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Select item 111468511.

Gene structure and function of the 2′-5′-oligoadenylate synthetase family

J. Justesen, R. Hartmann, N.O. Kjeldgaard

Cell Mol Life Sci. 2000 Oct; 57(11): 1593–1612. doi: 10.1007/PL00000644

PMCID:: PMC11146851

Abstract Article PDF–1.2M

Select item 110431472.

Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection

Fatima Zahra El Yousfi, Abbas Ermilo Haroun, Chaimae Nebhani, Jihane Belayachi, Omar Askander, Elmostafa El Fahime, Hakima Fares, Khalid Ennibi, Redouane Abouqal, Rachid Razine, Ahmed Bouhouche

Arch Virol. 2024; 169(5): 109. Published online 2024 Apr 25. doi: 10.1007/s00705-024-06038-y

PMCID:: PMC11043147

Abstract Article PDF–1.0M

Select item 100058983.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 99561314.

Genetic Ethnic Differences in Human 2′-5′-Oligoadenylate Synthetase and Disease Associations: A Systematic Review

Anmol Gokul, Thilona Arumugam, Veron Ramsuran

Genes (Basel) 2023 Feb; 14(2): 527. Published online 2023 Feb 19. doi: 10.3390/genes14020527

PMCID:: PMC9956131

Abstract Article PDF–1.2M

Select item 93558825.

Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

A. Rouf Banday, Megan L. Stanifer, Oscar Florez-Vargas, Olusegun O. Onabajo, Brenen W. Papenberg, Muhammad A. Zahoor, Lisa Mirabello, Timothy J. Ring, Chia-Han Lee, Paul S. Albert, Evangelos Andreakos, Evgeny Arons, Greg Barsh, Leslie G. Biesecker, David L. Boyle, Mark S. Brahier, Andrea Burnett-Hartman, Mary Carrington, Euijin Chang, Pyoeng Gyun Choe, Rex L. Chisholm, Leandro M. Colli, Clifton L. Dalgard, Carolynn M. Dude, Jeff Edberg, Nathan Erdmann, Heather S. Feigelson, Benedito A. Fonseca, Gary S. Firestein, Adam J. Gehring, Cuncai Guo, Michelle Ho, Steven Holland, Amy A. Hutchinson, Hogune Im, Les’Shon Irby, Michael G. Ison, Naima T. Joseph, Hong Bin Kim, Robert J. Kreitman, Bruce R. Korf, Steven M. Lipkin, Siham M. Mahgoub, Iman Mohammed, Guilherme L. Paschoalini, Jennifer A. Pacheco, Michael J. Peluso, Daniel J. Rader, David T. Redden, Marylyn D. Ritchie, Brooke Rosenblum, M. Elizabeth Ross, Hanaisa P. Sant Anna, Sharon A. Savage, Sudha Sharma, Eleni Siouti, Alicia K. Smith, Vasiliki Triantafyllia, Joselin M. Vargas, Jose D. Vargas, Anurag Verma, Vibha Vij, Duane R. Wesemann, Meredith Yeager, Xu Yu, Yu Zhang, Steeve Boulant, Stephen J. Chanock, Jordan J. Feld, Ludmila Prokunina-Olsson

Nat Genet. 2022; 54(8): 1103–1116. Published online 2022 Jul 14. doi: 10.1038/s41588-022-01113-z

PMCID:: PMC9355882

Abstract Article PDF–11M

Select item 90418306.

Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor

Oded Danziger, Roosheel S. Patel, Emma J. DeGrace, Mikaela R. Rosen, Brad R. Rosenberg

PLoS Pathog. 2022 Apr; 18(4): e1010464. Published online 2022 Apr 14. doi: 10.1371/journal.ppat.1010464

PMCID:: PMC9041830

Abstract Article PDF–2.5M

Select item 88375377.

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

Jennifer E. Huffman, Guillaume Butler-Laporte, Atlas Khan, Erola Pairo-Castineira, Theodore G. Drivas, Gina M. Peloso, Tomoko Nakanishi, COVID-19 Host Genetics Initiative, Andrea Ganna, Anurag Verma, J. Kenneth Baillie, Krzysztof Kiryluk, J. Brent Richards, Hugo Zeberg

Nat Genet. 2022; 54(2): 125–127. Published online 2022 Jan 13. doi: 10.1038/s41588-021-00996-8

PMCID:: PMC8837537

Abstract Article PDF–2.4M

Select item 87841498.

