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Select item 110941331.

Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma

Xing Jin, Lei Liu, Dan Liu, Jia Wu, Congcong Wang, Siliang Wang, Fengying Wang, Guanzhen Yu, Xiaoxia Jin, Yu-Wen Xue, Dan Jiang, Yan Ni, Xi Yang, Ming-Song Wang, Zhi-Wei Wang, Yuriy L. Orlov, Wei Jia, Gerry Melino, Ji-Bin Liu, Wen-Lian Chen

Cell Death Differ. 2024 May; 31(5): 558–573. Published online 2024 Apr 3. doi: 10.1038/s41418-024-01285-7

PMCID:: PMC11094133

Abstract Article PDF–7.3M

Select item 109316872.

Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia

David E. Phelan, Ben Reddan, Masahiko Shigemura, Jacob I. Sznajder, Daniel Crean, Eoin P. Cummins

Int J Mol Sci. 2024 Mar; 25(5): 2852. Published online 2024 Mar 1. doi: 10.3390/ijms25052852

PMCID:: PMC10931687

Abstract Article PDF–3.1M

Select item 104192443.

Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology

Ángel Juan García-Yagüe, Antonio Cuadrado

Int J Mol Sci. 2023 Aug; 24(15): 12280. Published online 2023 Jul 31. doi: 10.3390/ijms241512280

PMCID:: PMC10419244

Abstract Article PDF–1.9M

Select item 101080544.

Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis

Nila H. Servaas, Sanne Hiddingh, Eleni Chouri, Catharina G. K. Wichers, Alsya J. Affandi, Andrea Ottria, Cornelis P. J. Bekker, Marta Cossu, Sandra C. Silva‐Cardoso, Maarten van der Kroef, Anneline C. Hinrichs, Tiago Carvalheiro, Nadia Vazirpanah, Lorenzo Beretta, Marzia Rossato, Femke Bonte‐Mineur, Timothy R. D. J. Radstake, Jonas J. W. Kuiper, Marianne Boes, Aridaman Pandit

Arthritis Rheumatol. 2023 Feb; 75(2): 279–292. Published online 2022 Dec 8. doi: 10.1002/art.42319

PMCID:: PMC10108054

Abstract Article PDF–3.0M

Select item 99104635.

The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2

Tim Vierbuchen, Shiuli Agarwal, John L. Johnson, Liraz Galia, Xuqiu Lei, Karina Stein, David Olagnier, Karoline I. Gaede, Christian Herzmann, Christian K. Holm, Holger Heine, Athma Pai, Aisling O’Hara Hall, Kasper Hoebe, Katherine A. Fitzgerald

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2213715120. Published online 2022 Dec 28. doi: 10.1073/pnas.2213715120

PMCID:: PMC9910463

Abstract Article PDF–4.6M

Select item 93485766.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92959717.

Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells

Fengchun Ye, David Alvarez-Carbonell, Kien Nguyen, Konstantin Leskov, Yoelvis Garcia-Mesa, Sheetal Sreeram, Saba Valadkhan, Jonathan Karn

PLoS Pathog. 2022 Jul; 18(7): e1010110. Published online 2022 Jul 7. doi: 10.1371/journal.ppat.1010110

PMCID:: PMC9295971

Abstract Article PDF–6.3M

Select item 92824328.

NURR1 expression regulates retinal pigment epithelial–mesenchymal transition and age-related macular degeneration phenotypes

Pei-Li Yao, Vipul M. Parmar, Mayur Choudhary, Goldis Malek

Proc Natl Acad Sci U S A. 2022 Jul 12; 119(28): e2202256119. Published online 2022 Jul 8. doi: 10.1073/pnas.2202256119

PMCID:: PMC9282432

Abstract Article PDF–4.3M

Select item 92352369.

The role of NURR1 in metabolic abnormalities of Parkinson’s disease

Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng, Weidong Le

Mol Neurodegener. 2022; 17: 46. Published online 2022 Jun 27. doi: 10.1186/s13024-022-00544-w

PMCID:: PMC9235236

Abstract Article PDF–1.1M

Select item 910982810.

