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Select item 69375581.

Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments

Yasna Contreras-Baeza, Pamela Y. Sandoval, Romina Alarcón, Alex Galaz, Francisca Cortés-Molina, Karin Alegría, Felipe Baeza-Lehnert, Robinson Arce-Molina, Anita Guequén, Carlos A. Flores, Alejandro San Martín, L. Felipe Barros

J Biol Chem. 2019 Dec 27; 294(52): 20135–20147. Published online 2019 Nov 12. doi: 10.1074/jbc.RA119.009093

PMCID:: PMC6937558

Abstract Article PDF–2.4M

Select item 61439252.

Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma

Yaping Long, Zihe Gao, Xiao Hu, Feng Xiang, Zhaozhen Wu, Jiahui Zhang, Xiao Han, Liyong Yin, Junfang Qin, Lan Lan, Fuzai Yin, Yue Wang

Cancer Med. 2018 Sep; 7(9): 4690–4700. Published online 2018 Jul 26. doi: 10.1002/cam4.1713

PMCID:: PMC6143925

Abstract Article PDF–1.1M

Select item 48846723.

Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4)

Kerstin Ziegler, Asimina Kerimi, Laure Poquet, Gary Williamson

Arch Biochem Biophys. 2016 Jun 1; 599: 3–12. doi: 10.1016/j.abb.2016.01.018

PMCID:: PMC4884672

Abstract Article

Select item 31320804.

Basolateral sorting signals regulating tissue-specific polarity of heteromeric monocarboxylate transporters in epithelia

John J. Castorino, Sylvie Deborde, Ami Deora, Ryan Schreiner, Shannon M. Gallagher-Colombo, Enrique Rodriguez-Boulan, Nancy J. Philp

Traffic. Author manuscript; available in PMC 2012 Apr 1.

Published in final edited form as: Traffic. 2011 Apr; 12(4): 483–498. Published online 2011 Feb 1. doi: 10.1111/j.1600-0854.2010.01155.x

PMCID:: PMC3132080

Abstract Article PDF–3.9M

Select item 22702045.

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

Jocelyn E Manning Fox, David Meredith, Andrew P Halestrap

J Physiol. 2000 Dec 1; 529(Pt 2): 285–293. doi: 10.1111/j.1469-7793.2000.00285.x

PMCID:: PMC2270204

Abstract Article PDF–277K

Select item 86921356.

Identification and Validation of a Prognostic Model Based on Three MVI-Related Genes in Hepatocellular Carcinoma

Yongchang Tang, Lei Xu, Yupeng Ren, Yuxuan Li, Feng Yuan, Mingbo Cao, Yong Zhang, Meihai Deng, Zhicheng Yao

Int J Biol Sci. 2022; 18(1): 261–275. Published online 2022 Jan 1. doi: 10.7150/ijbs.66536

PMCID:: PMC8692135

Abstract Article PDF–2.9M

Select item 36557707.

Hyaluronan, CD44, and Emmprin Regulate Lactate Efflux and Membrane Localization of Monocarboxylate Transporters in Human Breast Carcinoma Cells

Mark G. Slomiany, G. Daniel Grass, Angela D. Robertson, Xiao Y. Yang, Bernard L. Maria, Craig Beeson, Bryan P. Toole

Cancer Res. Author manuscript; available in PMC 2013 May 16.

Published in final edited form as: Cancer Res. 2009 Feb 15; 69(4): 1293–1301. Published online 2009 Jan 27. doi: 10.1158/0008-5472.CAN-08-2491

PMCID:: PMC3655770

Abstract Article PDF–2.7M

Select item 3066138.

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

P. Kirk, M.C. Wilson, C. Heddle, M.H. Brown, A.N. Barclay, A.P. Halestrap

EMBO J. 2000 Aug 1; 19(15): 3896–3904. doi: 10.1093/emboj/19.15.3896

PMCID:: PMC306613

Abstract Article PDF–865K

Select item 12190479.

Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past.

N T Price, V N Jackson, A P Halestrap

Biochem J. 1998 Jan 15; 329(Pt 2): 321–328. doi: 10.1042/bj3290321

PMCID:: PMC1219047

Summary PDF–817K

Select item 122055210.

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.

A P Halestrap, N T Price

Biochem J. 1999 Oct 15; 343(Pt 2): 281–299.

PMCID:: PMC1220552

Summary PDF–389K

Select item 610072411.