Role of helical structure and dynamics in oligoadenylate synthetase 1 (OAS1) mismatch tolerance and activation by short dsRNAs

Samantha L. Schwartz, Debayan Dey, Julia Tanquary, Camden R. Bair, Anice C. Lowen, Graeme L. Conn

Proc Natl Acad Sci U S A. 2022 Jan 18; 119(3): e2107111119. Published online 2022 Jan 11. doi: 10.1073/pnas.2107111119

PMCID:: PMC8784149

Abstract Article PDF–2.2M

Select item 85000899.

A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene

Naciye Magusali, Andrew C Graham, Thomas M Piers, Pantila Panichnantakul, Umran Yaman, Maryam Shoai, Regina H Reynolds, Juan A Botia, Keeley J Brookes, Tamar Guetta-Baranes, Eftychia Bellou, Sevinc Bayram, Dimitra Sokolova, Mina Ryten, Carlo Sala Frigerio, Valentina Escott-Price, Kevin Morgan, Jennifer M Pocock, John Hardy, Dervis A Salih

Brain. 2021 Dec; 144(12): 3727–3741. Published online 2021 Oct 7. doi: 10.1093/brain/awab337

PMCID:: PMC8500089

Abstract Article PDF–1.3M

Select item 839250810.

Heterozygous OAS1 Gain-of-Function Variants Cause an Autoinflammatory Immunodeficiency

T. Magg, T. Okano, L.M. Koenig, D.F.R. Boehmer, S.L. Schwartz, K. Inoue, J. Heimall, F. Licciardi, J. Ley-Zaporozhan, R.M. Ferdman, A. Caballero-Oteyza, E.N. Park, B.M. Calderon, D. Dey, H. Kanegane, K. Cho, D. Montin, K. Reiter, M. Griese, M.H. Albert, M. Rohlfs, P. Gray, C. Walz, G.L. Conn, K.E. Sullivan, C. Klein, T. Morio, F. Hauck

Sci Immunol. Author manuscript; available in PMC 2021 Dec 18.

Published in final edited form as: Sci Immunol. 2021 Jun 18; 6(60): eabf9564. doi: 10.1126/sciimmunol.abf9564

PMCID:: PMC8392508

Abstract Article PDF–2.8M

Select item 835741611.

Endomembrane targeting of human OAS1 p46 augments antiviral activity

Frank W Soveg, Johannes Schwerk, Nandan S Gokhale, Karen Cerosaletti, Julian R Smith, Erola Pairo-Castineira, Alison M Kell, Adriana Forero, Shivam A Zaver, Katharina Esser-Nobis, Justin A Roby, Tien-Ying Hsiang, Snehal Ozarkar, Jonathan M Clingan, Eileen T McAnarney, Amy EL Stone, Uma Malhotra, Cate Speake, Joseph Perez, Chiraag Balu, Eric J Allenspach, Jennifer L Hyde, Vineet D Menachery, Saumendra N Sarkar, Joshua J Woodward, Daniel B Stetson, John Kenneth Baillie, Jane H Buckner, Michael Gale, Jr, Ram Savan

eLife. 2021; 10: e71047. Published online 2021 Aug 3. doi: 10.7554/eLife.71047

PMCID:: PMC8357416

Abstract Article PDF–8.6M

Select item 824537512.

Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity

Kristina Pedersen, Martin Haupt-Jorgensen, Lars Krogvold, Simranjeet Kaur, Ivan C. Gerling, Flemming Pociot, Knut Dahl-Jørgensen, Karsten Buschard

Diabetologia. 2021; 64(8): 1805–1815. Published online 2021 May 11. doi: 10.1007/s00125-021-05469-5

PMCID:: PMC8245375

Abstract Article PDF–850K

Select item 769311913.

