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Select item 79485701.

Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis

Georgi A. Georgiev, Mohammad Sharifian Gh., Jeff Romano, Karina L. Dias Teixeira, Craig Struble, Denise S. Ryan, Rose K. Sia, Jay P. Kitt, Joel M. Harris, Ku-Lung Hsu, Adam Libby, Marc G. Odrich, Tatiana Suárez, Robert L. McKown, Gordon W. Laurie

J Biol Chem. 2021 Jan-Jun; 296: 100070. Published online 2020 Nov 21. doi: 10.1074/jbc.RA120.015833

PMCID:: PMC7948570

Abstract Article PDF–3.2M

Select item 46809352.

Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death

Venkat Rao Vantaku, Geetika Gupta, Krishna Chaitanya Rapalli, Roy Karnati

Sci Rep. 2015; 5: 18362. Published online 2015 Dec 16. doi: 10.1038/srep18362

PMCID:: PMC4680935

Abstract Article PDF–755K

Select item 44560953.

A thermo-responsive protein treatment for dry eyes

Wan Wang, Aarti Jashnani, Suhaas R. Aluri, Joshua A. Gustafson, Pang-Yu Hsueh, Frances Yarber, Robert L. McKown, Gordon W. Laurie, Sarah F. Hamm-Alvarez, J. Andrew MacKay

J Control Release. Author manuscript; available in PMC 2016 Feb 10.

Published in final edited form as: J Control Release. 2015 Feb 10; 199: 156–167. Published online 2014 Dec 3. doi: 10.1016/j.jconrel.2014.11.016

PMCID:: PMC4456095

Abstract Article PDF–3.7M

Select item 42701044.

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

Wan Wang, Jordan Despanie, Pu Shi, Maria C. Edman-Woolcott, Yi-An Lin, Honggang Cui, J. Martin Heur, M. Elizabeth Fini, Sarah F. Hamm-Alvarez, J. Andrew MacKay

J Mater Chem B Mater Biol Med. Author manuscript; available in PMC 2015 Dec 14.

Published in final edited form as: J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46): 8131–8141. doi: 10.1039/C4TB00979G

PMCID:: PMC4270104

Abstract Article PDF–1.6M

Select item 41392305.

A Cleavage-potentiated Fragment of Tear Lacritin Is Bactericidal

Robert L. McKown, Erin V. Coleman Frazier, Kaneil K. Zadrozny, Andrea M. Deleault, Ronald W. Raab, Denise S. Ryan, Rose K. Sia, Jae K. Lee, Gordon W. Laurie

J Biol Chem. 2014 Aug 8; 289(32): 22172–22182. Published online 2014 Jun 18. doi: 10.1074/jbc.M114.570143

PMCID:: PMC4139230

Abstract Article PDF–2.2M

Select item 41131896.

Gene Expression in Human Accessory Lacrimal Glands of Wolfring

John L. Ubels, Ilene K. Gipson, Sandra J. Spurr-Michaud, Ann S. Tisdale, Rachel E. Van Dyken, Mark P. Hatton

Invest Ophthalmol Vis Sci. 2012 Oct; 53(11): 6738–6747. Published online 2012 Oct 1. doi: 10.1167/iovs.12-10750

PMCID:: PMC4113189

Abstract Article PDF–656K

Select item 38440477.

Lacritin and the Tear Proteome as Natural Replacement Therapy for Dry Eye

Roy Karnati, Diane E. Laurie, Gordon W. Laurie

Exp Eye Res. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Exp Eye Res. 2013 Dec; 117: 10.1016/j.exer.2013.05.020. Published online 2013 Jun 12. doi: 10.1016/j.exer.2013.05.020

PMCID:: PMC3844047

Abstract Article PDF–430K

Select item 36263148.

Lacritin-Induced Secretion of Tear Proteins From Cultured Monkey Lacrimal Acinar Cells

Atsuko Fujii, Ayumi Morimoto-Tochigi, Ryan D. Walkup, Thomas R. Shearer, Mitsuyoshi Azuma

Invest Ophthalmol Vis Sci. 2013 Apr; 54(4): 2533–2540. Published online 2013 Apr 5. doi: 10.1167/iovs.12-10394

PMCID:: PMC3626314

Abstract Article PDF–646K

Select item 36049099.

Conserved Regional 3′ Grouping of Rare Codons in the Coding Sequence of Ocular Prosecretory Mitogen Lacritin

Robert L. McKown, Ronald W. Raab, Patricia Kachelries, Sara Caldwell, Gordon W. Laurie

Invest Ophthalmol Vis Sci. 2013 Mar; 54(3): 1979–1987. Published online 2013 Mar 19. doi: 10.1167/iovs.12-10740

PMCID:: PMC3604909

Abstract Article PDF–784K

Select item 354007810.

