PMC Links for GEO Profiles (Select 106125689) - PMC

Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78515352.

MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC

ZiJun Liao, Qi Zheng, Ting Wei, YanBing Zhang, JieQun Ma, Zheng Zhao, HaiFeng Sun, KeJun Nan

Oncol Res. 2020; 28(2): 147–159. Published online 2020 Mar 27. doi: 10.3727/096504019X15732109856009

PMCID:: PMC7851535

Abstract Article PDF–7.7M

Select item 75668813.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 72215054.

CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction

Yiu To Yeung, Suyu Fan, Bingbing Lu, Shuying Yin, Sen Yang, Wenna Nie, Meixian Wang, Liting Zhou, Tiepeng Li, Xiang Li, Ann M Bode, Zigang Dong

Carcinogenesis. 2020 May; 41(3): 377–389. Published online 2019 Jun 25. doi: 10.1093/carcin/bgz113

PMCID:: PMC7221505

Abstract Article PDF–13M

Select item 63851915.

Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma

Ming-Hui Yang, Chia-Hung Yen, Yen-Fu Chen, Cheng-Chieh Fang, Chung-Hsien Li, Kuo-Jui Lee, Yi-Hsiung Lin, Chien-Hui Weng, Tze-Tze Liu, Shiu-Feng Huang, Bin Tean Teh, Yi-Ming Arthur Chen

Sci Rep. 2019; 9: 2552. Published online 2019 Feb 22. doi: 10.1038/s41598-018-36810-5

PMCID:: PMC6385191

Abstract Article PDF–1.7M

Select item 61666826.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 52459687.

Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

Stephen K Horrigan, Pascal Courville, Darryl Sampey, Faren Zhou, Steve Cai, Reproducibility Project: Cancer Biology

eLife. 2017; 6: e21634. Published online 2017 Jan 19. doi: 10.7554/eLife.21634

PMCID:: PMC5245968

Abstract Article PDF–1.1M

Select item 52459558.

Melanoma mystery

Roger J Davis

eLife. 2017; 6: e22662. Published online 2017 Jan 19. doi: 10.7554/eLife.22662

PMCID:: PMC5245955

Abstract Article PDF–489K

Select item 50035439.

Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma

Yonathan Lissanu Deribe

Small GTPases. 2016 Jul-Sep; 7(3): 178–185. Published online 2016 Apr 25. doi: 10.1080/21541248.2016.1178366

PMCID:: PMC5003543

Abstract Article PDF–760K

Select item 487466410.

PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion

Sarah M. Mense, Douglas Barrows, Cindy Hodakoski, Nicole Steinbach, David Schoenfeld, William Su, Benjamin D. Hopkins, Tao Su, Barry Fine, Hanina Hibshoosh, Ramon Parsons

Sci Signal. Author manuscript; available in PMC 2016 May 31.

Published in final edited form as: Sci Signal. 2015 Mar 31; 8(370): ra32. Published online 2015 Mar 31. doi: 10.1126/scisignal.2005840

PMCID:: PMC4874664

Abstract Article PDF–2.7M

Select item 478059911.

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, Lynda Chin

Proc Natl Acad Sci U S A. 2016 Mar 1; 113(9): E1296–E1305. Published online 2016 Feb 16. doi: 10.1073/pnas.1513801113

PMCID:: PMC4780599

Abstract Article PDF–2.0M

Select item 466140512.

p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase

Douglas Barrows, Sarah M. Schoenfeld, Cindy Hodakoski, Antonina Silkov, Barry Honig, Anthony Couvillon, Aliaksei Shymanets, Bernd Nürnberg, John M. Asara, Ramon Parsons

J Biol Chem. 2015 Nov 27; 290(48): 28915–28931. Published online 2015 Oct 5. doi: 10.1074/jbc.M115.668244

PMCID:: PMC4661405

Abstract Article PDF–2.8M

Select item 389080813.

Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis

Cindy Hodakoski, Benjamin D. Hopkins, Douglas Barrows, Sarah M. Mense, Megan Keniry, Karen E. Anderson, Philip A. Kern, Phillip T. Hawkins, Len R. Stephens, Ramon Parsons

Proc Natl Acad Sci U S A. 2014 Jan 7; 111(1): 155–160. Published online 2013 Dec 23. doi: 10.1073/pnas.1213773111

PMCID:: PMC3890808

Abstract Article PDF–1.0M

Select item 336779814.

Melanoma genome sequencing reveals frequent PREX2 mutations

Michael F. Berger, Eran Hodis, Timothy P. Heffernan, Yonathan Lissanu Deribe, Michael S. Lawrence, Alexei Protopopov, Elena Ivanova, Ian R. Watson, Elizabeth Nickerson, Papia Ghosh, Hailei Zhang, Rhamy Zeid, Xiaojia Ren, Kristian Cibulskis, Andrey Y. Sivachenko, Nikhil Wagle, Antje Sucker, Carrie Sougnez, Robert Onofrio, Lauren Ambrogio, Daniel Auclair, Timothy Fennell, Scott L. Carter, Yotam Drier, Petar Stojanov, Meredith A. Singer, Douglas Voet, Rui Jing, Gordon Saksena, Jordi Barretina, Alex H. Ramos, Trevor J. Pugh, Nicolas Stransky, Melissa Parkin, Wendy Winckler, Scott Mahan, Kristin Ardlie, Jennifer Baldwin, Jennifer Wargo, Dirk Schadendorf, Matthew Meyerson, Stacey B. Gabriel, Todd R. Golub, Stephan N. Wagner, Eric S. Lander, Gad Getz, Lynda Chin, Levi A. Garraway

Nature. Author manuscript; available in PMC 2012 Nov 24.

Published in final edited form as: Nature. 2012 May 24; 485(7399): 502–506. Published online 2012 May 9. doi: 10.1038/nature11071

PMCID:: PMC3367798

Abstract Article PDF–567K

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 293678416.

Activation of the PI3K Pathway in Cancer through Inhibition of PTEN by Exchange Factor P-REX2a

Barry Fine, Cindy Hodakoski, Susan Koujak, Tao Su, Lao H. Saal, Matthew Maurer, Benjamin Hopkins, Megan Keniry, Maria Luisa Sulis, Sarah Mense, Hanina Hibshoosh, Ramon Parsons

Science. Author manuscript; available in PMC 2010 Sep 10.

Published in final edited form as: Science. 2009 Sep 4; 325(5945): 1261–1265. doi: 10.1126/science.1173569

PMCID:: PMC2936784

Abstract Article PDF–1.7M

Select item 289646417.

Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score

Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, George R Uhl

Mol Med. 2010 Jul-Aug; 16(7-8): 247–253. Published online 2010 Mar 17. doi: 10.2119/molmed.2009.00159

Correction in:: Mol Med. 2012; 18(1): 729.

PMCID:: PMC2896464

Abstract Article PDF–2.4M

Select item 13924118.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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