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma

Mehrdad Zarei, Rupesh Shrestha, Sneha Johnson, Zuhua Yu, Keshav Karki, Ali Vaziri-Gohar, Jessica Epps, Heng Du, Larry Suva, Mahsa Zarei, Stephen Safe

Cancer Res Commun. 2021 Nov; 1(2): 65–78. Published online 2021 Nov 3. doi: 10.1158/2767-9764.CRC-21-0073

PMCID:: PMC9109828

Abstract Article PDF–6.5M

Select item 899892711.

Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 (SYNGR3) Gene: The Effects of NURR1 on Its Expression

Lingfei Li, Philip Wing-Lok Ho, Huifang Liu, Shirley Yin-Yu Pang, Eunice Eun-Seo Chang, Zoe Yuen-Kiu Choi, Yasine Malki, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho

Int J Mol Sci. 2022 Apr; 23(7): 3646. Published online 2022 Mar 26. doi: 10.3390/ijms23073646

PMCID:: PMC8998927

Abstract Article PDF–4.0M

Select item 880661612.

Exosomal lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)contributes to the progression of allergic rhinitis via modulating microRNA-511/Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) axis

Tao Wang, Weiyu Cai, Qinwei Wu, Dong Chen, Peihua Wang, Zhou Xu

Bioengineered. 2021; 12(1): 8067–8079. Published online 2021 Oct 21. doi: 10.1080/21655979.2021.1982313

PMCID:: PMC8806616

Abstract Article PDF–4.0M

Select item 852658813.

NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast

Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu’uhevaha J. Kaitu’u-Lino, Susan P. Walker, Owen Stock, Katie M. Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Natalie J. Hannan

Sci Rep. 2021; 11: 20670. Published online 2021 Oct 19. doi: 10.1038/s41598-021-00192-y

PMCID:: PMC8526588

Abstract Article PDF–1.5M

Select item 826790614.

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response

David E. Phelan, Masahiko Shigemura, Sarah Aldhafiri, Catarina Mota, Thomas J. Hall, Jacob I. Sznajder, Evelyn P. Murphy, Daniel Crean, Eoin P. Cummins

Front Immunol. 2021; 12: 676644. Published online 2021 Jun 25. doi: 10.3389/fimmu.2021.676644

PMCID:: PMC8267906

Abstract Article PDF–3.4M

Select item 800904815.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 787156516.

Working memory deficits in schizophrenia are associated with the rs34884856 variant and expression levels of the NR4A2 gene in a sample Mexican population: a case control study

Elizabeth Ruiz-Sánchez, Janet Jiménez-Genchi, Yessica M. Alcántara-Flores, Carlos J. Castañeda-González, Carlos L. Aviña-Cervantes, Petra Yescas, María del Socorro González-Valadez, Nancy Martínez-Rodríguez, Antonio Ríos-Ortiz, Martha González-González, María E. López-Navarro, Patricia Rojas

BMC Psychiatry. 2021; 21: 86. Published online 2021 Feb 9. doi: 10.1186/s12888-021-03081-w

PMCID:: PMC7871565

Abstract Article PDF–950K

Select item 786437917.

CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

Justin C. Boucher, Gongbo Li, Hiroshi Kotani, Maria L. Cabral, Dylan Morrissey, Sae Bom Lee, Kristen Spitler, Nolan J. Beatty, Estelle V. Cervantes, Bishwas Shrestha, Bin Yu, Aslamuzzaman Kazi, Xuefeng Wang, Said M. Sebti, Marco L. Davila

Cancer Immunol Res. Author manuscript; available in PMC 2022 Jan 1.

Published in final edited form as: Cancer Immunol Res. 2021 Jan; 9(1): 62–74. Published online 2020 Nov 13. doi: 10.1158/2326-6066.CIR-20-0253

Correction in:: Cancer Immunol Res. 2021 Apr; 9(4): 486.

