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Select item 111733061.

Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection

Jorge Lindo, Célia Nogueira, Rui Soares, Nuno Cunha, Maria Rosário Almeida, Lisa Rodrigues, Patrícia Coelho, Francisco Rodrigues, Rodrigo A. Cunha, Teresa Gonçalves

Int J Mol Sci. 2024 Jun; 25(11): 6135. Published online 2024 Jun 2. doi: 10.3390/ijms25116135

PMCID:: PMC11173306

Abstract Article PDF–295K

Select item 110838222.

Clinical and Biologic Correlates of ADORA2A Transcriptomic Expression in Cancer

Aditya Shreenivas, Daisuke Nishizaki, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Shumei Kato, Razelle Kurzrock

Int J Mol Sci. 2024 May; 25(9): 4742. Published online 2024 Apr 26. doi: 10.3390/ijms25094742

PMCID:: PMC11083822

Abstract Article PDF–1.7M

Select item 110323033.

A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis

Qingyang Lei, Shanshan Zhen, Lei Zhang, Qitai Zhao, Li Yang, Yi Zhang

Cancer Immunol Immunother. 2024 Jun; 73(6): 108. Published online 2024 Apr 20. doi: 10.1007/s00262-024-03689-3

PMCID:: PMC11032303

Abstract Article PDF–13M

Select item 110287874.

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

Sebastian F. M. Häusler, Itsaso Montalbán del Barrio, Jenny Strohschein, P. Anoop Chandran, Jörg B. Engel, Arnd Hönig, Monika Ossadnik, Evi Horn, Birgitt Fischer, Mathias Krockenberger, Stefan Heuer, Ahmed Adel Seida, Markus Junker, Hermann Kneitz, Doris Kloor, Karl-Norbert Klotz, Johannes Dietl, Jörg Wischhusen

Cancer Immunol Immunother. 2011 Oct; 60(10): 1405–1418. Published online 2011 Jun 3. doi: 10.1007/s00262-011-1040-4

PMCID:: PMC11028787

Abstract Article PDF–2.1M

Select item 110146735.

CD8⁺ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4

Siqi Chen, Jie Fan, Ping Xie, Jihae Ahn, Michelle Fernandez, Leah K. Billingham, Jason Miska, Jennifer D. Wu, Derek A. Wainwright, Deyu Fang, Jeffrey A. Sosman, Yong Wan, Yi Zhang, Navdeep S. Chandel, Bin Zhang

J Clin Invest. 2024 Apr 15; 134(8): e170071. Published online 2024 Mar 5. doi: 10.1172/JCI170071

PMCID:: PMC11014673

Abstract Article PDF–2.7M

Select item 107211526.

ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers

Na Jing, Kai Zhang, Xinyu Chen, Kaiyuan Liu, Jinming Wang, Lingling Xiao, Wentian Zhang, Pengfei Ma, Penghui Xu, Chaping Cheng, Deng Wang, Huifang Zhao, Yuman He, Zhongzhong Ji, Zhixiang Xin, Yujiao Sun, Yingchao Zhang, Wei Bao, Yiming Gong, Liancheng Fan, Yiyi Ji, Guanglei Zhuang, Qi Wang, Baijun Dong, Pengcheng Zhang, Wei Xue, Wei-Qiang Gao, Helen He Zhu

J Clin Invest. 2023 Dec 15; 133(24): e168670. Published online 2023 Dec 15. doi: 10.1172/JCI168670

PMCID:: PMC10721152

Abstract Article PDF–22M

Select item 106362007.

ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma

Longyan Ran, Xiao Mou, Zhenglin Peng, Xiaochen Li, Meirong Li, Duo Xu, Zixi Yang, Xingwang Sun, Tao Yin

Sci Rep. 2023; 13: 19477. Published online 2023 Nov 9. doi: 10.1038/s41598-023-46521-1

PMCID:: PMC10636200

Abstract Article PDF–4.6M

Select item 102960928.

Molecular Biophysics of Class A G Protein Coupled Receptors–Lipids Interactome at a Glance—Highlights from the A_2A Adenosine Receptor

Efpraxia Tzortzini, Antonios Kolocouris

Biomolecules. 2023 Jun; 13(6): 957. Published online 2023 Jun 7. doi: 10.3390/biom13060957

PMCID:: PMC10296092

Abstract Article PDF–5.2M

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1013205210.

Striatopallidal adenosine A_2A receptor modulation of goal-directed behavior: Homeostatic control with cognitive flexibility

Jiang-Fan Chen, Doo-Sup Choi, Rodrigo A. Cunha

Neuropharmacology. Author manuscript; available in PMC 2024 Mar 15.

Published in final edited form as: Neuropharmacology. 2023 Mar 15; 226: 109421. Published online 2023 Jan 10. doi: 10.1016/j.neuropharm.2023.109421

PMCID:: PMC10132052

Abstract Article PDF–804K

Select item 1009138011.

Role of adenosine A2a receptor in cancers and autoimmune diseases

Hongling Ye, Junqi Zhao, Xuejing Xu, Dagan Zhang, Han Shen, Sen Wang

Immun Inflamm Dis. 2023 Apr; 11(4): e826. Published online 2023 Apr 12. doi: 10.1002/iid3.826

PMCID:: PMC10091380

Abstract Article PDF–1015K

Select item 996350012.

Increased Density of Endogenous Adenosine A_2A Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients

Héctor Godoy-Marín, Verónica Jiménez-Sábado, Carmen Tarifa, Antonino Ginel, Joana Larupa Dos Santos, Bo Hjorth Bentzen, Leif Hove-Madsen, Francisco Ciruela

Int J Mol Sci. 2023 Feb; 24(4): 3668. Published online 2023 Feb 11. doi: 10.3390/ijms24043668

PMCID:: PMC9963500

Abstract Article PDF–1.6M

Select item 981303813.

Adenosine A_2A receptor availability in patients with early- and moderate-stage Parkinson’s disease

Imran Waggan, Eero Rissanen, Jouni Tuisku, Juho Joutsa, Semi Helin, Riitta Parkkola, Juha O. Rinne, Laura Airas

J Neurol. 2023; 270(1): 300–310. Published online 2022 Sep 2. doi: 10.1007/s00415-022-11342-1

PMCID:: PMC9813038

Abstract Article PDF–1.4M

Select item 979798814.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 969742515.

Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease

Vasileios Siokas, Dimitra S. Mouliou, Ioannis Liampas, Athina-Maria Aloizou, Vasiliki Folia, Elli Zoupa, Anastasios Papadimitriou, Eleftherios Lavdas, Dimitrios P. Bogdanos, Efthimios Dardiotis

Int J Mol Sci. 2022 Nov; 23(22): 14400. Published online 2022 Nov 19. doi: 10.3390/ijms232214400