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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79653582.

Differential activity and expression of human 5β-reductase (AKR1D1) splice variants

Nathan Appanna, Hylton Gibson, Elena Gangitano, Niall J Dempster, Karen Morris, Sherly George, Anastasia Arvaniti, Laura L Gathercole, Brian Keevil, Trevor M Penning, Karl-Heinz Storbeck, Jeremy W Tomlinson, Nikolaos Nikolaou

J Mol Endocrinol. 2021 Mar; 66(3): 181–194. Published online 2021 Jan 12. doi: 10.1530/JME-20-0160

PMCID:: PMC7965358

Abstract Article PDF–3.3M

Select item 79061553.

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma

Pengfei Zhu, Ruo Feng, Xu Lu, Yuan Liao, Zhicheng Du, Wenlong Zhai, Kunlun Chen

Aging (Albany NY) 2021 Feb 15; 13(3): 4138–4156. Published online 2021 Jan 20. doi: 10.18632/aging.202380

PMCID:: PMC7906155

Abstract Article PDF–2.3M

Select item 73899314.

先天性胆汁酸合成障碍2型一家系临床和遗传学分析:两个AKR1D1新突变的识别

程映, 郭丽, 邓梅, 宋元宗

Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jul 25; 19(7): 734–740. Chinese. doi: 10.7499/j.issn.1008-8830.2017.07.002

PMCID:: PMC7389931

Abstract Article PDF–2.8M

Select item 73758355.

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

Nikolaos Nikolaou, Laura L. Gathercole, Lucy Kirkwood, James E. Dunford, Beverly A. Hughes, Lorna C. Gilligan, Udo Oppermann, Trevor M. Penning, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2020 Jul 22.

Published in final edited form as: J Steroid Biochem Mol Biol. 2019 May; 189: 218–227. Published online 2019 Feb 12. doi: 10.1016/j.jsbmb.2019.02.002

PMCID:: PMC7375835

Abstract Article PDF–1.1M

Select item 67443726.

AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

Nikolaos Nikolaou, Laura L. Gathercole, Lea Marchand, Sara Althari, Niall J. Dempster, Charlotte J. Green, Martijn van de Bunt, Catriona McNeil, Anastasia Arvaniti, Beverly A. Hughes, Bruno Sgromo, Richard S. Gillies, Hanns-Ulrich Marschall, Trevor M. Penning, John Ryan, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson

Metabolism. 2019 Oct; 99: 67–80. doi: 10.1016/j.metabol.2019.153947

PMCID:: PMC6744372

Abstract Article

Select item 58913897.

Dysregulation of Δ⁴-3-oxosteroid 5β-reductase in Diabetic Patients: Implications and Mechanisms

Leila Valanejad, Mwlod Ghareeb, Stephanie Shiffka, Christina Nadolny, Yuan Chen, Liangran Guo, Ruchi Verma, Sangmin You, Fatemeh Akhlaghi, Ruitang Deng

Mol Cell Endocrinol. Author manuscript; available in PMC 2019 Jul 15.

Published in final edited form as: Mol Cell Endocrinol. 2018 Jul 15; 470: 127–141. Published online 2017 Oct 9. doi: 10.1016/j.mce.2017.10.005

PMCID:: PMC5891389

Abstract Article PDF–923K

Select item 55316118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 46967699.

In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency

Mo Chen, Yi Jin, Trevor M. Penning

Biochemistry. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Biochemistry. 2015 Oct 20; 54(41): 6343–6351. Published online 2015 Oct 6. doi: 10.1021/acs.biochem.5b00816

PMCID:: PMC4696769

Abstract Article PDF–986K

Select item 461721110.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 441469111.

The Rate-determining Steps of Aldo-keto Reductases (AKRs), a Study on Human Steroid 5β-Reductase (AKR1D1)

Mo Chen, Yi Jin, Trevor M. Penning

Chem Biol Interact. Author manuscript; available in PMC 2016 Jun 5.

