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Select item 110213211.

Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors

T. Al Tabosh, H. Liu, D. Koça, M. Al Tarrass, L. Tu, S. Giraud, L. Delagrange, M. Beaudoin, S. Rivière, V. Grobost, M. Rondeau-Lutz, O. Dupuis, N. Ricard, E. Tillet, P. Machillot, A. Salomon, C. Picart, C. Battail, S. Dupuis-Girod, C. Guignabert, A. Desroches-Castan, S. Bailly

Angiogenesis. 2024; 27(2): 211–227. Published online 2024 Jan 31. doi: 10.1007/s10456-023-09902-8

PMCID:: PMC11021321

Abstract Article PDF–3.7M

Select item 106296792.

Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development

Molly R. Kulikauskas, Morgan Oatley, Tianji Yu, Ziqing Liu, Lauren Matsumura, Elise Kidder, Dana Ruter, Victoria L. Bautch

Development. 2023 Nov 1; 150(21): dev201811. Published online 2023 Nov 3. doi: 10.1242/dev.201811

PMCID:: PMC10629679

Abstract Article

Select item 105189773.

ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15-mediated GPX2 stabilization

Xiaolin Lu, Ruiqi Liu, Yuanyu Liao, Luying Cui, Haoxiu Sun, Dongzhi Zhang, Bojun Wang, Lin Fang, Xin Guan, Yuanfei Yao, Chao Liu, Yanqiao Zhang

BMC Med. 2023; 21: 366. Published online 2023 Sep 25. doi: 10.1186/s12916-023-03066-4

PMCID:: PMC10518977

Abstract Article PDF–18M

Select item 93565574.

Hereditary hemorrhagic telangiectasia: First demonstration of a founder effect in Italy; the ACVRL1 c.289_294del variant originated in the country of Bergamo 200 years ago

Anna Sbalchiero, Yasmin Abu Hweij, Tommaso Mazza, Elisabetta Buscarini, Claudia Scotti, Fabio Pagella, Guido Manfredi, Elina Matti, Giuseppe Spinozzi, Carla Olivieri

Mol Genet Genomic Med. 2022 Aug; 10(8): e1972. Published online 2022 May 27. doi: 10.1002/mgg3.1972

PMCID:: PMC9356557

Abstract Article PDF–2.2M

Select item 85483965.

Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils

Yusuke Kimishima, Tomofumi Misaka, Tetsuro Yokokawa, Kento Wada, Koki Ueda, Koichi Sugimoto, Keiji Minakawa, Kazuhiko Nakazato, Takafumi Ishida, Motohiko Oshima, Shuhei Koide, Kotaro Shide, Kazuya Shimoda, Atsushi Iwama, Kazuhiko Ikeda, Yasuchika Takeishi

Nat Commun. 2021; 12: 6177. Published online 2021 Oct 26. doi: 10.1038/s41467-021-26435-0

PMCID:: PMC8548396

Abstract Article PDF–10M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81014647.

ALK1 regulates the internalization of endoglin and the type III TGF-β receptor

Keren Tazat, Leslie Pomeraniec-Abudy, Melissa Hector-Greene, Szabina Szófia Szilágyi, Swati Sharma, Elise M. Cai, Armando L. Corona, Marcelo Ehrlich, Gerard C. Blobe, Yoav I. Henis

Mol Biol Cell. 2021 Apr 1; 32(7): 605–621. doi: 10.1091/mbc.E20-03-0199

PMCID:: PMC8101464

Abstract Article PDF–4.1M

Select item 80709718.

Founder Effects in Hereditary Hemorrhagic Telangiectasia

Tamás Major, Réka Gindele, Gábor Balogh, Péter Bárdossy, Zsuzsanna Bereczky

J Clin Med. 2021 Apr; 10(8): 1682. Published online 2021 Apr 14. doi: 10.3390/jcm10081682

PMCID:: PMC8070971

Abstract Article PDF–1.2M

Select item 79969689.

ALK-1 to ALK-5 ratio dictated by the Akt1-β-catenin pathway regulates TGFβ-induced endothelial-to-mesenchymal transition

Arti Verma, Sandeep Artham, Payaningal R. Somanath

Gene. Author manuscript; available in PMC 2022 Feb 5.

Published in final edited form as: Gene. 2021 Feb 5; 768: 145293. Published online 2020 Nov 4. doi: 10.1016/j.gene.2020.145293

PMCID:: PMC7996968

Abstract Article PDF–673K

Select item 776337310.

Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations

Agnes S. Kim, Katharine J. Henderson, Sumeet Pawar, Min Jung Kim, Shahnaz Punjani, Jeffrey S. Pollak, John T. Fahey, Guadalupe Garcia‐Tsao, Lissa Sugeng, Lawrence H. Young

J Am Heart Assoc. 2020 Oct 20; 9(20): e016197. Published online 2020 Oct 15. doi: 10.1161/JAHA.120.016197

PMCID:: PMC7763373

Abstract Article PDF–566K

Select item 750768511.