Pathogen Induced Changes in the Protein Profile of Human Tears from Fusarium Keratitis Patients

Sivagnanam Ananthi, Namperumalsamy Venkatesh Prajna, Prajna Lalitha, Murugesan Valarnila, Kuppamuthu Dharmalingam

PLoS One. 2013; 8(1): e53018. Published online 2013 Jan 8. doi: 10.1371/journal.pone.0053018

PMCID:: PMC3540078

Abstract Article PDF–2.9M

Select item 346039011.

Tear Lacritin Levels by Age, Sex, and Time of Day in Healthy Adults

Kyle Seifert, Natasha C. Gandia, Jennifer K. Wilburn, Kraig S. Bower, Rose K. Sia, Denise S. Ryan, Michael L. Deaton, Katherine M. Still, Veronica C. Vassilev, Gordon W. Laurie, Robert L. McKown

Invest Ophthalmol Vis Sci. 2012 Sep; 53(10): 6610–6616. Published online 2012 Sep 25. doi: 10.1167/iovs.11-8729

PMCID:: PMC3460390

Abstract Article PDF–409K

Select item 344104412.

Detection of Prosecretory Mitogen Lacritin in Nonprimate Tears Primarily as a C-Terminal-Like Fragment

Diane E. Laurie, Rebecca K. Splan, Kari Green, Katherine M. Still, Robert L. McKown, Gordon W. Laurie

Invest Ophthalmol Vis Sci. 2012 Sep; 53(10): 6130–6136. Published online 2012 Sep 12. doi: 10.1167/iovs.11-8567

PMCID:: PMC3441044

Abstract Article PDF–534K

Select item 341066613.

iTRAQ Quantitative Proteomics in the Analysis of Tears in Dry Eye Patients

Sruthi Srinivasan, Mirunalni Thangavelu, Liwen Zhang, Kari B. Green, Kelly K. Nichols

Invest Ophthalmol Vis Sci. 2012 Jul; 53(8): 5052–5059. Published online 2012 Jul 31. doi: 10.1167/iovs.11-9022

PMCID:: PMC3410666

Abstract Article PDF–364K

Select item 225496914.

Mass spectrometry-based proteomic analyses of contact lens deposition

Kari B. Green-Church, Jason J. Nichols

Mol Vis. 2008; 14: 291–297. Published online 2008 Feb 8.

PMCID:: PMC2254969

Abstract Article PDF–245K

Select item 185697015.

Proteomic analysis of human meibomian gland secretions

P S Tsai, J E Evans, K M Green, R M Sullivan, D A Schaumberg, S M Richards, M R Dana, D A Sullivan

Br J Ophthalmol. 2006 Mar; 90(3): 372–377. doi: 10.1136/bjo.2005.080846

PMCID:: PMC1856970

Abstract Article PDF–157K

Select item 414892416.

Topical Administration of Lacritin Is a Novel Therapy for Aqueous-Deficient Dry Eye Disease

Trinka Vijmasi, Feeling Y. T. Chen, Suganthalakshmi Balasubbu, Marianne Gallup, Robert L. McKown, Gordon W. Laurie, Nancy A. McNamara

Invest Ophthalmol Vis Sci. 2014 Aug; 55(8): 5401–5409. Published online 2014 Aug 28. doi: 10.1167/iovs.14-13924

PMCID:: PMC4148924

Abstract Article PDF–611K

Select item 362150617.

Tissue Transglutaminase Is a Negative Regulator of Monomeric Lacritin Bioactivity

Francisco Velez V, Jeffrey A. Romano, Robert L. McKown, Kari Green, Liwen Zhang, Ronald W. Raab, Denise S. Ryan, Cindy M. L. Hutnik, Henry F. Frierson, Jr, Gordon W. Laurie

Invest Ophthalmol Vis Sci. 2013 Mar; 54(3): 2123–2132. Published online 2013 Mar 27. doi: 10.1167/iovs.12-11488

PMCID:: PMC3621506

Abstract Article PDF–1.1M

Select item 352564418.

Lacrimal Proline Rich 4 (LPRR4) Protein in the Tear Fluid Is a Potential Biomarker of Dry Eye Syndrome

Saijyothi Venkata Aluru, Shweta Agarwal, Bhaskar Srinivasan, Geetha Krishnan Iyer, Sivakumar M. Rajappa, Utpal Tatu, Prema Padmanabhan, Nirmala Subramanian, Angayarkanni Narayanasamy

PLoS One. 2012; 7(12): e51979. Published online 2012 Dec 18. doi: 10.1371/journal.pone.0051979