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Select item 111085191.

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

Lorraine Springuel, Elisabeth Losdyck, Pascale Saussoy, Béatrice Turcq, François-Xavier Mahon, Laurent Knoops, Jean-Christophe Renauld

Cell Mol Life Sci. 2016 Dec; 73(24): 4739–4748. Published online 2016 Jul 19. doi: 10.1007/s00018-016-2310-2

PMCID:: PMC11108519

Abstract Article PDF–1.2M

Select item 109457072.

Comparative interactome analysis of α-arrestin families in human and Drosophila

Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam

eLife. 2024; 12: RP88328. Published online 2024 Jan 25. doi: 10.7554/eLife.88328

PMCID:: PMC10945707

Abstract Article PDF–2.8M

Select item 109217543.

CD146⁺CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway

Zhicheng Yu, Qian Zhang, Sitian Wei, Yang Zhang, Ting Zhou, Qi Zhang, Rui Shi, Dmitry Zinovkin, Zahidul Islam Pranjol, Jun Zhang, Hongbo Wang

Cell Commun Signal. 2024; 22: 170. Published online 2024 Mar 8. doi: 10.1186/s12964-024-01550-9

PMCID:: PMC10921754

Abstract Article PDF–12M

Select item 109168664.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 109059335.

Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway

Bisheng Cheng, Lingfeng Li, Tianlong Luo, Qiong Wang, Yong Luo, Shoumin Bai, Kaiwen Li, Yiming Lai, Hai Huang

J Exp Clin Cancer Res. 2024; 43: 67. Published online 2024 Mar 1. doi: 10.1186/s13046-024-02962-8

PMCID:: PMC10905933

Abstract Article PDF–7.0M

Select item 108003526.

WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

Qingling Huang, Yi Xiao, Ting Lan, Youguang Lu, Li Huang, Dali Zheng

Int J Oral Sci. 2024; 16: 7. Published online 2024 Jan 22. doi: 10.1038/s41368-024-00279-y

PMCID:: PMC10800352

Abstract Article PDF–4.2M

Select item 106739317.

METTL3 promotes colorectal cancer progression through activating JAK1/STAT3 signaling pathway

Yuechao Sun, Weipeng Gong, Song Zhang

Cell Death Dis. 2023 Nov; 14(11): 765. Published online 2023 Nov 25. doi: 10.1038/s41419-023-06287-w

PMCID:: PMC10673931

Abstract Article PDF–6.5M

Select item 105085678.

Case control study: G-allele of rs4244165 in JAK1 gene correlated with high-level brief psychiatric rating scale in bipolar patients

Akila Ahlem Elouaer Benkortbi Elouaer, Bochra Ben Mohamed, Ferid Zaafrane, Lotfi Gaha, Besma Bel Hadj Jrad Tensaout

Medicine (Baltimore) 2023 Sep 15; 102(37): e34652. Published online 2023 Sep 15. doi: 10.1097/MD.0000000000034652

PMCID:: PMC10508567

Abstract Article PDF–529K

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1010465910.

EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1

Yihui Pan, Guannan Shu, Liangmin Fu, Kangbo Huang, Xinwei Zhou, Chengpeng Gui, Huashan Liu, Xiaohan Jin, Minyu Chen, Pengju Li, Junjie Cen, Zihao Feng, Jun Lu, Zhenhua Chen, Jiaying Li, Quanhui Xu, Yinghan Wang, Hui Liang, Zhu Wang, Qiong Deng, Wei Chen, Junhang Luo, Jiefeng Yang, Jiaxing Zhang, Jinhuan Wei

Adv Sci (Weinh) 2023 Apr; 10(11): 2206792. Published online 2023 Feb 12. doi: 10.1002/advs.202206792

PMCID:: PMC10104659

Abstract Article PDF–7.7M

Select item 1009507511.

JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling

Alice H. Grant, Alejandro C. Rodriguez, Omar J. Rodriguez Moncivais, Shengjie Sun, Lin Li, Jonathon E. Mohl, Ming-Ying Leung, Robert A. Kirken, Georgialina Rodriguez

Int J Mol Sci. 2023 Apr; 24(7): 6805. Published online 2023 Apr 6. doi: 10.3390/ijms24076805

PMCID:: PMC10095075

Abstract Article PDF–6.0M

Select item 1007290612.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 993818913.

KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer

Gang Quan, Jian Xu, Jie Wang, Xinyuan Liu, Jichuan Xu, Jianxin Jiang

Cell Death Dis. 2023 Feb; 14(2): 137. Published online 2023 Feb 17. doi: 10.1038/s41419-023-05679-2

PMCID:: PMC9938189

Abstract Article PDF–8.4M

Select item 988113614.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 986997215.

Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation

Catherine M. Biggs, Anna Cordeiro-Santanach, Sergey V. Prykhozhij, Adam P. Deveau, Yi Lin, Kate L. Del Bel, Felix Orben, Robert J. Ragotte, Aabida Saferali, Sara Mostafavi, Louie Dinh, Darlene Dai, Katja G. Weinacht, Kerry Dobbs, Lisa Ott de Bruin, Mehul Sharma, Kevin Tsai, John J. Priatel, Richard A. Schreiber, Jacob Rozmus, Martin C.K. Hosking, Kevin E. Shopsowitz, Margaret L. McKinnon, Suzanne Vercauteren, Michael Seear, Luigi D. Notarangelo, Francis C. Lynn, Jason N. Berman, Stuart E. Turvey

JCI Insight. 2022 Dec 22; 7(24): e150849. Published online 2022 Dec 22. doi: 10.1172/jci.insight.150849

PMCID:: PMC9869972

Abstract Article PDF–13M

Select item 966343316.

Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation

Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li, Wenqi Wang, Ruhong Zhou, Tianhua Zhou, Aifu Lin

Nat Commun. 2022; 13: 6951. Published online 2022 Nov 14. doi: 10.1038/s41467-022-34346-x

PMCID:: PMC9663433

Abstract Article PDF–4.4M

Select item 966175717.

JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

Qin Lin, Zheng Chen, Wei Shi, Zeheng Lv, Xiaoping Wan, Kun Gao

Cell Commun Signal. 2022; 20: 177. Published online 2022 Nov 14. doi: 10.1186/s12964-022-00990-5

PMCID:: PMC9661757

Abstract Article PDF–7.1M

Select item 952364518.

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han

Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6

PMCID:: PMC9523645

Abstract Article PDF–3.9M

Select item 950171419.

Partial human Janus kinase 1 deficiency predominantly impairs responses to interferon gamma and intracellular control of mycobacteria

Vanessa Daza-Cajigal, Adriana S. Albuquerque, Dan F. Young, Michael J. Ciancanelli, Dale Moulding, Ivan Angulo, Valentine Jeanne-Julien, Jérémie Rosain, Ekaterina Minskaia, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Richard E. Randall, Timothy D. McHugh, Adrian J. Thrasher, Siobhan O. Burns

Front Immunol. 2022; 13: 888427. Published online 2022 Sep 9. doi: 10.3389/fimmu.2022.888427