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Items: 1 to 20 of 29

1.
RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome
Irene Sambri, Marco Ferniani, Giulia Campostrini, Marialuisa Testa, Viviana Meraviglia, Mariana E. G. de Araujo, Ladislav Dokládal, Claudia Vilardo, Jlenia Monfregola, Nicolina Zampelli, Francesca Del Vecchio Blanco, Annalaura Torella, Carolina Ruosi, Simona Fecarotta, Giancarlo Parenti, Leopoldo Staiano, Milena Bellin, Lukas A. Huber, Claudio De Virgilio, Francesco Trepiccione, Vincenzo Nigro, Andrea Ballabio
Nat Commun. 2023; 14: 2775. Published online 2023 May 15. doi: 10.1038/s41467-023-38428-2
PMCID:
PMC10185561
AbstractArticlePDF–4.7M
2.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
3.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
4.
mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy
Karl P. Schlingmann, François Jouret, Kuang Shen, Anukrati Nigam, Francisco J. Arjona, Claudia Dafinger, Pascal Houillier, Deborah P. Jones, Felix Kleinerüschkamp, Jun Oh, Nathalie Godefroid, Mehmet Eltan, Tülay Güran, Stéphane Burtey, Marie-Christine Parotte, Jens König, Alina Braun, Caro Bos, Maria Ibars Serra, Holger Rehmann, Fried J.T. Zwartkruis, Kirsten Y. Renkema, Karin Klingel, Eric Schulze-Bahr, Bernhard Schermer, Carsten Bergmann, Janine Altmüller, Holger Thiele, Bodo B. Beck, Karin Dahan, David Sabatini, Max C. Liebau, Rosa Vargas-Poussou, Nine V.A.M. Knoers, Martin Konrad, Jeroen H.F. de Baaij
J Am Soc Nephrol. 2021 Nov; 32(11): 2885–2899. Published online 2021 Nov. doi: 10.1681/ASN.2021030333
PMCID:
PMC8806087
AbstractArticle
5.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
6.
Combinatorial CRISPR screen identifies fitness effects of gene paralogues
Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams
Nat Commun. 2021; 12: 1302. Published online 2021 Feb 26. doi: 10.1038/s41467-021-21478-9
PMCID:
PMC7910459
AbstractArticlePDF–3.3M
7.
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome
Gennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E.G. de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk, Diletta Siciliano, Alessandro Venuta, Marcella Cesana, Claudia Vilardo, Edoardo Nusco, Jlenia Monfregola, Alessia Calcagni, Pier Paolo Di Fiore, Lukas A. Huber, Andrea Ballabio
Nature. Author manuscript; available in PMC 2021 Mar 22.
Published in final edited form as: Nature. 2020 Sep 1; 585(7826): 597–602. Published online 2020 Jul 1. doi: 10.1038/s41586-020-2444-0
PMCID:
PMC7610377
AbstractArticlePDF–5.4M
8.
BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A
Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng
Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676
PMCID:
PMC7606008
AbstractArticlePDF–2.5M
9.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei
Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck
Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924
PMCID:
PMC6166682
AbstractArticlePDF–3.8M
10.
TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer
Jonathan M. Cooper, Yi-Hung Ou, Elizabeth A. McMillan, Rachel M. Vaden, Aubhishek Zaman, Brian O. Bodemann, Gurbani Makkar, Bruce A. Posner, Michael A. White
Cancer Res. Author manuscript; available in PMC 2018 Sep 15.
Published in final edited form as: Cancer Res. 2017 Sep 15; 77(18): 5077–5094. Published online 2017 Jul 17. doi: 10.1158/0008-5472.CAN-17-0829
PMCID:
PMC5833933
AbstractArticlePDF–2.9M
11.
TRANSCRIPTIONAL ACTIVATION OF RAGD GTPASE CONTROLS mTORC1 AND PROMOTES CANCER GROWTH
Chiara Di Malta, Diletta Siciliano, Alessia Calcagni, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea N. Eastes, Oliver Davis, Rossella de Cegli, Angela Zampelli, Luca G. Di Giovannantonio, Edoardo Nusco, Nick Platt, Alessandro Guida, Margret Helga Ogmundsdottir, Luisa Lanfrancone, Rushika M. Perera, Roberto Zoncu, Pier Giuseppe Pelicci, Carmine Settembre, Andrea Ballabio.
Science. Author manuscript; available in PMC 2017 Dec 16.