Published in final edited form as: Chem Biol Interact. 2015 Jun 5; 234: 360–365. Published online 2014 Dec 11. doi: 10.1016/j.cbi.2014.12.004

PMCID:: PMC4414691

Abstract Article PDF–910K

Select item 416383812.

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

Yi Jin, Mo Chen, Trevor M. Penning

Biochem J. Author manuscript; available in PMC 2015 Aug 15.

Published in final edited form as: Biochem J. 2014 Aug 15; 462(1): 163–171. doi: 10.1042/BJ20140220

PMCID:: PMC4163838

Abstract Article PDF–961K

Select item 416200513.

Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s

Amarjit S. Chaudhry, Ranjit K. Thirumaran, Kazuto Yasuda, Xia Yang, Yiping Fan, Stephen C. Strom, Erin G. Schuetz

Drug Metab Dispos. 2013 Aug; 41(8): 1538–1547. Published online 2013 Aug. doi: 10.1124/dmd.113.051672

Correction in:: Drug Metab Dispos. 2014 May; 42(5): 917.

PMCID:: PMC4162005

Abstract Article PDF–906K

Select item 406425414.

An atlas of genetic influences on human blood metabolites

So-Youn Shin, Eric B. Fauman, Ann-Kristin Petersen, Jan Krumsiek, Rita Santos, Jie Huang, Matthias Arnold, Idil Erte, Vincenzo Forgetta, Tsun-Po Yang, Klaudia Walter, Cristina Menni, Lu Chen, Louella Vasquez, Ana M. Valdes, Craig L. Hyde, Vicky Wang, Daniel Ziemek, Phoebe Roberts, Li Xi, Elin Grundberg, The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Melanie Waldenberger, J. Brent Richards, Robert P. Mohney, Michael V. Milburn, Sally L. John, Jeff Trimmer, Fabian J. Theis, John P. Overington, Karsten Suhre, M. Julia Brosnan, Christian Gieger, Gabi Kastenmüller, Tim D Spector, Nicole Soranzo

Nat Genet. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 543–550. Published online 2014 May 11. doi: 10.1038/ng.2982

PMCID:: PMC4064254

Abstract Article PDF–2.4M

Select item 397147315.

5β-Reduced Steroids and Human Δ⁴-3-Ketosteroid 5β-Reductase (AKR1D1)

Mo Chen, Trevor M. Penning

Steroids. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Steroids. 2014 May; 83: 17–26. Published online 2014 Feb 8. doi: 10.1016/j.steroids.2014.01.013

PMCID:: PMC3971473

Abstract Article PDF–2.6M

Select item 387046816.

Role of Aldo-Keto Reductase Family 1 (AKR1) Enzymes in Human Steroid Metabolism

Tea Lanišnik Rižner, Trevor M. Penning

Steroids. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Steroids. 2014 Jan; 79: 10.1016/j.steroids.2013.10.012. Published online 2013 Nov 1. doi: 10.1016/j.steroids.2013.10.012

PMCID:: PMC3870468

Abstract Article PDF–1.3M

Select item 365903117.

A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease

Neil V Morgan, Jane L Hartley, Kenneth DR Setchell, Michael A Simpson, Rachel Brown, Louise Tee, Sian Kirkham, Shanaz Pasha, Richard C Trembath, Eamonn R Maher, Paul Gissen, Deirdre A Kelly

Orphanet J Rare Dis. 2013; 8: 74. Published online 2013 May 16. doi: 10.1186/1750-1172-8-74

PMCID:: PMC3659031

Abstract Article PDF–344K

Select item 356581418.

Genome-wide association of mood-incongruent psychotic bipolar disorder

F S Goes, M L Hamshere, F Seifuddin, M Pirooznia, P Belmonte-Mahon, R Breuer, T Schulze, M Nöthen, S Cichon, M Rietschel, P Holmans, P P Zandi, Bipolar Genome Study (BiGS), N Craddock, J B Potash

Transl Psychiatry. 2012 Oct; 2(10): e180. Published online 2012 Oct 23. doi: 10.1038/tp.2012.106