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Select item 110467491.

Desmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer

Ji-Yuan Han, Na Che, Jing Mo, Dan-Fang Zhang, Xiao-Hui Liang, Xue-Yi Dong, Xiu-Lan Zhao, Bao-Cun Sun

BMC Cancer. 2024; 24: 532. Published online 2024 Apr 26. doi: 10.1186/s12885-024-12229-2

PMCID:: PMC11046749

Abstract Article PDF–2.7M

Select item 106415242.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 103739863.

DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway

Chao Sun, Kun Wen, Bin Zhang, Yan Dong, Chen Chen, Shi-Yong Neo, Bing Leng, Tian-Tian Gao, Jing Wu

Aging (Albany NY) 2023 Jul 15; 15(13): 6380–6399. Published online 2023 Jul 8. doi: 10.18632/aging.204858

PMCID:: PMC10373986

Abstract Article PDF–4.5M

Select item 103232524.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 95521185.

Claudin-4 localization in epithelial ovarian cancer

Margaret C. Neville, Patricia G. Webb, Heidi K. Baumgartner, Benjamin G. Bitler

Heliyon. 2022 Oct; 8(10): e10862. Published online 2022 Oct 4. doi: 10.1016/j.heliyon.2022.e10862

PMCID:: PMC9552118

Abstract Article PDF–4.5M

Select item 94339386.

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB

Fu‐Long Li, Zhengming Wu, Yong‐Qi Gao, Forrest Z Bowling, J Matthew Franklin, Chongze Hu, Raymond T Suhandynata, Michael A Frohman, Michael V Airola, Huilin Zhou, Kun‐Liang Guan

EMBO J. 2022 Sep; 41(17): e110698. Published online 2022 Jul 17. doi: 10.15252/embj.2022110698

PMCID:: PMC9433938

Abstract Article PDF–9.3M

Select item 91714117.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 89776008.

Verification and Validation of a Four-Gene Panel as a Prognostic Indicator in Triple Negative Breast Cancer

Mamta Pariyar, Rick F. Thorne, Rodney J. Scott, Kelly A. Avery-Kiejda

Front Oncol. 2022; 12: 821334. Published online 2022 Mar 21. doi: 10.3389/fonc.2022.821334

PMCID:: PMC8977600

Abstract Article PDF–1.7M

Select item 89451849.

Comparing Urinary Glycoproteins among Three Urogenital Cancers and Identifying Prostate Cancer-Specific Glycoproteins

Shao-Yung Chen, Tung-Shing Mamie Lih, Qing Kay Li, Hui Zhang

ACS Omega. 2022 Mar 22; 7(11): 9172–9180. Published online 2022 Mar 8. doi: 10.1021/acsomega.1c05223

PMCID:: PMC8945184

Abstract Article PDF–2.1M

Select item 892689910.

The PPARγ pathway determines electrophysiological remodelling and arrhythmia risks in DSC2 arrhythmogenic cardiomyopathy

Jean‐Baptiste Reisqs, Adrien Moreau, Azzouz Charrabi, Yvonne Sleiman, Albano C. Meli, Gilles Millat, Veronique Briand, Philippe Beauverger, Sylvain Richard, Philippe Chevalier

Clin Transl Med. 2022 Mar; 12(3): e748. Published online 2022 Mar 16. doi: 10.1002/ctm2.748

PMCID:: PMC8926899

Article PDF–991K

Select item 889203211.

Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2

Wenjuan Yang, Shiming Tan, Lixia Yang, Xiaohui Chen, Ruiqian Yang, Linda Oyang, Jinguan Lin, Longzheng Xia, Nayiyuan Wu, Yaqian Han, Yanyan Tang, Min Su, Xia Luo, Yiqing Yang, Lisheng Huang, Zifan Hu, Yi Tao, Lin Liu, Yi Jin, Hui Wang, Qianjin Liao, Yujuan Zhou

Mol Ther Oncolytics. 2022 Mar 17; 24: 612–623. Published online 2022 Feb 15. doi: 10.1016/j.omto.2022.02.008

PMCID:: PMC8892032

Abstract Article PDF–2.9M

Select item 861183412.

