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Select item 77050211.

ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin’s lymphoma and testicular cancer cells

Daniel Constantin, Christian Widmann

Cell Death Dis. 2020 Nov; 11(11): 1019. Published online 2020 Nov 30. doi: 10.1038/s41419-020-03231-0

Correction in:: Cell Death Dis. 2021 Jan; 12(1): 96.

PMCID:: PMC7705021

Abstract Article PDF–1.7M

Select item 59949182.

Low expression of ASH2L protein correlates with a favorable outcome in acute myeloid leukemia

Jill S. Butler, Yi Hua Qiu, Nianxiang Zhang, Suk-Young Yoo, Kevin R. Coombes, Sharon Y.R. Dent, Steven M. Kornblau

Leuk Lymphoma. Author manuscript; available in PMC 2018 Jun 11.

Published in final edited form as: Leuk Lymphoma. 2017 May; 58(5): 1207–1218. Published online 2016 Oct 13. doi: 10.1080/10428194.2016.1235272

PMCID:: PMC5994918

Abstract Article PDF–3.7M

Select item 31472543.

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

Yong Chen, Bingbing Wan, Kevin C Wang, Fang Cao, Yuting Yang, Angeline Protacio, Yali Dou, Howard Y Chang, Ming Lei

EMBO Rep. 2011 Aug; 12(8): 797–803. Published online 2011 Jun 10. doi: 10.1038/embor.2011.101

PMCID:: PMC3147254

Abstract Article PDF–1.4M

Select item 72930914.

ASH2L is involved in promotion of endometrial cancer progression via upregulation of PAX2 transcription

Kai Zeng, Yi Wu, Chunyu Wang, Shengli Wang, Hongmiao Sun, Renlong Zou, Ge Sun, Huijuan Song, Wei Liu, Ning Sun, Shan Wei, Wensu Liu, Yingjie Su, Tingting Zhou, Yi Zhang, Yue Zhao

Cancer Sci. 2020 Jun; 111(6): 2062–2077. Published online 2020 May 23. doi: 10.1111/cas.14413

PMCID:: PMC7293091

Abstract Article PDF–2.9M

Select item 39830465.

Crystal structure of the trithorax group protein Ash2L reveals a Forkhead-like DNA binding domain

Sabina Sarvan, Vanja Avdic, Véronique Tremblay, Chandra-Prakash Chaturvedi, Pamela Zhang, Sylvain Lanouette, Alexandre Blais, Joseph S. Brunzelle, Marjorie Brand, Jean-François Couture

Nat Struct Mol Biol. Author manuscript; available in PMC 2014 Apr 10.

Published in final edited form as: Nat Struct Mol Biol. 2011 Jun 5; 18(7): 857–859. Published online 2011 Jun 5. doi: 10.1038/nsmb.2093

PMCID:: PMC3983046

Abstract Article PDF–880K

Select item 36151076.

ASH2L Regulates Ubiquitylation Signaling to MLL: Trans-regulation of H3 K4 Methylation in Higher Eukaryotes

Lipeng Wu, Shirley Y. Lee, Bo Zhou, Uyen T Nguyen, Tom Muir, Song Tan, Yali Dou

Mol Cell. Author manuscript; available in PMC 2014 Mar 28.

Published in final edited form as: Mol Cell. 2013 Mar 28; 49(6): 1108–1120. Published online 2013 Feb 28. doi: 10.1016/j.molcel.2013.01.033

PMCID:: PMC3615107

Abstract Article PDF–2.7M

Select item 28344617.

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation

Dieter Pullirsch, Renate Härtel, Hiroyuki Kishimoto, Martin Leeb, Günter Steiner, Anton Wutz

Development. 2010 Mar 15; 137(6): 935–943. doi: 10.1242/dev.035956

PMCID:: PMC2834461

Abstract Article

Select item 68529278.

Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma

Yan Chen, Zhonghu Li, Mengyun Zhang, Bo Wang, Jiaxin Ye, Yang Zhang, Di Tang, Dandan Ma, Weidong Jin, Xiaowu Li, Shuguang Wang

J Exp Clin Cancer Res. 2019; 38: 466. Published online 2019 Nov 12. doi: 10.1186/s13046-019-1436-0

Correction in:: J Exp Clin Cancer Res. 2021; 40: 137.

PMCID:: PMC6852927

Abstract Article PDF–7.0M

Select item 46229249.

EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas

Parsa Erfani, Jessica Tome-Garcia, Peter Canoll, Fiona Doetsch, Nadejda M Tsankova

Epigenetics. 2015 Jun; 10(6): 496–507. Published online 2015 May 21. doi: 10.1080/15592294.2015.1042645

PMCID:: PMC4622924

Abstract Article PDF–788K

Select item 429500210.