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions

Gustav N Sundell, Roland Arnold, Muhammad Ali, Piangfan Naksukpaiboon, Julien Orts, Peter Güntert, Celestine N Chi, Ylva Ivarsson

Mol Syst Biol. 2018 Aug; 14(8): e8129. Published online 2018 Aug 20. doi: 10.15252/msb.20178129

PMCID:: PMC6100724

Abstract Article PDF–2.4M

Select item 816786612.

Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb‐202 in gastric cancer

Hitomi Sakai, Hisato Kawakami, Takeshi Teramura, Yuta Onodera, Elizabeth Somers, Keiji Furuuchi, Toshimitsu Uenaka, Ryoji Kato, Kazuhiko Nakagawa

Clin Transl Med. 2021 Jun; 11(6): e454. Published online 2021 Jun 1. doi: 10.1002/ctm2.454

PMCID:: PMC8167866

Abstract Article PDF–7.0M

Select item 925813213.

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutants

Laura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin Sternburg, Vanessa Gattringer, Henrick Riemenschneider, Riccardo Berutti, Elisabeth Graf, Jochen H Weishaupt, Monika S Brill, Angelika B Harbauer, Dorothee Dormann, Jörn Dengjel, Dieter Edbauer, Christian Behrends

Life Sci Alliance. 2022 Nov; 5(11): e202101327. Published online 2022 Jul 1. doi: 10.26508/lsa.202101327

PMCID:: PMC9258132

Abstract Article PDF–5.9M

Select item 636858414.

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer

Weimei Tang, Weijie Zhou, Li Xiang, Xiaosheng Wu, Pei Zhang, Jing Wang, Guangnan Liu, Wenjing Zhang, Ying Peng, Xiaoting Huang, Jianqun Cai, Yang Bai, Lan Bai, Wei Zhu, Hongxiang Gu, Jing Xiong, Chen Ye, Aimin Li, Side Liu, Jide Wang

Nat Commun. 2019; 10: 663. Published online 2019 Feb 8. doi: 10.1038/s41467-018-08225-3

PMCID:: PMC6368584

Abstract Article PDF–6.8M

Select item 765186215.

TRIM37 Mediates Chemoresistance and Maintenance of Stemness in Pancreatic Cancer Cells via Ubiquitination of PTEN and Activation of the AKT–GSK-3β–β-Catenin Signaling Pathway

Shiyu Chen, Zhiwei He, Changhao Zhu, Yanqing Liu, Lin Li, Lu Deng, Jun Wang, Chao Yu, Chengyi Sun

Front Oncol. 2020; 10: 554787. Published online 2020 Oct 16. doi: 10.3389/fonc.2020.554787

PMCID:: PMC7651862

Abstract Article PDF–5.4M

Select item 1032325216.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 1091686617.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 764232718.

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner

Nat Commun. 2020; 11: 5559. Published online 2020 Nov 3. doi: 10.1038/s41467-020-19032-0

PMCID:: PMC7642327

Abstract Article PDF–12M

Select item 340884719.

Interpreting cancer genomes using systematic host perturbations by tumour virus proteins

Orit Rozenblatt-Rosen, Rahul C. Deo, Megha Padi, Guillaume Adelmant, Michael A. Calderwood, Thomas Rolland, Miranda Grace, Amélie Dricot, Manor Askenazi, Maria Tavares, Sam Pevzner, Fieda Abderazzaq, Danielle Byrdsong, Anne-Ruxandra Carvunis, Alyce A. Chen, Jingwei Cheng, Mick Correll, Melissa Duarte, Changyu Fan, Mariet C. Feltkamp, Scott B. Ficarro, Rachel Franchi, Brijesh K. Garg, Natali Gulbahce, Tong Hao, Amy M. Holthaus, Robert James, Anna Korkhin, Larisa Litovchick, Jessica C. Mar, Theodore R. Pak, Sabrina Rabello, Renee Rubio, Yun Shen, Saurav Singh, Jennifer M. Spangle, Murat Tasan, Shelly Wanamaker, James T. Webber, Jennifer Roecklein-Canfield, Eric Johannsen, Albert-László Barabási, Rameen Beroukhim, Elliott Kieff, Michael E. Cusick, David E. Hill, Karl Münger, Jarrod A. Marto, John Quackenbush, Frederick P. Roth, James A. DeCaprio, Marc Vidal

Nature. Author manuscript; available in PMC 2013 Jan 26.

Published in final edited form as: Nature. 2012 Jul 26; 487(7408): 491–495. doi: 10.1038/nature11288

PMCID:: PMC3408847

Abstract Article PDF–937K

Select item 638658820.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

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