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Select item 95540691.

Variable skeletal phenotypes associated with biallelic variants in PRKG2

Alistair T Pagnamenta, Francisca Diaz-Gonzalez, Benito Banos-Pinero, Matteo P Ferla, Mehran B Toosi, Alistair D Calder, Ehsan G Karimiani, Mohammad Doosti, Andrew Wainwright, Paul Wordsworth, Kathryn Bailey, Katarina Ejeskär, Tracy Lester, Reza Maroofian, Karen E Heath, Homa Tajsharghi, Deborah Shears, Jenny C Taylor, The Genomics England Research Consortium

J Med Genet. 2022 Oct; 59(10): 947–950. Published online 2021 Nov 15. doi: 10.1136/jmedgenet-2021-108027

PMCID:: PMC9554069

Article PDF–1.8M

Select item 85640142.

Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes

Yingying Liu, Samantha Gokhale, Jaeyong Jung, Sining Zhu, Chang Luo, Debanjan Saha, Jessie Yanxiang Guo, Huaye Zhang, Saw Kyin, Wei-Xing Zong, Eileen White, Ping Xie

Front Immunol. 2021; 12: 670338. Published online 2021 Oct 20. doi: 10.3389/fimmu.2021.670338

PMCID:: PMC8564014

Abstract Article PDF–18M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 58967464.

Structural Basis of Analog Specificity in PKG I and II

James C. Campbell, Philipp Henning, Eugen Franz, Banumathi Sankaran, Friedrich W. Herberg, Choel Kim

ACS Chem Biol. Author manuscript; available in PMC 2018 Sep 15.

Published in final edited form as: ACS Chem Biol. 2017 Sep 15; 12(9): 2388–2398. Published online 2017 Aug 22. doi: 10.1021/acschembio.7b00369

PMCID:: PMC5896746

Abstract Article PDF–943K

Select item 58904355.

Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator

Oksana Gerlits, James C. Campbell, Matthew P. Blakeley, Choel Kim, Andrey Kovalevsky

Biochemistry. Author manuscript; available in PMC 2019 Mar 27.

Published in final edited form as: Biochemistry. 2018 Mar 27; 57(12): 1833–1837. Published online 2018 Mar 13. doi: 10.1021/acs.biochem.8b00010

PMCID:: PMC5890435

Abstract Article PDF–1.0M

Select item 58103676.

Protein Kinases Type II (PKG II) Combined with L-Arginine Significantly Ameliorated Xenograft Tumor Development: Is L-Arginine a Potential Alternative in PKG II Activation?

Yan Wu, Ying Liu, Zhensheng Cai, Huijuan Qin, Hongfan Li, Wenbin Su, Ying Wang, Hai Qian, Lu Jiang, Min Wu, Ji Pang, Yongchang Chen

Med Sci Monit. 2018; 24: 736–742. Published online 2018 Feb 5. doi: 10.12659/MSM.906213

PMCID:: PMC5810367

Abstract Article PDF–1.7M

Select item 55316117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 50851488.

PKG II reverses HGF-triggered cellular activities by phosphorylating serine 985 of c-Met in gastric cancer cells

Yan Wu, Xiaoyuan Yao, Miaolin Zhu, Hai Qian, Lu Jiang, Ting Lan, Min Wu, Ji Pang, Yongchang Chen

Oncotarget. 2016 Jun 7; 7(23): 34190–34200. Published online 2016 Apr 28. doi: 10.18632/oncotarget.9074

PMCID:: PMC5085148

Abstract Article PDF–4.9M

Select item 48691709.

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

Karsten Boldt, Jeroen van Reeuwijk, Qianhao Lu, Konstantinos Koutroumpas, Thanh-Minh T. Nguyen, Yves Texier, Sylvia E. C. van Beersum, Nicola Horn, Jason R. Willer, Dorus A. Mans, Gerard Dougherty, Ideke J. C. Lamers, Karlien L. M. Coene, Heleen H. Arts, Matthew J. Betts, Tina Beyer, Emine Bolat, Christian Johannes Gloeckner, Khatera Haidari, Lisette Hetterschijt, Daniela Iaconis, Dagan Jenkins, Franziska Klose, Barbara Knapp, Brooke Latour, Stef J. F. Letteboer, Carlo L. Marcelis, Dragana Mitic, Manuela Morleo, Machteld M. Oud, Moniek Riemersma, Susan Rix, Paulien A. Terhal, Grischa Toedt, Teunis J. P. van Dam, Erik de Vrieze, Yasmin Wissinger, Ka Man Wu, Gordana Apic, Philip L. Beales, Oliver E. Blacque, Toby J. Gibson, Martijn A. Huynen, Nicholas Katsanis, Hannie Kremer, Heymut Omran, Erwin van Wijk, Uwe Wolfrum, François Kepes, Erica E. Davis, Brunella Franco, Rachel H. Giles, Marius Ueffing, Robert B. Russell, Ronald Roepman, UK10K Rare Diseases Group

Nat Commun. 2016; 7: 11491. Published online 2016 May 13. doi: 10.1038/ncomms11491

PMCID:: PMC4869170

Abstract Article PDF–2.0M

Select item 478670310.

