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Items: 1 to 20 of 30

1.
Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity
Diego Esposito, Jane Dudley-Fraser, Acely Garza-Garcia, Katrin Rittinger
Nat Commun. 2022; 13: 7583. Published online 2022 Dec 8. doi: 10.1038/s41467-022-35300-7
PMCID:
PMC9732051
AbstractArticlePDF–4.5M
2.
A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer
Tiantian Xu, Qisheng Ma, Yanan Li, Qing Yu, Peichen Pan, Yawen Zheng, Zhijian Li, Xiufang Xiong, Tingjun Hou, Bin Yu, Hongmin Liu, Yi Sun
Signal Transduct Target Ther. 2022; 7: 354. Published online 2022 Oct 17. doi: 10.1038/s41392-022-01182-w
PMCID:
PMC9576757
AbstractArticlePDF–6.0M
3.
Structure of CRL7FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Linus V. M. Hopf, Kheewoong Baek, Maren Klügel, Susanne von Gronau, Yue Xiong, Brenda A. Schulman
Nat Struct Mol Biol. 2022; 29(9): 854–862. Published online 2022 Aug 18. doi: 10.1038/s41594-022-00815-6
PMCID:
PMC9507964
AbstractArticlePDF–15M
4.
NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis
Lisha ZHOU, Changsheng DONG, Zhuoming XU, Xinran WANG, Luyi ZHANG, Siyuan CHEN, Jiahao CHEN, Yingying ZHU
J Zhejiang Univ Sci B. 2021 Nov 15; 22(11): 959–965. Chinese. doi: 10.1631/jzus.B2100170
PMCID:
PMC8593528
ArticlePDF–1.0M
5.
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation
Sebastian Kostrhon, J. Rajan Prabu, Kheewoong Baek, Daniel Horn-Ghetko, Susanne von Gronau, Maren Klügel, Jérôme Basquin, Arno F. Alpi, Brenda A. Schulman
Nat Chem Biol. 2021; 17(10): 1075–1083. Published online 2021 Sep 13. doi: 10.1038/s41589-021-00858-8
PMCID:
PMC8460447
AbstractArticlePDF–13M
6.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M
7.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
8.
Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer
Shoufang Xu, Yilei Ma, Qingchao Tong, Jun Yang, Jia Liu, Yanzhong Wang, Guoli Li, Jin Zeng, Sining Fang, Fengying Li, Xinyou Xie, Jun Zhang
Cell Death Dis. 2021 Mar; 12(3): 265. Published online 2021 Mar 12. doi: 10.1038/s41419-021-03557-3
Correction in:
Cell Death Dis. 2021 Apr; 12(4): 369.
PMCID:
PMC7954848
AbstractArticlePDF–5.3M
9.
Induction of NEDD8-conjugating enzyme E2 UBE2F by platinum protects lung cancer cells from apoptosis and confers to platinum-insensitivity
Lisha Zhou, Jin Zhu, Wangyang Chen, Yanyu Jiang, Tao Hu, Yinxia Wang, Xiaoling Ye, Mengxi Zhan, Chenghao Ji, Zhuoming Xu, Xinran Wang, Yuanlong Gu, Lijun Jia
Cell Death Dis. 2020 Nov; 11(11): 975. Published online 2020 Nov 12. doi: 10.1038/s41419-020-03184-4
PMCID:
PMC7665193
AbstractArticlePDF–2.5M
10.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
11.
Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes
Qing Yu, Zhiguo Hu, Yanwen Shen, Yihan Jiang, Peichen Pan, Tingjun Hou, Zhen-Qiang Pan, Jing Huang, Yi Sun
Neoplasia. 2020 Apr; 22(4): 179–191. Published online 2020 Mar 16. doi: 10.1016/j.neo.2020.02.003
PMCID:
PMC7076571
AbstractArticlePDF–2.4M
12.
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC
Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223
PMCID:
PMC6927754
AbstractArticlePDF–5.1M
13.
Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling
Ian R. Kelsall, Yosua A. Kristariyanto, Axel Knebel, Nicola T. Wood, Yogesh Kulathu, Arno F. Alpi
J Biol Chem. 2019 Feb 22; 294(8): 2651–2664. Published online 2018 Dec 26. doi: 10.1074/jbc.RA118.005861
PMCID:
PMC6393609
AbstractArticlePDF–1.7M
14.
The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation
Yann Thomas, Daniel C. Scott, Yosua Adi Kristariyanto, Jesse Rinehart, Kristopher Clark, Philip Cohen, Thimo Kurz
PLoS One. 2018; 13(6): e0199197. Published online 2018 Jun 29. doi: 10.1371/journal.pone.0199197
PMCID:
PMC6025869
AbstractArticlePDF–6.3M
15.
UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F
Weihua Zhou, Jie Xu, Mingjia Tan, Haomin Li, Hua Li, Wenyi Wei, Yi Sun
Mol Cell. Author manuscript; available in PMC 2019 Jun 21.
Published in final edited form as: Mol Cell. 2018 Jun 21; 70(6): 1008–1024.e6. doi: 10.1016/j.molcel.2018.06.002
PMCID:
PMC6021141
AbstractArticlePDF–3.0M
16.
Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage
Weihua Zhou, Jie Xu, Haomin Li, Ming Xu, Zhijian J. Chen, Wenyi Wei, Zhenqiang Pan, Yi Sun
Clin Cancer Res. Author manuscript; available in PMC 2018 Feb 15.
Published in final edited form as: Clin Cancer Res. 2017 Feb 15; 23(4): 1104–1116. Published online 2016 Sep 2. doi: 10.1158/1078-0432.CCR-16-1585
PMCID:
PMC5315595
AbstractArticlePDF–3.1M
17.
Panorama of ancient metazoan macromolecular complexes
Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Berzginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, Brent Derry, Elisabeth Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili
Nature. Author manuscript; available in PMC 2016 Sep 26.
Published in final edited form as: Nature. 2015 Sep 17; 525(7569): 339–344. Published online 2015 Sep 7. doi: 10.1038/nature14877
PMCID:
PMC5036527
AbstractArticlePDF–4.7M
18.
New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins
Qi Zhang, Lixin Fan, Feng Hou, Aiping Dong, Yun-Xing Wang, Yufeng Tong
Sci Rep. 2015; 5: 15660. Published online 2015 Oct 22. doi: 10.1038/srep15660
PMCID:
PMC4614863
AbstractArticlePDF–1.5M
19.
Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes
Julie K. Monda, Daniel C. Scott, Darcie J. Miller, John Lydeard, David King, J. Wade Harper, Eric J. Bennett, Brenda A. Schulman
Structure. Author manuscript; available in PMC 2013 Sep 30.
Published in final edited form as: Structure. 2013 Jan 8; 21(1): 42–53. Published online 2012 Nov 29. doi: 10.1016/j.str.2012.10.013
PMCID:
PMC3786212
AbstractArticlePDF–4.8M
20.
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G
David J. Stanley, Koen Bartholomeeusen, David C. Crosby, Dong Young Kim, Eunju Kwon, Linda Yen, Nathalie Caretta Cartozo, Ming Li, Stefanie Jäger, Jeremy Mason-Herr, Fumiaki Hayashi, Shigeyuki Yokoyama, Nevan J. Krogan, Reuben S. Harris, Boris Matija Peterlin, John D. Gross
PLoS Pathog. 2012 Dec; 8(12): e1003085. Published online 2012 Dec 27. doi: 10.1371/journal.ppat.1003085
PMCID:
PMC3531493
AbstractArticlePDF–1.0M

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