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Select item 73822161.

Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin

Chao Dong, Kirk L. West, Xin Yi Tan, Junshi Li, Toyotaka Ishibashi, Cheng-han Yu, Shirley M. H. Sy, Justin W. C. Leung, Michael S. Y. Huen

Proc Natl Acad Sci U S A. 2020 Jul 21; 117(29): 17019–17030. Published online 2020 Jul 1. doi: 10.1073/pnas.2002193117

PMCID:: PMC7382216

Abstract Article PDF–2.6M

Select item 55269902.

DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain

Samira Abu Jhaisha, Esti W. Widowati, Isao Kii, Rie Sonamoto, Stefan Knapp, Chrisovalantis Papadopoulos, Walter Becker

Sci Rep. 2017; 7: 6420. Published online 2017 Jul 25. doi: 10.1038/s41598-017-06874-w

PMCID:: PMC5526990

Abstract Article PDF–2.2M

Select item 41464093.

Mirk/dyrk1B kinase is upregulated following inhibition of mTOR

Xiaobing Deng, Jing Hu, Daina Z. Ewton, Eileen Friedman

Carcinogenesis. 2014 Sep; 35(9): 1968–1976. Published online 2014 Mar 3. doi: 10.1093/carcin/bgu058

PMCID:: PMC4146409

Abstract Article PDF–3.1M

Select item 38393114.

Mirk/Dyrk1B, a novel therapeutic target, mediates cell survival in non-small cell lung cancer cells

Jingchun Gao, Zhong Zheng, Bhupendra Rawal, Michael J. Schell, Gerold Bepler, Eric B. Haura

Cancer Biol Ther. Author manuscript; available in PMC 2013 Nov 25.

Published in final edited form as: Cancer Biol Ther. 2009 Sep; 8(17): 1671–1679. Published online 2009 Sep 20. doi: 10.4161/cbt.8.17.9322

PMCID:: PMC3839311

Abstract Article PDF–2.8M

Select item 35863055.

Ovarian Cancer Cells, not Normal Cells, Are Damaged by Mirk/Dyrk1B Kinase Inhibition

Jing Hu, Holly Deng, Eileen A. Friedman

Int J Cancer. Author manuscript; available in PMC 2014 May 15.

Published in final edited form as: Int J Cancer. 2013 May 15; 132(10): 2258–2269. Published online 2012 Nov 21. doi: 10.1002/ijc.27917

Correction in:: Int J Cancer. 2015 Sep 15; 137(6): E13.

PMCID:: PMC3586305

Abstract Article PDF–2.6M

Select item 32133026.

Inactivation of Mirk/Dyrk1b Kinase Targets Quiescent Pancreatic Cancer Cells

Daina Z. Ewton, Jing Hu, Maria Vilenchik, Xiaobing Deng, Kin-chun Luk, Ann Polonskaia, Ann F. Hoffman, Karen Zipf, John F. Boylan, Eileen A. Friedman

Mol Cancer Ther. Author manuscript; available in PMC 2012 Nov 1.

Published in final edited form as: Mol Cancer Ther. 2011 Nov; 10(11): 2104–2114. Published online 2011 Aug 30. doi: 10.1158/1535-7163.MCT-11-0498

PMCID:: PMC3213302

Abstract Article PDF–3.5M

Select item 28470877.

The kinase Mirk is a potential therapeutic target in osteosarcoma

Cao Yang, Diana Ji, Edward J. Weinstein, Edwin Choy, Francis J. Hornicek, Kirkham B. Wood, Xianzhe Liu, Henry Mankin, Zhenfeng Duan

Carcinogenesis. 2010 Apr; 31(4): 552–558. Published online 2009 Dec 30. doi: 10.1093/carcin/bgp330

PMCID:: PMC2847087

Abstract Article PDF–667K

Select item 26698318.

Mirk/Dyrk1B Maintains the Viability of Quiescent Pancreatic Cancer Cells by Reducing Levels of Reactive Oxygen Species

Xiaobing Deng, Daina Z. Ewton, Eileen Friedman

Cancer Res. Author manuscript; available in PMC 2010 Apr 15.

Published in final edited form as: Cancer Res. 2009 Apr 15; 69(8): 3317–3324. Published online 2009 Apr 7. doi: 10.1158/0008-5472.CAN-08-2903

PMCID:: PMC2669831

Abstract Article PDF–566K

Select item 111053119.

DYRK1B regulates Hedgehog-induced microtubule acetylation

Rajeev Singh, Philipp Simon Holz, Katrin Roth, Anna Hupfer, Wolfgang Meissner, Rolf Müller, Malte Buchholz, Thomas M. Gress, Hans-Peter Elsässer, Ralf Jacob, Matthias Lauth

Cell Mol Life Sci. 2019 Jan; 76(1): 193–207. Published online 2018 Oct 13. doi: 10.1007/s00018-018-2942-5

PMCID:: PMC11105311

Abstract Article PDF–8.2M

Select item 473526110.

Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome

Anne L. Ashford, Tom P. J. Dunkley, Mark Cockerill, Rachel A. Rowlinson, Lisa M. Baak, Raffaella Gallo, Kathryn Balmanno, Louise M. Goodwin, Richard A. Ward, Pamela A. Lochhead, Sylvie Guichard, Kevin Hudson, Simon J. Cook

Cell Mol Life Sci. 2016 Feb; 73(4): 883–900. Published online 2015 Sep 7. doi: 10.1007/s00018-015-2032-x

PMCID:: PMC4735261

Abstract Article PDF–2.3M

Select item 451192011.

