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Select item 112786651.

Fatty Acid Synthase Promotes Hepatocellular Carcinoma Growth via S-Phase Kinase-Associated Protein 2/p27^KIP1 Regulation

Antonio Cigliano, Maria M. Simile, Gianpaolo Vidili, Giovanni M. Pes, Maria P. Dore, Francesco Urigo, Eleonora Cossu, Li Che, Claudio Feo, Sara M. Steinmann, Silvia Ribback, Rosa M. Pascale, Matthias Evert, Xin Chen, Diego F. Calvisi

Medicina (Kaunas) 2024 Jul; 60(7): 1160. Published online 2024 Jul 18. doi: 10.3390/medicina60071160

PMCID:: PMC11278665

Abstract Article PDF–7.9M

Select item 111593922.

Overexpressed Skp2 within 5p amplification detected by array‐based comparative genomic hybridization is associated with poor prognosis of glioblastomas

Kuniyasu Saigusa, Naoya Hashimoto, Hitoshi Tsuda, Sana Yokoi, Motohiko Maruno, Toshiki Yoshimine, Masaru Aoyagi, Kikuo Ohno, Issei Imoto, Johji Inazawa

Cancer Sci. 2005 Oct; 96(10): 676–683. Published online 2005 Sep 1. doi: 10.1111/j.1349-7006.2005.00099.x

PMCID:: PMC11159392

Abstract Article PDF–288K

Select item 111593443.

p27^Kip1 is overexpressed in very early stages of hepatocarcinogenesis

Shinichi Yachida, Michiie Sakamoto, Katsumi Imaida, Masanao Yokohira, Kousuke Saoo, Keiichi Okano, Hisao Wakabayashi, Hajime Maeta, Yasuyuki Suzuki

Cancer Sci. 2008 Nov; 99(11): 2152–2159. Published online 2008 Sep 19. doi: 10.1111/j.1349-7006.2008.00923.x

PMCID:: PMC11159344

Abstract Article PDF–336K

Select item 110722364.

GSTpi reduces DNA damage and cell death by regulating the ubiquitination and nuclear translocation of NBS1

Jinyi Zhou, Lili Gu, Yingying Shi, Ting Huang, Xirui Fan, Xiaowen Bi, Shuai Lu, Juanjuan Liang, Lan Luo, Peng Cao, Zhimin Yin

Cell Mol Life Sci. 2022 Jan; 79(1): 54. Published online 2021 Dec 22. doi: 10.1007/s00018-021-04057-5

PMCID:: PMC11072236

Abstract Article PDF–11M

Select item 109850915.

Targeting RCC1 to block the human soft-tissue sarcoma by disrupting nucleo-cytoplasmic trafficking of Skp2

Mingzhi Zhuang, Fengyue Li, Hong Liang, Yongfu Su, Lei Cheng, Bingkai Lin, Jun Zhou, Runzhi Deng, Linying Chen, Peng Lyu, Zhonglei Lu

Cell Death Dis. 2024 Apr; 15(4): 241. Published online 2024 Apr 1. doi: 10.1038/s41419-024-06629-2

PMCID:: PMC10985091

Abstract Article PDF–5.3M

Select item 109597476.

Targeted inhibition of SCF^SKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma

Jichuan Wang, Alexander Ferrena, Ranxin Zhang, Swapnil Singh, Valentina Viscarret, Waleed Al-Harden, Osama Aldahamsheh, Hasibagan Borjihan, Amit Singla, Simon Yaguare, Janet Tingling, Xiaolin Zi, Yungtai Lo, Richard Gorlick, Edward L. Schwartz, Hongling Zhao, Rui Yang, David S. Geller, Deyou Zheng, Bang H. Hoang

Oncogene. 2024; 43(13): 962–975. Published online 2024 Feb 14. doi: 10.1038/s41388-024-02942-4

PMCID:: PMC10959747

Abstract Article PDF–6.0M

Select item 108423467.

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

Alexander Ferrena, Jichuan Wang, Ranxin Zhang, Burcu Karadal-Ferrena, Waleed Al-Hardan, Swapnil Singh, Hasibagan Borjihan, Edward L. Schwartz, Hongling Zhao, Maja H. Oktay, Rui Yang, David S Geller, Bang H Hoang, Deyou Zheng

Mol Cancer Ther. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Mol Cancer Ther. 2024 Feb 1; 23(2): 223–234. doi: 10.1158/1535-7163.MCT-23-0173

PMCID:: PMC10842346

Abstract Article PDF–1.6M

Select item 107242758.

MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57^Kip2 targeting

Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Ajla Wasti, Marielle Yohe, Myron Ignatius, Concetta Quintarelli, Janet Shipley, Lucio Miele, Javed Khan, Peter J. Houghton, Francesco Marampon, Berkley E. Gryder, Biagio De Angelis, Franco Locatelli, Rossella Rota

Nat Commun. 2023; 14: 8373. Published online 2023 Dec 15. doi: 10.1038/s41467-023-44130-0

PMCID:: PMC10724275

Abstract Article PDF–8.9M

Select item 103973469.