Overlap phenotypes of the left ventricular noncompaction and hypertrophic cardiomyopathy with complex arrhythmias and heart failure induced by the novel truncated DSC2 mutation

Yubi Lin, Jiana Huang, Zhiling Zhu, Zuoquan Zhang, Jianzhong Xian, Zhe Yang, Tingfeng Qin, Linxi Chen, Jingmin Huang, Yin Huang, Qiaoyun Wu, Zhenyu Hu, Xiufang Lin, Geyang Xu

Orphanet J Rare Dis. 2021; 16: 496. Published online 2021 Nov 24. doi: 10.1186/s13023-021-02112-9

PMCID:: PMC8611834

Abstract Article PDF–2.3M

Select item 856647313.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 855290714.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 828437515.

Clinical Findings and Diagnostic Yield of Arrhythmogenic Cardiomyopathy Through Genomic Screening of Pathogenic or Likely Pathogenic Desmosome Gene Variants

Eric D. Carruth, Dominik Beer, Amro Alsaid, Marci L.B. Schwartz, Megan McMinn, Melissa A. Kelly, Adam H. Buchanan, Christopher D. Nevius, Hugh Calkins, Cynthia A. James, Brittney Murray, Crystal Tichnell, Martin E. Matsumura, H. Lester Kirchner, Brandon K. Fornwalt, Amy C. Sturm, Christopher M. Haggerty

Circ Genom Precis Med. 2021 Apr; 14(2): e003302. Published online 2021 Apr 19. doi: 10.1161/CIRCGEN.120.003302

PMCID:: PMC8284375

Abstract Article PDF–534K

Select item 827099916.

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

Rui Liu, Lin-Wen Zeng, Rong Gong, Fanen Yuan, Hong-Bing Shu, Shu Li

Nat Commun. 2021; 12: 4227. Published online 2021 Jul 9. doi: 10.1038/s41467-021-24321-3

PMCID:: PMC8270999

Abstract Article PDF–3.8M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810852018.

Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2

Arturo Raya-Sandino, Anny-Claude Luissint, Dennis H. M. Kusters, Vani Narayanan, Sven Flemming, Vicky Garcia-Hernandez, Lisa M. Godsel, Kathleen J. Green, Susan J. Hagen, Daniel E. Conway, Charles A. Parkos, Asma Nusrat

Mol Biol Cell. 2021 Apr 15; 32(8): 753–768. doi: 10.1091/mbc.E20-12-0775

PMCID:: PMC8108520

Abstract Article PDF–11M

Select item 790804719.

Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy

Adrien Moreau, Jean‐Baptiste Reisqs, Helene Delanoe‐Ayari, Marion Pierre, Alexandre Janin, Antoine Deliniere, Francis Bessière, Albano C. Meli, Azzouz Charrabi, Estele Lafont, Camille Valla, Delphine Bauer, Elodie Morel, Vincent Gache, Gilles Millat, Xavier Nissan, Adele Faucherre, Chris Jopling, Sylvain Richard, Alexandre Mejat, Philippe Chevalier

Clin Transl Med. 2021 Mar; 11(3): e319. Published online 2021 Feb 26. doi: 10.1002/ctm2.319

PMCID:: PMC7908047

Abstract Article PDF–9.8M

Select item 766412020.

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane

Molly M. Hannigan, Alyson M. Hoffman, J. Will Thompson, Tianli Zheng, Christopher V. Nicchitta

Mol Cell Proteomics. 2020 Nov; 19(11): 1826–1849. Published online 2020 Aug 10. doi: 10.1074/mcp.RA120.002228

PMCID:: PMC7664120

Abstract Article PDF–4.8M

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