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Items: 1 to 20 of 61

1.
PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age
Huimin Zhang, Hirohisa Okuyama, Abhinav Jain, Rohit R. Jadhav, Bowen Wu, Ines Sturmlechner, Jose Morales, Shozo Ohtsuki, Cornelia M. Weyand, Jӧrg J. Goronzy
JCI Insight. 2024 Mar 8; 9(5): e172848. Published online 2024 Feb 8. doi: 10.1172/jci.insight.172848
PMCID:
PMC10972599
AbstractArticlePDF–4.9M
2.
P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease
L. Kumarasinghe, M.A. Garcia-Gimeno, J. Ramirez, U. Mayor, JL. Zugaza, P Sanz
Neurobiol Dis. Author manuscript; available in PMC 2023 Nov 28.
Published in final edited form as: Neurobiol Dis. 2023 Feb; 177: 105998. Published online 2023 Jan 10. doi: 10.1016/j.nbd.2023.105998
PMCID:
PMC10682699
AbstractArticlePDF–1.7M
3.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
4.
Silencing Rac1 and Prex1 Inhibit Epithelial–Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1
Xinyan Gao, Xiaoyan Lin, Mengxin Lin, Yanqin Lan, Yao Wang, Riping Wu, Junde Li, Chuanyong Huang, Dongta Zhong
Turk J Gastroenterol. 2023 Sep; 34(9): 975–981. Published online 2023 Sep 1. doi: 10.5152/tjg.2023.23108
PMCID:
PMC10543419
AbstractArticlePDF–1.4M
5.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
6.
Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Yong-Gang Chang, Christopher J. Lupton, Charles Bayly-Jones, Alastair C. Keen, Laura D’Andrea, Christina M. Lucato, Joel R. Steele, Hari Venugopal, Ralf B. Schittenhelm, James C. Whisstock, Michelle L. Halls, Andrew M. Ellisdon
Nat Struct Mol Biol. 2022; 29(8): 767–773. Published online 2022 Jul 21. doi: 10.1038/s41594-022-00804-9
PMCID:
PMC9371973
AbstractArticlePDF–16M
7.
Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease
Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205
PMCID:
PMC9348576
AbstractArticlePDF–3.0M
8.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
9.
A dual-activity topoisomerase complex regulates mRNA translation and turnover
Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang
Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538
PMCID:
PMC9262614
AbstractArticlePDF–3.6M
10.
Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma
Sylvie J. Lavictoire, Danny Jomaa, Alexander Gont, Karen Jardine, David P. Cook, Ian A.J. Lorimer
J Biol Chem. 2021 Nov; 297(5): 101172. Published online 2021 Oct 6. doi: 10.1016/j.jbc.2021.101172
PMCID:
PMC8551657
AbstractArticlePDF–4.3M
11.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
12.
Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway
Wancheng Qiu, Yanhua Chang, Jing Liu, Xu Yang, Yan Yu, Jiajia Li, Qing Liang, Guangchun Sun
Onco Targets Ther. 2020; 13: 9481–9495. Published online 2020 Sep 24. doi: 10.2147/OTT.S265592
PMCID:
PMC7522411
AbstractArticlePDF–8.3M
13.
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding
Sandeep K. Ravala, Jesse B. Hopkins, Caroline B. Plescia, Samantha R. Allgood, Madison A. Kane, Jennifer N. Cash, Robert V. Stahelin, John J. G. Tesmer
J Biol Chem. 2020 Sep 4; 295(36): 12635–12647. Published online 2020 Jul 13. doi: 10.1074/jbc.RA120.014534
PMCID:
PMC7476721
AbstractArticlePDF–2.3M
14.
PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells
Miranda E. Clements, Rachelle W. Johnson
Oncogene. Author manuscript; available in PMC 2020 Apr 21.
Published in final edited form as: Oncogene. 2020 Feb; 39(6): 1318–1334. Published online 2019 Oct 21. doi: 10.1038/s41388-019-1064-3
PMCID:
PMC7007387
AbstractArticlePDF–3.2M
15.
Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold
Jennifer N. Cash, Sarah Urata, Sheng Li, Sandeep K. Ravala, Larisa V. Avramova, Michael D. Shost, J. Silvio Gutkind, John J. G. Tesmer, Michael A. Cianfrocco
Sci Adv. 2019 Oct; 5(10): eaax8855. Published online 2019 Oct 16. doi: 10.1126/sciadv.aax8855
PMCID:
PMC6795519
AbstractArticlePDF–6.7M
16.
Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis
Anthony W. Harrington, Ju Young Kim, Sung Ok Yoon
J Neurosci. 2002 Jan 1; 22(1): 156–166. doi: 10.1523/JNEUROSCI.22-01-00156.2002
PMCID:
PMC6757583
AbstractArticlePDF–582K
17.
The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei
Giovanni Nassa, Giorgio Giurato, Annamaria Salvati, Valerio Gigantino, Giovanni Pecoraro, Jessica Lamberti, Francesca Rizzo, Tuula A. Nyman, Roberta Tarallo, Alessandro Weisz
Sci Data. 2019; 6: 173. Published online 2019 Sep 16. doi: 10.1038/s41597-019-0179-2
PMCID:
PMC6746822
AbstractArticlePDF–2.0M
18.
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (PREX1) is a Novel Predictor of Prognosis for Breast Cancer Patients: A Retrospective Case Series
Ying Zhong, Jing Zhang, Yidong Zhou, Feng Mao, Yan Lin, Yali Xu, Jinghong Guan, Songjie Shen, Bo Pan, Changjun Wang, Li Peng, Xin Huang, Yan Li, Xi Cao, Qiang Sun
Med Sci Monit. 2019; 25: 6554–6562. Published online 2019 Sep 1. doi: 10.12659/MSM.915845
PMCID:
PMC6738004
AbstractArticlePDF–2.1M
19.
TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Karen Dendoncker, Steven Timmermans, Jolien Vandewalle, Melanie Eggermont, Joanna Lempiäinen, Evelien Van Hamme, Sylviane Dewaele, Sofie Vandevyver, Marlies Ballegeer, Jolien Souffriau, Lise Van Wyngene, Kelly Van Looveren, Tineke Vanderhaeghen, Rudi Beyaert, Karolien De Bosscher, Jorma J. Palvimo, Marc Van Montagu, Claude Libert
Proc Natl Acad Sci U S A. 2019 Jun 25; 116(26): 12942–12951. Published online 2019 Jun 10. doi: 10.1073/pnas.1821565116
Correction in:
Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31): 15745.
PMCID:
PMC6600915
AbstractArticlePDF–1.7M
20.
cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits
Sendi Rafael Adame-García, Rodolfo Daniel Cervantes-Villagrana, Lennis Beatriz Orduña-Castillo, Jason C. del Rio, J. Silvio Gutkind, Guadalupe Reyes-Cruz, Susan S. Taylor, José Vázquez-Prado
J Biol Chem. 2019 Feb 15; 294(7): 2232–2246. Published online 2018 Dec 10. doi: 10.1074/jbc.RA118.006691
PMCID:
PMC6378977
AbstractArticlePDF–4.1M

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