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Select item 63894691.

Novel mutation in the MED23 gene for intellectual disability: A case report and literature review

Feyzollah Hashemi‐Gorji, Majid Fardaei, Seyed Mohammad Bagher Tabei, Mohammad Miryounesi

Clin Case Rep. 2019 Feb; 7(2): 331–335. Published online 2019 Jan 9. doi: 10.1002/ccr3.1942

PMCID:: PMC6389469

Abstract Article PDF–204K

Select item 61076632.

Crystal structure of human Mediator subunit MED23

Didier Monté, Bernard Clantin, Frédérique Dewitte, Zoé Lens, Prakash Rucktooa, Els Pardon, Jan Steyaert, Alexis Verger, Vincent Villeret

Nat Commun. 2018; 9: 3389. Published online 2018 Aug 23. doi: 10.1038/s41467-018-05967-y

PMCID:: PMC6107663

Abstract Article PDF–4.1M

Select item 56717613.

MED23-associated Intellectual Disability in a Non-consanguineous Family

Aditi Trehan, Jacqueline M. Brady, Valerie Maduro, William Bone, Yan Huang, Gretchen A. Golas, Megan Kane, Paul R. Lee, Audrey Thurm, Andrea L. Gropman, Scott M. Paul, Gilbert Vezina, Thomas C. Markello, William A. Gahl, Cornelius F. Boerkoel, Cynthia J. Tifft

Am J Med Genet A. Author manuscript; available in PMC 2017 Nov 5.

Published in final edited form as: Am J Med Genet A. 2015 Jun; 167(6): 1374–1380. Published online 2015 Apr 2. doi: 10.1002/ajmg.a.37047

PMCID:: PMC5671761

Abstract Article PDF–425K

Select item 36440424.

Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb

Wei Wang, Xiao Yao, Yan Huang, Xiangming Hu, Runzhong Liu, Dongming Hou, Ruichuan Chen, Gang Wang

Transcription. 2013 Jan 1; 4(1): 39–51. Published online 2013 Jan 1. doi: 10.4161/trns.22874

PMCID:: PMC3644042

Abstract Article PDF–1.2M

Select item 1305315.

External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator

Shinichi Asada, Yongmun Choi, Masaki Yamada, Shao-Chun Wang, Mien-Chie Hung, Jun Qin, Motonari Uesugi

Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20): 12747–12752. Published online 2002 Sep 19. doi: 10.1073/pnas.202162199

PMCID:: PMC130531

Abstract Article PDF–410K

Select item 34786176.

Selective requirement for Mediator MED23 in Ras-active lung cancer

Xu Yang, Meng Zhao, Min Xia, Yuting Liu, Jun Yan, Hongbin Ji, Gang Wang

Proc Natl Acad Sci U S A. 2012 Oct 9; 109(41): E2813–E2822. Published online 2012 Sep 17. doi: 10.1073/pnas.1204311109

PMCID:: PMC3478617

Abstract Article PDF–1.6M

Select item 47976377.

Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine

Nicole Lüneburg, Wolfgang Lieb, Tanja Zeller, Ming-Huei Chen, Renke Maas, Angela M. Carter, Vanessa Xanthakis, Nicole L Glazer, Edzard Schwedhelm, Sudha Seshadri, M. Arfan Ikram, W.T. Longstreth, Jr, Myriam Fornage, Inke R. König, Christina Loley, Francisco M. Ojeda, Arne Schillert, Thomas J. Wang, Heinrich Sticht, Anja Kittel, Jörg König, Emelia J. Benjamin, Lisa M. Sullivan, Isabel Bernges, Maike Anderssohn, Andreas Ziegler, Christian Gieger, Thomas Illig, Christa Meisinger, H.-Erich Wichmann, Philipp S. Wild, Heribert Schunkert, Bruce M. Psaty, Kerri L. Wiggins, Susan R. Heckbert, Nicholas Smith, Karl Lackner, Kathryn L. Lunetta, Stefan Blankenberg, Jeanette Erdmann, Thomas Munzel, Peter J. Grant, Ramachandran S. Vasan, Rainer H. Böger

Circ Cardiovasc Genet. Author manuscript; available in PMC 2016 Mar 18.

Published in final edited form as: Circ Cardiovasc Genet. 2014 Dec; 7(6): 864–872. Published online 2014 Sep 21. doi: 10.1161/CIRCGENETICS.113.000264

PMCID:: PMC4797637

Abstract Article PDF–2.2M

Select item 871238.

Characterization of Mediator Complexes from HeLa Cell Nuclear Extract

Gang Wang, Greg T. Cantin, Jennitte L. Stevens, Arnold J. Berk

Mol Cell Biol. 2001 Jul; 21(14): 4604–4613. doi: 10.1128/MCB.21.14.4604-4613.2001

PMCID:: PMC87123

Abstract Article PDF–417K

Select item 25839399.

Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation

Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan, Thomas G. Boyer

Mol Cell. Author manuscript; available in PMC 2009 Aug 8.

Published in final edited form as: Mol Cell. 2008 Aug 8; 31(3): 347–359. doi: 10.1016/j.molcel.2008.05.023

PMCID:: PMC2583939

Abstract Article PDF–4.4M

Select item 500701210.

