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Select item 53253891.

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy

José M. García-Heredia, Eva M. Verdugo Sivianes, Antonio Lucena-Cacace, Sonia Molina-Pinelo, Amancio Carnero

Oncotarget. 2016 Sep 27; 7(39): 63611–63628. Published online 2016 Aug 23. doi: 10.18632/oncotarget.11553

PMCID:: PMC5325389

Abstract Article PDF–11M

Select item 36956272.

REGULATION OF LUNG CANCER METASTASIS BY Klf4-Numb-like SIGNALING

Valentina Vaira, Alice Faversani, Nina M. Martin, David S. Garlick, Stefano Ferrero, Mario Nosotti, Joseph L. Kissil, Silvano Bosari, Dario C. Altieri

Cancer Res. Author manuscript; available in PMC 2014 Apr 15.

Published in final edited form as: Cancer Res. 2013 Apr 15; 73(8): 2695–2705. Published online 2013 Feb 25. doi: 10.1158/0008-5472.CAN-12-4232

PMCID:: PMC3695627

Abstract Article PDF–3.9M

Select item 92759603.

SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis

Yunchao Xin, Xiaoling Shang, Xiaoran Sun, Guogang Xu, Yachao Liu, Yanbin Liu

Bioengineered. 2022; 13(5): 12572–12582. Published online 2022 May 21. doi: 10.1080/21655979.2022.2073125

PMCID:: PMC9275960

Abstract Article PDF–4.2M

Select item 52954364.

Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl

Clifford C. Nwaeburu, Natalie Bauer, Zhefu Zhao, Alia Abukiwan, Jury Gladkich, Axel Benner, Ingrid Herr

Oncotarget. 2016 Sep 6; 7(36): 58367–58380. Published online 2016 Aug 8. doi: 10.18632/oncotarget.11122

PMCID:: PMC5295436

Abstract Article PDF–6.9M

Select item 33956535.

Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation

Tao Tao, Chun Cheng, Yuhong Ji, Guangfei Xu, Jianguo Zhang, Li Zhang, Aiguo Shen

Mol Biol Cell. 2012 Jul 15; 23(14): 2635–2644. doi: 10.1091/mbc.E11-09-0805

PMCID:: PMC3395653

Abstract Article PDF–4.5M

Select item 1245356.

The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling

Roberta Roncarati, Nenad Šestan, Meir H. Scheinfeld, Bridget E. Berechid, Peter A. Lopez, Olimpia Meucci, Jane C. McGlade, Pasko Rakic, Luciano D'Adamio

Proc Natl Acad Sci U S A. 2002 May 14; 99(10): 7102–7107. doi: 10.1073/pnas.102192599

PMCID:: PMC124535

Abstract Article PDF–410K

Select item 408357.

A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.

W T Wong, C Schumacher, A E Salcini, A Romano, P Castagnino, P G Pelicci, P Di Fiore

Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21): 9530–9534. doi: 10.1073/pnas.92.21.9530

PMCID:: PMC40835

Summary Page Browse PDF–1.5M

Select item 56267498.

NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis

Gaurav Swarnkar, Tim Hung-Po Chen, Manoj Arra, Amjad M. Nasir, Gabriel Mbalaviele, Yousef Abu-Amer

Sci Rep. 2017; 7: 12600. Published online 2017 Oct 3. doi: 10.1038/s41598-017-12707-7

PMCID:: PMC5626749

Abstract Article PDF–3.8M

Select item 2753909.

Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module

Anna Elisabetta Salcini, Stefano Confalonieri, Margherita Doria, Elisa Santolini, Elena Tassi, Olga Minenkova, Gianni Cesareni, Pier Giuseppe Pelicci, Pier Paolo Di Fiore

Genes Dev. 1997 Sep 1; 11(17): 2239–2249. doi: 10.1101/gad.11.17.2239

PMCID:: PMC275390

Abstract Article PDF–1.7M

Select item 527219010.

Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation

Maretoshi Hirai, Yoh Arita, C. Jane McGlade, Kuo-Fen Lee, Ju Chen, Sylvia M. Evans

J Clin Invest. 2017 Feb 1; 127(2): 569–582. Published online 2017 Jan 9. doi: 10.1172/JCI91081

PMCID:: PMC5272190

Abstract Article PDF–6.4M

Select item 567959711.

Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase

Joan A. Lenihan, Orthis Saha, Paul W. Young

PLoS One. 2017; 12(11): e0187352. Published online 2017 Nov 9. doi: 10.1371/journal.pone.0187352

PMCID:: PMC5679597

Abstract Article PDF–10M

Select item 702154912.

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

Leena Yadav, Elina Pietilä, Tiina Öhman, Xiaonan Liu, Arun K. Mahato, Yulia Sidorova, Kaisa Lehti, Mart Saarma, Markku Varjosalo

iScience. 2020 Feb 21; 23(2): 100871. Published online 2020 Jan 31. doi: 10.1016/j.isci.2020.100871

PMCID:: PMC7021549

Abstract Article PDF–8.1M

Select item 679415813.

LZTR1 is a regulator of RAS ubiquitination and signaling

Johannes W. Bigenzahn, Giovanna M. Collu, Felix Kartnig, Melanie Pieraks, Gregory I. Vladimer, Leonhard X. Heinz, Vitaly Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen, Katja Parapatics, Vincent A. Blomen, André C. Müller, Georg E. Winter, Robert Kralovics, Thijn R. Brummelkamp, Marek Mlodzik, Giulio Superti-Furga

Science. Author manuscript; available in PMC 2019 Oct 15.

Published in final edited form as: Science. 2018 Dec 7; 362(6419): 1171–1177. Published online 2018 Nov 15. doi: 10.1126/science.aap8210

PMCID:: PMC6794158

Abstract Article PDF–1.9M

Select item 671971814.

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

Michael S. Haney, Christopher J. Bohlen, David W Morgens, James A. Ousey, Amira A. Barkal, C. Kimberly Tsui, Braeden Ego, Roni Levin, Roarke Kamber, Hannah Collins, Andrew Tucker, Amy Li, Daan Vorselen, Lorenzo Labitigan, Emily Crane, Evan Boyle, Lihua Jiang, Joanne Chan, Esther Rincón, William J. Greenleaf, Billy Li, Michael P. Snyder, Irving L. Weissman, Julie A. Theriot, Sean R. Collins, Ben A. Barres, Michael C. Bassik

Nat Genet. Author manuscript; available in PMC 2019 Sep 3.

Published in final edited form as: Nat Genet. 2018 Dec; 50(12): 1716–1727. Published online 2018 Nov 5. doi: 10.1038/s41588-018-0254-1

PMCID:: PMC6719718

Abstract Article PDF–1.3M

Select item 682384615.

BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion

Calvin J. Chan, Roberta Le, Kaylan Burns, Khadra Ahmed, Etienne Coyaud, Estelle M. N. Laurent, Brian Raught, Paul Melançon

Mol Cell Proteomics. 2019 Nov; 18(11): 2285–2297. Published online 2019 Sep 13. doi: 10.1074/mcp.RA119.001645

PMCID:: PMC6823846

Abstract Article PDF–2.2M

Select item 794845216.

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Evan M. Kerek, Kevin H. Yoon, Shu Y. Luo, Jerry Chen, Robert Valencia, Olivier Julien, Andrew J. Waskiewicz, Basil P. Hubbard

J Biol Chem. 2021 Jan-Jun; 296: 100073. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015839

PMCID:: PMC7948452

Abstract Article PDF–3.6M

Select item 262894617.

Global analysis of host-pathogen interactions that regulate early stage HIV-1 replication

Renate König, Yingyao Zhou, Daniel Elleder, Tracy L. Diamond, Ghislain M.C. Bonamy, Jeffrey T. Irelan, Chih-yuan Chiang, Buu P. Tu, Paul D. De Jesus, Caroline E. Lilley, Shannon Seidel, Amanda M. Opaluch, Jeremy S. Caldwell, Matthew D. Weitzman, Kelli L. Kuhen, Sourav Bandyopadhyay, Trey Ideker, Anthony P. Orth, Loren J. Miraglia, Frederic D. Bushman, John A. Young, Sumit K. Chanda

Cell. Author manuscript; available in PMC 2009 Oct 3.

Published in final edited form as: Cell. 2008 Oct 3; 135(1): 49–60. doi: 10.1016/j.cell.2008.07.032

PMCID:: PMC2628946

Abstract Article PDF–3.4M

Select item 1032325218.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468