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Select item 107800381.

ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia

Justine Lai, Claire Yang, Chuquan Shang, Will Chen, Michael P. Chu, Joseph Brandwein, Raymond Lai, Peng Wang

Int J Mol Sci. 2024 Jan; 25(1): 646. Published online 2024 Jan 4. doi: 10.3390/ijms25010646

PMCID:: PMC10780038

Abstract Article PDF–5.0M

Select item 88125922.

Association between Unc-51-like autophagy activating kinase 2 gene polymorphisms and schizophrenia in the Korean population

Won Sub Kang, Sang Min Lee, Dongkee Hwang, Hae Jeong Park, Jong Woo Kim

Medicine (Baltimore) 2022 Feb 4; 101(5): e28745. Published online 2022 Feb 4. doi: 10.1097/MD.0000000000028745

PMCID:: PMC8812592

Abstract Article PDF–241K

Select item 102754113.

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

Apirat Chaikuad, Sebastian E. Koschade, Alexandra Stolz, Katarina Zivkovic, Shabnam Shaid, Huiyu Ren, Lester J. Lambert, Nicholas D.P. Cosford, Christian H. Brandts, Stefan Knapp

Biochem J. Author manuscript; available in PMC 2023 Jun 16.

Published in final edited form as: Biochem J. 2019 Mar 12; 476(5): 875–887. Published online 2019 Mar 12. doi: 10.1042/BCJ20190038

PMCID:: PMC10275411

Abstract Article PDF–2.2M

Select item 76424114.

Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes

Yasir Mohamud, Junyan Shi, Hui Tang, Pinhao Xiang, Yuan Chao Xue, Huitao Liu, Chen Seng Ng, Honglin Luo

Sci Rep. 2020; 10: 19068. Published online 2020 Nov 4. doi: 10.1038/s41598-020-76227-7

PMCID:: PMC7642411

Abstract Article PDF–4.7M

Select item 53864935.

CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship

Ivan Scudiero, Pellegrino Mazzone, Luca E D'Andrea, Angela Ferravante, Tiziana Zotti, Gianluca Telesio, Gabriele De Rubis, Carla Reale, Maddalena Pizzulo, Shanmugakonar Muralitharan, Pasquale Vito, Romania Stilo

Cell Death Dis. 2017 Feb; 8(2): e2627. Published online 2017 Feb 23. doi: 10.1038/cddis.2017.51

PMCID:: PMC5386493

Abstract Article PDF–2.6M

Select item 41392406.

Methylation Silencing of ULK2, an Autophagy Gene, Is Essential for Astrocyte Transformation and Tumor Growth

Sudhanshu Shukla, Irene Rosita Pia Patric, Vikas Patil, Shivayogi D. Shwetha, Alangar S. Hegde, Bangalore A. Chandramouli, Arimappamagan Arivazhagan, Vani Santosh, Kumaravel Somasundaram

J Biol Chem. 2014 Aug 8; 289(32): 22306–22318. Published online 2014 Jun 12. doi: 10.1074/jbc.M114.567032

PMCID:: PMC4139240

Abstract Article PDF–3.0M

Select item 85710547.

PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

Juan F. Linares, Xiao Zhang, Anxo Martinez-Ordoñez, Angeles Duran, Hiroto Kinoshita, Hiroaki Kasashima, Naoko Nakanishi, Yuki Nakanishi, Ryan Carelli, Luca Cappelli, Esperanza Arias, Masakazu Yashiro, Masaichi Ohira, Sanjay Patel, Giorgio Inghirami, Massimo Loda, Ana Maria Cuervo, Maria T. Diaz-Meco, Jorge Moscat

Mol Cell. Author manuscript; available in PMC 2022 Nov 4.

Published in final edited form as: Mol Cell. 2021 Nov 4; 81(21): 4509–4526.e10. Published online 2021 Sep 23. doi: 10.1016/j.molcel.2021.08.039

PMCID:: PMC8571054

Abstract Article PDF–4.2M

Select item 74113908.

