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Select item 109168661.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 105565932.

A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells

Lucy Ginn, Joe Maltas, Martin J. Baker, Anshuman Chaturvedi, Leah Wilson, Ryan Guilbert, Fabio M. R. Amaral, Lynsey Priest, Holly Mole, Fiona Blackhall, Zoi Diamantopoulou, Tim C. P. Somervaille, Adam Hurlstone, Angeliki Malliri

Proc Natl Acad Sci U S A. 2023 Oct 3; 120(40): e2300489120. Published online 2023 Sep 25. doi: 10.1073/pnas.2300489120

PMCID:: PMC10556593

Abstract Article PDF–6.6M

Select item 103713403.

TIAM1 acts as an actin organization regulator to control adipose tissue–derived pericyte cell fate

Ginny Ching-Yun Hsu, Yiyun Wang, Amy Z. Lu, Mario A. Gomez-Salazar, Jiajia Xu, Dongqing Li, Carolyn Meyers, Stefano Negri, Sintawat Wangsiricharoen, Kristen Broderick, Bruno Peault, Carol Morris, Aaron W. James

JCI Insight. 2023 Jul 10; 8(13): e159141. Published online 2023 Jul 10. doi: 10.1172/jci.insight.159141

PMCID:: PMC10371340

Abstract Article PDF–13M

Select item 103170234.

TIAM1–RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy

Renu A. Kowluru, Anjaneyulu Kowluru, Rajakrishnan Veluthakal, Ghulam Mohammad, Ismail Syed, Julia M. Santos, Manish Mishra

Diabetologia. Author manuscript; available in PMC 2023 Jul 3.

Published in final edited form as: Diabetologia. 2014 May; 57(5): 1047–1056. Published online 2014 Feb 20. doi: 10.1007/s00125-014-3194-z

PMCID:: PMC10317023

Abstract Article PDF–1.3M

Select item 93485765.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 91197366.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90163207.

A Hypoxia-Induced SCF^FBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis

Jun Zeng, Xiao-qing Xiao, Zhi-yong Zhou

Cancer Res Treat. 2022 Apr; 54(2): 525–540. Published online 2021 Jun 29. doi: 10.4143/crt.2021.373

PMCID:: PMC9016320

Abstract Article PDF–3.0M

Select item 85956428.

TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change

Aishwarya Payapilly, Ryan Guilbert, Tine Descamps, Gavin White, Peter Magee, Cong Zhou, Alastair Kerr, Kathryn L. Simpson, Fiona Blackhall, Caroline Dive, Angeliki Malliri

Cell Rep. 2021 Nov 9; 37(6): 109979. Published online 2021 Nov 9. doi: 10.1016/j.celrep.2021.109979

PMCID:: PMC8595642

Abstract Article

Select item 85516579.

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

Sylvie J. Lavictoire, Danny Jomaa, Alexander Gont, Karen Jardine, David P. Cook, Ian A.J. Lorimer

J Biol Chem. 2021 Nov; 297(5): 101172. Published online 2021 Oct 6. doi: 10.1016/j.jbc.2021.101172

PMCID:: PMC8551657

Abstract Article PDF–4.3M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 801772011.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

Select item 796299412.

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy

Yanke Chen, Ting Jiang, Hongyi Zhang, Xingchun Gou, Cong Han, Jianhui Wang, Ann T. Chen, Jun Ma, Jun Liu, Zeming Chen, Xintao Jing, Hong Lei, Zhenzhen Wang, Youmei Bao, Mehdi Baqri, Yong Zhu, Ranjit S. Bindra, James E. Hansen, Jun Dou, Chen Huang, Jiangbing Zhou

Nat Cell Biol. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: Nat Cell Biol. 2020 Oct; 22(10): 1276–1285. Published online 2020 Oct 1. doi: 10.1038/s41556-020-00586-6

PMCID:: PMC7962994

Abstract Article PDF–5.5M

Select item 793792213.

Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer

Aayushi Srivastava, Sara Giangiobbe, Diamanto Skopelitou, Beiping Miao, Nagarajan Paramasivam, Chiara Diquigiovanni, Elena Bonora, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli

Front Endocrinol (Lausanne) 2021; 12: 600682. Published online 2021 Feb 22. doi: 10.3389/fendo.2021.600682

PMCID:: PMC7937922

Abstract Article PDF–2.1M

Select item 742732714.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 711324315.

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity

Simone Kosol, Sara Contreras-Martos, Alessandro Piai, Mihaly Varadi, Tamas Lazar, Angela Bekesi, Pierre Lebrun, Isabella C. Felli, Roberta Pierattelli, Peter Tompa

Sci Rep. 2020; 10: 5753. Published online 2020 Apr 1. doi: 10.1038/s41598-020-62069-w