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells

Huiling Zhou, Li Zhou, Qing Guan, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu

Commun Biol. 2023; 6: 805. Published online 2023 Aug 2. doi: 10.1038/s42003-023-05166-6

PMCID:: PMC10397346

Abstract Article PDF–3.5M

Select item 1039700510.

CXC趋化因子受体4通过S期激酶相关蛋白2调控乳腺癌细胞周期的机制

Haifeng WANG, Tiantian CHEN, Yueyue WANG, Yu LI, Lingyu ZHANG, Yongxing DING, Sulian CHEN, Wenrui WANG, Qingling YANG, Changjie CHEN

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017 Aug 25; 46(4): 357–363. Chinese. doi: 10.3785/j.issn.1008-9292.2017.08.03

PMCID:: PMC10397005

Abstract Article PDF–3.4M

Select item 1031267411.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Abstract Article PDF–9.6M

Select item 1025845612.

SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma

Yuan Shao, Wanli Ren, Hao Dai, Fangli Yang, Xiang Li, Shaoqiang Zhang, Junsong Liu, Xiaobao Yao, Qian Zhao, Xin Sun, Zhiwei Zheng, Chongwen Xu

Mol Cells. 2023 Jun 30; 46(6): 360–373. Published online 2023 Jan 24. doi: 10.14348/molcells.2022.2242

PMCID:: PMC10258456

Abstract Article PDF–73M

Select item 1017409113.

Cytoplasmic YAP1‐mediated ESCRT‐III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer

Yan Guo, Yuqing Cui, Yangyang Li, Xiaoying Jin, Dandan Wang, Mengxia Lei, Fengzhi Chen, Yali Liu, Jinwen Xu, Guanyu Yao, Guangchun Zeng, Xuesong Chen

Cancer Commun (Lond) 2023 May; 43(5): 582–612. Published online 2023 Apr 2. doi: 10.1002/cac2.12417

PMCID:: PMC10174091

Abstract Article PDF–22M

Select item 1015617514.

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes

Kheewoong Baek, Daniel C. Scott, Lukas T. Henneberg, Moeko T. King, Matthias Mann, Brenda A. Schulman

Cell. 2023 Apr 27; 186(9): 1895–1911.e21. doi: 10.1016/j.cell.2023.02.035

Correction in:: Cell. 2023 May 25; 186(11): 2492.

PMCID:: PMC10156175

Abstract Article

Select item 1007290615.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1000966816.

METTL5 stabilizes c‐Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression

Peng Xia, Hao Zhang, Haofeng Lu, Kequan Xu, Xiang Jiang, Yuke Jiang, Xiangdong Gongye, Zhang Chen, Jie Liu, Xi Chen, Weijie Ma, Zhonglin Zhang, Yufeng Yuan

Cancer Commun (Lond) 2023 Mar; 43(3): 338–364. Published online 2023 Jan 5. doi: 10.1002/cac2.12403

PMCID:: PMC10009668

Abstract Article PDF–14M

Select item 992674317.

Extracellular matrix stiffness regulates degradation of MST2 via SCF ^βTrCP

Ana Paula Zen Petisco Fiore, Ana Maria Rodrigues, Helder Veras Ribeiro-Filho, Antonio Carlos Manucci, Pedro de Freitas Ribeiro, Mayara Carolinne Silva Botelho, Christine Vogel, Paulo Sergio Lopes-de-Oliveira, Michele Pagano, Alexandre Bruni-Cardoso

Biochim Biophys Acta Gen Subj. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: Biochim Biophys Acta Gen Subj. 2022 Dec; 1866(12): 130238. Published online 2022 Aug 28. doi: 10.1016/j.bbagen.2022.130238

PMCID:: PMC9926743

Abstract Article PDF–1.0M

Select item 973832318.

Reduced SKP2 Expression Adversely Impacts Genome Stability and Promotes Cellular Transformation in Colonic Epithelial Cells

Nicole M. Neudorf, Laura L. Thompson, Zelda Lichtensztejn, Tooba Razi, Kirk J. McManus

Cells. 2022 Dec; 11(23): 3731. Published online 2022 Nov 22. doi: 10.3390/cells11233731

PMCID:: PMC9738323

Abstract Article PDF–2.8M

Select item 973375119.

ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation

Hsuan-Hsiang Peng, Hao-Chin Yang, Darius Rupa, Chun-Han Yen, Ya-Wen Chiu, Wei-Jia Yang, Fuh-Jinn Luo, Ta-Chun Yuan

J Cell Commun Signal. 2022 Dec; 16(4): 567–578. Published online 2022 Mar 5. doi: 10.1007/s12079-022-00670-6

PMCID:: PMC9733751

Abstract Article PDF–2.5M

Select item 972764720.

Identification of an E3 ligase that targets the catalytic subunit of RNA Polymerase I upon transcription stress

Stephanie Pitts, Hester Liu, Adel Ibrahim, Amit Garg, Catarina Mendes Felgueira, Asma Begum, Wenjun Fan, Selina Teh, Jin-Yih Low, Brittany Ford, David A. Schneider, Ronald Hay, Marikki Laiho

J Biol Chem. 2022 Dec; 298(12): 102690. Published online 2022 Nov 11. doi: 10.1016/j.jbc.2022.102690

PMCID:: PMC9727647

Abstract Article PDF–3.5M

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