Ash2L enables P53–dependent apoptosis by favoring stable transcription pre–initiation complex formation on its pro-apoptotic target promoters

Sathish Kumar Mungamuri, Shaomeng Wang, James J. Manfredi, Wei Gu, Stuart A. Aaronson

Oncogene. Author manuscript; available in PMC 2015 Nov 7.

Published in final edited form as: Oncogene. 2015 May 7; 34(19): 2461–2470. Published online 2014 Jul 14. doi: 10.1038/onc.2014.198

PMCID:: PMC4295002

Abstract Article PDF–1.1M

Select item 329230311.

Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30

Yong Chen, Fang Cao, Bingbing Wan, Yali Dou, Ming Lei

Cell Res. 2012 Mar; 22(3): 598–602. Published online 2012 Jan 10. doi: 10.1038/cr.2012.9

PMCID:: PMC3292303

Article PDF–510K

Select item 813463512.

Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin

Young-Tae Lee, Alex Ayoub, Sang-Ho Park, Liang Sha, Jing Xu, Fengbiao Mao, Wei Zheng, Yang Zhang, Uhn-Soo Cho, Yali Dou

Nat Commun. 2021; 12: 2953. Published online 2021 May 19. doi: 10.1038/s41467-021-23268-9

PMCID:: PMC8134635

Abstract Article PDF–3.4M

Select item 810612713.

CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis

Xia Li, Meiting Qu, Jie Zhang, Kuanyin Chen, Xianghui Ma

J Orthop Surg Res. 2021; 16: 302. Published online 2021 May 8. doi: 10.1186/s13018-021-02432-3

PMCID:: PMC8106127

Abstract Article PDF–5.1M

Select item 583244014.

Molecular Basis for DPY-30 Association to COMPASS-like and NURF Complexes

Véronique Tremblay, Pamela Zhang, Chandra-Prakash Chaturvedi, Janet Thornton, Joseph S. Brunzelle, Georgios Skiniotis, Ali Shilatifard, Marjorie Brand, Jean-François Couture

Structure. Author manuscript; available in PMC 2018 Mar 1.

Published in final edited form as: Structure. 2014 Dec 2; 22(12): 1821–1830. Published online 2014 Nov 20. doi: 10.1016/j.str.2014.10.002

PMCID:: PMC5832440

Abstract Article PDF–1.2M

Select item 306185515.

NF-Y Recruits Ash2L to Impart H3K4 Trimethylation on CCAAT Promoters

Andrea Fossati, Diletta Dolfini, Giacomo Donati, Roberto Mantovani

PLoS One. 2011; 6(3): e17220. Published online 2011 Mar 21. doi: 10.1371/journal.pone.0017220

PMCID:: PMC3061855

Abstract Article PDF–1.4M

Select item 281874216.

A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit

Gerd A. Blobel, Stephan Kadauke, Eric Wang, Alan W. Lau, Johannes Zuber, Margaret M. Chou, Christopher R. Vakoc

Mol Cell. Author manuscript; available in PMC 2010 Dec 25.

Published in final edited form as: Mol Cell. 2009 Dec 25; 36(6): 970. doi: 10.1016/j.molcel.2009.12.001

PMCID:: PMC2818742

Abstract Article PDF–3.4M

Select item 273981417.

Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex

Iain W. McKinnell, Jeff Ishibashi, Fabien Le Grand, Vincent J. G. Punch, Gregory C. Addicks, Jack F. Greenblatt, F. Jeffrey Dilworth, Michael A. Rudnicki

Nat Cell Biol. Author manuscript; available in PMC 2009 Sep 8.

Published in final edited form as: Nat Cell Biol. 2008 Jan; 10(1): 77–84. Published online 2007 Dec 9. doi: 10.1038/ncb1671

PMCID:: PMC2739814

Abstract Article PDF–1.9M

Select item 682119518.

The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex

Jianming Han, Tingting Li, Yanjing Li, Muchun Li, Xiaoman Wang, Chao Peng, Chen Su, Na Li, Yiwen Li, Ying Xu, Yong Chen

Nucleic Acids Res. 2019 Nov 4; 47(19): 10426–10438. Published online 2019 Sep 23. doi: 10.1093/nar/gkz819

PMCID:: PMC6821195

Abstract Article PDF–3.9M

Select item 648897519.

Dissecting KMT2D missense mutations in Kabuki syndrome patients

Dario Cocciadiferro, Bartolomeo Augello, Pasquelena De Nittis, Jiyuan Zhang, Barbara Mandriani, Natascia Malerba, Gabriella M Squeo, Alessandro Romano, Barbara Piccinni, Tiziano Verri, Lucia Micale, Laura Pasqualucci, Giuseppe Merla

Hum Mol Genet. 2018 Nov 1; 27(21): 3651–3668. Published online 2018 Jun 22. doi: 10.1093/hmg/ddy241