Long non-coding RNA growth arrest-specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer

Guangping Li, Lin Qian, Xiaoqin Tang, Yuan Chen, Ziyi Zhao, Cuiwei Zhang

Mol Med Rep. 2020 Sep; 22(3): 2460–2468. Published online 2020 Jul 10. doi: 10.3892/mmr.2020.11334

PMCID:: PMC7411390

Abstract Article PDF–1.4M

Select item 73374939.

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

Xiaoshan Shi, Adam L. Yokom, Chunxin Wang, Lindsey N. Young, Richard J. Youle, James H. Hurley

J Cell Biol. 2020 Jul 6; 219(7): e201911047. Published online 2020 Jun 9. doi: 10.1083/jcb.201911047

PMCID:: PMC7337493

Abstract Article PDF–5.5M

Select item 446007510.

ULK2 Ser 1027 Phosphorylation by PKA Regulates Its Nuclear Localization Occurring through Karyopherin Beta 2 Recognition of a PY-NLS Motif

Sung Hwa Shin, Eun Jeoung Lee, Jaesun Chun, Sunghee Hyun, Sang Sun Kang

PLoS One. 2015; 10(6): e0127784. Published online 2015 Jun 8. doi: 10.1371/journal.pone.0127784

PMCID:: PMC4460075

Abstract Article PDF–7.2M

Select item 446785511.

Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy

Jie Xu, Maryam Fotouhi, Peter S McPherson

EMBO Rep. 2015 Jun; 16(6): 709–718. Published online 2015 Apr 29. doi: 10.15252/embr.201440006

PMCID:: PMC4467855

Abstract Article PDF–1.0M

Select item 317211812.

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

W Gao, Z Shen, L Shang, X Wang

Cell Death Differ. 2011 Oct; 18(10): 1598–1607. Published online 2011 Apr 8. doi: 10.1038/cdd.2011.33

PMCID:: PMC3172118

Abstract Article PDF–633K

Select item 761025813.

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

Tiffany Tsang, Jessica M. Posimo, Andrea A. Gudiel, Michelle Cicchini, David M. Feldser, Donita C. Brady

Nat Cell Biol. Author manuscript; available in PMC 2020 Nov 4.

Published in final edited form as: Nat Cell Biol. 2020 Apr; 22(4): 412–424. Published online 2020 Mar 16. doi: 10.1038/s41556-020-0481-4

PMCID:: PMC7610258

Abstract Article PDF–5.2M

Select item 569971014.

Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9

Jonathan M. Goodwin, William E. Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Marek Kobylarz, Alicia Lindeman, Ramnik Xavier, Gregory McAllister, Beat Nyfeler, Gregory Hoffman, Leon O. Murphy

Cell Rep. Author manuscript; available in PMC 2017 Nov 22.

Published in final edited form as: Cell Rep. 2017 Sep 5; 20(10): 2341–2356. doi: 10.1016/j.celrep.2017.08.034

PMCID:: PMC5699710

Abstract Article PDF–2.6M

Select item 499360115.

Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis

Joung Hyuck Joo, Bo Wang, Elisa Frankel, Liang Ge, Lu Xu, Rekha Iyengar, XiuJie Li-Harms, Christopher Wright, Timothy I. Shaw, Tullia Lindsten, Douglas R. Green, Junmin Peng, Linda M. Hendershot, Fusun Kilic, Ji Ying Sze, Anjon Audhya, Mondira Kundu

Mol Cell. Author manuscript; available in PMC 2017 May 19.

Published in final edited form as: Mol Cell. 2016 May 19; 62(4): 491–506. doi: 10.1016/j.molcel.2016.04.020

PMCID:: PMC4993601

Abstract Article PDF–2.6M

Select item 483598216.

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

Ji-Man Park, Chang Hwa Jung, Minchul Seo, Neil Michael Otto, Douglas Grunwald, Kwan Hyun Kim, Branden Moriarity, Young-Mi Kim, Colby Starker, Richard Seonghun Nho, Daniel Voytas, Do-Hyung Kim

Autophagy. 2016 Mar; 12(3): 547–564. Published online 2016 Apr 5. doi: 10.1080/15548627.2016.1140293