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Select item 110839501.

Herpes Simplex Virus ICP27 Protein Inhibits AIM 2-Dependent Inflammasome Influencing Pro-Inflammatory Cytokines Release in Human Pigment Epithelial Cells (hTert-RPE 1)

Anna Caproni, Chiara Nordi, Riccardo Fontana, Martina Facchini, Sara Melija, Mariangela Pappadà, Mattia Buratto, Peggy Marconi

Int J Mol Sci. 2024 May; 25(9): 4608. Published online 2024 Apr 23. doi: 10.3390/ijms25094608

PMCID:: PMC11083950

Abstract Article PDF–3.6M

Select item 107651212.

Absent in melanoma 2 attenuates proliferation and migration and promotes apoptosis of human colorectal cancer cells by activating P38MAPK signaling pathway

ZHI ZHANG, XIAOSONG LI, YING ZHANG, HAO ZHU, ZHENGUO QIAO, YANG LU, XIUWEI MI, HUIHUA CAO, GENHAI SHEN, SONGBING HE

Oncol Res. 2024; 32(2): 353–360. Published online 2023 Dec 28. doi: 10.32604/or.2023.042986

PMCID:: PMC10765121

Abstract Article PDF–4.8M

Select item 106175673.

Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection

Yongqi Li, Yang Yang, Tianyang Li, Zhengmin Wang, Chunfeng Gao, Rilin Deng, Faxiang Ma, Xinyang Li, Licong Ma, Renyun Tian, Huiyi Li, Haizhen Zhu, Lei Zeng, Yanhang Gao, Guoyue Lv, Junqi Niu, Ian Nicholas Crispe, Zhengkun Tu

J Virol. 2023 Oct; 97(10): e01090-23. Published online 2023 Oct 3. doi: 10.1128/jvi.01090-23

PMCID:: PMC10617567

Abstract Article PDF–7.0M

Select item 100087004.

AIM2 promotes renal cell carcinoma progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis

Qi Wang, Su Gao, Yi Shou, Yujie Jia, Zhihao Wei, Yuenan Liu, Jian Shi, Daojia Miao, Qi Miao, Chuanyi Zhao, Chenchen Liu, Hongmei Yang, Tianbo Xu, Xiaoping Zhang

Int J Biol Sci. 2023; 19(4): 1266–1283. Published online 2023 Feb 13. doi: 10.7150/ijbs.79853

PMCID:: PMC10008700

Abstract Article PDF–18M

Select item 99262195.

AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes

Camila Marques-da-Silva, Barun Poudel, Rodrigo P. Baptista, Kristen Peissig, Lisa S. Hancox, Justine C. Shiau, Lecia L. Pewe, Melanie J. Shears, Thirumala-Devi Kanneganti, Photini Sinnis, Dennis E. Kyle, Prajwal Gurung, John T. Harty, Samarchith P. Kurup

Proc Natl Acad Sci U S A. 2023 Jan 10; 120(2): e2210181120. Published online 2023 Jan 3. doi: 10.1073/pnas.2210181120

PMCID:: PMC9926219

Abstract Article PDF–4.0M

Select item 98896396.

AIM2 and Psoriasis

Yuxi Zhang, Xiaoqing Xu, Hui Cheng, Fusheng Zhou

Front Immunol. 2023; 14: 1085448. Published online 2023 Jan 18. doi: 10.3389/fimmu.2023.1085448

PMCID:: PMC9889639

Abstract Article PDF–1.9M

Select item 97509767.

dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury

Chintogtokh Baatarjav, Takanori Komada, Tadayoshi Karasawa, Naoya Yamada, Ariunaa Sampilvanjil, Takayoshi Matsumura, Masafumi Takahashi

Cell Death Differ. 2022 Dec; 29(12): 2487–2502. Published online 2022 Jun 23. doi: 10.1038/s41418-022-01033-9

PMCID:: PMC9750976

Abstract Article PDF–11M

Select item 95595858.

Pan-cancer analysis of AIM2 inflammasomes with potential implications for immunotherapy in human cancer: A bulk omics research and single cell sequencing validation

Yan Qin, Liuxian Pan, Tianyu Qin, Hanyi Ruan, Yujie Zhang, Yan Zhang, Jianli Li, Jianrong Yang, Wei Li

Front Immunol. 2022; 13: 998266. Published online 2022 Sep 29. doi: 10.3389/fimmu.2022.998266

PMCID:: PMC9559585

Abstract Article PDF–13M

Select item 92673459.

The P2X7R-NLRP3 and AIM2 Inflammasome Platforms Mark the Complexity/Severity of Viral or Metabolic Liver Damage

Chiara Rossi, Antonio Salvati, Mariarosaria Distaso, Daniela Campani, Francesco Raggi, Edoardo Biancalana, Domenico Tricò, Maurizia Rossana Brunetto, Anna Solini

Int J Mol Sci. 2022 Jul; 23(13): 7447. Published online 2022 Jul 4. doi: 10.3390/ijms23137447

PMCID:: PMC9267345

Abstract Article PDF–3.6M

Select item 912412210.

The Association of Serum AIM2 Level with the Prediction and Short-Term Prognosis of Coronary Artery Disease

Wenkang Zhang, Gaoliang Yan, Chunyang Xu, Chengchun Tang

J Renin Angiotensin Aldosterone Syst. 2022; 2022: 6774416. Published online 2022 May 14. doi: 10.1155/2022/6774416

PMCID:: PMC9124122

Abstract Article PDF–513K

Select item 899633211.

