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Select item 94368141.

Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia

Haixia Zhuang, Ying Ren, Chenyu Mao, Yueya Zhong, Zubin Zhang, Biyin Cao, Yuming Zhang, Jinqi Huang, Guoqiang Xu, Zhenqian Huang, Yujia Xu, Xinliang Mao

J Biol Chem. 2022 Sep; 298(9): 102314. Published online 2022 Aug 1. doi: 10.1016/j.jbc.2022.102314

PMCID:: PMC9436814

Abstract Article PDF–3.8M

Select item 90291062.

Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6

Dhanraj Deshmukh, Jin Xu, Xi Yang, Hermela Shimelis, Shengyun Fang, Yun Qiu

Pharmaceutics. 2022 Apr; 14(4): 802. Published online 2022 Apr 6. doi: 10.3390/pharmaceutics14040802

PMCID:: PMC9029106

Abstract Article PDF–3.0M

Select item 89712053.

RING-Finger Protein 6 promotes Drug Resistance in Retinoblastoma via JAK2/STAT3 Signaling Pathway

Yong Chai, Shoufeng Jiao, Xin Peng, Qiang Gan, Leifeng Chen, Xiaolu Hu, Liang Hao, Shouhua Zhang, Qiang Tao

Pathol Oncol Res. 2022; 28: 1610273. Published online 2022 Mar 18. doi: 10.3389/pore.2022.1610273

PMCID:: PMC8971205

Abstract Article PDF–1.4M

Select item 87131794.

RNF6 promotes the migration and invasion of breast cancer by promoting the ubiquitination and degradation of MST1

Yajuan Huang, Yufeng Zou, Zhigang Jie

Exp Ther Med. 2022 Feb; 23(2): 118. Published online 2021 Dec 6. doi: 10.3892/etm.2021.11041

Correction in:: Exp Ther Med. 2022 May; 23(5): 326.

PMCID:: PMC8713179

Abstract Article PDF–5.1M

Select item 86167605.

RING-finger protein 6 promotes colorectal tumorigenesis by transcriptionally activating SF3B2

Hui Xu, Chi Chun Wong, Weilin Li, Yunfei Zhou, Yan Li, Lifu Wang, Lei Liu, Jun Yu

Oncogene. 2021; 40(47): 6513–6526. Published online 2021 Oct 5. doi: 10.1038/s41388-021-01872-9

PMCID:: PMC8616760

Abstract Article PDF–6.6M

Select item 82558366.

Knockdown of RNF6 inhibits HeLa cervical cancer cell growth via suppression of MAPK/ERK signaling

Kang Zhu, He Bai, Mingzhu Mu, Yuanyuan Xue, Zhao Duan

FEBS Open Bio. 2021 Jul; 11(7): 2041–2049. Published online 2021 Jun 18. doi: 10.1002/2211-5463.13216

PMCID:: PMC8255836

Abstract Article PDF–3.0M

Select item 81650307.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81080938.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 74708019.

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination

Ying Ren, Xin Xu, Chen-yu Mao, Kun-kun Han, Yu-jia Xu, Bi-yin Cao, Zu-bin Zhang, Gautam Sethi, Xiao-wen Tang, Xin-liang Mao

Acta Pharmacol Sin. 2020 Mar; 41(3): 394–403. Published online 2019 Oct 23. doi: 10.1038/s41401-019-0309-6

PMCID:: PMC7470801

Abstract Article PDF–2.7M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 545599611.

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

Joseph Rosenbluh, Johnathan Mercer, Yashaswi Shrestha, Rachel Oliver, Pablo Tamayo, John G. Doench, Itay Tirosh, Federica Piccioni, Ella Hartenian, Heiko Horn, Lola Fagbami, David E. Root, Jacob Jaffe, Kasper Lage, Jesse S. Boehm, William C. Hahn

Cell Syst. Author manuscript; available in PMC 2017 Sep 28.

Published in final edited form as: Cell Syst. 2016 Sep 28; 3(3): 302–316.e4. doi: 10.1016/j.cels.2016.09.001

PMCID:: PMC5455996

Abstract Article PDF–3.1M

Select item 538674712.

Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha

Yuanying Zeng, Xin Xu, Siyu Wang, Zubin Zhang, Yan Liu, Kunkun Han, Biyin Cao, Xinliang Mao

Oncotarget. 2017 Mar 21; 8(12): 20103–20112. Published online 2017 Feb 16. doi: 10.18632/oncotarget.15384

PMCID:: PMC5386747

Abstract Article PDF–4.1M

Select item 488910513.

Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins

Hirotaka Takahashi, Atsushi Uematsu, Satoshi Yamanaka, Mei Imamura, Tatsuro Nakajima, Kousuke Doi, Saki Yasuoka, Chikako Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki

PLoS One. 2016; 11(6): e0156718. Published online 2016 Jun 1. doi: 10.1371/journal.pone.0156718

PMCID:: PMC4889105

Abstract Article PDF–3.3M

Select item 488219014.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 485029915.

The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1

Xin Xu, Kunkun Han, Xiaowen Tang, Yuanying Zeng, Xu Lin, Yun Zhao, Zubin Zhang, Biyin Cao, Depei Wu, Xinliang Mao

J Biol Chem. 2016 Apr 29; 291(18): 9617–9628. Published online 2016 Mar 12. doi: 10.1074/jbc.M115.701979

PMCID:: PMC4850299

Abstract Article PDF–2.1M

Select item 396961216.

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium

Nat Genet. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Nat Genet. 2014 Mar; 46(3): 234–244. Published online 2014 Feb 9. doi: 10.1038/ng.2897

PMCID:: PMC3969612

Abstract Article PDF–725K

Select item 335692117.

A Comprehensive Genetic Association Study of Alzheimer Disease in African Americans

Dr. Mark W. Logue, Messr. Matthew Schu, Messr. Badri N. Vardarajan, Ms Jacki Buros, Dr. Robert C. Green, Dr. Rodney C. P. Go, Dr. Patrick Griffith, Dr. Thomas O. Obisesan, Dr. Rhonna Shatz, Dr. Amy Borenstein, Dr. L. Adrienne Cupples, Dr. Kathryn L. Lunetta, Dr. M. Daniele Fallin, Dr. Clinton T. Baldwin, Dr. Lindsay A. Farrer

Arch Neurol. Author manuscript; available in PMC 2012 May 21.

Published in final edited form as: Arch Neurol. 2011 Dec; 68(12): 1569–1579. doi: 10.1001/archneurol.2011.646

PMCID:: PMC3356921

Abstract Article PDF–1.4M

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 284896919.

Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination

Kexin Xu, Hermela Shimelis, Douglas E. Linn, Richeng Jiang, Xi Yang, Feng Sun, Zhiyong Guo, Hege Chen, Wei Li, Hegang Chen, Xiangtian Kong, Jonathan Melamed, Shengyun Fang, Zhen Xiao, Timothy D. Veenstra, Yun Qiu

Cancer Cell. Author manuscript; available in PMC 2010 Apr 7.

Published in final edited form as: Cancer Cell. 2009 Apr 7; 15(4): 270–282. doi: 10.1016/j.ccr.2009.02.021

PMCID:: PMC2848969

Abstract Article PDF–2.6M

Select item 276528020.

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Gabriel Markson, Christina Kiel, Russell Hyde, Stephanie Brown, Panagoula Charalabous, Anja Bremm, Jennifer Semple, Jonathan Woodsmith, Simon Duley, Kourosh Salehi-Ashtiani, Marc Vidal, David Komander, Luis Serrano, Paul Lehner, Christopher M. Sanderson

Genome Res. 2009 Oct; 19(10): 1905–1911. doi: 10.1101/gr.093963.109

PMCID:: PMC2765280

Abstract Article PDF–425K

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PMC Links for GEO Profiles (Select 1019566) (27)
PMC
GSM4494872[Accession] (3)
GEO DataSets
001607
001607

biosample
CHRNA7-FAM7A fusion protein isoform X2 [Homo sapiens]
CHRNA7-FAM7A fusion protein isoform X2 [Homo sapiens]
gi|2462546501|ref|XP_054235081.1|

Protein
CHRNA7-FAM7A fusion protein isoform X3 [Homo sapiens]
CHRNA7-FAM7A fusion protein isoform X3 [Homo sapiens]
gi|2462546503|ref|XP_054235082.1|

Protein

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