The Tumor Suppressor NKX3.1 is Targeted for Degradation by DYRK1B Kinase

Liang-Nian Song, Jose Silva, Antonius Koller, Andrew Rosenthal, Emily I. Chen, Edward P. Gelmann

Mol Cancer Res. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mol Cancer Res. 2015 May; 13(5): 913–922. Published online 2015 Mar 16. doi: 10.1158/1541-7786.MCR-14-0680

PMCID:: PMC4511920

Abstract Article PDF–1.3M

Select item 406926012.

A Form of the Metabolic Syndrome Associated with Mutations in DYRK1B

Ali R. Keramati, Mohsen Fathzadeh, Gwang-Woong Go, Rajvir Singh, Murim Choi, Saeed Faramarzi, Shrikant Mane, Mohammad Kasaei, Kazem Sarajzadeh-Fard, John Hwa, Kenneth K. Kidd, Mohammad A. Babaee Bigi, Reza Malekzadeh, Adallat Hosseinian, Masoud Babaei, Richard P. Lifton, Arya Mani

N Engl J Med. Author manuscript; available in PMC 2014 Nov 15.

Published in final edited form as: N Engl J Med. 2014 May 15; 370(20): 1909–1919. doi: 10.1056/NEJMoa1301824

PMCID:: PMC4069260

Abstract Article PDF–1.1M

Select item 346654913.

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control

Walter Becker

Cell Cycle. 2012 Sep 15; 11(18): 3389–3394. doi: 10.4161/cc.21404

PMCID:: PMC3466549

Abstract Article PDF–305K

Select item 275569914.

Mirk Regulates the Exit of Colon Cancer Cells from Quiescence

Kideok Jin, Daina Z. Ewton, Sunju Park, Jing Hu, Eileen Friedman

J Biol Chem. 2009 Aug 21; 284(34): 22916–22925. Published online 2009 Jun 19. doi: 10.1074/jbc.M109.035519

PMCID:: PMC2755699

Abstract Article PDF–2.4M

Select item 122344115.

Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties.

Susanne Leder, Hanna Czajkowska, Barbara Maenz, Katrin De Graaf, Andreas Barthel, Hans-Georg Joost, Walter Becker

Biochem J. 2003 Jun 15; 372(Pt 3): 881–888. doi: 10.1042/BJ20030182

PMCID:: PMC1223441

Summary PDF–303K

Select item 120150116.

MIRK/DYRK1B MEDIATES SURVIVAL DURING THE DIFFERENTIATION OF C2C12 MYOBLASTS

Stephen E. Mercer, Daina Z. Ewton, Xiaobing Deng, Seunghwan Lim, Thomas R. Mazur, Eileen Friedman

J Biol Chem. Author manuscript; available in PMC 2005 Sep 13.

Published in final edited form as: J Biol Chem. 2005 Jul 8; 280(27): 25788–25801. Published online 2005 Apr 25. doi: 10.1074/jbc.M413594200

PMCID:: PMC1201501

Abstract Article PDF–2.0M

Select item 784937017.

Proline hydroxylation primes protein kinases for autophosphorylation and activation

Sang Bae Lee, Aram Ko, Young Taek Oh, Peiguo Shi, Fulvio D’Angelo, Brulinda Frangaj, Antonius Koller, Emily I. Chen, Timothy Cardozo, Antonio lavarone, Anna Lasorella

Mol Cell. Author manuscript; available in PMC 2021 Aug 6.

Published in final edited form as: Mol Cell. 2020 Aug 6; 79(3): 376–389.e8. Published online 2020 Jul 7. doi: 10.1016/j.molcel.2020.06.021

PMCID:: PMC7849370

Abstract Article PDF–1.1M

Select item 626484818.

DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B

Mina Yousefelahiyeh, Jingyi Xu, Estibaliz Alvarado, Yang Yu, David Salven, Robert M. Nissen

PLoS One. 2018; 13(11): e0207779. Published online 2018 Nov 29. doi: 10.1371/journal.pone.0207779

PMCID:: PMC6264848

Abstract Article PDF–2.6M

Select item 487277419.

DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance

Wolfgang Gruber, Martin Hutzinger, Dominik Patrick Elmer, Thomas Parigger, Christina Sternberg, Lukasz Cegielkowski, Mirko Zaja, Johann Leban, Susanne Michel, Svetlana Hamm, Daniel Vitt, Fritz Aberger

Oncotarget. 2016 Feb 9; 7(6): 7134–7148. Published online 2016 Jan 13. doi: 10.18632/oncotarget.6910

PMCID:: PMC4872774

Abstract Article PDF–4.2M

Select item 358458420.

The involvement of FoxO in cell survival and chemosensitivity mediated by Mirk/Dyrk1B in ovarian cancer

JINGCHUN GAO, XIANGJUN YANG, PING YIN, WENFENG HU, HONGFENG LIAO, ZHIHUI MIAO, CHAO PAN, NA LI

Int J Oncol. 2012 Apr; 40(4): 1203–1209. Published online 2011 Dec 12. doi: 10.3892/ijo.2011.1293

PMCID:: PMC3584584

Abstract Article PDF–480K

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PMC Links for Gene (Select 9149) (41)
PMC
molybdate ABC transporter substrate-binding protein [Shimia marina]
molybdate ABC transporter substrate-binding protein [Shimia marina]
gi|1717260001|ref|WP_144432639.1|

Protein
HEAT repeat-containing protein [Arabidopsis thaliana]
HEAT repeat-containing protein [Arabidopsis thaliana]
gi|1063729275|ref|NP_001330014.1|

Protein
ubiquinone biosynthesis COQ4-like protein (macronuclear) [Tetrahymena thermophil...
ubiquinone biosynthesis COQ4-like protein (macronuclear) [Tetrahymena thermophila SB210]
gi|586738270|gnl|WGS:AAGF|cds.TTHER 75760A|gb|EAR95772.2|

Protein

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