Li, Marc R. Mansour, Lijun Liu, Haizhen Wang, Bryan King, Shavali Shaik, Alejandro Gutierrez, Alban Ordureau, Tobias Otto, Taras Kreslavsky, Lukas Baitsch, Leah Bury, Clifford A. Meyer, Nan Ke, Kristin A. Mulry, Michael J. Kluk, Moni Roy, Sunkyu Kim, Xiaowu Zhang, Yan Geng, Agnieszka Zagozdzon, Sarah Jenkinson, Rosemary E. Gale, David C. Linch, Jean J. Zhao, Charles G. Mullighan, J. Wade Harper, Jon C. Aster, Iannis Aifantis, Harald von Boehmer, Steven P. Gygi, Wenyi Wei, A. Thomas Look, Piotr Sicinski

Nat Cell Biol. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Nat Cell Biol. 2014 Nov; 16(11): 1080–1091. Published online 2014 Oct 26. doi: 10.1038/ncb3046

PMCID:: PMC4235773

Abstract Article PDF–4.3M

Select item 51453620.

A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1

Reena Pinhero, Peter Liaw, Krassimir Yankulov

Biol Proced Online. 2004; 6: 163–172. Published online 2004 Aug 18. doi: 10.1251/bpo86

PMCID:: PMC514536

Abstract Article PDF–874K

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