Methylation of the AIM2 gene: An epigenetic mediator of PTSD-related inflammation and neuropathology plasma biomarkers

Sage E. Hawn, Zoe Neale, Erika J. Wolf, Xiang Zhao, Meghan Pierce, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark Logue, Mark W. Miller

Depress Anxiety. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Depress Anxiety. 2022 Apr; 39(4): 323–333. Published online 2022 Mar 21. doi: 10.1002/da.23247

PMCID:: PMC8996332

Abstract Article PDF–428K

Select item 871102212.

AIM2 inhibits the proliferation, invasion and migration, and promotes the apoptosis of osteosarcoma cells by inactivating the PI3K/AKT/mTOR signaling pathway

Jianping Zheng, Changhao Liu, Jiandang Shi, Kun Wen, Xiangxin Wang

Mol Med Rep. 2022 Feb; 25(2): 53. Published online 2021 Dec 14. doi: 10.3892/mmr.2021.12569

PMCID:: PMC8711022

Abstract Article PDF–12M

Select item 811569413.

Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome

Mariusz Matyszewski, Weili Zheng, Jacob Lueck, Zachary Mazanek, Naveen Mohideen, Albert Y. Lau, Edward H. Egelman, Jungsan Sohn

Nat Commun. 2021; 12: 2735. Published online 2021 May 12. doi: 10.1038/s41467-021-23045-8

PMCID:: PMC8115694

Abstract Article PDF–5.5M

Select item 805021814.

Absent in melanoma 2 suppresses gastric cancer cell proliferation and migration via inactivation of AKT signaling pathway

Dong Wang, Junwei Zou, Jun Dai, Zhengwu Cheng

Sci Rep. 2021; 11: 8235. Published online 2021 Apr 15. doi: 10.1038/s41598-021-87744-4

PMCID:: PMC8050218

Abstract Article PDF–1.8M

Select item 804719515.

Single-Nucleotide Variants in the AIM2 – Absent in Melanoma 2 Gene (rs1103577) Associated With Protection for Tuberculosis

Mariana Brasil de Andrade Figueira, Dhêmerson Souza de Lima, Antonio Luiz Boechat, Milton Gomes do Nascimento Filho, Irineide Assumpção Antunes, Joycenéa da Silva Matsuda, Thaís Rodrigues de Albuquerque Ribeiro, Luana Sousa Felix, Ariane Senna Fonseca Gonçalves, Allyson Guimarães da Costa, Rajendranath Ramasawmy, Alessandra Pontillo, Mauricio Morishi Ogusku, Aya Sadahiro

Front Immunol. 2021; 12: 604975. Published online 2021 Apr 1. doi: 10.3389/fimmu.2021.604975

PMCID:: PMC8047195

Abstract Article PDF–561K

Select item 783502216.

AIM2 inhibits colorectal cancer cell proliferation and migration through suppression of Gli1

Menglin Xu, Junfeng Wang, Haoran Li, Zhengrong Zhang, Zhengwu Cheng

Aging (Albany NY) 2021 Jan 15; 13(1): 1017–1031. Published online 2020 Dec 3. doi: 10.18632/aging.202226

PMCID:: PMC7835022

Abstract Article PDF–1.8M

Select item 760593417.

Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes

Yong Chen, Qiu Fujuan, Ensheng Chen, Beijia Yu, Fangfang Zuo, Yi Yuan, Xiaofeng Zhao, Changhong Xiao

Mediators Inflamm. 2020; 2020: 1693730. Published online 2020 Oct 26. doi: 10.1155/2020/1693730

PMCID:: PMC7605934

Abstract Article PDF–2.1M

Select item 722701118.

The DNA Sensor AIM2 Protects against Streptozotocin-Induced Type 1 Diabetes by Regulating Intestinal Homeostasis via the IL-18 Pathway

Jefferson Antônio Leite, Gabriela Pessenda, Isabel C. Guerra-Gomes, Alynne Karen Mendonça de Santana, Camila André Pereira, Frederico Ribeiro Campos Costa, Simone G. Ramos, Dario Simões Zamboni, Ana Maria Caetano Faria, Danilo Candido de Almeida, Niels Olsen Saraiva Câmara, Rita C. Tostes, João Santana Silva, Daniela Carlos

Cells. 2020 Apr; 9(4): 959. Published online 2020 Apr 14. doi: 10.3390/cells9040959

PMCID:: PMC7227011

Abstract Article PDF–4.0M

Select item 701566219.

Role of AIM2 inflammasome in inflammatory diseases, cancer and infection

Bhesh Raj Sharma, Rajendra Karki, Thirumala-Devi Kanneganti

Eur J Immunol. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Eur J Immunol. 2019 Nov; 49(11): 1998–2011. Published online 2019 Aug 14. doi: 10.1002/eji.201848070

PMCID:: PMC7015662

Abstract Article PDF–944K

Select item 620133920.

H1/pAIM2 nanoparticles exert anti‐tumour effects that is associated with the inflammasome activation in renal carcinoma

Dafei Chai, Nianli Liu, Huizhong Li, Gang Wang, Jingyuan Song, Lin Fang, Zheng Lu, Hong Yao, Junnian Zheng

J Cell Mol Med. 2018 Nov; 22(11): 5670–5681. Published online 2018 Aug 30. doi: 10.1111/jcmm.13842

PMCID:: PMC6201339

Abstract Article PDF–1.2M

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