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Select item 103180431.

Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation

Jaewon Lee, Jihoon Ha, Jun-Hyeong Kim, Dongyeob Seo, Minbeom Kim, Yerin Lee, Seong Shil Park, Dahee Choi, Jin Seok Park, Young Jae Lee, Siyoung Yang, Kyung-Min Yang, Su Myung Jung, Suntaek Hong, Seung-Hoi Koo, Yong-Soo Bae, Seong-Jin Kim, Seok Hee Park

Exp Mol Med. 2023 Jun; 55(6): 1218–1231. Published online 2023 Jun 1. doi: 10.1038/s12276-023-01009-w

PMCID:: PMC10318043

Abstract Article PDF–3.0M

Select item 100729062.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 95012183.

MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway in HEK293 and RAW264.7 Cells

Anh Thu Ha, Jae Youl Cho, Daewon Kim

Int J Mol Sci. 2022 Sep; 23(18): 10874. Published online 2022 Sep 17. doi: 10.3390/ijms231810874

PMCID:: PMC9501218

Abstract Article PDF–2.0M

Select item 93992924.

Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division

Luis Cedeno-Rosario, David Honda, Autumn M. Sunderland, Mark D. Lewandowski, William R. Taylor, Deborah N. Chadee

J Biol Chem. 2022 Aug; 298(8): 102263. Published online 2022 Jul 14. doi: 10.1016/j.jbc.2022.102263

PMCID:: PMC9399292

Abstract Article PDF–3.3M

Select item 93485765.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 92792856.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 92626147.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 90869968.

Mechanisms underlying melanoma invasion as a consequence of MLK3 loss

Henriette U. Balinda, Alanna Sedgwick, Crislyn D’Souza-Schorey

Exp Cell Res. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Cell Res. 2022 Jun 1; 415(1): 113106. Published online 2022 Mar 18. doi: 10.1016/j.yexcr.2022.113106

PMCID:: PMC9086996

Abstract Article PDF–2.7M

Select item 85536099.

MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3

Sunil Kumar Singh, Sandeep Kumar, Navin Viswakarma, Daniel R. Principe, Subhasis Das, Gautam Sondarva, Rakesh Sathish Nair, Piush Srivastava, Subhash C. Sinha, Paul J. Grippo, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana

Oncogene. 2021; 40(43): 6153–6165. Published online 2021 Sep 13. doi: 10.1038/s41388-021-02007-w

PMCID:: PMC8553609

Abstract Article PDF–6.9M

Select item 849099710.

BioID reveals an ATG9A interaction with ATG13‐ATG101 in the degradation of p62/SQSTM1‐ubiquitin clusters

Ashari R Kannangara, Daniel M Poole, Colten M McEwan, Joshua C Youngs, Vajira K Weerasekara, Alex M Thornock, Misael T Lazaro, Eranga R Balasooriya, Laura M Oh, Erik J Soderblom, Jonathan J Lee, Daniel L Simmons, Joshua L Andersen

EMBO Rep. 2021 Oct 5; 22(10): e51136. Published online 2021 Aug 9. doi: 10.15252/embr.202051136

PMCID:: PMC8490997

Abstract Article PDF–4.5M

Select item 822423611.

LATS1 Regulates Mixed-Lineage Kinase 3 (MLK3) Subcellular Localization and MLK3-Mediated Invasion in Ovarian Epithelial Cells

Srimathi Kasturirangan, Batool Mehdi, Deborah N. Chadee

Mol Cell Biol. 2021 Jul; 41(7): e00078-21. Prepublished online 2021 Apr 19. Published online 2021 Jun 23. doi: 10.1128/MCB.00078-21

PMCID:: PMC8224236

Abstract Article PDF–2.7M

Select item 821590012.

Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development

Navin Viswakarma, Gautam Sondarva, Daniel R. Principe, Rakesh Sathish Nair, Sandeep Kumar, Sunil Kumar Singh, Subhasis Das, Subhash C. Sinha, Paul J Grippo, Sam Grimaldo, Pier Cristoforo Giulianotti, Basabi Rana, Ajay Rana

Cancer Lett. Author manuscript; available in PMC 2022 Sep 1.

Published in final edited form as: Cancer Lett. 2021 Sep 1; 515: 1–13. Published online 2021 May 27. doi: 10.1016/j.canlet.2021.04.015

PMCID:: PMC8215900

Abstract Article PDF–2.4M

Select item 796055013.

USP11 mediates repair of DNA–protein cross-links by deubiquitinating SPRTN metalloprotease

Megan Perry, Meghan Biegert, Sai Sundeep Kollala, Halle Mallard, Grace Su, Manohar Kodavati, Natasha Kreiling, Alexander Holbrook, Gargi Ghosal

J Biol Chem. 2021 Jan-Jun; 296: 100396. Published online 2021 Feb 7. doi: 10.1016/j.jbc.2021.100396

PMCID:: PMC7960550

Abstract Article PDF–1.5M

Select item 756868614.

Mixed Lineage Kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-Activated Kinase 1

Subhasis Das, Rakesh Sathish Nair, Rajakishore Mishra, Gautam Sondarva, Navin Viswakarma, Hazem Abdelkarim, Vadim Gaponenko, Basabi Rana, Ajay Rana

Oncogene. Author manuscript; available in PMC 2020 Oct 17.

Published in final edited form as: Oncogene. 2019 May; 38(19): 3569–3584. Published online 2019 Jan 21. doi: 10.1038/s41388-019-0690-0

Correction in:: Oncogene. 2019 Sep 17

PMCID:: PMC7568686

Abstract Article PDF–1.8M

Select item 732206715.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 714938916.

Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity

Sandeep Kumar, Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Subhash C. Sinha, Rajyasree Emmadi, Kent Hoskins, Oana Danciu, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana

Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7961–7970. Published online 2020 Mar 24. doi: 10.1073/pnas.1921325117

PMCID:: PMC7149389

Abstract Article PDF–2.4M

Select item 709855417.

MLK3 is a newly identified microRNA-520b target that regulates liver cancer cell migration

Fei Zhang, Yu Zhu, Shuhua Wu, Guodong Hou, Nianxiang Wu, Lirun Qian, Dong Yang

PLoS One. 2020; 15(3): e0230716. Published online 2020 Mar 26. doi: 10.1371/journal.pone.0230716

PMCID:: PMC7098554

Abstract Article PDF–1.2M

Select item 668424018.

IFNγ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5

Diana Saleiro, Gavin T. Blyth, Ewa M. Kosciuczuk, Patrick A. Ozark, Beata Majchrzak-Kita, Ahmet D. Arslan, Mariafausta Fischietti, Neha K. Reddy, Curt M. Horvath, Roger J. Davis, Eleanor N. Fish, Leonidas C. Platanias

Sci Signal. Author manuscript; available in PMC 2019 Nov 20.

Published in final edited form as: Sci Signal. 2018 Nov 20; 11(557): eaap9921. Published online 2018 Nov 20. doi: 10.1126/scisignal.aap9921

PMCID:: PMC6684240

Abstract Article PDF–2.2M

Select item 612019019.

Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3

Malgorzata E. Kokoszka, Stefanie L. Kall, Sehar Khosla, Jennifer E. McGinnis, Arnon Lavie, Brian K. Kay

J Biol Chem. 2018 Aug 31; 293(35): 13553–13565. Published online 2018 Jul 6. doi: 10.1074/jbc.RA117.000262

PMCID:: PMC6120190

Abstract Article PDF–2.3M

Select item 583915820.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

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