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Select item 111589741.

SIAH1 induced apoptosis by activation of the JNK pathway and inhibited invasion by inactivation of the ERK pathway in breast cancer cells

Yuan‐Yuan Wen, Zhi‐Qiang Yang, Min Song, Bai‐Lin Li, Ji‐Jiang Zhu, En‐Hua Wang

Cancer Sci. 2010 Jan; 101(1): 73–79. Published online 2009 Sep 2. doi: 10.1111/j.1349-7006.2009.01339.x

PMCID:: PMC11158974

Abstract Article PDF–1.3M

Select item 111583592.

Hypoxia‐induced β‐catenin downregulation involves p53‐dependent activation of Siah‐1

Dapeng Wang, Yongxing Wang, Tao Kong, Feiyue Fan, Yongguang Jiang

Cancer Sci. 2011 Jul; 102(7): 1322–1328. Published online 2011 May 12. doi: 10.1111/j.1349-7006.2011.01950.x

PMCID:: PMC11158359

Abstract Article PDF–765K

Select item 111054653.

PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues

Marcin Sajek, Damian Mikolaj Janecki, Maciej Jerzy Smialek, Barbara Ginter-Matuszewska, Anna Spik, Slawomir Oczkowski, Erkut Ilaslan, Kamila Kusz-Zamelczyk, Maciej Kotecki, Jacek Blazewicz, Jadwiga Jaruzelska

Cell Mol Life Sci. 2019 Jan; 76(1): 147–161. Published online 2018 Sep 29. doi: 10.1007/s00018-018-2926-5

PMCID:: PMC11105465

Abstract Article PDF–1.6M

Select item 103302994.

Ubiquitin ligases Siah1a/2 control alveolar macrophage functions to limit carcinogen-induced lung adenocarcinoma

Marzia Scortegagna, Yuanning Du, Linda M. Bradley, Kun Wang, Alfredo Molinolo, Eytan Ruppin, Rabi Murad, Ze’ev A. Ronai

Cancer Res. Author manuscript; available in PMC 2023 Dec 15.

Published in final edited form as: Cancer Res. 2023 Jun 15; 83(12): 2016–2033. doi: 10.1158/0008-5472.CAN-23-0258

PMCID:: PMC10330299

Abstract Article PDF–2.6M

Select item 101059495.

SIAH1 ubiquitination-modified HMGCR inhibits lung cancer progression and promotes drug sensitivity through cholesterol synthesis

Hongmei Yuan, Hongge Wu, Jing Cheng, Jie Xiong

Cancer Cell Int. 2023; 23: 71. Published online 2023 Apr 16. doi: 10.1186/s12935-023-02914-w

PMCID:: PMC10105949

Abstract Article PDF–12M

Select item 98172806.

LINC00963 promotes the malignancy and metastasis of lung adenocarcinoma by stabilizing Zeb1 and exosomes-induced M2 macrophage polarization

Ronghang Hu, Baobin Xu, Jiajun Ma, Linfeng Li, Liming Zhang, Li Wang, Jiebo Zhu, Tao Guo, Heng Zhang, Shaoqiang Wang

Mol Med. 2023; 29: 1. Published online 2023 Jan 5. doi: 10.1186/s10020-022-00598-y

PMCID:: PMC9817280

Abstract Article PDF–14M

Select item 97415057.

SIAH proteins regulate the degradation and intra‐mitochondrial aggregation of PINK1: Implications for mitochondrial pathology in Parkinson's disease

Fatimah Abd Elghani, Hazem Safory, Haya Hamza, Mor Savyon, Malik Farhoud, Michal Toren‐Hershoviz, Zagorka Vitic, Kirsten Ebanks, Vered Shani, Sleman Bisharat, Lihi Shaulov, Claude Brodski, Zhiyin Song, Rina Bandopadhyay, Simone Engelender

Aging Cell. 2022 Dec; 21(12): e13731. Published online 2022 Oct 28. doi: 10.1111/acel.13731

PMCID:: PMC9741505

Abstract Article PDF–5.1M

Select item 97135218.

FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1

Yan Wang, Kai Wang, Jiale Fu, Yu Zhang, Yufei Mao, Xu Wang, Xiang Wang, Rutong Yu, Xiuping Zhou

Neuro Oncol. 2022 Dec; 24(12): 2107–2120. Published online 2022 Jun 20. doi: 10.1093/neuonc/noac156

PMCID:: PMC9713521

Abstract Article PDF–51M

Select item 94449779.

MAB21L4 deficiency drives squamous cell carcinoma via activation of RET

Ankit Srivastava, Cristina Tommasi, Dane Sessions, Angela Mah, Tomas Bencomo, Jasmine M. Garcia, Tiffany Jiang, Michael Lee, Joseph Y. Shen, Lek Wei Seow, Audrey Nguyen, Kimal Rajapakshe, Cristian Coarfa, Kenneth Y. Tsai, Vanessa Lopez-Pajares, Carolyn S. Lee

Cancer Res. Author manuscript; available in PMC 2023 Mar 2.

Published in final edited form as: Cancer Res. 2022 Sep 2; 82(17): 3143–3157. doi: 10.1158/0008-5472.CAN-22-0047

PMCID:: PMC9444977

Abstract Article PDF–3.8M

Select item 934857610.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 934345511.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 912252912.

P-TEFb is degraded by Siah1/2 in quiescent cells

Fang Huang, Yongmei Feng, B Matija Peterlin, Koh Fujinaga

Nucleic Acids Res. 2022 May 20; 50(9): 5000–5013. Published online 2022 May 7. doi: 10.1093/nar/gkac291

PMCID:: PMC9122529

Abstract Article PDF–6.1M

Select item 910523513.

Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling

Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser

Int J Mol Sci. 2022 May; 23(9): 5151. Published online 2022 May 5. doi: 10.3390/ijms23095151

PMCID:: PMC9105235

Abstract Article PDF–5.8M

Select item 899544314.

Reactive oxygen species‐induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure

Li Lin, Wujiang Gao, Yumei Chen, Taoqiong Li, Chunli Sha, Lu Chen, Meiling Yang, Hong Wei, Yunpeng Chen, Xiaolan Zhu

J Cell Mol Med. 2022 Apr; 26(8): 2417–2427. Published online 2022 Mar 9. doi: 10.1111/jcmm.17264

PMCID:: PMC8995443

Abstract Article PDF–1.6M

Select item 896577015.

m⁶A-induced repression of SIAH1 facilitates alternative splicing of androgen receptor variant 7 by regulating CPSF1

Lei Xia, Qing Han, Xuehui Duan, Yinjie Zhu, Jiahua Pan, Baijun Dong, Weiliang Xia, Wei Xue, Jianjun Sha

Mol Ther Nucleic Acids. 2022 Jun 14; 28: 219–230. Published online 2022 Mar 15. doi: 10.1016/j.omtn.2022.03.008

PMCID:: PMC8965770

Abstract Article PDF–2.7M

Select item 891366316.

SIAH1 reverses chemoresistance in epithelial ovarian cancer via ubiquitination of YBX-1

Wujiang Gao, Lu Chen, Li Lin, Meiling Yang, Taoqiong Li, Hong Wei, Chunli Sha, Jie Xing, Mengxue Zhang, Shijie Zhao, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu

Oncogenesis. 2022 Dec; 11(1): 13. Published online 2022 Mar 10. doi: 10.1038/s41389-022-00387-6

PMCID:: PMC8913663

Abstract Article PDF–6.0M

Select item 816503017.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 796902318.

DAZAP2 acts as specifier of the p53 response to DNA damage

Magdalena C Liebl, Jutta Moehlenbrink, Huong Becker, Günter Raddatz, Suhaib K Abdeen, Rami I Aqeilan, Frank Lyko, Thomas G Hofmann

Nucleic Acids Res. 2021 Mar 18; 49(5): 2759–2776. Published online 2021 Feb 16. doi: 10.1093/nar/gkab084

PMCID:: PMC7969023

Abstract Article PDF–3.5M

Select item 736718419.

Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2

Jun Wu, Yuhua Xue, Xiang Gao, Qiang Zhou

Nucleic Acids Res. 2020 Jul 27; 48(13): 7321–7332. Published online 2020 Jun 1. doi: 10.1093/nar/gkaa461

PMCID:: PMC7367184

Abstract Article PDF–3.8M

Select item 732206720.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

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