PMCID:: PMC7864379

Abstract Article PDF–2.0M

Select item 739487918.

De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy

Sakshi Singh, Aditi Gupta, Michael Zech, Ashley N. Sigafoos, Karl J. Clark, Yasemin Dincer, Matias Wagner, Jennifer B. Humberson, Sarah Green, Koen van Gassen, Tracy Brandt, Rhonda E. Schnur, Francisca Millan, Yue Si, Volker Mall, Juliane Winkelmann, Ralitza H. Gavrilova, Eric W. Klee, Kendra Engleman, Nicole P. Safina, Rachel Slaugh, Emily M. Bryant, Wen-Hann Tan, Jorge Granadillo, Sunita N. Misra, G. Bradley Schaefer, Shelley Towner, Eva H. Brilstra, Bobby P. C. Koeleman

Genet Med. 2020; 22(8): 1413–1417. Published online 2020 May 5. doi: 10.1038/s41436-020-0815-4

PMCID:: PMC7394879

Abstract Article PDF–489K

Select item 733264519.

De Novo Variants in CNOT1, a Central Component of the CCR4-NOT Complex Involved in Gene Expression and RNA and Protein Stability, Cause Neurodevelopmental Delay

Lisenka E.L.M. Vissers, Sreehari Kalvakuri, Elke de Boer, Sinje Geuer, Machteld Oud, Inge van Outersterp, Michael Kwint, Melde Witmond, Simone Kersten, Daniel L. Polla, Dilys Weijers, Amber Begtrup, Kirsty McWalter, Anna Ruiz, Elisabeth Gabau, Jenny E.V. Morton, Christopher Griffith, Karin Weiss, Candace Gamble, James Bartley, Hilary J. Vernon, Kendra Brunet, Claudia Ruivenkamp, Sarina G. Kant, Paul Kruszka, Austin Larson, Alexandra Afenjar, Thierry Billette de Villemeur, Kimberly Nugent, the DDD Study, F. Lucy Raymond, Hanka Venselaar, Florence Demurger, Claudia Soler-Alfonso, Dong Li, Elizabeth Bhoj, Ian Hayes, Nina Powell Hamilton, Ayesha Ahmad, Rachel Fisher, Myrthe van den Born, Marjolaine Willems, Arthur Sorlin, Julian Delanne, Sebastien Moutton, Philippe Christophe, Frederic Tran Mau-Them, Antonio Vitobello, Himanshu Goel, Lauren Massingham, Chanika Phornphutkul, Jennifer Schwab, Boris Keren, Perrine Charles, Maaike Vreeburg, Lenika De Simone, George Hoganson, Maria Iascone, Donatella Milani, Lucie Evenepoel, Nicole Revencu, D. Isum Ward, Kaitlyn Burns, Ian Krantz, Sarah E. Raible, Jill R. Murrell, Kathleen Wood, Megan T. Cho, Hans van Bokhoven, Maximilian Muenke, Tjitske Kleefstra, Rolf Bodmer, Arjan P.M. de Brouwer

Am J Hum Genet. 2020 Jul 2; 107(1): 164–172. Published online 2020 Jun 17. doi: 10.1016/j.ajhg.2020.05.017

PMCID:: PMC7332645

Abstract Article PDF–1.0M

Select item 733235720.

Genome-Wide Analysis Identifies NURR1-Controlled Network of New Synapse Formation and Cell Cycle Arrest in Human Neural Stem Cells

Soo Min Kim, Soo Young Cho, Min Woong Kim, Seung Ryul Roh, Hee Sun Shin, Young Ho Suh, Dongho Geum, Myung Ae Lee

Mol Cells. 2020 Jun 30; 43(6): 551–571. Published online 2020 Jun 10. doi: 10.14348/molcells.2020.0071

PMCID:: PMC7332357

Abstract Article PDF–2.6M

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