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Items: 1 to 20 of 1171

1.
Human α‐synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing
Noelia Morales‐Prieto, Rebekah Bevans, Adam O'Mahony, Aaron Barron, Conor Giles Doran, Erin McCarthy, Ruth M. Concannon, Susan R. Goulding, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Aging Cell. 2024 Jun; 23(6): e14155. Published online 2024 Mar 26. doi: 10.1111/acel.14155
PMCID:
PMC11296121
AbstractArticlePDF–2.5M
2.
Mechanistic Insight into Intestinal α-Synuclein Aggregation in Parkinson’s Disease Using a Laser-Printed Electrochemical Sensor
Julia M. Balsamo, Keren Zhou, Vinay Kammarchedu, Aida Ebrahimi, Elizabeth N. Bess
ACS Chem Neurosci. 2024 Jul 17; 15(14): 2623–2632. Published online 2024 Jul 3. doi: 10.1021/acschemneuro.4c00106
PMCID:
PMC11258680
AbstractArticlePDF–4.5M
3.
Misfolded alpha‐synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment
Richard Smith, Hanna Hovren, Robert Bowser, Nadine Bakkar, Ralph Garruto, Albert Ludolph, John Ravits, Lia Gaertner, Davan Murphy, Russ Lebovitz
Eur J Neurol. 2024 Apr; 31(4): e16206. Published online 2024 Jan 25. doi: 10.1111/ene.16206
PMCID:
PMC11235862
AbstractArticlePDF–2.6M
4.
Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons
Ching-Chi Chiu, Ying-Ling Chen, Yi-Hsin Weng, Shu-Yu Liu, Hon-Lun Li, Tu-Hsueh Yeh, Hung-Li Wang
Int J Mol Sci. 2024 Jun; 25(12): 6711. Published online 2024 Jun 18. doi: 10.3390/ijms25126711
PMCID:
PMC11204255
AbstractArticlePDF–9.0M
5.
Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration
Modestos Nakos Bimpos, Katerina Karali, Christine Antoniou, Dionysios Palermos, Maria Fouka, Anastasios Delis, Iason Tzieras, George Panagiotis Chrousos, Yassemi Koutmani, Leonidas Stefanis, Alexia Polissidis
Acta Neuropathol Commun. 2024; 12: 100. Published online 2024 Jun 17. doi: 10.1186/s40478-024-01797-w
PMCID:
PMC11181569
AbstractArticlePDF–7.4M
6.
Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology
Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson
Nat Commun. 2024; 15: 5133. Published online 2024 Jun 15. doi: 10.1038/s41467-024-49402-x
PMCID:
PMC11180185
AbstractArticlePDF–2.7M
7.
Elevated ApoE, ApoJ and lipoprotein-bound α-synuclein levels in cerebrospinal fluid from Parkinson’s disease patients – Validation in the BioFIND cohort
Wojciech Paslawski, Per Svenningsson
Parkinsonism Relat Disord. Author manuscript; available in PMC 2024 May 31.
Published in final edited form as: Parkinsonism Relat Disord. 2023 Nov; 116: 105765. Published online 2023 Jul 12. doi: 10.1016/j.parkreldis.2023.105765
PMCID:
PMC11140586
AbstractArticlePDF–1.2M
8.
Synphilin-1 isoforms in Parkinson’s disease: regulation by phosphorylation and ubiquitylation
R. Szargel, R. Rott, S. Engelender
Cell Mol Life Sci. 2008 Jan; 65(1): 80–88. Published online 2007 Nov 5. doi: 10.1007/s00018-007-7343-0
PMCID:
PMC11131774
AbstractArticlePDF–898K
9.
Mitochondrial association of alpha-synuclein causes oxidative stress
M. S. Parihar, A. Parihar, M. Fujita, M. Hashimoto, P. Ghafourifar
Cell Mol Life Sci. 2008 Apr; 65(7-8): 1272–1284. Published online 2008 Feb 25. doi: 10.1007/s00018-008-7589-1
PMCID:
PMC11131648
AbstractArticlePDF–2.8M
10.
Synphilin-1 inhibits alpha-synuclein degradation by the proteasome
Beatriz Alvarez-Castelao, José G. Castaño
Cell Mol Life Sci. 2011 Aug; 68(15): 2643–2654. Published online 2010 Nov 20. doi: 10.1007/s00018-010-0592-3
PMCID:
PMC11114841
AbstractArticlePDF–595K
11.
Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1
Dajana Galka, Tariq T. Ali, Alexander Bast, Marie Niederleithinger, Ellen Gerhardt, Ryo Motosugi, Eri Sakata, Michael Knop, Tiago F. Outeiro, Blagovesta Popova, Gerhard H. Braus
Aging Cell. 2024 May; 23(5): e14128. Published online 2024 Feb 28. doi: 10.1111/acel.14128
PMCID:
PMC11113265
AbstractArticlePDF–7.8M
12.
Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson’s disease
Sandeep K. Sharma, Smriti Priya
Cell Mol Life Sci. 2017 Feb; 74(4): 617–629. Published online 2016 Aug 13. doi: 10.1007/s00018-016-2340-9
PMCID:
PMC11107554
AbstractArticlePDF–1.6M
13.
Synucleinopathies: common features and hippocampal manifestations
Weiwei Yang, Shun Yu
Cell Mol Life Sci. 2017 Apr; 74(8): 1485–1501. Published online 2016 Nov 8. doi: 10.1007/s00018-016-2411-y
PMCID:
PMC11107502
AbstractArticlePDF–536K
14.
A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons
Shogo Moriya, Michiko Hanazono, Takeshi Fukuhara, Katsuro Iwase, Nobutaka Hattori, Masaki Takiguchi
Cell Mol Life Sci. 2022 May; 79(5): 234. Published online 2022 Apr 10. doi: 10.1007/s00018-022-04263-9
PMCID:
PMC11073293
AbstractArticlePDF–2.8M
15.
Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein–VDAC complexation as a potential therapeutic target for Parkinson’s disease treatment
Megha Rajendran, María Queralt-Martín, Philip A. Gurnev, William M. Rosencrans, Amandine Rovini, Daniel Jacobs, Kaitlin Abrantes, David P. Hoogerheide, Sergey M. Bezrukov, Tatiana K. Rostovtseva
Cell Mol Life Sci. 2022 Jul; 79(7): 368. Published online 2022 Jun 19. doi: 10.1007/s00018-022-04389-w
PMCID:
PMC11072225
AbstractArticlePDF–2.3M
16.
Plasma exosomes impair microglial degradation of α‐synuclein through V‐ATPase subunit V1G1
Yunna Li, Yiming Wang, Liang Kou, Sijia Yin, Xiaosa Chi, Yadi Sun, Jiawei Wu, Zongjie Jin, Qiulu Zhou, Wenkai Zou, Tao Wang, Yun Xia
CNS Neurosci Ther. 2024 May; 30(5): e14738. Published online 2024 May 3. doi: 10.1111/cns.14738
PMCID:
PMC11069054
AbstractArticlePDF–25M
17.
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue
Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Deborah A. Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Y. O’Shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
Nat Commun. 2024; 15: 2750. Published online 2024 Mar 29. doi: 10.1038/s41467-024-46832-5
PMCID:
PMC10980826
AbstractArticlePDF–5.5M
18.
Peripheral Upregulation of Parkinson’s Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression
Razvan-Marius Brazdis, Claudia von Zimmermann, Bernd Lenz, Johannes Kornhuber, Christiane Mühle
Int J Mol Sci. 2024 Mar; 25(6): 3219. Published online 2024 Mar 12. doi: 10.3390/ijms25063219
PMCID:
PMC10970259
AbstractArticlePDF–1.5M
19.
Alpha-Synuclein and GM1 Ganglioside Co-Localize in Neuronal Cytosol Leading to Inverse Interaction—Relevance to Parkinson’s Disease
Ranjeet Kumar, Suman Chowdhury, Robert Ledeen
Int J Mol Sci. 2024 Mar; 25(6): 3323. Published online 2024 Mar 15. doi: 10.3390/ijms25063323
PMCID:
PMC10970170
AbstractArticlePDF–2.7M
20.
Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin–Proteasome Pathways in Lewy Body Disease
Tomoya Kon, Seojin Lee, Ivan Martinez-Valbuena, Koji Yoshida, Satoshi Tanikawa, Anthony E. Lang, Gabor G. Kovacs
Int J Mol Sci. 2024 Mar; 25(5): 2676. Published online 2024 Feb 26. doi: 10.3390/ijms25052676
PMCID:
PMC10932332
AbstractArticlePDF–1.9M

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