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Select item 108447191.

Cav‐1 regulates the bile salt export pump on the canalicular membrane of hepatocytes by PKCα‐associated signalling under cholesterol stimulation

Liwei Pang, Meiying Cui, Shuodong Wu, Jing Kong

J Cell Mol Med. 2024 Feb; 28(3): e18110. Published online 2024 Jan 1. doi: 10.1111/jcmm.18110

PMCID:: PMC10844719

Abstract Article PDF–34M

Select item 106384402.

Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP

Hongtao Liu, Rossitza N. Irobalieva, Julia Kowal, Dongchun Ni, Kamil Nosol, Rose Bang-Sørensen, Loïck Lancien, Henning Stahlberg, Bruno Stieger, Kaspar P. Locher

Nat Commun. 2023; 14: 7296. Published online 2023 Nov 10. doi: 10.1038/s41467-023-43109-1

PMCID:: PMC10638440

Abstract Article PDF–4.8M

Select item 100698623.

Native liver survival in bile salt export pump deficiency: results of a retrospective cohort study

Eva-Doreen Pfister, Veronika K Jaeger, André Karch, Denys Shay, Nagoud Schukfeh, Johanna Ohlendorf, Norman Junge, Imeke Goldschmidt, Amelie Stalke, Verena Keitel-Anselmino, Ulrich Baumann

Hepatol Commun. 2023 Apr; 7(4): e0092. Published online 2023 Mar 30. doi: 10.1097/HC9.0000000000000092

PMCID:: PMC10069862

Abstract Article PDF–465K

Select item 95124614.

Clinical phenotype of adult‐onset liver disease in patients with variants in ABCB4, ABCB11, and ATP8B1

Jeremy S. Nayagam, Pierre Foskett, Sandra Strautnieks, Kosh Agarwal, Rosa Miquel, Deepak Joshi, Richard J. Thompson

Hepatol Commun. 2022 Oct; 6(10): 2654–2664. Published online 2022 Jul 27. doi: 10.1002/hep4.2051

PMCID:: PMC9512461

Abstract Article PDF–814K

Select item 88970225.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 86154396.

The role of p.Val444Ala variant in the ABCB11 gene and susceptibility to biliary atresia in Vietnamese patients

Nguyen Van Tung, Nguyen Thi Kim Lien, Nguyen Ngoc Lan, Nguyen Thi Phuong Mai, Pham Thi Hai Yen, Nguyen Pham Anh Hoa, Nguyen Huy Hoang

Medicine (Baltimore) 2021 Nov 24; 100(47): e28011. Published online 2021 Nov 24. doi: 10.1097/MD.0000000000028011

PMCID:: PMC8615439

Abstract Article PDF–492K

Select item 79419887.

The ESCRT-III molecules regulate the apical targeting of bile salt export pump

Shang-Hsin Wu, Mei-Hwei Chang, Ya-Hui Chen, Hui-Lin Wu, Huey-Huey Chua, Chin-Sung Chien, Yen-Hsuan Ni, Hui-Ling Chen, Huey-Ling Chen

J Biomed Sci. 2021; 28: 19. Published online 2021 Mar 9. doi: 10.1186/s12929-020-00706-2

PMCID:: PMC7941988

Abstract Article PDF–7.0M

Select item 78586168.

Bsep expression in hilar cholangiocarcinoma of rat model

Meng-yu Zhang, Jie-ping Wang, Kai He, Xian-ming Xia

Sci Rep. 2021; 11: 2861. Published online 2021 Feb 3. doi: 10.1038/s41598-021-82636-z

PMCID:: PMC7858616

Abstract Article PDF–1.4M

Select item 78302939.

The Bile Salt Export Pump: Molecular Structure, Study Models and Small-Molecule Drugs for the Treatment of Inherited BSEP Deficiencies

Muhammad Imran Sohail, Yaprak Dönmez-Cakil, Dániel Szöllősi, Thomas Stockner, Peter Chiba

Int J Mol Sci. 2021 Jan; 22(2): 784. Published online 2021 Jan 14. doi: 10.3390/ijms22020784

PMCID:: PMC7830293

Abstract Article PDF–1.5M

Select item 758502510.

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

Kamil Nosol, Ksenija Romane, Rossitza N. Irobalieva, Amer Alam, Julia Kowal, Naoya Fujita, Kaspar P. Locher

Proc Natl Acad Sci U S A. 2020 Oct 20; 117(42): 26245–26253. Published online 2020 Oct 5. doi: 10.1073/pnas.2010264117

PMCID:: PMC7585025

Abstract Article PDF–2.2M

Select item 754409511.

Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

Katalin Goda, Yaprak Dönmez-Cakil, Szabolcs Tarapcsák, Gábor Szalóki, Dániel Szöllősi, Zahida Parveen, Dóra Türk, Gergely Szakács, Peter Chiba, Thomas Stockner

PLoS Genet. 2020 Oct; 16(10): e1009016. Published online 2020 Oct 8. doi: 10.1371/journal.pgen.1009016

PMCID:: PMC7544095

Abstract Article PDF–2.5M

Select item 737304812.

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis

Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Xin Wang, Xing Yang, Ping Wu, Chengrong Liu, Zixuan Xiao, Yafei Qu, Yue Yin, Chunxia Wang, Yucai Zhang, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu, Qiming Liang

Med (N Y) 2021 Jan 15; 2(1): 99–112.e7. Published online 2020 Jul 21. doi: 10.1016/j.medj.2020.07.002

PMCID:: PMC7373048

Abstract Article PDF–3.8M

Select item 736077413.

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90

Wenwen Chen, Wei Wang, Xiaoxia Sun, Shanshan Xie, Xiaoyang Xu, Min Liu, Chunxia Yang, Min Li, Wen Zhang, Wei Liu, Liangjing Wang, Tianhua Zhou, Yuehong Yang

Cell Death Dis. 2020 Jul; 11(7): 534. Published online 2020 Jul 14. doi: 10.1038/s41419-020-02739-9

PMCID:: PMC7360774

Abstract Article PDF–3.3M

Select item 734385514.

Cryo-EM structure of human bile salts exporter ABCB11

Liang Wang, Wen-Tao Hou, Li Chen, Yong-Liang Jiang, Da Xu, Linfeng Sun, Cong-Zhao Zhou, Yuxing Chen

Cell Res. 2020 Jul; 30(7): 623–625. Published online 2020 Mar 20. doi: 10.1038/s41422-020-0302-0

PMCID:: PMC7343855

Article PDF–1.3M

Select item 716998315.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 692582416.

Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases

Cornelia Thoeni, Ruediger Waldherr, Jutta Scheuerer, Stefanie Schmitteckert, Ralph Roeth, Beate Niesler, Ernest Cutz, Christa Flechtenmacher, Benjamin Goeppert, Peter Schirmacher, Felix Lasitschka

Can J Gastroenterol Hepatol. 2019; 2019: 1085717. Published online 2019 Dec 10. doi: 10.1155/2019/1085717

PMCID:: PMC6925824

Abstract Article PDF–6.1M

Select item 629778717.

Functional analysis of the correlation between ABCB11 gene mutation and primary intrahepatic stone

Lang Gan, Shuguang Pan, Jinchi Cui, Jie Bai, Peng Jiang, Yu He

Mol Med Rep. 2019 Jan; 19(1): 195–204. Published online 2018 Nov 15. doi: 10.3892/mmr.2018.9661

PMCID:: PMC6297787

Abstract Article PDF–1.1M

Select item 628466418.

Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: Role of ABCB11 genotype polymorphism and plasma bile acid levels

Tarek Besheer, Mona Arafa, Mohamed Abd El-Maksoud, Hatem Elalfy, Amany Hasson, Khaled Zalata, Wagdi Elkashef, Heba Elshahawy, Doaa Raafat, Wafaa Elemshaty, Eman Elsayed, Hosam Zaghloul, Ahmed Abdel Razek, Mahmoud El-Bendary

Turk J Gastroenterol. 2018 May; 29(3): 299–307. Published online 2018 May 1. doi: 10.5152/tjg.2018.17570

PMCID:: PMC6284664

Abstract Article PDF–804K

Select item 616668219.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 555077820.

Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation

Philipp Ellinger, Jan Stindt, Carola Dröge, Katharina Sattler, Claudia Stross, Stefanie Kluge, Diran Herebian, Sander H J Smits, Martin Burdelski, Sebastian Schulz-Jürgensen, Antje Ballauff, Jan Schulte am Esch, Ertan Mayatepek, Dieter Häussinger, Ralf Kubitz, Lutz Schmitt

World J Gastroenterol. 2017 Aug 7; 23(29): 5295–5303. Published online 2017 Aug 7. doi: 10.3748/wjg.v23.i29.5295

PMCID:: PMC5550778

Abstract Article PDF–1.4M

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