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Select item 112102451.

Prognostic and therapeutic roles of SETD2 in cutaneous melanoma

Jiani Xiong, Liping Zhu, Yunrong Fu, Zhoujie Ye, Cuimin Deng, Xinrui Wang, Yu Chen

Aging (Albany NY) 2024 Jun 15; 16(11): 9692–9708. Published online 2024 Jun 5. doi: 10.18632/aging.205894

PMCID:: PMC11210245

Abstract Article PDF–2.3M

Select item 111481842.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 108952703.

Methyltransferase Setd2 prevents T cell–mediated autoimmune diseases via phospholipid remodeling

Yali Chen, Kun Chen, Ha Zhu, Hua Qin, Juan Liu, Xuetao Cao

Proc Natl Acad Sci U S A. 2024 Feb 20; 121(8): e2314561121. Published online 2024 Feb 15. doi: 10.1073/pnas.2314561121

PMCID:: PMC10895270

Abstract Article PDF–7.5M

Select item 107661984.

SETD2 loss in renal epithelial cells drives epithelial‐to‐mesenchymal transition in a TGF‐β‐independent manner

Tianchu Wang, Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Xia Zhao, Sungho Kim, Liguo Wang, Jeong‐Heon Lee, Huijun Luo, Erik P. Castle, Douglas F. Lake, Thai H. Ho, Keith D. Robertson

Mol Oncol. 2024 Jan; 18(1): 44–61. Published online 2023 Jul 17. doi: 10.1002/1878-0261.13487

PMCID:: PMC10766198

Abstract Article PDF–2.7M

Select item 106443295.

Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway

Chunxiao Ma, Min Liu, Wenxin Feng, Hanyu Rao, Wei Zhang, Changwei Liu, Yue Xu, Ziyi Wang, Yan Teng, Xiao Yang, Li Ni, Jin Xu, Wei‐Qiang Gao, Bing Lu, Li Li

Clin Transl Med. 2023 Nov; 13(11): e1475. Published online 2023 Nov 14. doi: 10.1002/ctm2.1475

PMCID:: PMC10644329

Abstract Article PDF–2.7M

Select item 106302526.

Epigenotype–genotype–phenotype correlations in SETD1A and SETD2 chromatin disorders

Sunwoo Lee, Lara Menzies, Eleanor Hay, Eguzkine Ochoa, France Docquier, Fay Rodger, Charu Deshpande, Nicola C Foulds, Sébastien Jacquemont, Khadije Jizi, Henriette Kiep, Alison Kraus, Katharina Löhner, Patrick J Morrison, Bernt Popp, Ruth Richardson, Arie van Haeringen, Ezequiel Martin, Ana Toribio, Fudong Li, Wendy D Jones, Francis H Sansbury, Eamonn R Maher

Hum Mol Genet. 2023 Nov 15; 32(22): 3123–3134. Published online 2023 May 11. doi: 10.1093/hmg/ddad079

PMCID:: PMC10630252

Abstract Article PDF–1.4M

Select item 106291557.

SETD2 deficiency promotes renal fibrosis through the TGF‐β/Smad signalling pathway in the absence of VHL

Changwei Liu, Li Ni, Xiaoxue Li, Hanyu Rao, Wenxin Feng, Yiwen Zhu, Wei Zhang, Chunxiao Ma, Yue Xu, Liming Gui, Ziyi Wang, Rebiguli Aji, Jin Xu, Wei‐Qiang Gao, Li Li

Clin Transl Med. 2023 Nov; 13(11): e1468. Published online 2023 Nov 7. doi: 10.1002/ctm2.1468

PMCID:: PMC10629155

Abstract Article PDF–24M

Select item 105658768.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105236809.

SETD2 safeguards the genome against isochromosome formation

Frank M. Mason, Emily S. Kounlavong, Anteneh T. Tebeje, Rashmi Dahiya, Tiffany Guess, Abid Khan, Logan Vlach, Stephen R. Norris, Courtney A. Lovejoy, Ruhee Dere, Brian D. Strahl, Ryoma Ohi, Peter Ly, Cheryl Lyn Walker, W. Kimryn Rathmell

Proc Natl Acad Sci U S A. 2023 Sep 26; 120(39): e2303752120. Published online 2023 Sep 18. doi: 10.1073/pnas.2303752120

PMCID:: PMC10523680

Abstract Article PDF–3.5M

Select item 1041923210.

Investigating the Role of FoxP3 in Renal Cell Carcinoma Metastasis with BAP1 or SEDT2 Mutation

Shan Xu, Xinfeng Hu, Yue Chong, Guodong Zhu

Int J Mol Sci. 2023 Aug; 24(15): 12301. Published online 2023 Aug 1. doi: 10.3390/ijms241512301

PMCID:: PMC10419232

Abstract Article PDF–4.7M

Select item 1036027011.

SETD2 variation correlates with tumor mutational burden and MSI along with improved response to immunotherapy

Xiaobin Zheng, Jing Lin, Jiani Xiong, Yanfang Guan, Bin Lan, Yi Li, Xuan Gao, Zhaodong Fei, Lisha Chen, Lizhu Chen, Ling Chen, Gang Chen, Zengqing Guo, Xin Yi, Weiguo Cao, Xinghao Ai, Chengzhi Zhou, Xiaofeng Li, Jun Zhao, Xiangtao Yan, Qitao Yu, Lu Si, Yu Chen, Chuanben Chen

BMC Cancer. 2023; 23: 686. Published online 2023 Jul 21. doi: 10.1186/s12885-023-10920-4

PMCID:: PMC10360270

Abstract Article PDF–1.9M

Select item 1029783212.

