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Items: 1 to 20 of 88

1.
Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer
Shuyong Yu, Ruisha Tu, Zhaowei Chen, Jian Song, Ping Li, Feixiang Hu, Guihong Yuan, Ronglin Zhang, Yini Li
BMC Med Genomics. 2023; 16: 209. Published online 2023 Sep 5. doi: 10.1186/s12920-023-01645-1
PMCID:
PMC10478487
AbstractArticlePDF–5.1M
2.
The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway
Hu Xu, Bingying Fang, Chengzhen Bao, Xiuhui Mao, Chunhua Zhu, Lan Ye, Qian Liu, Yaqing Li, Chunxiu Du, Hang Qi, Xiaoyan Zhang, Youfei Guan
Cells. 2022 Sep; 11(17): 2720. Published online 2022 Aug 31. doi: 10.3390/cells11172720
PMCID:
PMC9454981
AbstractArticlePDF–6.2M
3.
Nanomolar EP4 receptor potency and expression of eicosanoid-related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia
Ulrike Ries Feddersen, Sebastian Kjærgaard Hendel, Mark Alexander Berner-Hansen, Thomas Andrew Jepps, Mark Berner-Hansen, Niels Bindslev
BMC Gastroenterol. 2022; 22: 234. Published online 2022 May 12. doi: 10.1186/s12876-022-02311-z
Correction in:
BMC Gastroenterol. 2022; 22: 298.
PMCID:
PMC9097415
AbstractArticlePDF–1.2M
4.
Prostaglandin E2 directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF‐β signalling
Marie Goepp, Siobhan Crittenden, You Zhou, Adriano G Rossi, Shuh Narumiya, Chengcan Yao
Immunology. 2021 Dec; 164(4): 777–791. Published online 2021 Oct 1. doi: 10.1111/imm.13417
PMCID:
PMC8561111
AbstractArticlePDF–1.4M
5.
Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage
Lin Peng, Anca Chelariu-Raicu, Yao Ye, Zhi Ma, Huixia Yang, Hellen Ishikawa-Ankerhold, Martina Rahmeh, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt
Int J Mol Sci. 2021 Sep; 22(17): 9134. Published online 2021 Aug 24. doi: 10.3390/ijms22179134
PMCID:
PMC8430623
AbstractArticlePDF–30M
6.
CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression
Hong-Yong Cui, Shi-Jie Wang, Fei Song, Xu Cheng, Gang Nan, Yu Zhao, Mei-Rui Qian, Xi Chen, Jia-Yue Li, Fen-Ling Liu, Yu-Meng Zhu, Ruo-Fei Tian, Bin Wang, Bin Wu, Yang Zhang, Xiu-Xuan Sun, Ting Guo, Xiang-Min Yang, Hai Zhang, Ling Li, Jing Xu, Hui-Jie Bian, Jian-Li Jiang, Zhi-Nan Chen
Signal Transduct Target Ther. 2021; 6: 268. Published online 2021 Jul 14. doi: 10.1038/s41392-021-00677-2
PMCID:
PMC8280106
AbstractArticlePDF–5.2M
7.
Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease
Hari K. Somineni, Sini Nagpal, Suresh Venkateswaran, David J. Cutler, David T. Okou, Talin Haritunians, Claire L. Simpson, Ferdouse Begum, Lisa W. Datta, Antonio J. Quiros, Jenifer Seminerio, Emebet Mengesha, Jonathan S. Alexander, Robert N. Baldassano, Sharon Dudley-Brown, Raymond K. Cross, Themistocles Dassopoulos, Lee A. Denson, Tanvi A. Dhere, Heba Iskandar, Gerald W. Dryden, Jason K. Hou, Sunny Z. Hussain, Jeffrey S. Hyams, Kim L. Isaacs, Howard Kader, Michael D. Kappelman, Jeffry Katz, Richard Kellermayer, John F. Kuemmerle, Mark Lazarev, Ellen Li, Peter Mannon, Dedrick E. Moulton, Rodney D. Newberry, Ashish S. Patel, Joel Pekow, Shehzad A. Saeed, John F. Valentine, Ming-Hsi Wang, Jacob L. McCauley, Maria T. Abreu, Traci Jester, Zarela Molle-Rios, Sirish Palle, Ellen J. Scherl, John Kwon, John D. Rioux, Richard H. Duerr, Mark S. Silverberg, Michael E. Zwick, Christine Stevens, Mark J. Daly, Judy H. Cho, Greg Gibson, Dermot P.B. McGovern, Steven R. Brant, Subra Kugathasan
Am J Hum Genet. 2021 Mar 4; 108(3): 431–445. Published online 2021 Feb 17. doi: 10.1016/j.ajhg.2021.02.001
PMCID:
PMC8008495
AbstractArticlePDF–1.5M
8.
Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis
Peng-Bo Wu, Rao Qian, Chai Hong, Yi-tian Guo, Yuan-jie Yu, Guo Zhang, Shi-Yun Tan
Medicine (Baltimore) 2020 Aug 21; 99(34): e19756. Published online 2020 Aug 21. doi: 10.1097/MD.0000000000019756
PMCID:
PMC7447366
AbstractArticlePDF–199K
9.
Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E2 Activation in Human Podocytes
Eva Mangelsen, Michael Rothe, Angela Schulz, Aikaterini Kourpa, Daniela Panáková, Reinhold Kreutz, Juliane Bolbrinker
Cells. 2020 May; 9(5): 1256. Published online 2020 May 19. doi: 10.3390/cells9051256
PMCID:
PMC7290667
AbstractArticlePDF–2.1M
10.
Excessive EP4 Signaling in Smooth Muscle Cells Induces Abdominal Aortic Aneurysm by Amplifying Inflammation
Taro Hiromi, Utako Yokoyama, Daisuke Kurotaki, Al Mamun, Ryo Ishiwata, Yasuhiro Ichikawa, Hiroshi Nishihara, Masanari Umemura, Takayuki Fujita, Shota Yasuda, Tomoyuki Minami, Motohiko Goda, Keiji Uchida, Shinichi Suzuki, Ichiro Takeuchi, Munetaka Masuda, Richard M. Breyer, Tomohiko Tamura, Yoshihiro Ishikawa
Arterioscler Thromb Vasc Biol. 2020 Jun; 40(6): 1559–1573. Published online 2020 Apr 23. doi: 10.1161/ATVBAHA.120.314297
PMCID:
PMC7253191
AbstractArticlePDF–4.1M
11.
Improved homology modeling of the human & rat EP4 prostanoid receptors
Melissa C. Holt, Chi S. Ho, M. Inés Morano, Stephen D. Barrett, Adam J. Stein
BMC Mol Cell Biol. 2019; 20: 37. Published online 2019 Aug 27. doi: 10.1186/s12860-019-0212-5
PMCID:
PMC6712885
AbstractArticlePDF–6.4M
12.
Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis
Charlotte Klasen, Anja Meyer, Paula S. Wittekind, Iris Waqué, Schafiq Nabhani, David M. Kofler
Arthritis Res Ther. 2019; 21: 159. Published online 2019 Jun 28. doi: 10.1186/s13075-019-1948-1
PMCID:
PMC6599260
AbstractArticlePDF–1.7M
13.
Cellular density‐dependent increases in HIF‐1α compete with c‐Myc to down‐regulate human EP4 receptor promoter activity through Sp‐1‐binding region
Naofumi Seira, Kazuyuki Yamagata, Keijo Fukushima, Yumi Araki, Naoki Kurata, Naoki Yanagisawa, Masato Mashimo, Hiroyuki Nakamura, John W. Regan, Toshihiko Murayama, Hiromichi Fujino
Pharmacol Res Perspect. 2018 Dec; 6(6): e00441. Published online 2018 Nov 11. doi: 10.1002/prp2.441
PMCID:
PMC6230926
AbstractArticlePDF–3.1M
14.
