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Select item 103135411.

Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs

Yan Shi, Bin Qin, Xiongwei Fan, Yongqing Li, Yuequn Wang, Wuzhou Yuan, Zhigang Jiang, Ping Zhu, Jimei Chen, Yu Chen, Fang Li, Yongqi Wan, Xiushan Wu, Jian Zhuang

Cell Tissue Res. 2023; 393(1): 163–179. Published online 2023 May 26. doi: 10.1007/s00441-023-03774-6

PMCID:: PMC10313541

Abstract Article PDF–7.9M

Select item 67141442.

miR‐516a‐3p inhibits breast cancer cell growth and EMT by blocking the Pygo2/Wnt signalling pathway

Yanyan Chi, Feng Wang, Tengfei Zhang, Han Xu, Yana Zhang, Zhengzheng Shan, Shaoxuan Wu, Qingxia Fan, Yan Sun

J Cell Mol Med. 2019 Sep; 23(9): 6295–6307. Published online 2019 Jul 5. doi: 10.1111/jcmm.14515

PMCID:: PMC6714144

Abstract Article PDF–2.6M

Select item 63813933.

An in vivo screen identifies PYGO2 as a driver for metastatic prostate cancer

Xin Lu, Xiaolu Pan, Chang-Jiun Wu, Di Zhao, Shan Feng, Yong Zang, Rumi Lee, Sunada Khadka, Samirkumar B. Amin, Eun-Jung Jin, Xiaoying Shang, Pingna Deng, Yanting Luo, William R. Morgenlander, Jacqueline Weinrich, Xuemin Lu, Shan Jiang, Qing Chang, Nora M. Navone, Patricia Troncoso, Ronald A. DePinho, Y. Alan Wang

Cancer Res. Author manuscript; available in PMC 2019 Jul 15.

Published in final edited form as: Cancer Res. 2018 Jul 15; 78(14): 3823–3833. Published online 2018 May 16. doi: 10.1158/0008-5472.CAN-17-3564

PMCID:: PMC6381393

Abstract Article PDF–2.9M

Select item 37187264.

Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer

Yang Liu, Qian-Ze Dong, Si Wang, Chang-Qing Fang, Yuan Miao, Liang Wang, Ming-Zhu Li, En-Hua Wang

BMC Cancer. 2013; 13: 346. Published online 2013 Jul 16. doi: 10.1186/1471-2407-13-346

PMCID:: PMC3718726

Abstract Article PDF–2.6M

Select item 32722335.

Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells

Bingnan Gu, Kazuhide Watanabe, Xing Dai

Cell Cycle. 2012 Jan 1; 11(1): 79–87. Published online 2012 Jan 1. doi: 10.4161/cc.11.1.18402

PMCID:: PMC3272233

Abstract Article PDF–4.6M

Select item 98434576.

Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients

Sanaz Soleymani Moud, Katayun Kamal Seraji, Mina Ramezani, Zeynab Piravar

Iran J Med Sci. 2023 Jan; 48(1): 77–84. doi: 10.30476/IJMS.2022.93009.2433

PMCID:: PMC9843457

Abstract Article PDF–392K

Select item 96830667.

Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2

Weidong Yuan, Hewei Zhao, Ang Zhou, Shaochuang Wang

Cancer Biol Ther. 2022; 23(1): 1–12. Published online 2022 Nov 20. doi: 10.1080/15384047.2022.2149039

PMCID:: PMC9683066

Abstract Article PDF–9.8M

Select item 95287738.

Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease ‐like colitis via the Axin2/GSK3β pathway

Jing Li, Lugen Zuo, Zhijun Geng, Qingqing Li, Yang Cheng, Zi Yang, Ruohan Shi, Yueqing Zhou, Wenhu Nie, Yueyue Wang, Xiaofeng Zhang, Sitang Ge, Xue Song, Jianguo Hu

Cell Prolif. 2022 Oct; 55(10): e13292. Published online 2022 Jun 16. doi: 10.1111/cpr.13292

PMCID:: PMC9528773

Abstract Article PDF–3.9M

Select item 54386189.

Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells

Cefan Zhou, Hongxia Cheng, Wenying Qin, Yi Zhang, Hui Xiong, Jing Yang, Huang Huang, Yefu Wang, Xing-Zhen Chen, Jingfeng Tang

Oncotarget. 2017 Apr 25; 8(17): 27915–27928. Published online 2017 Mar 2. doi: 10.18632/oncotarget.15843

PMCID:: PMC5438618

Abstract Article PDF–11M

Select item 448444010.

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

Sheng Zhang, Jie Li, Pingguo Liu, Jianfeng Xu, Wenxiu Zhao, Chengrong Xie, Zhenyu Yin, Xiaomin Wang

Oncotarget. 2015 May 10; 6(13): 11074–11086. Published online 2015 Mar 14. doi: 10.18632/oncotarget.3570

PMCID:: PMC4484440

Abstract Article PDF–3.7M

Select item 834907911.

Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis

Jintao Qian, Xinhan Lei, Yue Sun, Lu Zheng, Jia Li, Shuai Zhang, Lei Zhang, Wanwan Li, Jianing Shi, Wenjun Jia, Tong Tang

Biol Direct. 2021; 16: 13. Published online 2021 Aug 6. doi: 10.1186/s13062-021-00295-6

PMCID:: PMC8349079

Abstract Article PDF–5.2M

Select item 476326612.

Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment

Cefan Zhou, Yi Zhang, Jun Dai, Mengzhou Zhou, Miao Liu, Yefu Wang, Xing-Zhen Chen, Jingfeng Tang

Sci Rep. 2016; 6: 22066. Published online 2016 Feb 23. doi: 10.1038/srep22066

PMCID:: PMC4763266

Abstract Article PDF–2.6M

Select item 292778113.

Allosteric Remodelling of the Histone H3 Binding Pocket in the Pygo2 PHD Finger Triggered by Its Binding to the B9L/BCL9 Co-Factor

Thomas C.R. Miller, Trevor J. Rutherford, Christopher M. Johnson, Marc Fiedler, Mariann Bienz

J Mol Biol. 2010 Sep 3; 401(5-3): 969–984. doi: 10.1016/j.jmb.2010.07.007

PMCID:: PMC2927781

Abstract Article

Select item 738968414.

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

Cefan Zhou, Changhua Yi, Yongxiang Yi, Wenying Qin, Yanan Yan, Xueying Dong, Xuewen Zhang, Yuan Huang, Rui Zhang, Jie Wei, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Jingfeng Tang

Mol Cancer. 2020; 19: 118. Published online 2020 Jul 29. doi: 10.1186/s12943-020-01237-y

PMCID:: PMC7389684

Abstract Article PDF–12M

Select item 457188015.

Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation

Qiuling Li, Yuewei Li, Bingnan Gu, Lei Fang, Pengbo Zhou, Shilai Bao, Lan Huang, Xing Dai

J Biol Chem. 2015 Aug 28; 290(35): 21553–21567. Published online 2015 Jul 13. doi: 10.1074/jbc.M115.639419

PMCID:: PMC4571880

Abstract Article PDF–2.7M

Select item 389747316.

LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-catenin/BCL9 Interaction

Jiong Li, Xiaohong Chen, Xiangming Ding, Yingduan Cheng, Bin Zhao, Zhi-chun Lai, Khalid Al Hezaimi, Razqallah Hakem, Kun-liang Guan, Cun-Yu Wang

Cell Rep. Author manuscript; available in PMC 2014 Dec 26.

Published in final edited form as: Cell Rep. 2013 Dec 26; 5(6): 1650–1663. Published online 2013 Dec 19. doi: 10.1016/j.celrep.2013.11.037

Correction in:: Cell Rep. 2020 Jun 16; 31(11): 107792.

PMCID:: PMC3897473

Abstract Article PDF–2.1M

Select item 300427517.

Pygo2 Associates with MLL2 Histone Methyltransferase and GCN5 Histone Acetyltransferase Complexes To Augment Wnt Target Gene Expression and Breast Cancer Stem-Like Cell Expansion

Jiakun Chen, Qicong Luo, Yuanyang Yuan, Xiaoli Huang, Wangyu Cai, Chao Li, Tongzhen Wei, Ludi Zhang, Meng Yang, Qingfeng Liu, Guodong Ye, Xing Dai, Boan Li

Mol Cell Biol. 2010 Dec; 30(24): 5621–5635. Published online 2010 Oct 11. doi: 10.1128/MCB.00465-10