Single-Cell Transcriptome Analysis Highlights a Role for Neutrophils and Inflammatory Macrophages in the Pathogenesis of Severe COVID-19

Hibah Shaath, Radhakrishnan Vishnubalaji, Eyad Elkord, Nehad M. Alajez

Cells. 2020 Nov; 9(11): 2374. Published online 2020 Oct 29. doi: 10.3390/cells9112374

PMCID:: PMC7693119

Abstract Article PDF–6.0M

Select item 761283414.

A prenylated dsRNA sensor protects against severe COVID-19

Arthur Wickenhagen, Elena Sugrue, Spyros Lytras, Srikeerthana Kuchi, Marko Noerenberg, Matthew L. Turnbull, Colin Loney, Vanessa Herder, Jay Allan, Innes Jarmson, Natalia Cameron-Ruiz, Margus Varjak, Rute M. Pinto, Jeffrey Y. Lee, Louisa Iselin, Natasha Palmalux, Douglas G. Stewart, Simon Swingler, Edward J. D. Greenwood, Thomas W. M. Crozier, Quan Gu, Emma L. Davies, Sara Clohisey, Bo Wang, Fabio Trindade Maranhão Costa, Monique Freire Santana, Luiz Carlos de Lima Ferreira, Lee Murphy, Angie Fawkes, Alison Meynert, Graeme Grimes, ISARIC4C Investigators, Joao Luiz Da Silva Filho, Matthias Marti, Joseph Hughes, Richard J. Stanton, Eddie C. Y. Wang, Antonia Ho, Ilan Davis, Ruth F. Jarrett, Alfredo Castello, David L. Robertson, Malcolm G. Semple, Peter J. M. Openshaw, Massimo Palmarini, Paul J. Lehner, J. Kenneth Baillie, Suzannah J. Rihn, Sam J. Wilson

Science. 2021 Oct 29; 374(6567): eabj3624. Published online 2021 Oct 29. doi: 10.1126/science.abj3624

PMCID:: PMC7612834

Abstract Article PDF–2.6M

Select item 736715615.

Human OAS1 activation is highly dependent on both RNA sequence and context of activating RNA motifs

Samantha L Schwartz, Esther N Park, Virginia K Vachon, Shamika Danzy, Anice C Lowen, Graeme L Conn

Nucleic Acids Res. 2020 Jul 27; 48(13): 7520–7531. Published online 2020 Jun 17. doi: 10.1093/nar/gkaa513

PMCID:: PMC7367156

Abstract Article PDF–3.9M

Select item 732206716.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 726523717.

Suppressing PARylation by 2′,5′‐oligoadenylate synthetase 1 inhibits DNA damage‐induced cell death

Anna A Kondratova, HyeonJoo Cheon, Beihua Dong, Elise G Holvey‐Bates, Metis Hasipek, Irina Taran, Christina Gaughan, Babal K Jha, Robert H Silverman, George R Stark

EMBO J. 2020 Jun 2; 39(11): e101573. Published online 2020 Apr 23. doi: 10.15252/embj.2019101573

Correction in:: EMBO J. 2020 Oct 15; 39(20): e106593.

PMCID:: PMC7265237

Abstract Article PDF–16M

Select item 719415618.

Polymorphism of OAS‐1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication

Chang‐Zheng Li, Naoya Kato, Jin‐Hai Chang, Ryosuke Muroyama, Run‐Xuan Shao, Narayan Dharel, Radsamee Sermsathanasawadi, Takao Kawabe, Masao Omata

Liver Int. 2009 Oct; 29(9): 1413–1421. Published online 2009 Jun 9. doi: 10.1111/j.1478-3231.2009.02061.x

PMCID:: PMC7194156

Abstract Article PDF–190K

Select item 716998319.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 716679320.

Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy

Mostafa K El Awady, Mohamed A Anany, Gamal Esmat, Naglaa Zayed, Ashraf A Tabll, Amr Helmy, Abdel Rahman El Zayady, Mohga S Abdalla, Hayat M Sharada, Maissa El Raziky, Wafaa El Akel, Shadia Abdalla, Noha G Bader El Din

J Gastroenterol Hepatol. 2011 May; 26(5): 843–850. Published online 2011 Apr 13. doi: 10.1111/j.1440-1746.2010.06605.x

PMCID:: PMC7166793

Abstract Article PDF–255K

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