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II

James C. Campbell, Jeong Joo Kim, Kevin Y. Li, Gilbert Y. Huang, Albert S. Reger, Shinya Matsuda, Banumathi Sankaran, Todd M. Link, Keizo Yuasa, John E. Ladbury, Darren E. Casteel, Choel Kim

J Biol Chem. 2016 Mar 11; 291(11): 5623–5633. Published online 2016 Jan 14. doi: 10.1074/jbc.M115.691303

PMCID:: PMC4786703

Abstract Article PDF–3.4M

Select item 461721111.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 440234812.

Gene–Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study

Yun J. Sung, Lisa de las Fuentes, Karen L. Schwander, Jeannette Simino, Dabeeru C. Rao

Am J Hypertens. 2015 Mar; 28(3): 343–354. Published online 2014 Sep 3. doi: 10.1093/ajh/hpu149

PMCID:: PMC4402348

Abstract Article PDF–38M

Select item 416214413.

Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions

Albert S. Reger, Matthew P. Yang, Shizuyo Koide-Yoshida, Elaine Guo, Shrenik Mehta, Keizo Yuasa, Alan Liu, Darren E. Casteel, Choel Kim

J Biol Chem. 2014 Sep 12; 289(37): 25393–25403. Published online 2014 Jul 28. doi: 10.1074/jbc.M114.575894

PMCID:: PMC4162144

Abstract Article PDF–3.5M

Select item 397301814.