Sequence variations of ACVRL1 play a critical role in hepatic vascular malformations in hereditary hemorrhagic telangiectasia

Sophie Giraud, Claire Bardel, Sophie Dupuis-Girod, Marie-France Carette, Brigitte Gilbert-Dussardier, Sophie Riviere, Jean-Christophe Saurin, Mélanie Eyries, Sylvie Patri, Evelyne Decullier, Alain Calender, Gaëtan Lesca

Orphanet J Rare Dis. 2020; 15: 254. Published online 2020 Sep 22. doi: 10.1186/s13023-020-01533-2

PMCID:: PMC7507685

Abstract Article PDF–651K

Select item 750256612.

Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn’s Disease

Takahiko Toyonaga, Erin C. Steinbach, Benjamin P. Keith, Jasmine B. Barrow, Matthew R. Schaner, Elisabeth A. Wolber, Caroline Beasley, Jennifer Huling, Yuli Wang, Nancy L. Allbritton, Nicole Chaumont, Timothy S. Sadiq, Mark J. Koruda, Animesh Jain, Millie D. Long, Edward L. Barnes, Hans H. Herfarth, Kim L. Isaacs, Jonathan J. Hansen, Michael T. Shanahan, Reza Rahbar, Terrence S. Furey, Praveen Sethupathy, Shehzad Z. Sheikh

Cell Mol Gastroenterol Hepatol. 2020; 10(4): 779–796. Published online 2020 Jun 16. doi: 10.1016/j.jcmgh.2020.06.005

PMCID:: PMC7502566

Abstract Article PDF–3.3M

Select item 732880113.

A Phase I Study of the Anti-Activin Receptor-Like Kinase 1 (ALK-1) Monoclonal Antibody PF-03446962 in Patients with Advanced Solid Tumors

Laura W. Goff, Roger B. Cohen, Jordan D. Berlin, Filippo G. de Braud, Andrej Lyshchik, Cristina Noberasco, Francesco Bertolini, Marina Carpentieri, Corrado Gallo Stampino, Antonello Abbattista, Erjan Wang, Hossein Borghaei

Clin Cancer Res. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Clin Cancer Res. 2016 May 1; 22(9): 2146–2154. Published online 2015 Dec 11. doi: 10.1158/1078-0432.CCR-15-1622

PMCID:: PMC7328801

Abstract Article PDF–853K

Select item 728705714.

Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage

Mercedes Garzon-Martinez, Nuria Perretta-Tejedor, Luis Garcia-Ortiz, Manuel A. Gomez-Marcos, Rogelio Gonzalez-Sarmiento, Francisco J. Lopez-Hernandez, Carlos Martinez-Salgado

Sci Rep. 2020; 10: 9383. Published online 2020 Jun 10. doi: 10.1038/s41598-020-66238-9

PMCID:: PMC7287057

Abstract Article PDF–1.0M

Select item 700256215.

MiR-199b-5p Suppresses Tumor Angiogenesis Mediated by Vascular Endothelial Cells in Breast Cancer by Targeting ALK1

Xiao Lin, Wuxia Qiu, Yunyun Xiao, Jianhua Ma, Fang Xu, Kewen Zhang, Yongguang Gao, Qiang Chen, Yu Li, Hui Li, Airong Qian

Front Genet. 2019; 10: 1397. Published online 2020 Jan 30. doi: 10.3389/fgene.2019.01397

PMCID:: PMC7002562

Abstract Article PDF–7.9M

Select item 694554616.

Future treatments for hereditary hemorrhagic telangiectasia

Florian Robert, Agnès Desroches-Castan, Sabine Bailly, Sophie Dupuis-Girod, Jean-Jacques Feige

Orphanet J Rare Dis. 2020; 15: 4. Published online 2020 Jan 7. doi: 10.1186/s13023-019-1281-4

PMCID:: PMC6945546

Abstract Article PDF–1.3M

Select item 684899217.

Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Bi-allelic Loss of ENG or ACVRL1

Daniel A. Snellings, Carol J. Gallione, Dewi S. Clark, Nicholas T. Vozoris, Marie E. Faughnan, Douglas A. Marchuk

Am J Hum Genet. 2019 Nov 7; 105(5): 894–906. Published online 2019 Oct 17. doi: 10.1016/j.ajhg.2019.09.010

PMCID:: PMC6848992

Abstract Article PDF–1.3M

Select item 651088618.

Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer

Matteo Bocci, Jonas Sjölund, Ewa Kurzejamska, David Lindgren, Nour-Al-Dain Marzouka, Michael Bartoschek, Mattias Höglund, Kristian Pietras

Angiogenesis. 2019; 22(1): 117–131. Published online 2018 Aug 21. doi: 10.1007/s10456-018-9642-5

PMCID:: PMC6510886

Abstract Article PDF–3.4M

Select item 639532419.

ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells

Federica Portale, Giulia Cricrì, Silvia Bresolin, Monica Lupi, Stefania Gaspari, Daniela Silvestri, Barbara Russo, Noemi Marino, Paolo Ubezio, Fabio Pagni, Patrizia Vergani, Geertruy Te Kronnie, Maria Grazia Valsecchi, Franco Locatelli, Carmelo Rizzari, Andrea Biondi, Erica Dander, Giovanna D’Amico

Haematologica. 2019 Mar; 104(3): 533–545. Prepublished online 2018 Sep 27. doi: 10.3324/haematol.2018.188664