Evidence for PTGER4,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level
Sophie K. M. Heinrichs, Timo Hess, Jessica Becker, Lutz Hamann, Yogesh K. Vashist, Katja Butterbach, Thomas Schmidt, Hakan Alakus, Iurii Krasniuk, Aksana Höblinger, Philipp Lingohr, Monika Ludwig, Alexander F. Hagel, Claus W. Schildberg, Lothar Veits, Ugne Gyvyte, Katharina Weise, Vitalia Schüller, Anne C. Böhmer, Julia Schröder, Jan Gehlen, Nicole Kreuser, Sebastian Hofer, Hauke Lang, Florian Lordick, Peter Malfertheiner, Markus Moehler, Oliver Pech, Nikolaos Vassos, Ernst Rodermann, Jakob R. Izbicki, Martin Kruschewski, Katja Ott, Ralf R. Schumann, Michael Vieth, Elisabeth Mangold, Evita Gasenko, Limas Kupcinskas, Hermann Brenner, Peter Grimminger, Luis Bujanda, Federico Sopeña, Jesús Espinel, Concha Thomson, Ángeles Pérez‐Aísa, Rafael Campo, Fernando Geijo, Daniela Collette, Christiane Bruns, Katharina Messerle, Ines Gockel, Markus M. Nöthen, Hans Lippert, Karsten Ridwelski, Angel Lanas, Gisela Keller, Michael Knapp, Marcis Leja, Juozas Kupcinskas, Maria A. García‐González, Marino Venerito, Johannes Schumacher
Cancer Med. 2018 Oct; 7(10): 5057–5065. Published online 2018 Sep 6. doi: 10.1002/cam4.1719
PMCID:
PMC6198243
AbstractArticlePDF–408K
15.
Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases
Lin-Li Chang, Wen-Hung Hsu, Mou-Chieh Kao, Chih-Chung Chou, Chung-Cheng Lin, Chung-Jung Liu, Bi-Chuang Weng, Fu-Chen Kuo, Chao-Hung Kuo, Ming-Hong Lin, Chun-Jen Wang, Chun-Hung Lin, Deng-Chyang Wu, Shau-Ku Huang
Sci Rep. 2018; 8: 3821. Published online 2018 Feb 28. doi: 10.1038/s41598-018-20957-2
PMCID:
PMC5830506
AbstractArticlePDF–1.4M
16.
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu
Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0
PMCID:
PMC5826926
AbstractArticlePDF–2.3M
17.
COX-1/PGE2/EP4 alleviates mucosal injury by upregulating β-arr1-mediated Akt signaling in colitis
Xiaojie Peng, Jianzhong Li, Siwei Tan, Minyi Xu, Jin Tao, Jie Jiang, Huiling Liu, Bin Wu
Sci Rep. 2017; 7: 1055. Published online 2017 Apr 21. doi: 10.1038/s41598-017-01169-6
PMCID:
PMC5430694
AbstractArticlePDF–9.0M
18.
Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms
Sakhila K. Banu, JeHoon Lee, V. O. Speights, Jr., Anna Starzinski-Powitz, Joe A. Arosh
Mol Endocrinol. August 1, 2009; 23(8): 1291–1305. doi: 10.1210/me.2009-0017
PMCID:
PMC5419188
AbstractArticle
19.
Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer
Jeffrey F. Hiken, James I. McDonald, Keith F. Decker, Cesar Sanchez, Jeremy Hoog, Nathan D. VanderKraats, Kyle L. Jung, Margaret Akinhanmi, Lisa E. Rois, Matthew J. Ellis, John R. Edwards
Oncogene. Author manuscript; available in PMC 2017 May 21.
Published in final edited form as: Oncogene. 2017 Apr 20; 36(16): 2319–2327. Published online 2016 Nov 21. doi: 10.1038/onc.2016.397
PMCID:
PMC5398938
AbstractArticlePDF–1.0M
20.
Systematic protein–protein interaction mapping for clinically relevant human GPCRs
Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar
Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430
PMCID:
PMC5371730
AbstractArticlePDF–4.1M

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