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Sonja I. Berndt, Stefan Gustafsson, Reedik Mägi, Andrea Ganna, Eleanor Wheeler, Mary F. Feitosa, Anne E. Justice, Keri L. Monda, Damien C. Croteau-Chonka, Felix R. Day, Tõnu Esko, Tove Fall, Teresa Ferreira, Davide Gentilini, Anne U. Jackson, Jian’an Luan, Joshua C. Randall, Sailaja Vedantam, Cristen J. Willer, Thomas W. Winkler, Andrew R. Wood, Tsegaselassie Workalemahu, Yi-Juan Hu, Sang Hong Lee, Liming Liang, Dan-Yu Lin, Josine L. Min, Benjamin M. Neale, Gudmar Thorleifsson, Jian Yang, Eva Albrecht, Najaf Amin, Jennifer L. Bragg-Gresham, Gemma Cadby, Martin den Heijer, Niina Eklund, Krista Fischer, Anuj Goel, Jouke-Jan Hottenga, Jennifer E. Huffman, Ivonne Jarick, Åsa Johansson, Toby Johnson, Stavroula Kanoni, Marcus E. Kleber, Inke R. König, Kati Kristiansson, Zoltán Kutalik, Claudia Lamina, Cecile Lecoeur, Guo Li, Massimo Mangino, Wendy L. McArdle, Carolina Medina-Gomez, Martina Müller-Nurasyid, Julius S. Ngwa, Ilja M. Nolte, Lavinia Paternoster, Sonali Pechlivanis, Markus Perola, Marjolein J. Peters, Michael Preuss, Lynda M. Rose, Jianxin Shi, Dmitry Shungin, Albert Vernon Smith, Rona J. Strawbridge, Ida Surakka, Alexander Teumer, Mieke D. Trip, Jonathan Tyrer, Jana V. Van Vliet-Ostaptchouk, Liesbeth Vandenput, Lindsay L. Waite, Jing Hua Zhao, Devin Absher, Folkert W. Asselbergs, Mustafa Atalay, Antony P. Attwood, Anthony J. Balmforth, Hanneke Basart, John Beilby, Lori L. Bonnycastle, Paolo Brambilla, Marcel Bruinenberg, Harry Campbell, Daniel I. Chasman, Peter S. Chines, Francis S. Collins, John M. Connell, William Cookson, Ulf de Faire, Femmie de Vegt, Mariano Dei, Maria Dimitriou, Sarah Edkins, Karol Estrada, David M. Evans, Martin Farrall, Marco M. Ferrario, Jean Ferrières, Lude Franke, Francesca Frau, Pablo V. Gejman, Harald Grallert, Henrik Grönberg, Vilmundur Gudnason, Alistair S. Hall, Per Hall, Anna-Liisa Hartikainen, Caroline Hayward, Nancy L. Heard-Costa, Andrew C. Heath, Johannes Hebebrand, Georg Homuth, Frank B. Hu, Sarah E. Hunt, Elina Hyppönen, Carlos Iribarren, Kevin B. Jacobs, John-Olov Jansson, Antti Jula, Mika Kähönen, Sekar Kathiresan, Frank Kee, Kay-Tee Khaw, Mika Kivimaki, Wolfgang Koenig, Aldi T. Kraja, Meena Kumari, Kari Kuulasmaa, Johanna Kuusisto, Jaana H. Laitinen, Timo A. Lakka, Claudia Langenberg, Lenore J. Launer, Lars Lind, Jaana Lindström, Jianjun Liu, Antonio Liuzzi, Marja-Liisa Lokki, Mattias Lorentzon, Pamela A. Madden, Patrik K. Magnusson, Paolo Manunta, Diana Marek, Winfried März, Irene Mateo Leach, Barbara McKnight, Sarah E. Medland, Evelin Mihailov, Lili Milani, Grant W. Montgomery, Vincent Mooser, Thomas W. Mühleisen, Patricia B. Munroe, Arthur W. Musk, Narisu Narisu, Gerjan Navis, George Nicholson, Ellen A. Nohr, Ken K. Ong, Ben A. Oostra, Colin N.A. Palmer, Aarno Palotie, John F. Peden, Nancy Pedersen, Annette Peters, Ozren Polasek, Anneli Pouta, Peter P. Pramstaller, Inga Prokopenko, Carolin Pütter, Aparna Radhakrishnan, Olli Raitakari, Augusto Rendon, Fernando Rivadeneira, Igor Rudan, Timo E. Saaristo, Jennifer G. Sambrook, Alan R. Sanders, Serena Sanna, Jouko Saramies, Sabine Schipf, Stefan Schreiber, Heribert Schunkert, So-Youn Shin, Stefano Signorini, Juha Sinisalo, Boris Skrobek, Nicole Soranzo, Alena Stancáková, Klaus Stark, Jonathan C. Stephens, Kathleen Stirrups, Ronald P. Stolk, Michael Stumvoll, Amy J. Swift, Eirini V. Theodoraki, Barbara Thorand, David-Alexandre Tregouet, Elena Tremoli, Melanie M. Van der Klauw, Joyce B.J. van Meurs, Sita H. Vermeulen, Jorma Viikari, Jarmo Virtamo, Veronique Vitart, Gérard Waeber, Zhaoming Wang, Elisabeth Widén, Sarah H. Wild, Gonneke Willemsen, Bernhard R. Winkelmann, Jacqueline C.M. Witteman, Bruce H.R. Wolffenbuttel, Andrew Wong, Alan F. Wright, M. Carola Zillikens, Philippe Amouyel, Bernhard O. Boehm, Eric Boerwinkle, Dorret I. Boomsma, Mark J. Caulfield, Stephen J. Chanock, L. Adrienne Cupples, Daniele Cusi, George V. Dedoussis, Jeanette Erdmann, Johan G. Eriksson, Paul W. Franks, Philippe Froguel, Christian Gieger, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Christian Hengstenberg, Andrew A. Hicks, Aroon Hingorani, Anke Hinney, Albert Hofman, Kees G. Hovingh, Kristian Hveem, Thomas Illig, Marjo-Riitta Jarvelin, Karl-Heinz Jöckel, Sirkka M. Keinanen-Kiukaanniemi, Lambertus A. Kiemeney, Diana Kuh, Markku Laakso, Terho Lehtimäki, Douglas F. Levinson, Nicholas G. Martin, Andres Metspalu, Andrew D. Morris, Markku S. Nieminen, Inger Njølstad, Claes Ohlsson, Albertine J. Oldehinkel, Willem H. Ouwehand, Lyle J. Palmer, Brenda Penninx, Chris Power, Michael A. Province, Bruce M. Psaty, Lu Qi, Rainer Rauramaa, Paul M. Ridker, Samuli Ripatti, Veikko Salomaa, Nilesh J. Samani, Harold Snieder, Thorkild I.A. Sørensen, Timothy D. Spector, Kari Stefansson, Anke Tönjes, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Peter Vollenweider, Henri Wallaschofski, Nicholas J. Wareham, Hugh Watkins, H.-Erich Wichmann, James F. Wilson, Goncalo R. Abecasis, Themistocles L. Assimes, Inês Barroso, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Timothy Frayling, Leif C. Groop, Talin Haritunian, Iris M. Heid, David Hunter, Robert C. Kaplan, Fredrik Karpe, Miriam Moffatt, Karen L. Mohlke, Jeffrey R. O’Connell, Yudi Pawitan, Eric E. Schadt, David Schlessinger, Valgerdur Steinthorsdottir, David P. Strachan, Unnur Thorsteinsdottir, Cornelia M. van Duijn, Peter M. Visscher, Anna Maria Di Blasio, Joel N. Hirschhorn, Cecilia M. Lindgren, Andrew P. Morris, David Meyre, André Scherag, Mark I. McCarthy, Elizabeth K. Speliotes, Kari E. North, Ruth J.F. Loos, Erik Ingelsson

Nat Genet. Author manuscript; available in PMC 2014 Apr 2.