Clinical Heterogeneity and Different Phenotypes in Patients with SETD2 Variants: 18 New Patients and Review of the Literature

Alejandro Parra, Rachel Rabin, John Pappas, Patricia Pascual, Mario Cazalla, Pedro Arias, Natalia Gallego-Zazo, Alfredo Santana, Ignacio Arroyo, Mercè Artigas, Harry Pachajoa, Yasemin Alanay, Ozlem Akgun-Dogan, Lyse Ruaud, Nathalie Couque, Jonathan Levy, Gloria Liliana Porras-Hurtado, Fernando Santos-Simarro, Maria Juliana Ballesta-Martinez, Encarna Guillén-Navarro, Hugo Muñoz-Hernández, Julián Nevado, Spanish OverGrowth Registry Initiative, Jair Tenorio-Castano, Pablo Lapunzina

Genes (Basel) 2023 Jun; 14(6): 1179. Published online 2023 May 29. doi: 10.3390/genes14061179

PMCID:: PMC10297832

Abstract Article PDF–1.8M

Select item 1023117713.

The SETD2 Methyltransferase Supports Productive HPV31 Replication through the LEDGF/CtIP/Rad51 Pathway

Michelle Mac, Brianna M. DeVico, Sophia M. Raspanti, Cary A. Moody

J Virol. 2023 May; 97(5): e00201-23. Published online 2023 May 8. doi: 10.1128/jvi.00201-23

PMCID:: PMC10231177

Abstract Article PDF–4.2M

Select item 988113614.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 987555615.

Clinical and Histopathologic Characterization of SETD2-Mutated Colorectal Cancer

Omar Bushara, James Wester, Danielle Jacobsen, Leyu Sun, Samuel Weinberg, Juehua Gao, Lawrence J Jennings, Lu Wang, Shannon M. Lauberth, Feng Yue, Jie Liao, Guang-Yu Yang

Hum Pathol. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Hum Pathol. 2023 Jan; 131: 9–16. Published online 2022 Dec 9. doi: 10.1016/j.humpath.2022.12.001

PMCID:: PMC9875556

Abstract Article PDF–1.1M

Select item 985197316.

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

Yadi Zhou, Yuan Liu, Shagun Gupta, Mauricio I. Paramo, Yuan Hou, Chengsheng Mao, Yuan Luo, Julius Judd, Shayne Wierbowski, Marta Bertolotti, Mriganka Nerkar, Lara Jehi, Nir Drayman, Vlad Nicolaescu, Haley Gula, Savaş Tay, Glenn Randall, Peihui Wang, John T. Lis, Cédric Feschotte, Serpil C. Erzurum, Feixiong Cheng, Haiyuan Yu

Nat Biotechnol. Author manuscript; available in PMC 2023 Jan 20.

Published in final edited form as: Nat Biotechnol. 2023 Jan; 41(1): 128–139. Published online 2022 Oct 10. doi: 10.1038/s41587-022-01474-0

PMCID:: PMC9851973

Abstract Article PDF–4.0M

Select item 983984517.

Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis

Ningning Niu, Xuqing Shen, Li Zhang, Yueyue Chen, Ping Lu, Wenjuan Yang, Mingzhu Liu, Juanjuan Shi, Dapeng Xu, Yingying Tang, Xiaotong Yang, Yawen Weng, Xinxin Zhao, Lian‐Ming Wu, Yongwei Sun, Jing Xue

Adv Sci (Weinh) 2023 Jan; 10(2): 2202937. Published online 2022 Dec 1. doi: 10.1002/advs.202202937

PMCID:: PMC9839845

Abstract Article PDF–5.6M

Select item 982519218.

CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing

Emanuela Kerschbamer, Michele Arnoldi, Takshashila Tripathi, Miguel Pellegrini, Samuele Maturi, Serkan Erdin, Elisa Salviato, Francesca Di Leva, Endre Sebestyén, Erik Dassi, Giulia Zarantonello, Matteo Benelli, Eric Campos, M Albert Basson, James F Gusella, Stefano Gustincich, Silvano Piazza, Francesca Demichelis, Michael E Talkowski, Francesco Ferrari, Marta Biagioli

Nucleic Acids Res. 2022 Dec 9; 50(22): 12809–12828. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1134

PMCID:: PMC9825192

Abstract Article PDF–2.1M

Select item 976969819.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 971951020.

Setd2 supports GATA3⁺ST2⁺ thymic-derived Treg cells and suppresses intestinal inflammation

Zhaoyun Ding, Ting Cai, Jupei Tang, Hanxiao Sun, Xinyi Qi, Yunpeng Zhang, Yan Ji, Liyun Yuan, Huidan Chang, Yanhui Ma, Hong Zhou, Li Li, Huiming Sheng, Ju Qiu

Nat Commun. 2022; 13: 7468. Published online 2022 Dec 3. doi: 10.1038/s41467-022-35250-0

PMCID:: PMC9719510

Abstract Article PDF–4.5M

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