A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis

Vibe Skov, Mark Burton, Mads Thomassen, Thomas Stauffer Larsen, Caroline H. Riley, Ann Brinch Madelung, Lasse Kjær, Henrik Bondo, Inger Stamp, Mats Ehinger, Rasmus Dahl-Sørensen, Nana Brochmann, Karsten Nielsen, Jürgen Thiele, Morten K. Jensen, Ole Weis Bjerrum, Torben A. Kruse, Hans Carl Hasselbalch

PLoS One. 2016; 11(8): e0161570. Published online 2016 Aug 31. doi: 10.1371/journal.pone.0161570

PMCID:: PMC5007012

Abstract Article PDF–720K

Select item 53397511.

Ras/Mitogen-Activated Protein Kinase Signaling Activates Ets-1 and Ets-2 by CBP/p300 Recruitment

Charles E. Foulds, Mary L. Nelson, Adam G. Blaszczak, Barbara J. Graves

Mol Cell Biol. 2004 Dec; 24(24): 10954–10964. doi: 10.1128/MCB.24.24.10954-10964.2004

PMCID:: PMC533975

Abstract Article PDF–390K

Select item 1858412.

Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator

Lan Ko, Guemalli R. Cardona, William W. Chin

Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6212–6217. doi: 10.1073/pnas.97.11.6212

PMCID:: PMC18584

Abstract Article PDF–512K

Select item 368142913.

HIF1A employs CDK8-Mediator to stimulate RNAPII elongation

Matthew D. Galbraith, Mary A. Allen, Claire L. Bensard, Xiaoxing Wang, Marie K. Schwinn, Bo Qin, Henry W. Long, Danette L. Daniels, William C. Hahn, Robin D. Dowell, Joaquín M. Espinosa

Cell. Author manuscript; available in PMC 2014 Jun 6.

Published in final edited form as: Cell. 2013 Jun 6; 153(6): 1327–1339. doi: 10.1016/j.cell.2013.04.048

PMCID:: PMC3681429

Abstract Article PDF–2.7M

Select item 319815314.

Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneity

R Abou Jamra, Sigrun Wohlfart, Markus Zweier, Steffen Uebe, Lutz Priebe, Arif Ekici, Susanne Giesebrecht, Ahmad Abboud, Mohammed Ayman Al Khateeb, Mahmoud Fakher, Saber Hamdan, Amina Ismael, Safia Muhammad, Markus M Nöthen, Johannes Schumacher, André Reis

Eur J Hum Genet. 2011 Nov; 19(11): 1161–1166. Published online 2011 Jun 1. doi: 10.1038/ejhg.2011.98

PMCID:: PMC3198153

Abstract Article PDF–414K

Select item 284527515.

Crosstalk between C/EBPβ phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code

Elisabeth Kowenz-Leutz, Ole Pless, Gunnar Dittmar, Maria Knoblich, Achim Leutz

EMBO J. 2010 Mar 17; 29(6): 1105–1115. Published online 2010 Jan 28. doi: 10.1038/emboj.2010.3

PMCID:: PMC2845275

Abstract Article PDF–1.3M

Select item 292028616.

CDK8 is a positive regulator of transcriptional elongation within the serum response network

Aaron J. Donner, Christopher C. Ebmeier, Dylan J. Taatjes, Joaquín M. Espinosa

Nat Struct Mol Biol. Author manuscript; available in PMC 2010 Aug 11.

Published in final edited form as: Nat Struct Mol Biol. 2010 Feb; 17(2): 194–201. Published online 2010 Jan 24. doi: 10.1038/nsmb.1752

PMCID:: PMC2920286

Abstract Article PDF–2.1M

Select item 29181417.

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells

Gerhard Mittler, Thomas Stühler, Lisa Santolin, Thomas Uhlmann, Elisabeth Kremmer, F. Lottspeich, Lucia Berti, Michael Meisterernst

EMBO J. 2003 Dec 15; 22(24): 6494–6504. doi: 10.1093/emboj/cdg619

PMCID:: PMC291814

Abstract Article PDF–382K

Select item 239639518.

Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3

Krista D Meyer, Aaron J Donner, Matthew T Knuesel, Autumn G York, Joaquín M Espinosa, Dylan J Taatjes

EMBO J. 2008 May 21; 27(10): 1447–1457. Published online 2008 Apr 17. doi: 10.1038/emboj.2008.78

PMCID:: PMC2396395

Abstract Article PDF–303K

Select item 581585319.

Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers

Xuehui Hong, He Huang, Xingfeng Qiu, Zhijie Ding, Xing Feng, Yuekun Zhu, Huiqin Zhuo, Jingjing Hou, Jiabao Zhao, Wangyu Cai, Ruihua Sha, Xinya Hong, Yongxiang Li, Hongjiang Song, Zhiyong Zhang

eLife. 2018; 7: e29511. Published online 2018 Jan 31. doi: 10.7554/eLife.29511

PMCID:: PMC5815853

Abstract Article PDF–6.9M

Select item 356630720.

The SCF–Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

Michael A. Davis, Elizabeth A. Larimore, Brian M. Fissel, Jherek Swanger, Dylan J. Taatjes, Bruce E. Clurman

Genes Dev. 2013 Jan 15; 27(2): 151–156. doi: 10.1101/gad.207720.112

PMCID:: PMC3566307

Abstract Article PDF–1.2M

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