Published in final edited form as: Nat Genet. 2013 May; 45(5): 501–512. Published online 2013 Apr 7. doi: 10.1038/ng.2606

PMCID:: PMC3973018

Abstract Article PDF–567K

Select item 389478615.

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva, Can Kayatekin, Kenneth D. Westover, Georgios I. Karras, Susan Lindquist

Cell. Author manuscript; available in PMC 2014 Jan 17.

Published in final edited form as: Cell. 2012 Aug 31; 150(5): 987–1001. doi: 10.1016/j.cell.2012.06.047

PMCID:: PMC3894786

Abstract Article PDF–5.0M

Select item 378472616.

The F-box Protein FBXO25 Promotes the Proteasome-dependent Degradation of ELK-1 Protein

Felipe R. Teixeira, Adriana O. Manfiolli, Cláudia S. Soares, Munira M. A. Baqui, Tie Koide, Marcelo D. Gomes

J Biol Chem. 2013 Sep 27; 288(39): 28152–28162. Published online 2013 Aug 12. doi: 10.1074/jbc.M113.504308

PMCID:: PMC3784726

Abstract Article PDF–856K

Select item 367479717.

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

Diana L. Cousminer, Diane J. Berry, Nicholas J. Timpson, Wei Ang, Elisabeth Thiering, Enda M. Byrne, H. Rob Taal, Ville Huikari, Jonathan P. Bradfield, Marjan Kerkhof, Maria M. Groen-Blokhuis, Eskil Kreiner-Møller, Marcella Marinelli, Claus Holst, Jaakko T. Leinonen, John R.B. Perry, Ida Surakka, Olli Pietiläinen, Johannes Kettunen, Verneri Anttila, Marika Kaakinen, Ulla Sovio, Anneli Pouta, Shikta Das, Vasiliki Lagou, Chris Power, Inga Prokopenko, David M. Evans, John P. Kemp, Beate St Pourcain, Susan Ring, Aarno Palotie, Eero Kajantie, Clive Osmond, Terho Lehtimäki, Jorma S. Viikari, Mika Kähönen, Nicole M. Warrington, Stephen J. Lye, Lyle J. Palmer, Carla M.T. Tiesler, Claudia Flexeder, Grant W. Montgomery, Sarah E. Medland, Albert Hofman, Hakon Hakonarson, Mònica Guxens, Meike Bartels, Veikko Salomaa, The ReproGen Consortium, Joanne M. Murabito, Jaakko Kaprio, Thorkild I.A. Sørensen, Ferran Ballester, Hans Bisgaard, Dorret I. Boomsma, Gerard H. Koppelman, Struan F.A. Grant, Vincent W.V. Jaddoe, Nicholas G. Martin, Joachim Heinrich, Craig E. Pennell, Olli T. Raitakari, Johan G. Eriksson, George Davey Smith, Elina Hyppönen, Marjo-Riitta Järvelin, Mark I. McCarthy, Samuli Ripatti, Elisabeth Widén, for the Early Growth Genetics (EGG) Consortium

Hum Mol Genet. 2013 Jul 1; 22(13): 2735–2747. Published online 2013 Feb 27. doi: 10.1093/hmg/ddt104

PMCID:: PMC3674797

Abstract Article PDF–432K

Select item 367091918.

cGMP-Dependent Protein Kinase Iβ Interacts with p44/WDR77 to Regulate Androgen Receptor-Driven Gene Expression

Liran Zhou, Keiko Hosohata, Shen Gao, Zhongping Gu, Zhengxin Wang

PLoS One. 2013; 8(6): e63119. Published online 2013 Jun 3. doi: 10.1371/journal.pone.0063119

PMCID:: PMC3670919

Abstract Article PDF–6.8M

Select item 323620319.

Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure

Jairam R. Lingappa, Slavé Petrovski, Erin Kahle, Jacques Fellay, Kevin Shianna, M. Juliana McElrath, Katherine K. Thomas, Jared M. Baeten, Connie Celum, Anna Wald, Guy de Bruyn, James I. Mullins, Edith Nakku-Joloba, Carey Farquhar, Max Essex, Deborah Donnell, James Kiarie, Bart Haynes, David Goldstein, for the Partners in Prevention HSV/HIV Transmission Study Team

PLoS One. 2011; 6(12): e28632. Published online 2011 Dec 12. doi: 10.1371/journal.pone.0028632

Correction in:: PLoS One. 2012; 7(1): 10.1371/annotation/1dcd8ee4-bcf4-4cf6-97a3-2e26f0f77060.

PMCID:: PMC3236203

Abstract Article PDF–273K

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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