Published in final edited form as: Science. 2017 Jun 16; 356(6343): 1188–1192. doi: 10.1126/science.aag2553
PMCID:
PMC5730647
AbstractArticlePDF–521K
12.
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Jong Hyun Kim, Chulho Lee, Minji Lee, Haipeng Wang, Kibum Kim, Seung Joon Park, Ina Yoon, Jayun Jang, Hanchao Zhao, Hoi Kyoung Kim, Nam Hoon Kwon, Seung Jae Jeong, Hee Chan Yoo, Jae Hyun Kim, Jee Sun Yang, Myeong Youl Lee, Chang Woo Lee, Jieun Yun, Soo Jin Oh, Jong Soon Kang, Susan A. Martinis, Kwang Yeon Hwang, Min Guo, Gyoonhee Han, Jung Min Han, Sunghoon Kim
Nat Commun. 2017; 8: 732. Published online 2017 Sep 29. doi: 10.1038/s41467-017-00785-0
PMCID:
PMC5622079
AbstractArticlePDF–2.0M
13.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
14.
TRIMs and Galectins globally cooperate and TRIM16 and Galectin-3 co-direct autophagy in endomembrane damage homeostasis
Santosh Chauhan, Suresh Kumar, Ashish Jain, Marisa Ponpuak, Michal H. Mudd, Tomonori Kimura, Seong Won Choi, Ryan Peters, Michael Mandell, Jack-Ansgar Bruun, Terje Johansen, Vojo Deretic
Dev Cell. Author manuscript; available in PMC 2017 Oct 10.
Published in final edited form as: Dev Cell. 2016 Oct 10; 39(1): 13–27. Published online 2016 Sep 29. doi: 10.1016/j.devcel.2016.08.003
PMCID:
PMC5104201
AbstractArticlePDF–2.0M
15.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
16.
SLC38A9 is a component of the lysosomal amino acid-sensing machinery that controls mTORC1
Manuele Rebsamen, Lorena Pochini, Taras Stasyk, Mariana E. G. de Araújo, Michele Galluccio, Richard K. Kandasamy, Berend Snijder, Astrid Fauster, Elena L. Rudashevskaya, Manuela Bruckner, Stefania Scorzoni, Przemyslaw A. Filipek, Kilian V. M. Huber, Johannes Bigenzahn, Leonhard X. Heinz, Claudine Kraft, Keiryn L. Bennett, Cesare Indiveri, Lukas A. Huber, Giulio Superti-Furga
Nature. Author manuscript; available in PMC 2015 Sep 26.
Published in final edited form as: Nature. 2015 Mar 26; 519(7544): 477–481. Published online 2015 Jan 7. doi: 10.1038/nature14107
PMCID:
PMC4376665
AbstractArticlePDF–2.4M
17.
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
Constantinos Demetriades, Nikolaos Doumpas, Aurelio A. Teleman
Cell. Author manuscript; available in PMC 2015 Mar 2.
Published in final edited form as: Cell. 2014 Feb 13; 156(4): 786–799. doi: 10.1016/j.cell.2014.01.024
PMCID:
PMC4346203
AbstractArticlePDF–2.7M
18.
Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
Min Peng, Na Yin, Ming O. Li
Cell. Author manuscript; available in PMC 2015 Sep 25.
Published in final edited form as: Cell. 2014 Sep 25; 159(1): 122–133. doi: 10.1016/j.cell.2014.08.038
PMCID:
PMC4181352
AbstractArticlePDF–2.7M
19.
Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
Noriko Oshiro, Joseph Rapley, Joseph Avruch
J Biol Chem. 2014 Jan 31; 289(5): 2658–2674. Published online 2013 Dec 11. doi: 10.1074/jbc.M113.528505
PMCID:
PMC3908400
AbstractArticlePDF–2.6M
20.
The Folliculin tumor suppressor is a GAP for RagC/D GTPases that signal amino acid levels to mTORC1
Zhi-Yang Tsun, Liron Bar-Peled, Lynne Chantranupong, Roberto Zoncu, Tim Wang, Choah Kim, Eric Spooner, David M. Sabatini
Mol Cell. Author manuscript; available in PMC 2014 Nov 21.
Published in final edited form as: Mol Cell. 2013 Nov 21; 52(4): 10.1016/j.molcel.2013.09.016. Published online 2013 Oct 3. doi: 10.1016/j.molcel.2013.09.016
PMCID:
PMC3867817
AbstractArticlePDF–3.2M

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