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Select item 109544791.

Structural insights into the HDAC4–MEF2A–DNA complex and its implication in long-range transcriptional regulation

Shuyan Dai, Liang Guo, Raja Dey, Ming Guo, Xiangqian Zhang, Darren Bates, Justin Cayford, Longying Jiang, Hudie Wei, Zhuchu Chen, Ye Zhang, Lin Chen, Yongheng Chen

Nucleic Acids Res. 2024 Mar 21; 52(5): 2711–2723. Published online 2024 Jan 28. doi: 10.1093/nar/gkae036

PMCID:: PMC10954479

Abstract Article PDF–3.1M

Select item 109332672.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108173983.

ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis

Mingkui Shen, Kuankuan Li, Lulu Wang, Li Feng, Xinyu Zhang, Haoping Zhang, Honggang Zhou, Guoxian Pei

Aging (Albany NY) 2024 Jan 15; 16(1): 685–700. Published online 2024 Jan 12. doi: 10.18632/aging.205412

PMCID:: PMC10817398

Abstract Article PDF–2.6M

Select item 104995264.

Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4

Meng Zhang, Mei Wang, Zhiming Jiang, Ziyi Fu, Jingjing Ma, Sheng Gao

Breast J. 2023; 2023: 2875972. Published online 2023 Sep 6. doi: 10.1155/2023/2875972

PMCID:: PMC10499526

Abstract Article PDF–698K

Select item 101847035.

WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis

Jincheng Liu, Yunhao You, Zhenqian Sun, Lu Zhang, Xiang Li, Zihan Dai, Jinlong Ma, Yunzhen Chen, Guangjun Jiao

Stem Cells Transl Med. 2023 May; 12(5): 307–321. Published online 2023 Apr 3. doi: 10.1093/stcltm/szad020

PMCID:: PMC10184703

Abstract Article PDF–61M

Select item 96018646.

HDAC4 depletion ameliorates IL‐13‐triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF‐κB signaling

Hangyu Xu, Lingjun Wang, Huaqun Chen, Hefei Cai

Immun Inflamm Dis. 2022 Nov; 10(11): e692. Published online 2022 Oct 11. doi: 10.1002/iid3.692

PMCID:: PMC9601864

Abstract Article PDF–3.7M

Select item 94705347.

Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

Xueya Zhou, Pamela Feliciano, Chang Shu, Tianyun Wang, Irina Astrovskaya, Jacob B. Hall, Joseph U. Obiajulu, Jessica R. Wright, Shwetha C. Murali, Simon Xuming Xu, Leo Brueggeman, Taylor R. Thomas, Olena Marchenko, Christopher Fleisch, Sarah D. Barns, LeeAnne Green Snyder, Bing Han, Timothy S. Chang, Tychele N. Turner, William T. Harvey, Andrew Nishida, Brian J. O’Roak, Daniel H. Geschwind, The SPARK Consortium, Jacob J. Michaelson, Natalia Volfovsky, Evan E. Eichler, Yufeng Shen, Wendy K. Chung

Nat Genet. 2022; 54(9): 1305–1319. Published online 2022 Aug 18. doi: 10.1038/s41588-022-01148-2

PMCID:: PMC9470534

Abstract Article PDF–11M

Select item 93545708.

Whole genomic approach in mutation discovery of infantile spasms patients

Seungbok Lee, Sesong Jang, Jong-Il Kim, Jong Hee Chae, Ki Joong Kim, Byung Chan Lim

Front Neurol. 2022; 13: 944905. Published online 2022 Jul 22. doi: 10.3389/fneur.2022.944905

PMCID:: PMC9354570

Abstract Article PDF–698K

Select item 92950539.

Deacetylation of Glutaminase by HDAC4 contributes to Lung Cancer Tumorigenesis

Tao Wang, Zhuo Lu, Tianyu Han, Yanan Wang, Mingxi Gan, Jian-Bin Wang

Int J Biol Sci. 2022; 18(11): 4452–4465. Published online 2022 Jul 4. doi: 10.7150/ijbs.69882

PMCID:: PMC9295053

Abstract Article PDF–2.8M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910263011.

Clinical role of serum histone deacetylase 4 measurement in acute ischemic stroke: Relation to disease risk, severity, and prognosis

Min Wang, XuYang Pang, Huaihai Lu, Xudong Wang

J Clin Lab Anal. 2022 May; 36(5): e24372. Published online 2022 Mar 30. doi: 10.1002/jcla.24372

PMCID:: PMC9102630

Abstract Article PDF–3.9M

Select item 897796812.

Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy

Alessandra Renzini, Nicoletta Marroncelli, Giorgia Cavioli, Silvia Di Francescantonio, Laura Forcina, Alessandro Lambridis, Eros Di Giorgio, Sergio Valente, Antonello Mai, Claudio Brancolini, Claudia Giampietri, Alessandra Magenta, Francesca De Santa, Sergio Adamo, Dario Coletti, Viviana Moresi

J Cachexia Sarcopenia Muscle. 2022 Apr; 13(2): 1339–1359. Published online 2022 Feb 15. doi: 10.1002/jcsm.12891

PMCID:: PMC8977968

Abstract Article PDF–24M

Select item 889702213.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 876907214.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 866444315.

A synthetic lethal screen identifies HDAC4 as a potential target in MELK overexpressing cancers

Lin Zhou, Siqi Zheng, Fernando R Rosas Bringas, Bjorn Bakker, Judith E Simon, Petra L Bakker, Hinke G Kazemier, Michael Schubert, Maurits Roorda, Marcel A T M van Vugt, Michael Chang, Floris Foijer

G3 (Bethesda) 2021 Dec; 11(12): jkab335. Published online 2021 Sep 22. doi: 10.1093/g3journal/jkab335

PMCID:: PMC8664443

Abstract Article PDF–1.6M

Select item 843171716.

Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation

Hongyi Zhou, Huabo Su, Weiqin Chen

Int J Mol Sci. 2021 Sep; 22(17): 9509. Published online 2021 Sep 1. doi: 10.3390/ijms22179509

PMCID:: PMC8431717

Abstract Article PDF–3.4M

Select item 822039117.

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα

Evelyn Ramberger, Valeria Sapozhnikova, Elisabeth Kowenz-Leutz, Karin Zimmermann, Nathalie Nicot, Petr V. Nazarov, Daniel Perez-Hernandez, Ulf Reimer, Philipp Mertins, Gunnar Dittmar, Achim Leutz

iScience. 2021 Jun 25; 24(6): 102686. Published online 2021 Jun 4. doi: 10.1016/j.isci.2021.102686

PMCID:: PMC8220391

Abstract Article PDF–4.4M

Select item 819984318.

HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation

Wendi Wei, Weida Chen, Naifeng He

J Transl Med. 2021; 19: 258. Published online 2021 Jun 12. doi: 10.1186/s12967-021-02812-7

PMCID:: PMC8199843

Abstract Article PDF–1.1M

Select item 816503019.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 810836020.

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

Eros Di Giorgio, Harikrishnareddy Paluvai, Emiliano Dalla, Liliana Ranzino, Alessandra Renzini, Viviana Moresi, Martina Minisini, Raffaella Picco, Claudio Brancolini

Genome Biol. 2021; 22: 129. Published online 2021 May 10. doi: 10.1186/s13059-021-02340-z

PMCID:: PMC8108360

Abstract Article PDF–2.7M

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Hepatoerythropoietic porphyria model
Hepatoerythropoietic porphyria model
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Oxidative stress-vulnerable and -resistant neurons
Oxidative stress-vulnerable and -resistant neurons
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